Kurianlab
@kurianlab.bsky.social
RNA biology of embryonic development and disease #heart #ribosome #translational_control #RBP #splicing @UK_Frankfurt Alum:@salkinstitute @UcSandiego
https://kurianlab.com/
https://kurianlab.com/
Pinned
Kurianlab
@kurianlab.bsky.social
· Sep 8
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Kurianlab
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications
Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...
www.nature.com
November 10, 2025 at 5:09 PM
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Reposted by Kurianlab
pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 9, 2025 at 12:55 AM
pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.
Reposted by Kurianlab
What happens to transcription upon oxidative DNA damage? 🧬💥
RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦
👀📄 How does this happen? Find out in our new preprint👇 www.biorxiv.org/cgi/content/...
RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦
👀📄 How does this happen? Find out in our new preprint👇 www.biorxiv.org/cgi/content/...
Oxidative stress triggers RNAPII arrest through PARylation and DNA damage
UV or gamma irradiation, as well as certain chemicals, generate DNA damage that disrupts transcription through a variety of well-characterised mechanisms. In contrast, the transcriptional response to ...
www.biorxiv.org
November 7, 2025 at 12:13 PM
What happens to transcription upon oxidative DNA damage? 🧬💥
RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦
👀📄 How does this happen? Find out in our new preprint👇 www.biorxiv.org/cgi/content/...
RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦
👀📄 How does this happen? Find out in our new preprint👇 www.biorxiv.org/cgi/content/...
Reposted by Kurianlab
If said women work for your competitors, I guess maybe
November 6, 2025 at 6:46 PM
If said women work for your competitors, I guess maybe
Reposted by Kurianlab
Less than an hour later the first preprint was already paired to q.e.d! 🔥🍷
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 4:33 PM
Less than an hour later the first preprint was already paired to q.e.d! 🔥🍷
Reposted by Kurianlab
Starting your own lab is exciting—but challenging.
Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026.
Professional coaching, peer networking & practical tips for new PIs.
Apply by Nov 30, 2025.
👉https://yi-workshop.gbm-online.de/yi-workshop-2.html
Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026.
Professional coaching, peer networking & practical tips for new PIs.
Apply by Nov 30, 2025.
👉https://yi-workshop.gbm-online.de/yi-workshop-2.html
November 6, 2025 at 9:56 AM
Starting your own lab is exciting—but challenging.
Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026.
Professional coaching, peer networking & practical tips for new PIs.
Apply by Nov 30, 2025.
👉https://yi-workshop.gbm-online.de/yi-workshop-2.html
Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026.
Professional coaching, peer networking & practical tips for new PIs.
Apply by Nov 30, 2025.
👉https://yi-workshop.gbm-online.de/yi-workshop-2.html
Reposted by Kurianlab
As a mindfulness advocate, it is important to stress that meditation can have downsides if approached carelessly. It’s crucial to prepare and practice moderation. If meditation causes distress, that’s okay! Adjust your approach to your mindfulness journey.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
November 6, 2025 at 10:42 AM
As a mindfulness advocate, it is important to stress that meditation can have downsides if approached carelessly. It’s crucial to prepare and practice moderation. If meditation causes distress, that’s okay! Adjust your approach to your mindfulness journey.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Reposted by Kurianlab
🚀 Exciting news! ERC Synergy Grant of €8.5 million to Sara Wickström @sarawickstrom.bsky.social, Daniel St Jonston @gurdoninstitute.bsky.social and Ewa Paluch @universitypress.cambridge.org! This highly interdisciplinary project will boost our understanding of tissue biology. #ERCSyG @erc.europa.eu
November 6, 2025 at 11:21 AM
🚀 Exciting news! ERC Synergy Grant of €8.5 million to Sara Wickström @sarawickstrom.bsky.social, Daniel St Jonston @gurdoninstitute.bsky.social and Ewa Paluch @universitypress.cambridge.org! This highly interdisciplinary project will boost our understanding of tissue biology. #ERCSyG @erc.europa.eu
Reposted by Kurianlab
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature
Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...
www.nature.com
November 5, 2025 at 6:27 PM
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kurianlab
Just 1 week to apply! 4 year @erc.europa.eu funded PhD position working in an interdisciplinary team to study #culturalEvolution as a process of reuse, recombination, and creative re-engineering of past solutions. Details 👉 hmc-lab.com/ERCPhDCultur... 🙏Please share!
November 5, 2025 at 10:24 AM
Just 1 week to apply! 4 year @erc.europa.eu funded PhD position working in an interdisciplinary team to study #culturalEvolution as a process of reuse, recombination, and creative re-engineering of past solutions. Details 👉 hmc-lab.com/ERCPhDCultur... 🙏Please share!
www.biorxiv.org/content/10.1...
Check this from @campaslab.bsky.social and @jesseveenvliet.bsky.social
Check this from @campaslab.bsky.social and @jesseveenvliet.bsky.social
Tissue surface mechanics constrains proliferation-driven forces to guide mammalian body axis elongation
Mammalian embryos undergo complex morphogenetic changes after implantation in the uterus. The elongation of the body along a head-to-tail axis is a pivotal event, as it lays the foundation of the body...
www.biorxiv.org
November 6, 2025 at 6:51 AM
www.biorxiv.org/content/10.1...
Check this from @campaslab.bsky.social and @jesseveenvliet.bsky.social
Check this from @campaslab.bsky.social and @jesseveenvliet.bsky.social
Reposted by Kurianlab
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
October 2, 2025 at 5:11 PM
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
Reposted by Kurianlab
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Language models cannot reliably distinguish belief from knowledge and fact - Nature Machine Intelligence
Suzgun et al. find that current large language models cannot reliably distinguish between belief, knowledge and fact, raising concerns for their use in healthcare, law and journalism, where such disti...
www.nature.com
November 4, 2025 at 10:13 AM
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Reposted by Kurianlab
Mamdani: "New York will remain a city of immigrants, a city built by immigrants, powered by immigrants, and as of tonight, led by an immigrant."
November 5, 2025 at 4:40 AM
Mamdani: "New York will remain a city of immigrants, a city built by immigrants, powered by immigrants, and as of tonight, led by an immigrant."
Reposted by Kurianlab
I think a thing we'll learn tonight is that people fucking hate what is going on and they will straight ticket vote against anyone involved in starving people while pillaging the country and kidnapping their neighbors. I don't think it matters at all who that person is.
November 5, 2025 at 12:44 AM
I think a thing we'll learn tonight is that people fucking hate what is going on and they will straight ticket vote against anyone involved in starving people while pillaging the country and kidnapping their neighbors. I don't think it matters at all who that person is.
Check this from the talented and unimitable Bibli lab
"Nuclear cystine oxidation boosts acetyl-CoA, decorating histones and opening chromatin"
www.cell.com/cell-metabol...
"Nuclear cystine oxidation boosts acetyl-CoA, decorating histones and opening chromatin"
www.cell.com/cell-metabol...
www.cell.com
November 3, 2025 at 7:46 AM
Check this from the talented and unimitable Bibli lab
"Nuclear cystine oxidation boosts acetyl-CoA, decorating histones and opening chromatin"
www.cell.com/cell-metabol...
"Nuclear cystine oxidation boosts acetyl-CoA, decorating histones and opening chromatin"
www.cell.com/cell-metabol...
Reposted by Kurianlab
Good Sunday, mitolovers. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
November 2, 2025 at 5:49 AM
Good Sunday, mitolovers. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Coming back to where you started is not the same as never leaving."-Terry Pratchett
Reposted by Kurianlab
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by Kurianlab
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
October 31, 2025 at 2:42 PM
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
Reposted by Kurianlab
The Wilkinson Lab is open for science! @mskcancercenter.bsky.social
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
Wilkinson Lab
We discover and study reverse transcriptases
wilkinsonlab.bio
October 31, 2025 at 7:00 PM
The Wilkinson Lab is open for science! @mskcancercenter.bsky.social
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)