Paul Knoepfler
@stemcells.bsky.social
Professor at UC Davis studying cancer & stem cell epigenomics. I also do outreach and blog The Niche http://ipscell.com Also stem cell YouTube channel http://cutt.ly/vcsev4J STAT column https://www.statnews.com/category/lab-dish-paul-knoepfler/
Pinned
Paul Knoepfler
@stemcells.bsky.social
· Jun 11
Top UC Davis Graduate Aims To Transform Experience of Aging
Only on annual visits to India was Avantika Gokulnatha able to help care for her now late grandfather as his health failed. But the San Jose resident endeavored to help others near her.Gokulnatha did ...
www.ucdavis.edu
Congrats to my student Avantika Gokulnatha on receiving @ucdavis.bsky.social the UC Davis University Medal as the top graduating senior this year. Out of something like 8000+ seniors! She's done some great research on H3.3 mutant glioma www.ucdavis.edu/news/top-uc-... Very proud of her
Yikes. This story is being overblown. Using the word "cure" here even in mice is way misleading & there's no particular reason to be confident that this would work in people even to reduce symptoms let alone cure. Research funding is crucial but overstating things doesn't help anything.
Wanna see real-life miracles? Fund scientific research.
A team of US scientists just cured Alzheimer’s in mice — and there is now hope that the disease can be reversed in humans.
futurism.com/health-medic...
A team of US scientists just cured Alzheimer’s in mice — and there is now hope that the disease can be reversed in humans.
futurism.com/health-medic...
Alzheimer's Fully Reversed in Mice, Scientists Say
A new compound has been shown to reverse late stage Alzheimer's disease in lab mice, which gives millions of sufferers new cause for hope.
futurism.com
December 31, 2025 at 4:44 AM
Yikes. This story is being overblown. Using the word "cure" here even in mice is way misleading & there's no particular reason to be confident that this would work in people even to reduce symptoms let alone cure. Research funding is crucial but overstating things doesn't help anything.
Colossal Biosciences wins 2025 The Screamers Award for science hype on incorrect dire wolf de-extinction claim ipscell.com/2025/12/colo... #genetics #stemcells #scicomm
Colossal Biosciences wins 2025 The Screamers Award for science hype on dire wolf de-extinction claim - The Niche
Biologist awards Colossal Biosciences as the winner of the 2025 The Screamers science hype award for their dire wolf de-extinction claims.
ipscell.com
December 30, 2025 at 6:44 PM
Colossal Biosciences wins 2025 The Screamers Award for science hype on incorrect dire wolf de-extinction claim ipscell.com/2025/12/colo... #genetics #stemcells #scicomm
Reposted by Paul Knoepfler
Top 5 stem cell good news stories of 2025 ipscell.com/2025/12/top-... Duchenne, diabetes, vision loss, and more #stemcells #stemcell
Top 5 stem cell good news stories of 2025 - The Niche
Biologist discusses the stem cell good news stories of 2025 including encouraging clinical trial results around the world.
ipscell.com
December 29, 2025 at 5:17 PM
Top 5 stem cell good news stories of 2025 ipscell.com/2025/12/top-... Duchenne, diabetes, vision loss, and more #stemcells #stemcell
Top 5 stem cell good news stories of 2025 ipscell.com/2025/12/top-... Duchenne, diabetes, vision loss, and more #stemcells #stemcell
Top 5 stem cell good news stories of 2025 - The Niche
Biologist discusses the stem cell good news stories of 2025 including encouraging clinical trial results around the world.
ipscell.com
December 29, 2025 at 5:17 PM
Top 5 stem cell good news stories of 2025 ipscell.com/2025/12/top-... Duchenne, diabetes, vision loss, and more #stemcells #stemcell
Reposted by Paul Knoepfler
Weekly reads: Unlimited Bio gene therapy enhancement ‘trial’, Pluribus, brain growth, MYC ipscell.com/2025/12/week... one of my predictions for 2026 -> more characterization of eugenics as supposedly good #stemcells #stemcell
Weekly reads: Unlimited Bio gene therapy enhancement 'trial', Pluribus, brain growth, MYC - The Niche
Biologist discusses the week's research & news: Unlimited Bio gene 'therapy' for enhancement, stem cells on show Pluribus, brain growth.
ipscell.com
December 28, 2025 at 4:38 PM
Weekly reads: Unlimited Bio gene therapy enhancement ‘trial’, Pluribus, brain growth, MYC ipscell.com/2025/12/week... one of my predictions for 2026 -> more characterization of eugenics as supposedly good #stemcells #stemcell
One of the oddest stories this year was FDA warning on immunotherapy toothpaste ipscell.com/2025/10/week...
Weekly reads: FDA warnings on immunotherapy toothpaste & exosomes, upbeat SCID work, animal model alternatives - The Niche
immunotherapy toothpaste
ipscell.com
December 28, 2025 at 8:14 PM
One of the oddest stories this year was FDA warning on immunotherapy toothpaste ipscell.com/2025/10/week...
Weekly reads: Unlimited Bio gene therapy enhancement ‘trial’, Pluribus, brain growth, MYC ipscell.com/2025/12/week... one of my predictions for 2026 -> more characterization of eugenics as supposedly good #stemcells #stemcell
Weekly reads: Unlimited Bio gene therapy enhancement 'trial', Pluribus, brain growth, MYC - The Niche
Biologist discusses the week's research & news: Unlimited Bio gene 'therapy' for enhancement, stem cells on show Pluribus, brain growth.
ipscell.com
December 28, 2025 at 4:38 PM
Weekly reads: Unlimited Bio gene therapy enhancement ‘trial’, Pluribus, brain growth, MYC ipscell.com/2025/12/week... one of my predictions for 2026 -> more characterization of eugenics as supposedly good #stemcells #stemcell
ICYMI: Iowa AG wins $1M from stem cell clinic ipscell.com/2025/12/iowa... Some state AGs are killing it on stem cell oversight & helping consumers, better than FDA #stemcells #stemcell
Iowa AG wins $1M from stem cell clinic - The Niche
Stem cell biologist discusses how the Iowa AG won $1 million from a stem cell clinic in that state and how it fits into the bigger picture.
ipscell.com
December 27, 2025 at 5:43 PM
ICYMI: Iowa AG wins $1M from stem cell clinic ipscell.com/2025/12/iowa... Some state AGs are killing it on stem cell oversight & helping consumers, better than FDA #stemcells #stemcell
Reposted by Paul Knoepfler
All the press had to do every election year was ask him about groceries
Trump, a silver spoon nepo baby that received a “small loan of a million dollars” from his dad to start his business, has publicly expressed wonder at the word “groceries” for more than a year now.
“Who uses the word?” Trump told Meet the Press with a straight face.
trib.al/LidRK0u
“Who uses the word?” Trump told Meet the Press with a straight face.
trib.al/LidRK0u
Cognitive Decline? These Were Trump’s 11 Most Senile Moments This Year
When Donald Trump wasn’t busy falling asleep in front of the cameras, he spent his first year in office struggling to form coherent thoughts.
trib.al
December 27, 2025 at 5:41 PM
All the press had to do every election year was ask him about groceries
Reposted by Paul Knoepfler
Of course, biggest factors in a long & healthy life: luck, socioeconomics, luck, and more luck!
Remember to pick your parents & socio-economic situation carefully!
Remember to pick your parents & socio-economic situation carefully!
I've worked in this space for so long that I get too grumpy about these kinda "healthy" lists...
Reality (my take): we've long known all about the basics, including...
1) Exercise
2) Real food
3) Sleep
4) Prevention (vaccines, don't smoke, etc)
5) Community!
www.washingtonpost.com/wellness/202...
Reality (my take): we've long known all about the basics, including...
1) Exercise
2) Real food
3) Sleep
4) Prevention (vaccines, don't smoke, etc)
5) Community!
www.washingtonpost.com/wellness/202...
5 tips from ‘super agers’ on how to live a healthy life
This year, we learned a lot from people in their 80s, 90s and 100s (and the scientists who study them).
www.washingtonpost.com
December 26, 2025 at 7:22 PM
Of course, biggest factors in a long & healthy life: luck, socioeconomics, luck, and more luck!
Remember to pick your parents & socio-economic situation carefully!
Remember to pick your parents & socio-economic situation carefully!
Iowa AG wins $1M from stem cell clinic ipscell.com/2025/12/iowa... #stemcells #stemcell why can't FDA learn from state & local officials?
Iowa AG wins $1M from stem cell clinic - The Niche
Stem cell biologist discusses how the Iowa AG won $1 million from a stem cell clinic in that state and how it fits into the bigger picture.
ipscell.com
December 26, 2025 at 4:22 PM
Iowa AG wins $1M from stem cell clinic ipscell.com/2025/12/iowa... #stemcells #stemcell why can't FDA learn from state & local officials?
Red-shouldered hawk. Love the wing pattern
December 25, 2025 at 9:28 PM
Red-shouldered hawk. Love the wing pattern
Reposted by Paul Knoepfler
Felony charges against 3 in Utah related to stem cell clinic, undercover agents visited clinic ipscell.com/2025/12/felo... #stemcells #stemcell
Felony charges against 3 in Utah related to stem cells, undercover agents visited clinic - The Niche
Stem cell biologist discusses news of 3 people charged with felonies in Utah related to selling unproven stem cells.
ipscell.com
December 23, 2025 at 5:05 PM
Felony charges against 3 in Utah related to stem cell clinic, undercover agents visited clinic ipscell.com/2025/12/felo... #stemcells #stemcell
Reposted by Paul Knoepfler
Felony charges against 3 in Utah related to stem cell clinic, undercover agents visited clinic ipscell.com/2025/12/felo... #stemcells #stemcell
Felony charges against 3 in Utah related to stem cells, undercover agents visited clinic - The Niche
Stem cell biologist discusses news of 3 people charged with felonies in Utah related to selling unproven stem cells.
ipscell.com
December 23, 2025 at 5:05 PM
Felony charges against 3 in Utah related to stem cell clinic, undercover agents visited clinic ipscell.com/2025/12/felo... #stemcells #stemcell
Reposted by Paul Knoepfler
Remember: Almost all of us are the descendants of immigrants who fled persecution, or were brought to America under duress, or sought better lives for themselves and their descendants.
Politicians who stoke fear and hatred over immigration want you to forget this.
Do not.
Politicians who stoke fear and hatred over immigration want you to forget this.
Do not.
December 21, 2025 at 9:00 PM
Remember: Almost all of us are the descendants of immigrants who fled persecution, or were brought to America under duress, or sought better lives for themselves and their descendants.
Politicians who stoke fear and hatred over immigration want you to forget this.
Do not.
Politicians who stoke fear and hatred over immigration want you to forget this.
Do not.
Reposted by Paul Knoepfler
Weekly #stemcell & regenerative reads: stem cells for vision loss hope, gene therapy trial death, NFL doc on clinics ipscell.com/2025/12/week... #stemcells
Weekly reads: stem cells for vision loss hope, gene therapy trial death, NFL doc on clinics - The Niche
Professor discusses the week's news and research on regenerative medicine including hopeful new trial data on stem cells for vision loss.
ipscell.com
December 21, 2025 at 3:15 PM
Weekly #stemcell & regenerative reads: stem cells for vision loss hope, gene therapy trial death, NFL doc on clinics ipscell.com/2025/12/week... #stemcells
Reposted by Paul Knoepfler
“Once-unthinkable” here should be “in wild and blatant violation of the law and the US Constitution.”
At NIH alone:
The RIFs were illegal (as a judge, Illston, ruled). The grant terminations were illegal (Young ruling). The probationary firings were illegal (Alsop ruling).
We must say this. 1/
At NIH alone:
The RIFs were illegal (as a judge, Illston, ruled). The grant terminations were illegal (Young ruling). The probationary firings were illegal (Alsop ruling).
We must say this. 1/
This account of how the Trump admin carried out a once-unthinkable overhaul of government in 2025 is based on a year’s worth of messages and interviews with more than 1,200 current and former federal workers. Please read from me and @merylkornfield.bsky.social. wapo.st/4b14KAy
The year Trump broke the federal government
How DOGE and the White House carried out a once-unthinkable transformation of the nation’s sprawling bureaucracy.
wapo.st
December 21, 2025 at 4:41 PM
“Once-unthinkable” here should be “in wild and blatant violation of the law and the US Constitution.”
At NIH alone:
The RIFs were illegal (as a judge, Illston, ruled). The grant terminations were illegal (Young ruling). The probationary firings were illegal (Alsop ruling).
We must say this. 1/
At NIH alone:
The RIFs were illegal (as a judge, Illston, ruled). The grant terminations were illegal (Young ruling). The probationary firings were illegal (Alsop ruling).
We must say this. 1/
Weekly #stemcell & regenerative reads: stem cells for vision loss hope, gene therapy trial death, NFL doc on clinics ipscell.com/2025/12/week... #stemcells
Weekly reads: stem cells for vision loss hope, gene therapy trial death, NFL doc on clinics - The Niche
Professor discusses the week's news and research on regenerative medicine including hopeful new trial data on stem cells for vision loss.
ipscell.com
December 21, 2025 at 3:15 PM
Weekly #stemcell & regenerative reads: stem cells for vision loss hope, gene therapy trial death, NFL doc on clinics ipscell.com/2025/12/week... #stemcells
Reposted by Paul Knoepfler
“Rather than relying on an implant or a patient's own body fat to add volume to hips or augment breasts, alloClae — which can cost as much as $100,000 per procedure — uses donor fat from a cadaver as a first-of-its-kind body filler.”
Corporate types are clamoring for a new kind of plastic surgery — using dead people's fat
Corporate types are waiting weeks for — and spending big on — alloClae, which cuts out the recovery time typically associated with body enhancements.
www.businessinsider.com
December 20, 2025 at 5:05 PM
“Rather than relying on an implant or a patient's own body fat to add volume to hips or augment breasts, alloClae — which can cost as much as $100,000 per procedure — uses donor fat from a cadaver as a first-of-its-kind body filler.”
Reposted by Paul Knoepfler
Should the US adopt Denmark's vaccine schedule for children? @jakescottmd.bsky.social argues no in a piece that points out the risks such a move would pose for American kids. www.statnews.com/2025/12/19/d...
Why Denmark's vaccine schedule works for Denmark — but not for the United States
With its vaccine schedule, “Denmark has made a values choice to accept preventable hospitalizations and illnesses that other countries have chosen to prevent.”
www.statnews.com
December 20, 2025 at 1:02 AM
Should the US adopt Denmark's vaccine schedule for children? @jakescottmd.bsky.social argues no in a piece that points out the risks such a move would pose for American kids. www.statnews.com/2025/12/19/d...
ICYMI: New review of stem cell supplements and pills ipscell.com/2024/09/new-... #stemcells
New review of stem cell supplements and pills - The Niche
Cell biologist reviews stem cell supplements and pills, analyzes research data, and raises concerns about risks and costs.
ipscell.com
December 20, 2025 at 6:42 PM
ICYMI: New review of stem cell supplements and pills ipscell.com/2024/09/new-... #stemcells
Reposted by Paul Knoepfler
· MedSky ·
Sen. Rand Paul has demanded Science release confidential information and external private communications about coronaviruses, citing allegations that dangerous research produced the COVID-19 virus.
Sen. Rand Paul has demanded Science release confidential information and external private communications about coronaviruses, citing allegations that dangerous research produced the COVID-19 virus.
U.S. senator asks Science to provide its coronavirus manuscripts, emails
Rand Paul has blasted government science officials and scientists over COVID-19’s origin
www.science.org
December 20, 2025 at 6:09 PM
· MedSky ·
Sen. Rand Paul has demanded Science release confidential information and external private communications about coronaviruses, citing allegations that dangerous research produced the COVID-19 virus.
Sen. Rand Paul has demanded Science release confidential information and external private communications about coronaviruses, citing allegations that dangerous research produced the COVID-19 virus.
Reposted by Paul Knoepfler
The role of flour type and feeding schedule on the sourdough microbiome
#microbiology #FoodMicrobiology #microSky
journals.asm.org/doi/10.1128/...
#microbiology #FoodMicrobiology #microSky
journals.asm.org/doi/10.1128/...
The role of flour type and feeding schedule on the sourdough microbiome | Microbiology Spectrum
How organisms disperse and colonize new environments is central to our understanding
of biodiversity. Sourdough, the often spontaneously inoculated fermentation of grains
by bacteria and yeast, repres...
journals.asm.org
December 20, 2025 at 12:34 AM
The role of flour type and feeding schedule on the sourdough microbiome
#microbiology #FoodMicrobiology #microSky
journals.asm.org/doi/10.1128/...
#microbiology #FoodMicrobiology #microSky
journals.asm.org/doi/10.1128/...
Reposted by Paul Knoepfler
Two government officials told STAT that the White House has been involved in final decisions about the FDA's new priority review voucher program for drug companies. www.statnews.com/2025/12/19/f...
FDA voucher program has become vehicle for political interference in drug review decisions, staffers say
Two government officials told STAT that the White House has been involved in final decisions about the FDA's new priority review voucher program for drug companies.
www.statnews.com
December 19, 2025 at 4:36 PM
Two government officials told STAT that the White House has been involved in final decisions about the FDA's new priority review voucher program for drug companies. www.statnews.com/2025/12/19/f...