Marco Trizzino
@marcotrizzino.bsky.social
Associate Professor of Developmental and Evolutionary Genomics at Imperial College London, Department of Life Sciences. Spent a decade in Philly, #FlyEaglesFly
https://marcotrizzino.wordpress.com/
https://marcotrizzino.wordpress.com/
Pinned
Marco Trizzino
@marcotrizzino.bsky.social
· Dec 19
This is now a published peer-reviewed paper, in which we show, for the first time (to my knowledge) an interaction and co-operation between SALL4 and BAF (SWI/SNF). Together, they induce neural crest fate early on, by priming thousands of enhancers in the neuroectoderm.
doi.org/10.1242/dev....
doi.org/10.1242/dev....
Reposted by Marco Trizzino
Another update from #UKRI CEO on #UKsciencefunding #UKRI
www.ukri.org/news/ukri-ce...
No new information and fails to address/explain the severe funding rate cuts taking place at MRC for the round currently under review (Sept2025). That's 2025/26 budget so should *not* be affected by SR.
www.ukri.org/news/ukri-ce...
No new information and fails to address/explain the severe funding rate cuts taking place at MRC for the round currently under review (Sept2025). That's 2025/26 budget so should *not* be affected by SR.
UKRI CEO updates the research community on areas of uncertainty
Following an open letter of 1 February, Sir Ian Chapman responds to feedback and provides an update.
www.ukri.org
February 17, 2026 at 10:27 AM
Another update from #UKRI CEO on #UKsciencefunding #UKRI
www.ukri.org/news/ukri-ce...
No new information and fails to address/explain the severe funding rate cuts taking place at MRC for the round currently under review (Sept2025). That's 2025/26 budget so should *not* be affected by SR.
www.ukri.org/news/ukri-ce...
No new information and fails to address/explain the severe funding rate cuts taking place at MRC for the round currently under review (Sept2025). That's 2025/26 budget so should *not* be affected by SR.
This week, two of our PhD students successfully passed their PhD VIVA! Congratulations Dr. Zoe Mitchell and Dr. Martina Demurtas! We are so proud of you both!
February 12, 2026 at 8:22 PM
This week, two of our PhD students successfully passed their PhD VIVA! Congratulations Dr. Zoe Mitchell and Dr. Martina Demurtas! We are so proud of you both!
Reposted by Marco Trizzino
We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Direct visualization and tracing of chromatin folding in the Drosophila embryo - The EMBO Journal
Chromatin organization, through the assembly of DNA with histones and the folding of nucleosome chains, regulates DNA accessibility for transcription, DNA replication and repair. Although models deriv...
link.springer.com
February 10, 2026 at 3:44 PM
We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10.1...
link.springer.com/article/10.1...
My goodness 😞
James Van Der Beek, who rose to fame playing Dawson Leery on the 1990s-era hit teen drama “Dawson’s Creek,” has died. He was 48. https://cnn.it/3ZwnNfk
February 11, 2026 at 8:24 PM
My goodness 😞
Reposted by Marco Trizzino
So now we have it- not only the reduction from 12-13 to 3 grants from each board recommended for funding but the budget for applicant-led research to be reduced from £200 million to £113 million per year. This is appalling, Especially given all that is happening with medical research in the US.
Medical Research Council ‘will fund fewer applicant-led grants’.
Confirmation from deputy leader comes as council restructures investments, with calls on hold until summer.
www.researchprofessionalnews.com/rr-news-uk-r...
Confirmation from deputy leader comes as council restructures investments, with calls on hold until summer.
www.researchprofessionalnews.com/rr-news-uk-r...
Medical Research Council ‘will fund fewer applicant-led grants’ - Research Professional News
Confirmation from deputy leader comes as council restructures investments, with calls on hold until summer
www.researchprofessionalnews.com
February 6, 2026 at 10:04 AM
So now we have it- not only the reduction from 12-13 to 3 grants from each board recommended for funding but the budget for applicant-led research to be reduced from £200 million to £113 million per year. This is appalling, Especially given all that is happening with medical research in the US.
Reposted by Marco Trizzino
Genomic clues to the origin of eukaryotic cells www.nature.com/articles/d41...
Genomic clues to the origin of eukaryotic cells
How did eukaryotic cells with complex architecture evolve from simpler prokaryotic cells? DNA analyses offer possible answers.
www.nature.com
February 6, 2026 at 9:55 AM
Genomic clues to the origin of eukaryotic cells www.nature.com/articles/d41...
Reposted by Marco Trizzino
I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..
A few points and new information that bioscientists may find interesting...
A 🧵
A few points and new information that bioscientists may find interesting...
A 🧵
February 3, 2026 at 1:57 PM
I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..
A few points and new information that bioscientists may find interesting...
A 🧵
A few points and new information that bioscientists may find interesting...
A 🧵
Reposted by Marco Trizzino
Leaks everywhere and finally we get an official statement, one that somehow manages to say a lot while; No timelines. No clarity. No acknowledgement of impact on ECRs whose careers depend UKRI funding.
“Later this year” isn’t a plan. And the sector deserves better than reassurance without detail.
“Later this year” isn’t a plan. And the sector deserves better than reassurance without detail.
Today, we're sharing an open letter from our Chief Executive, Professor Sir Ian Chapman, outlining changes to UKRI investment approach, and addressing concerns about research funding and the financial position of STFC. Read his letter here: www.ukri.org/news/open-le...
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
www.ukri.org
February 1, 2026 at 7:54 PM
Leaks everywhere and finally we get an official statement, one that somehow manages to say a lot while; No timelines. No clarity. No acknowledgement of impact on ECRs whose careers depend UKRI funding.
“Later this year” isn’t a plan. And the sector deserves better than reassurance without detail.
“Later this year” isn’t a plan. And the sector deserves better than reassurance without detail.
Reposted by Marco Trizzino
I worry this is going to kill a lot of careers. Mine being one of them.
But beyond the selfish...there's going to be a whole generation of scientists who are not going to be able to support their careers, this is going to affect UK research in a big way...
But beyond the selfish...there's going to be a whole generation of scientists who are not going to be able to support their careers, this is going to affect UK research in a big way...
Today, we're sharing an open letter from our Chief Executive, Professor Sir Ian Chapman, outlining changes to UKRI investment approach, and addressing concerns about research funding and the financial position of STFC. Read his letter here: www.ukri.org/news/open-le...
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
www.ukri.org
February 2, 2026 at 8:57 AM
I worry this is going to kill a lot of careers. Mine being one of them.
But beyond the selfish...there's going to be a whole generation of scientists who are not going to be able to support their careers, this is going to affect UK research in a big way...
But beyond the selfish...there's going to be a whole generation of scientists who are not going to be able to support their careers, this is going to affect UK research in a big way...
Reposted by Marco Trizzino
1 budget for 26-30 is rising 🎉
2 quota for basic research stable 🙂
BUT
3 we're slashing success rate for currently assessed grants 🫠
4 next call hopefully in Apri 2027 (with £s for lucky few going out months later, suppose) 💀
How does this make us more competitive?
www.ukri.org/news/open-le...
2 quota for basic research stable 🙂
BUT
3 we're slashing success rate for currently assessed grants 🫠
4 next call hopefully in Apri 2027 (with £s for lucky few going out months later, suppose) 💀
How does this make us more competitive?
www.ukri.org/news/open-le...
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
www.ukri.org
February 2, 2026 at 8:49 AM
1 budget for 26-30 is rising 🎉
2 quota for basic research stable 🙂
BUT
3 we're slashing success rate for currently assessed grants 🫠
4 next call hopefully in Apri 2027 (with £s for lucky few going out months later, suppose) 💀
How does this make us more competitive?
www.ukri.org/news/open-le...
2 quota for basic research stable 🙂
BUT
3 we're slashing success rate for currently assessed grants 🫠
4 next call hopefully in Apri 2027 (with £s for lucky few going out months later, suppose) 💀
How does this make us more competitive?
www.ukri.org/news/open-le...
Reposted by Marco Trizzino
Today, we're sharing an open letter from our Chief Executive, Professor Sir Ian Chapman, outlining changes to UKRI investment approach, and addressing concerns about research funding and the financial position of STFC. Read his letter here: www.ukri.org/news/open-le...
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
www.ukri.org
February 1, 2026 at 5:16 PM
Today, we're sharing an open letter from our Chief Executive, Professor Sir Ian Chapman, outlining changes to UKRI investment approach, and addressing concerns about research funding and the financial position of STFC. Read his letter here: www.ukri.org/news/open-le...
This UKRI situation is batshit insane.
Some initial reactions to the 'published on a Sunday afternoon' letter from the CEO of UKRI. 🧵
www.ukri.org/news/open-le...
www.ukri.org/news/open-le...
February 2, 2026 at 11:45 AM
This UKRI situation is batshit insane.
Reposted by Marco Trizzino
New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
www.biorxiv.org
February 2, 2026 at 10:25 AM
New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
Reposted by Marco Trizzino
Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...
February 2, 2026 at 7:19 AM
Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...
Reposted by Marco Trizzino
Academics vying for a spot in Epstein‘s world. There are so many. I feel the need to make a thread, so I don’t keep confusing them. 1/
January 31, 2026 at 9:02 PM
Academics vying for a spot in Epstein‘s world. There are so many. I feel the need to make a thread, so I don’t keep confusing them. 1/
Reposted by Marco Trizzino
New NIH funding strategy has been formalized.
I really do hope scientists understand what this means for the future of science (funding) - it's not subtle.
www.niaid.nih.gov/about/unifie...
I really do hope scientists understand what this means for the future of science (funding) - it's not subtle.
www.niaid.nih.gov/about/unifie...
NIH Unified Funding Strategy
Objective peer review, and HHS- and NIH- specific priorities, and a standardized, transparent process for incorporating NIAID-specific priorities will guide funding selections.
www.niaid.nih.gov
January 30, 2026 at 8:31 PM
New NIH funding strategy has been formalized.
I really do hope scientists understand what this means for the future of science (funding) - it's not subtle.
www.niaid.nih.gov/about/unifie...
I really do hope scientists understand what this means for the future of science (funding) - it's not subtle.
www.niaid.nih.gov/about/unifie...
New goal for life: being able to play this (well not this good) even if it takes 20 years of practice
www.youtube.com/watch?v=wj1x...
www.youtube.com/watch?v=wj1x...
Beethoven - Moonlight Sonata, 3rd Mvt. (Marnie Laird - Brooklyn Classical)
YouTube video by Brooklyn Classical
www.youtube.com
January 30, 2026 at 8:29 PM
New goal for life: being able to play this (well not this good) even if it takes 20 years of practice
www.youtube.com/watch?v=wj1x...
www.youtube.com/watch?v=wj1x...
Reposted by Marco Trizzino
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.
Stay free
Stay free
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen
youtu.be
January 28, 2026 at 5:02 PM
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.
Stay free
Stay free
Reposted by Marco Trizzino
UKRI pauses several funding calls amid priorities shake-up www.researchprofessional.com/news-article...
Research Professional Sign-in
www.researchprofessional.com
January 23, 2026 at 6:51 PM
UKRI pauses several funding calls amid priorities shake-up www.researchprofessional.com/news-article...
Reposted by Marco Trizzino
Happy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5.
Thanks to all collaborators, we could not have done it without you 🤩
rdcu.be/eWMfA
Thanks to all collaborators, we could not have done it without you 🤩
rdcu.be/eWMfA
Double stranded RNA sensing is silenced during early embryonic development
Nature Communications - The type I interferon response is suppressed during early development, making embryos susceptible to pathogens. Here, the authors show that this suppression contributes to...
rdcu.be
January 7, 2026 at 3:28 PM
Happy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5.
Thanks to all collaborators, we could not have done it without you 🤩
rdcu.be/eWMfA
Thanks to all collaborators, we could not have done it without you 🤩
rdcu.be/eWMfA
Reposted by Marco Trizzino
Reposted by Marco Trizzino
Cell migration is a key cellular process that drives major developmental programs and diseases.
Different assays have been developed, but they are often used interchangeably.
In our new paper, we describe how to select the optimal assay.
More details here: www.nature.com/articles/s41...
Different assays have been developed, but they are often used interchangeably.
In our new paper, we describe how to select the optimal assay.
More details here: www.nature.com/articles/s41...
December 27, 2025 at 12:46 PM
Cell migration is a key cellular process that drives major developmental programs and diseases.
Different assays have been developed, but they are often used interchangeably.
In our new paper, we describe how to select the optimal assay.
More details here: www.nature.com/articles/s41...
Different assays have been developed, but they are often used interchangeably.
In our new paper, we describe how to select the optimal assay.
More details here: www.nature.com/articles/s41...
Reposted by Marco Trizzino
This is now a published peer-reviewed paper, in which we show, for the first time (to my knowledge) an interaction and co-operation between SALL4 and BAF (SWI/SNF). Together, they induce neural crest fate early on, by priming thousands of enhancers in the neuroectoderm.
doi.org/10.1242/dev....
doi.org/10.1242/dev....
December 19, 2025 at 12:48 PM
This is now a published peer-reviewed paper, in which we show, for the first time (to my knowledge) an interaction and co-operation between SALL4 and BAF (SWI/SNF). Together, they induce neural crest fate early on, by priming thousands of enhancers in the neuroectoderm.
doi.org/10.1242/dev....
doi.org/10.1242/dev....
Reposted by Marco Trizzino
Read the #OpenAccess Research Article ‘Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers’ here:
doi.org/10.1242/dev....
doi.org/10.1242/dev....
December 23, 2025 at 9:29 AM
Read the #OpenAccess Research Article ‘Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers’ here:
doi.org/10.1242/dev....
doi.org/10.1242/dev....
Reposted by Marco Trizzino
Saving face: SALL4 is required for early specification of craniofacial precursors
This Research Highlight showcases work by Martina Demurtas, Marco Trizzino (@marcotrizzino.bsky.social) and colleagues:
journals.biologists.com/dev/article/...
This Research Highlight showcases work by Martina Demurtas, Marco Trizzino (@marcotrizzino.bsky.social) and colleagues:
journals.biologists.com/dev/article/...
December 23, 2025 at 9:29 AM
Saving face: SALL4 is required for early specification of craniofacial precursors
This Research Highlight showcases work by Martina Demurtas, Marco Trizzino (@marcotrizzino.bsky.social) and colleagues:
journals.biologists.com/dev/article/...
This Research Highlight showcases work by Martina Demurtas, Marco Trizzino (@marcotrizzino.bsky.social) and colleagues:
journals.biologists.com/dev/article/...