Jesse Raab
@jraab.bsky.social
Chromatin and cancer research at UNC Chapel Hill. Opinions are my own. Raab-lab.org
Pinned
Jesse Raab
@jraab.bsky.social
· Nov 13
Since there are lots of new people here I'll do the reintroduction thing. My lab is focused on gene regulation and chromatin remodelers. We're interested in how these complexes are regulated, how their disruption of complexes contribute to tumor growth, and whether they modulate therapy response
Reposted by Jesse Raab
My reviewing style has changed over time. Rather than litigate every little thing, and pushing my own ideas, I focus only on 2 things:
(1) Are the claims interesting/important?
(2) Does the evidence support the claims?
Most of my reviews these days are short and focused.
(1) Are the claims interesting/important?
(2) Does the evidence support the claims?
Most of my reviews these days are short and focused.
November 8, 2025 at 11:22 AM
My reviewing style has changed over time. Rather than litigate every little thing, and pushing my own ideas, I focus only on 2 things:
(1) Are the claims interesting/important?
(2) Does the evidence support the claims?
Most of my reviews these days are short and focused.
(1) Are the claims interesting/important?
(2) Does the evidence support the claims?
Most of my reviews these days are short and focused.
very cool paper on the location of tumor mutations within the liver changing cancer initiation www.science.org/doi/10.1126/...
The origin of hepatocellular carcinoma depends on metabolic zonation
The origin of cancer is poorly understood because premalignant cells are rarely followed in their native environments. While the spatial compartmentalization of metabolic functions is critical for pro...
www.science.org
November 8, 2025 at 2:18 PM
very cool paper on the location of tumor mutations within the liver changing cancer initiation www.science.org/doi/10.1126/...
Reposted by Jesse Raab
PUT HER IN THE HALL AS A CONTRIBUTOR YOU COWARDS
November 6, 2025 at 1:26 AM
PUT HER IN THE HALL AS A CONTRIBUTOR YOU COWARDS
Reposted by Jesse Raab
oh. alright. two R01 at 5 years. 268 funded for 4 years, 57 for 3 years, 48 for 2 years. 8+804+114+48=974 excess new R01 years. Therefore something around 974 (some wobble based on actual budget amount of each grant) R01 grants that will not be funded FY2025 onward.
November 5, 2025 at 5:53 PM
oh. alright. two R01 at 5 years. 268 funded for 4 years, 57 for 3 years, 48 for 2 years. 8+804+114+48=974 excess new R01 years. Therefore something around 974 (some wobble based on actual budget amount of each grant) R01 grants that will not be funded FY2025 onward.
Reposted by Jesse Raab
Some hardcore mechanism, for the aficionados (from Peter Jones @vai.org and Ting-Hai Xu @slu-official.bsky.social labs) @natsmb.nature.com www.nature.com/articles/s41...
Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin - Nature Structural & Molecular Biology
Yan et al. use cryo-EM to obtain structures that reveal how DNMT3A2 and DNMT3L cooperate to read histone signals and bind chromatin, illustrating a mechanism that controls DNA methylation and shapes e...
www.nature.com
November 4, 2025 at 2:55 PM
Some hardcore mechanism, for the aficionados (from Peter Jones @vai.org and Ting-Hai Xu @slu-official.bsky.social labs) @natsmb.nature.com www.nature.com/articles/s41...
oh wow, this is amazing
🧪hey all, a friend and colleague, @maddoxfornc.bsky.social, is running for Congress in North Carolina. He is a scientist, professor, and parent, perspectives that are especially important right now. I hope you will support his run for Congress. Find out more here: www.maddoxforcongress.com/about/
Meet Paul Maddox
Paul Maddox is a world-renowned cancer researcher, two-time entrepreneur, and native son of Western North Carolina–and now, a candidate for U.S. Congress. ....
www.maddoxforcongress.com
October 30, 2025 at 11:26 PM
oh wow, this is amazing
Reposted by Jesse Raab
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
#JobOffer
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
October 28, 2025 at 1:51 PM
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
October 28, 2025 at 4:28 PM
Reposted by Jesse Raab
Excited to share our new preprint on molecular gene x treatment interactions led by Jordan Valone, Brandon Le, and @nanamatoba.bsky.social. www.medrxiv.org/content/10.1.... Here, we tried to further develop the "pharmacogenomics in a dish" approach for psychiatry.
Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium
Gene by treatment (GxT) interactions likely contribute to variability in clinical response, but are difficult to identify in population studies. Here, we applied psychiatric and neurological disorder ...
www.medrxiv.org
October 27, 2025 at 3:21 PM
Excited to share our new preprint on molecular gene x treatment interactions led by Jordan Valone, Brandon Le, and @nanamatoba.bsky.social. www.medrxiv.org/content/10.1.... Here, we tried to further develop the "pharmacogenomics in a dish" approach for psychiatry.
Reposted by Jesse Raab
YEATS4 reads histone crotonylation to promote fatty acid metabolism and cancer cell stemness
YEATS4 reads histone crotonylation to promote fatty acid metabolism and cancer cell stemness
Peng et al. identify YEATS4 as a reader of H3K14cr, by which it activates genes in fatty acid metabolism and enhances the self-renewal of breast cancer stem cells, highlighting the role of YEATS4 as an amplifier in the circuit of histone crotonylation and fatty acid metabolism in breast cancer.
dlvr.it
October 18, 2025 at 7:50 PM
YEATS4 reads histone crotonylation to promote fatty acid metabolism and cancer cell stemness
Reposted by Jesse Raab
"Our study reveals that the current understanding of chromatin states is extensively incomplete, and newer in situ chromatin fragmentation-based techniques are preferred for investigating repetitive elements and retrotransposons"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci
New in situ chromatin profiling methods, such as CUT&Tag, have streamlined studies of chromatin features by eliminating the need for up-front purifica…
www.sciencedirect.com
October 18, 2025 at 6:17 PM
"Our study reveals that the current understanding of chromatin states is extensively incomplete, and newer in situ chromatin fragmentation-based techniques are preferred for investigating repetitive elements and retrotransposons"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jesse Raab
Latest version of #depmap added to r2platform.com
R2: academic open online nocode data science platform for biomedical research
#DataScientist #biologist #clinician #genomics #Cancer
R2: academic open online nocode data science platform for biomedical research
#DataScientist #biologist #clinician #genomics #Cancer
October 18, 2025 at 7:14 PM
Latest version of #depmap added to r2platform.com
R2: academic open online nocode data science platform for biomedical research
#DataScientist #biologist #clinician #genomics #Cancer
R2: academic open online nocode data science platform for biomedical research
#DataScientist #biologist #clinician #genomics #Cancer
Reposted by Jesse Raab
🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on www.biorxiv.org/content/10.1.... Here's a thread summarizing our findings!👇
#CancerResearch #Epigenetics #Chromatin #Lymphoma
#CancerResearch #Epigenetics #Chromatin #Lymphoma
AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma
The catalytic subunit of Polycomb Repressive Complex 2 (PRC2), EZH2, is recurrently mutated in 25% of diffuse large B-cell lymphomas (DLBCL), causing increased H3K27me3 and decreased H3K27me2 levels. ...
www.biorxiv.org
October 17, 2025 at 7:11 AM
🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on www.biorxiv.org/content/10.1.... Here's a thread summarizing our findings!👇
#CancerResearch #Epigenetics #Chromatin #Lymphoma
#CancerResearch #Epigenetics #Chromatin #Lymphoma
Reposted by Jesse Raab
Now that the data for fiscal year 2025 are complete, what did NIH's investments in training look like?
There are three mechanism classes to consider: T awards (institutional training grants), F awards (fellowships to individual scientists), and K awards (career development awards)
2/12
There are three mechanism classes to consider: T awards (institutional training grants), F awards (fellowships to individual scientists), and K awards (career development awards)
2/12
October 16, 2025 at 12:25 AM
Now that the data for fiscal year 2025 are complete, what did NIH's investments in training look like?
There are three mechanism classes to consider: T awards (institutional training grants), F awards (fellowships to individual scientists), and K awards (career development awards)
2/12
There are three mechanism classes to consider: T awards (institutional training grants), F awards (fellowships to individual scientists), and K awards (career development awards)
2/12
Reposted by Jesse Raab
🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
October 15, 2025 at 4:02 PM
🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Reposted by Jesse Raab
UNC Sends Delegation for Capitol Event
Rally for Medical Research – September 18, 2025 Washington, DC
www.med.unc.edu/biochem/news...
Rally for Medical Research – September 18, 2025 Washington, DC
www.med.unc.edu/biochem/news...
UNC Sends Delegation for Capitol Event | Biochemistry and Biophysics
Rally for Medical Research – September 18, 2025 | Washington, DC A delegation from UNC joined more than 400 advocates from across the country in Washington DC to urge Congress to prioritize funding fo...
www.med.unc.edu
October 6, 2025 at 1:17 PM
UNC Sends Delegation for Capitol Event
Rally for Medical Research – September 18, 2025 Washington, DC
www.med.unc.edu/biochem/news...
Rally for Medical Research – September 18, 2025 Washington, DC
www.med.unc.edu/biochem/news...
Reposted by Jesse Raab
Buffalo peeps! I am hosting a science spooktacular event at the new Third Space venue downtown on Oct 30 at 6PM! Come hear fun stories about science from trainees, all geared towards a non-specialist audience. Check the flyer for all the info! Please RT
October 7, 2025 at 10:58 PM
Buffalo peeps! I am hosting a science spooktacular event at the new Third Space venue downtown on Oct 30 at 6PM! Come hear fun stories about science from trainees, all geared towards a non-specialist audience. Check the flyer for all the info! Please RT
Reposted by Jesse Raab
We are in this odd climate where people are pretending no barriers exist to careers in science for some groups, but this conversation with 2 outstanding emerging scientists highlights that is just not true.
youtube.com/watch?v=u850...
youtube.com/watch?v=u850...
BIBPSSpotlight - 2025 Black In Biophysics Week
YouTube video by Black In Biophys
youtube.com
October 1, 2025 at 11:53 AM
We are in this odd climate where people are pretending no barriers exist to careers in science for some groups, but this conversation with 2 outstanding emerging scientists highlights that is just not true.
youtube.com/watch?v=u850...
youtube.com/watch?v=u850...
Reposted by Jesse Raab
Amazing science continues to happen in the US, and we continue to hire remarkable new faculty. Already this term UNC Biology has had terrific promotion seminars from two rising stars: Eric Riddell and Rob Dowen. 1/n
October 1, 2025 at 11:22 AM
Amazing science continues to happen in the US, and we continue to hire remarkable new faculty. Already this term UNC Biology has had terrific promotion seminars from two rising stars: Eric Riddell and Rob Dowen. 1/n
Reposted by Jesse Raab
New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com
September 29, 2025 at 3:01 PM
New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com
Great department and job opportunity
The link for a junior tenure-track position with UNC-CH Biochemistry and Biophysics is now live. Learn about the search here www.med.unc.edu/biochem/join..., then apply here unc.peopleadmin.com/postings/307... Help us inspire tomorrow’s discoveries by decoding the molecular basis of life!
UNC Department of Biochemistry and Biophysics
Our mission is to perform transformative biochemical and biophysical research in an inclusive and stimulating training environment.
www.med.unc.edu
September 30, 2025 at 3:33 PM
Great department and job opportunity
Reposted by Jesse Raab
Hey remember when the CDC dropped 6 of the 8 foodborne illnesses from the nationwide monitoring system in July and one of them was listeria? Mentioning for no particular reason www.nbcnews.com/health/healt...
September 30, 2025 at 12:34 PM
Hey remember when the CDC dropped 6 of the 8 foodborne illnesses from the nationwide monitoring system in July and one of them was listeria? Mentioning for no particular reason www.nbcnews.com/health/healt...
I think the same thing while I fill out my 800th conflict of interest declaration for submitting a grant
I have to take this Research Security training to be eligible to submit Federal grants and as I'm going through it the contrast between what is being presented and how the current Federal administration is acting is enraging
September 29, 2025 at 7:50 PM
I think the same thing while I fill out my 800th conflict of interest declaration for submitting a grant
Reposted by Jesse Raab
Here are the results in terms of the number of projects.
The number of funded projects in FY2025 is 4014 fewer than the number for FY2024.
2/3
The number of funded projects in FY2025 is 4014 fewer than the number for FY2024.
2/3
September 29, 2025 at 5:38 PM
Here are the results in terms of the number of projects.
The number of funded projects in FY2025 is 4014 fewer than the number for FY2024.
2/3
The number of funded projects in FY2025 is 4014 fewer than the number for FY2024.
2/3
Reposted by Jesse Raab
Wonderful news. A salutary reminder of the absolute benefits of scientific progress, and the absolute evil of conspiracist bollocks.
Huntington's disease successfully treated for first time www.bbc.com/news/article...
Huntington's disease successfully treated for first time www.bbc.com/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that could transform lives, tearful doctors tell BBC
www.bbc.com
September 24, 2025 at 12:20 PM
Wonderful news. A salutary reminder of the absolute benefits of scientific progress, and the absolute evil of conspiracist bollocks.
Huntington's disease successfully treated for first time www.bbc.com/news/article...
Huntington's disease successfully treated for first time www.bbc.com/news/article...