Kurianlab
@kurianlab.bsky.social
RNA biology of embryonic development and disease #heart #ribosome #translational_control #RBP #splicing @UK_Frankfurt Alum:@salkinstitute @UcSandiego
https://kurianlab.com/
https://kurianlab.com/
Pinned
Kurianlab
@kurianlab.bsky.social
· Sep 8
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Kurianlab
🥂 Happy 2026 all! I 'm looking forward to working with as many of you as possible this year! I 'll be back in the office on Monday, so feel free to shoot emails for meetings and papers you might wanna discuss for @natcellbio.nature.com ! Let's see where #CellBiology takes us this year :D
January 3, 2026 at 10:59 AM
🥂 Happy 2026 all! I 'm looking forward to working with as many of you as possible this year! I 'll be back in the office on Monday, so feel free to shoot emails for meetings and papers you might wanna discuss for @natcellbio.nature.com ! Let's see where #CellBiology takes us this year :D
Reposted by Kurianlab
😂
and this is after a full round of review at Nature...
read the paper anyway, it's still good :) www.biorxiv.org/content/10.1...
and this is after a full round of review at Nature...
read the paper anyway, it's still good :) www.biorxiv.org/content/10.1...
Proteome-wide Prediction of the Functional Impact of Missense Variants with ProteoCast
Background Dissecting the functional impact of genetic mutations is essential to advancing our understanding of genotype-phenotype relationships and identifying new therapeutic targets. Despite the pr...
www.biorxiv.org
December 24, 2025 at 8:26 AM
😂
and this is after a full round of review at Nature...
read the paper anyway, it's still good :) www.biorxiv.org/content/10.1...
and this is after a full round of review at Nature...
read the paper anyway, it's still good :) www.biorxiv.org/content/10.1...
Reposted by Kurianlab
manuscript transfer they said...
December 24, 2025 at 7:58 AM
manuscript transfer they said...
Reposted by Kurianlab
Reminder - a great job opportunity at @ucdavis.bsky.social
Dean, College of Biological Sciences jobs.sciencecareers.org/job/676649/d...
Dean, College of Biological Sciences jobs.sciencecareers.org/job/676649/d...
Dean, College of Biological Sciences - Davis job with University of California, Davis | 676649
University of California, Davis Dean, College of Biological Sciences The University of California, Davis (UC Davis) seeks a dynamic, effective, and
jobs.sciencecareers.org
December 24, 2025 at 1:27 AM
Reminder - a great job opportunity at @ucdavis.bsky.social
Dean, College of Biological Sciences jobs.sciencecareers.org/job/676649/d...
Dean, College of Biological Sciences jobs.sciencecareers.org/job/676649/d...
Reposted by Kurianlab
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Multiscale structure of chromatin condensates explains phase separation and material properties
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...
www.science.org
December 5, 2025 at 5:24 AM
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Reposted by Kurianlab
Do viruses use RNA to rewire bacteria?
Yes!
In our paper in @cp-molcell.bsky.social RIL-seq reveals interkingdom RNA interactions during λ infection. Phages don’t just encode proteins, they use small RNAs to hijack bacterial replication and fine-tune infection.
#RNA #Phage
doi.org/10.1016/j.mo...
Yes!
In our paper in @cp-molcell.bsky.social RIL-seq reveals interkingdom RNA interactions during λ infection. Phages don’t just encode proteins, they use small RNAs to hijack bacterial replication and fine-tune infection.
#RNA #Phage
doi.org/10.1016/j.mo...
Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle
Using RIL-seq, Silverman et al. map the RNA interactome of E. coli during phage lambda
infection and uncover a conserved phage-encoded sRNA that activates host replication
machinery. Their findings re...
www.cell.com
December 19, 2025 at 6:43 AM
Do viruses use RNA to rewire bacteria?
Yes!
In our paper in @cp-molcell.bsky.social RIL-seq reveals interkingdom RNA interactions during λ infection. Phages don’t just encode proteins, they use small RNAs to hijack bacterial replication and fine-tune infection.
#RNA #Phage
doi.org/10.1016/j.mo...
Yes!
In our paper in @cp-molcell.bsky.social RIL-seq reveals interkingdom RNA interactions during λ infection. Phages don’t just encode proteins, they use small RNAs to hijack bacterial replication and fine-tune infection.
#RNA #Phage
doi.org/10.1016/j.mo...
Reposted by Kurianlab
And here's the report @qedscience.bsky.social generated for our new paper, summarizing what's new and what was already known before. I'm planning to submit q.e.d's reports as cover letters together with my pre-prints from now on (and so should you!)
December 18, 2025 at 11:30 AM
And here's the report @qedscience.bsky.social generated for our new paper, summarizing what's new and what was already known before. I'm planning to submit q.e.d's reports as cover letters together with my pre-prints from now on (and so should you!)
Reposted by Kurianlab
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...
www.nature.com
December 17, 2025 at 8:59 PM
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kurianlab
Good to see the peer reviewed version of this published
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Benzinger et al. develop a chemo-optogenetic system for precise spatiotemporal control
of morphogen production in vitro. Using light-controlled Sonic hedgehog expression,
they recapitulate neural tube...
www.cell.com
December 16, 2025 at 1:45 AM
Good to see the peer reviewed version of this published
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
Reposted by Kurianlab
2/2 This work completes a framework to think about mammalian gastrulation as a modular system with GRNs Eomes and TbxT driven) that spin our a sequence of cell fates under the control of Nodal and Wnt signalling www.biorxiv.org/content/10.1...
Opposing Nodal and Wnt signalling activities govern the emergence of the mammalian body plan
Nodal and Wnt signalling play an important role in the emergence of the mammalian body plan, primarily by orchestrating gastrulation. While the literature suggests they cooperate to build the primitiv...
www.biorxiv.org
December 16, 2025 at 5:02 AM
2/2 This work completes a framework to think about mammalian gastrulation as a modular system with GRNs Eomes and TbxT driven) that spin our a sequence of cell fates under the control of Nodal and Wnt signalling www.biorxiv.org/content/10.1...
Reposted by Kurianlab
NSF plans to streamline merit review to heal self-inflicted staffing wound www.science.org/content/arti...
NSF pares down grant-review process, reducing influence of outside scientists
Memo cites overburdened staff, but some say move also aims to elevate White House priorities
www.science.org
December 15, 2025 at 10:54 PM
NSF plans to streamline merit review to heal self-inflicted staffing wound www.science.org/content/arti...
Reposted by Kurianlab
Our study with @stadtfeldlab.bsky.social on the dual mechanism by which EHMT2 is repressing totipotency-associated vs lineage-specific loci is now out @emboreports.org. See thread by @cmuyehara.bsky.social who led the study with K Chatterjee. Full article here link.springer.com/article/10.1...
December 14, 2025 at 8:15 PM
Our study with @stadtfeldlab.bsky.social on the dual mechanism by which EHMT2 is repressing totipotency-associated vs lineage-specific loci is now out @emboreports.org. See thread by @cmuyehara.bsky.social who led the study with K Chatterjee. Full article here link.springer.com/article/10.1...
Reposted by Kurianlab
Organisers
- Victoria Shabardina | @ibe-barcelona.bsky.social
- @ankarn.bsky.social | University of Warsaw
Invited Speaker
- @vikramalva.bsky.social | @mpi-bio-fml.bsky.social
- Victoria Shabardina | @ibe-barcelona.bsky.social
- @ankarn.bsky.social | University of Warsaw
Invited Speaker
- @vikramalva.bsky.social | @mpi-bio-fml.bsky.social
December 12, 2025 at 12:13 PM
Organisers
- Victoria Shabardina | @ibe-barcelona.bsky.social
- @ankarn.bsky.social | University of Warsaw
Invited Speaker
- @vikramalva.bsky.social | @mpi-bio-fml.bsky.social
- Victoria Shabardina | @ibe-barcelona.bsky.social
- @ankarn.bsky.social | University of Warsaw
Invited Speaker
- @vikramalva.bsky.social | @mpi-bio-fml.bsky.social
Reposted by Kurianlab
New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Retroviral insertions contributed to the divergence of human and chimpanzee brains
Over the past 5 to 7 million years, humans and chimpanzees have diverged in brain size, structural complexity, and cognitive abilities despite high conservation of protein-coding genes. Notably, the e...
www.biorxiv.org
December 14, 2025 at 8:16 PM
New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Kurianlab
I feel like a parent seeing your first kid leave home ;-).
While the entire Pauli lab family will greatly miss @lorenzoorts.bsky.social as Laura has become a real role model, it makes me incredibly happy & proud to have her establish the Lorenzo-Orts lab at the @imbmainz.bsky.social! All the best!
While the entire Pauli lab family will greatly miss @lorenzoorts.bsky.social as Laura has become a real role model, it makes me incredibly happy & proud to have her establish the Lorenzo-Orts lab at the @imbmainz.bsky.social! All the best!
December 14, 2025 at 8:26 PM
I feel like a parent seeing your first kid leave home ;-).
While the entire Pauli lab family will greatly miss @lorenzoorts.bsky.social as Laura has become a real role model, it makes me incredibly happy & proud to have her establish the Lorenzo-Orts lab at the @imbmainz.bsky.social! All the best!
While the entire Pauli lab family will greatly miss @lorenzoorts.bsky.social as Laura has become a real role model, it makes me incredibly happy & proud to have her establish the Lorenzo-Orts lab at the @imbmainz.bsky.social! All the best!
Reposted by Kurianlab
Nucleus Genomics too ipscell.com/2025/11/nucl...
Nucleus Genomics faces criticism as it and other firms promise embryo optimization despite unresolved scientific, ethical questions - The Niche
Stem cell biologist discusses how elective IVF firm Nucleus Genomics faces serious accusations including of plagiarism.
ipscell.com
December 14, 2025 at 5:11 AM
Nucleus Genomics too ipscell.com/2025/11/nucl...
Reposted by Kurianlab
Good Sunday, all! What a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology. I couldn't stop selecting!! biomed.news/bims-camemi/... Biomed News
"There are three musts that hold us back: I must do well. You must treat me well. And the world must be easy."-Albert Ellis
"There are three musts that hold us back: I must do well. You must treat me well. And the world must be easy."-Albert Ellis
December 14, 2025 at 6:48 AM
Good Sunday, all! What a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology. I couldn't stop selecting!! biomed.news/bims-camemi/... Biomed News
"There are three musts that hold us back: I must do well. You must treat me well. And the world must be easy."-Albert Ellis
"There are three musts that hold us back: I must do well. You must treat me well. And the world must be easy."-Albert Ellis
Congrats @claudiocantu81.bsky.social 👏🏾 👏🏾 👏🏾
CUT&ID for simultaneous profiling of protein-DNA and protein-protein interactions https://www.biorxiv.org/content/10.64898/2025.12.11.693662v1
December 13, 2025 at 8:55 AM
Congrats @claudiocantu81.bsky.social 👏🏾 👏🏾 👏🏾
Reposted by Kurianlab
Mastodon: the Command Center for Large-Scale Lineage-Tracing Microscopy Datasets https://www.biorxiv.org/content/10.64898/2025.12.10.693416v1
December 13, 2025 at 6:46 AM
Mastodon: the Command Center for Large-Scale Lineage-Tracing Microscopy Datasets https://www.biorxiv.org/content/10.64898/2025.12.10.693416v1
Reposted by Kurianlab
We're hiring!
We are looking for an Associate or Senior Editor to join our cell and developmental biology team
Apply here:
https://bit.ly/3KEeCFN
We are looking for an Associate or Senior Editor to join our cell and developmental biology team
Apply here:
https://bit.ly/3KEeCFN
December 12, 2025 at 11:16 AM
We're hiring!
We are looking for an Associate or Senior Editor to join our cell and developmental biology team
Apply here:
https://bit.ly/3KEeCFN
We are looking for an Associate or Senior Editor to join our cell and developmental biology team
Apply here:
https://bit.ly/3KEeCFN
Before you decorate the tree, come decorate your RNA next Thursday, 4 pm, 18.12.2025
Our last RNA event before the holidays.
Also:Glühwein&snacks
Registration: rmu-rna-salon.idloom.events/2-rmu-rna-sa...
Please share
@mixmue.bsky.social @cpi-exstra.bsky.social @scale-cluster-ffm.bsky.social
Our last RNA event before the holidays.
Also:Glühwein&snacks
Registration: rmu-rna-salon.idloom.events/2-rmu-rna-sa...
Please share
@mixmue.bsky.social @cpi-exstra.bsky.social @scale-cluster-ffm.bsky.social
December 11, 2025 at 2:02 PM
Before you decorate the tree, come decorate your RNA next Thursday, 4 pm, 18.12.2025
Our last RNA event before the holidays.
Also:Glühwein&snacks
Registration: rmu-rna-salon.idloom.events/2-rmu-rna-sa...
Please share
@mixmue.bsky.social @cpi-exstra.bsky.social @scale-cluster-ffm.bsky.social
Our last RNA event before the holidays.
Also:Glühwein&snacks
Registration: rmu-rna-salon.idloom.events/2-rmu-rna-sa...
Please share
@mixmue.bsky.social @cpi-exstra.bsky.social @scale-cluster-ffm.bsky.social