Danica Milovanović
@1995dana.bsky.social
scientist | pacifist | transposable elements | evo-devo
PhD @trono-lab.bsky.social
PhD @trono-lab.bsky.social
Pinned
Danica Milovanović
@1995dana.bsky.social
· May 19
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
Reposted by Danica Milovanović
Welcome to Day 3 of #EMBOMobileGenome 🙌🏼
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
November 6, 2025 at 9:48 AM
Welcome to Day 3 of #EMBOMobileGenome 🙌🏼
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸
➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
Reposted by Danica Milovanović
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by Danica Milovanović
🌟Im happy to share that this winter I'll be starting my lab at the Wallenberg Center for Molecular Medicine at Umeå University! Excited to join the Department of Medical and Translational Biology as a Wallenberg Fellow and looking forward to new collaborations and cool transposon research 🤩 🧬
October 26, 2025 at 4:49 PM
🌟Im happy to share that this winter I'll be starting my lab at the Wallenberg Center for Molecular Medicine at Umeå University! Excited to join the Department of Medical and Translational Biology as a Wallenberg Fellow and looking forward to new collaborations and cool transposon research 🤩 🧬
Reposted by Danica Milovanović
"Our study reveals that the current understanding of chromatin states is extensively incomplete, and newer in situ chromatin fragmentation-based techniques are preferred for investigating repetitive elements and retrotransposons"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci
New in situ chromatin profiling methods, such as CUT&Tag, have streamlined studies of chromatin features by eliminating the need for up-front purifica…
www.sciencedirect.com
October 18, 2025 at 6:17 PM
"Our study reveals that the current understanding of chromatin states is extensively incomplete, and newer in situ chromatin fragmentation-based techniques are preferred for investigating repetitive elements and retrotransposons"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Beautiful 🦋
Which journal would publish such a fragmented mess?
www.cell.com/current-biol...
www.cell.com/current-biol...
October 8, 2025 at 2:11 PM
Beautiful 🦋
Reposted by Danica Milovanović
Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...
Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells - Nature Communications
Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also ...
www.nature.com
July 9, 2025 at 11:58 AM
Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...
Reposted by Danica Milovanović
🚨 Check out the latest from @trono-lab.bsky.social showing how evolutionarily young transcription factors contribute to human cell cycle regulation!
Brilliant work led by Romain Forey and Cyril Pulver, now published in Cell Genomics. Check it out !
www.cell.com/cell-genomic...
Brilliant work led by Romain Forey and Cyril Pulver, now published in Cell Genomics. Check it out !
www.cell.com/cell-genomic...
Evolutionarily recent transcription factors partake in human cell cycle regulation
Pulver and Forey et al. generated a novel atlas reporting (1) gene expression over
the cell cycle and (2) how systematic gene depletion affects cell cycle progression.
They thereby identified evolutio...
www.cell.com
June 25, 2025 at 7:21 AM
🚨 Check out the latest from @trono-lab.bsky.social showing how evolutionarily young transcription factors contribute to human cell cycle regulation!
Brilliant work led by Romain Forey and Cyril Pulver, now published in Cell Genomics. Check it out !
www.cell.com/cell-genomic...
Brilliant work led by Romain Forey and Cyril Pulver, now published in Cell Genomics. Check it out !
www.cell.com/cell-genomic...
Reposted by Danica Milovanović
🔔Upcoming Wednesday, June 4th! Join us for another #FragileNucleosome series! Two amazing talks by @1995dana.bsky.social & @chrishsiung.bsky.social! If you haven’t jooned for any of 2025 talks, register here:
us06web.zoom.us/webinar/regi...
us06web.zoom.us/webinar/regi...
May 30, 2025 at 12:49 PM
🔔Upcoming Wednesday, June 4th! Join us for another #FragileNucleosome series! Two amazing talks by @1995dana.bsky.social & @chrishsiung.bsky.social! If you haven’t jooned for any of 2025 talks, register here:
us06web.zoom.us/webinar/regi...
us06web.zoom.us/webinar/regi...
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
May 19, 2025 at 2:01 PM
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
Reposted by Danica Milovanović
Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity https://www.biorxiv.org/content/10.1101/2025.05.13.653700v1
May 16, 2025 at 4:33 AM
Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity https://www.biorxiv.org/content/10.1101/2025.05.13.653700v1
Reposted by Danica Milovanović
And with that the afternoon of @gensocuk.bsky.social short talks is done! We've had: 1) KRABs binding L2/MIR elements, which would effect cardiovascular development; 2) DGCR8 prevents the accumulation of TE-made double-stranded RNA; 1/3 🧵
November 21, 2024 at 5:15 PM
And with that the afternoon of @gensocuk.bsky.social short talks is done! We've had: 1) KRABs binding L2/MIR elements, which would effect cardiovascular development; 2) DGCR8 prevents the accumulation of TE-made double-stranded RNA; 1/3 🧵