Sara MaciasRNA
@saramaciasrna.bsky.social
Molecular biologist | Wellcome Trust Senior Fellow | antiviral defence | RNA processing | interferons | transposable elements | small RNAs | embryonic development
Free Palestine 🍉
Free Palestine 🍉
Pinned
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...
www.biorxiv.org
In our last preprint we identify endogenous dsRNAs capable of activating the interferon response. Could these be relevant to our understanding of DiGeorge syndrome (22qDS)?
In collaboration with @herassr.bsky.social and @heick.bsky.social labs
www.biorxiv.org/content/10.1...
In collaboration with @herassr.bsky.social and @heick.bsky.social labs
www.biorxiv.org/content/10.1...
In our last preprint we identify endogenous dsRNAs capable of activating the interferon response. Could these be relevant to our understanding of DiGeorge syndrome (22qDS)?
In collaboration with @herassr.bsky.social and @heick.bsky.social labs
www.biorxiv.org/content/10.1...
In collaboration with @herassr.bsky.social and @heick.bsky.social labs
www.biorxiv.org/content/10.1...
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...
www.biorxiv.org
June 2, 2025 at 12:55 PM
In our last preprint we identify endogenous dsRNAs capable of activating the interferon response. Could these be relevant to our understanding of DiGeorge syndrome (22qDS)?
In collaboration with @herassr.bsky.social and @heick.bsky.social labs
www.biorxiv.org/content/10.1...
In collaboration with @herassr.bsky.social and @heick.bsky.social labs
www.biorxiv.org/content/10.1...
Reposted by Sara MaciasRNA
Happy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...
www.biorxiv.org
June 2, 2025 at 12:03 PM
Happy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sara MaciasRNA
As tighter immigration policies are announced today, scientists continue to stress the importance of attracting international talent.
Our director Paul Nurse spoke to the Observer about how this affects science in the UK:
observer.co.uk/news/politic...
Our director Paul Nurse spoke to the Observer about how this affects science in the UK:
observer.co.uk/news/politic...
Is the UK paying the price for world’s most expensive visas? | The Observer
Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK
observer.co.uk
May 12, 2025 at 2:18 PM
As tighter immigration policies are announced today, scientists continue to stress the importance of attracting international talent.
Our director Paul Nurse spoke to the Observer about how this affects science in the UK:
observer.co.uk/news/politic...
Our director Paul Nurse spoke to the Observer about how this affects science in the UK:
observer.co.uk/news/politic...
Reposted by Sara MaciasRNA
Our latest paper is out in NAR! 🥳
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects
Abstract. The 22q11.2 deletion syndrome (22qDS) is a human disorder where the majority of clinical manifestations originate during embryonic development. 2
academic.oup.com
March 27, 2025 at 10:13 AM
Our latest paper is out in NAR! 🥳
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
Our last paper in collaboration with Sara RHeras is finally out 🥳we modelled Dgcr8 haploinsufficiency in hESCs and exciting differences between 🧘🏽♂️and 🐭 at the transposon and miRNA content -HERVH & C19MC
Thanks to all the coauthors and funders
academic.oup.com/nar/article/...
Thanks to all the coauthors and funders
academic.oup.com/nar/article/...
March 27, 2025 at 9:46 AM
Our last paper in collaboration with Sara RHeras is finally out 🥳we modelled Dgcr8 haploinsufficiency in hESCs and exciting differences between 🧘🏽♂️and 🐭 at the transposon and miRNA content -HERVH & C19MC
Thanks to all the coauthors and funders
academic.oup.com/nar/article/...
Thanks to all the coauthors and funders
academic.oup.com/nar/article/...
Reposted by Sara MaciasRNA
I'm so excited about @saramaciasrna.bsky.social invitation to visit the Institute of Immunology and Infection Research, @edinburgh-uni.bsky.social on the 5th of February. I will be sharing our latest research on #RNAmodifications in #cancer
January 25, 2025 at 9:00 PM
I'm so excited about @saramaciasrna.bsky.social invitation to visit the Institute of Immunology and Infection Research, @edinburgh-uni.bsky.social on the 5th of February. I will be sharing our latest research on #RNAmodifications in #cancer
RECRUITING-PhD student to study the role of RNA-binding proteins in antiviral defence during early development.
#crispr #iclip #omics
Interested candidates, please email a full CV and a statement of interest. Open to both UK and overseas
www.findaphd.com/phds/project...
#crispr #iclip #omics
Interested candidates, please email a full CV and a statement of interest. Open to both UK and overseas
www.findaphd.com/phds/project...
Antiviral defence during early development at University of Edinburgh on FindAPhD.com
PhD Project - Antiviral defence during early development at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
December 2, 2024 at 4:06 PM
RECRUITING-PhD student to study the role of RNA-binding proteins in antiviral defence during early development.
#crispr #iclip #omics
Interested candidates, please email a full CV and a statement of interest. Open to both UK and overseas
www.findaphd.com/phds/project...
#crispr #iclip #omics
Interested candidates, please email a full CV and a statement of interest. Open to both UK and overseas
www.findaphd.com/phds/project...
Important reading - unfortunately not open access
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
December 1, 2024 at 1:08 PM
Important reading - unfortunately not open access
Reposted by Sara MaciasRNA
And since we're here... 🥼
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
November 28, 2024 at 10:31 AM
And since we're here... 🥼
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
Had an amazing time visiting King’s college dept of Infectious diseases. Thanks @Rocio Nunez and @Hannah Mischo for the hosting and great tapas with @charlotte odendall
…and a beautiful early morning walk by the river!
…and a beautiful early morning walk by the river!
November 28, 2024 at 11:07 AM
Had an amazing time visiting King’s college dept of Infectious diseases. Thanks @Rocio Nunez and @Hannah Mischo for the hosting and great tapas with @charlotte odendall
…and a beautiful early morning walk by the river!
…and a beautiful early morning walk by the river!
Reposted by Sara MaciasRNA
Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)
November 26, 2024 at 1:45 PM
Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)
Reposted by Sara MaciasRNA
#Immunosky #neuroskyence our team is expanding and we’re recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...
www.jobs.manchester.ac.uk
November 27, 2024 at 5:05 AM
#Immunosky #neuroskyence our team is expanding and we’re recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...
This is so good! Thanks @tillysscott.bsky.social
And with that the afternoon of @gensocuk.bsky.social short talks is done! We've had: 1) KRABs binding L2/MIR elements, which would effect cardiovascular development; 2) DGCR8 prevents the accumulation of TE-made double-stranded RNA; 1/3 🧵
November 22, 2024 at 11:10 AM
This is so good! Thanks @tillysscott.bsky.social
Great discussion at the Genetics Society conference 🧬
Next up is @SaraMaciasRNA
discussing how DGCR8 acts as a gatekeeper of the interferon response by preventing cytoplasmic TE-dsRNA accumulation #GStransposons
discussing how DGCR8 acts as a gatekeeper of the interferon response by preventing cytoplasmic TE-dsRNA accumulation #GStransposons
November 21, 2024 at 3:46 PM
Great discussion at the Genetics Society conference 🧬
Reposted by Sara MaciasRNA
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism?
Then come join me & @juanquintana.bsky.social at
@lydiabeckeriii.bsky.social as a
research assistant
Email to arrange
an informal chat 🧪 #ImmunoSky #LGBTQSTEM www.jobs.manchester.ac.uk/Job/JobDetai...
Then come join me & @juanquintana.bsky.social at
@lydiabeckeriii.bsky.social as a
research assistant
Email to arrange
an informal chat 🧪 #ImmunoSky #LGBTQSTEM www.jobs.manchester.ac.uk/Job/JobDetai...
Research Assistant in Tissue Immunology:Oxford Road
www.jobs.manchester.ac.uk
November 20, 2024 at 7:38 PM
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism?
Then come join me & @juanquintana.bsky.social at
@lydiabeckeriii.bsky.social as a
research assistant
Email to arrange
an informal chat 🧪 #ImmunoSky #LGBTQSTEM www.jobs.manchester.ac.uk/Job/JobDetai...
Then come join me & @juanquintana.bsky.social at
@lydiabeckeriii.bsky.social as a
research assistant
Email to arrange
an informal chat 🧪 #ImmunoSky #LGBTQSTEM www.jobs.manchester.ac.uk/Job/JobDetai...
On our way to the Genetics Society meeting at Leicester. We cannot wait to hear all about transposable elements 🧬 with my friend and collaborator Sara R Heras (soon joining this network too 😂)
November 20, 2024 at 9:42 AM
On our way to the Genetics Society meeting at Leicester. We cannot wait to hear all about transposable elements 🧬 with my friend and collaborator Sara R Heras (soon joining this network too 😂)
New EdiRNA events for the new year! Funded by the @RNASociety. Great opportunity to network with other RNA biologists 🧬 (dsRNA included) from Edinburgh and beyond 🚀
Jan 29, 2025
Apr 9, 2025
Jun 11, 2025
Oct TBD, 2025
www.edirna.com/meetings
Jan 29, 2025
Apr 9, 2025
Jun 11, 2025
Oct TBD, 2025
www.edirna.com/meetings
EVENTS | EdiRNA
ediRNA aims to establish new collaborations, encourage scientific discussion, and enhance interactions between RNA researchers across Edinburgh.
www.edirna.com
November 18, 2024 at 4:37 PM
New EdiRNA events for the new year! Funded by the @RNASociety. Great opportunity to network with other RNA biologists 🧬 (dsRNA included) from Edinburgh and beyond 🚀
Jan 29, 2025
Apr 9, 2025
Jun 11, 2025
Oct TBD, 2025
www.edirna.com/meetings
Jan 29, 2025
Apr 9, 2025
Jun 11, 2025
Oct TBD, 2025
www.edirna.com/meetings
recruiting a PhD student interested in the role of RNA binding proteins 🧬for antiviral defence 🦠during embryonic development🐁 👶. Funding routes for both UK and international students are available 🌻. Please send your CV and motivation letter if interested
saramaciasribela.wixsite.com/maciaslab
saramaciasribela.wixsite.com/maciaslab
November 18, 2024 at 4:16 PM
recruiting a PhD student interested in the role of RNA binding proteins 🧬for antiviral defence 🦠during embryonic development🐁 👶. Funding routes for both UK and international students are available 🌻. Please send your CV and motivation letter if interested
saramaciasribela.wixsite.com/maciaslab
saramaciasribela.wixsite.com/maciaslab