Alasdair Hubbard
@dralhubb.bsky.social
Assistant Professor - research group works on the evolution of AMR and understanding cryptic mechanisms of resistance. All views my own. T1D
Pinned
Really cool to have given a talk at #microbio25, I can cross it off the list! If anyone want to chat about looking into the urobiome as a reservoir of AMR and replicating AMR acquisition in a 3D bladder model, give me a shout!! #microsky #utisky
Reposted by Alasdair Hubbard
I’m honored to be serving as the BMC Microbiology - AMR collection’s Guest Editor and eager to read your submission. Learn more about the collection and how to contribute:
#BMCmicrobiology #AMR #genomics #CPE #CPPA #CRAb #MRSA #Resistance @BioMedCentral @springernature
#BMCmicrobiology #AMR #genomics #CPE #CPPA #CRAb #MRSA #Resistance @BioMedCentral @springernature
January 9, 2026 at 2:56 PM
I’m honored to be serving as the BMC Microbiology - AMR collection’s Guest Editor and eager to read your submission. Learn more about the collection and how to contribute:
#BMCmicrobiology #AMR #genomics #CPE #CPPA #CRAb #MRSA #Resistance @BioMedCentral @springernature
#BMCmicrobiology #AMR #genomics #CPE #CPPA #CRAb #MRSA #Resistance @BioMedCentral @springernature
Reposted by Alasdair Hubbard
This study study aims were to explore the independent predictors for CO-ESBL SUTI and to compare the effectiveness of several oral therapeutics, which are used for this indication in community health settings...read on to find out what they found! doi.org/10.1017/ash....
January 9, 2026 at 2:38 PM
This study study aims were to explore the independent predictors for CO-ESBL SUTI and to compare the effectiveness of several oral therapeutics, which are used for this indication in community health settings...read on to find out what they found! doi.org/10.1017/ash....
Reposted by Alasdair Hubbard
📢 MicrobesNG POPUP is coming to Nottingham! It's a FREE #MicrobialGenomics & #Microbiome symposium on 5th June 🦠🧬
We're accepting abstracts now! Focus on #ECRs Please RT
Submit by 9th Feb 👉 www.surveymonkey.com/r/POPUP_NOTT...
@bugsinyourguts.bsky.social & Microbiome-Net
#MNGPopUp #MicroSky
We're accepting abstracts now! Focus on #ECRs Please RT
Submit by 9th Feb 👉 www.surveymonkey.com/r/POPUP_NOTT...
@bugsinyourguts.bsky.social & Microbiome-Net
#MNGPopUp #MicroSky
January 7, 2026 at 9:30 AM
📢 MicrobesNG POPUP is coming to Nottingham! It's a FREE #MicrobialGenomics & #Microbiome symposium on 5th June 🦠🧬
We're accepting abstracts now! Focus on #ECRs Please RT
Submit by 9th Feb 👉 www.surveymonkey.com/r/POPUP_NOTT...
@bugsinyourguts.bsky.social & Microbiome-Net
#MNGPopUp #MicroSky
We're accepting abstracts now! Focus on #ECRs Please RT
Submit by 9th Feb 👉 www.surveymonkey.com/r/POPUP_NOTT...
@bugsinyourguts.bsky.social & Microbiome-Net
#MNGPopUp #MicroSky
Attention parents, uncles and aunties... if you want to make Christmas even more magical, an AI tool is available to turn a picture of your Christmas tree into a 10 second CCTV video of "proof" of Santa delivering presents to your house (costs £5):
#Christmas
santacctv.christmas
#Christmas
santacctv.christmas
📽️ SANTA CCTV
This christmas, catch Santa in the act in your own home!
santacctv.christmas
December 20, 2025 at 7:47 PM
Attention parents, uncles and aunties... if you want to make Christmas even more magical, an AI tool is available to turn a picture of your Christmas tree into a 10 second CCTV video of "proof" of Santa delivering presents to your house (costs £5):
#Christmas
santacctv.christmas
#Christmas
santacctv.christmas
Reposted by Alasdair Hubbard
New preprint:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Pyocyanin produced by Pseudomonas aeruginosa Creates Legacy Effects That Boost Antibiotic Resistance Evolution in Enterococci
Polymicrobial infections are small communities of multiple interacting bacterial species. Interactions among constituent species may modify the growth of community members in the presence of antibioti...
www.biorxiv.org
December 5, 2025 at 2:27 PM
New preprint:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
🔔New Preprint🔔
Just posted on Access Microbiology (first time using this platform, seems great!) our work on looking for antimicrobial proteins in snake venom. This is work from the first bit of funding I received and the project (1/3)
www.microbiologyresearch.org/content/jour...
#MicroSky
Just posted on Access Microbiology (first time using this platform, seems great!) our work on looking for antimicrobial proteins in snake venom. This is work from the first bit of funding I received and the project (1/3)
www.microbiologyresearch.org/content/jour...
#MicroSky
An iterative fractionation approach to identify antimicrobial proteins in snake venom
Antimicrobial resistance (AMR) increasingly poses a significant global health challenge. New antimicrobials are desperately needed, driving the need to explore novel sources of natural products. Snake...
www.microbiologyresearch.org
December 10, 2025 at 3:19 PM
🔔New Preprint🔔
Just posted on Access Microbiology (first time using this platform, seems great!) our work on looking for antimicrobial proteins in snake venom. This is work from the first bit of funding I received and the project (1/3)
www.microbiologyresearch.org/content/jour...
#MicroSky
Just posted on Access Microbiology (first time using this platform, seems great!) our work on looking for antimicrobial proteins in snake venom. This is work from the first bit of funding I received and the project (1/3)
www.microbiologyresearch.org/content/jour...
#MicroSky
Reposted by Alasdair Hubbard
Wrapped up a great few days at the 2025 @bsacandjac.bsky.social ARM Workshop! 🎉
Huge thanks to @friendlymicrobe.bsky.social and @conmeehan.bsky.social for organising a fantastic event. Loved hearing about the latest in AMR, from novel fundamentals to therapeutics.
Already excited for next year! 💊
Huge thanks to @friendlymicrobe.bsky.social and @conmeehan.bsky.social for organising a fantastic event. Loved hearing about the latest in AMR, from novel fundamentals to therapeutics.
Already excited for next year! 💊
November 28, 2025 at 8:41 PM
Wrapped up a great few days at the 2025 @bsacandjac.bsky.social ARM Workshop! 🎉
Huge thanks to @friendlymicrobe.bsky.social and @conmeehan.bsky.social for organising a fantastic event. Loved hearing about the latest in AMR, from novel fundamentals to therapeutics.
Already excited for next year! 💊
Huge thanks to @friendlymicrobe.bsky.social and @conmeehan.bsky.social for organising a fantastic event. Loved hearing about the latest in AMR, from novel fundamentals to therapeutics.
Already excited for next year! 💊
Reposted by Alasdair Hubbard
Evolution at @bsacandjac.bsky.social
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
Danna Gifford
School of Biological Sciences | Faculty of Biology Medicine and Health | University of Manchester
dannagifford.com
November 28, 2025 at 11:45 AM
Evolution at @bsacandjac.bsky.social
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
Reposted by Alasdair Hubbard
🎉 Congratulations to Oluwatosin Orababa @tosinorababa.bsky.social, one of the winners of our 2025 Infection Science Award! 🦠👏
Get to know them in our new interview: microb.io/3XFyCui
#InfectionScience #Microbiology #ResearchSpotlight
Get to know them in our new interview: microb.io/3XFyCui
#InfectionScience #Microbiology #ResearchSpotlight
November 25, 2025 at 10:00 AM
🎉 Congratulations to Oluwatosin Orababa @tosinorababa.bsky.social, one of the winners of our 2025 Infection Science Award! 🦠👏
Get to know them in our new interview: microb.io/3XFyCui
#InfectionScience #Microbiology #ResearchSpotlight
Get to know them in our new interview: microb.io/3XFyCui
#InfectionScience #Microbiology #ResearchSpotlight
Reposted by Alasdair Hubbard
What drives the acquisition and loss of #AntibioticResistance in Salmonella? @flashton.bsky.social kicking off the @bsacandjac.bsky.social resistance & mechanisms meeting, talking about pathogen genomic surveillance around the world, particularly in Africa www.psi.ox.ac.uk/our-team/phi... #MicroSky
Philip Ashton
Philip Ashton
www.psi.ox.ac.uk
November 27, 2025 at 2:02 PM
What drives the acquisition and loss of #AntibioticResistance in Salmonella? @flashton.bsky.social kicking off the @bsacandjac.bsky.social resistance & mechanisms meeting, talking about pathogen genomic surveillance around the world, particularly in Africa www.psi.ox.ac.uk/our-team/phi... #MicroSky
Reposted by Alasdair Hubbard
Next at @bsacandjac.bsky.social #AntibioticResistance & mechanisms, @jodywinter.bsky.social is explaining how a partnership between academics, clinicians & health workers in Nottingham & Makerere is is sharing best practice in stewardship between UK & Uganda jodywinter.wixsite.com/waaw/cop #MicroSky
COP | Waaw
jodywinter.wixsite.com
November 27, 2025 at 2:36 PM
Next at @bsacandjac.bsky.social #AntibioticResistance & mechanisms, @jodywinter.bsky.social is explaining how a partnership between academics, clinicians & health workers in Nottingham & Makerere is is sharing best practice in stewardship between UK & Uganda jodywinter.wixsite.com/waaw/cop #MicroSky
Reposted by Alasdair Hubbard
Now at @bsacandjac.bsky.social #AntibioticResistance & mechanisms workshop, Kirsty Sands @ineosoxford.bsky.social stresses the dominance of Kleb pneumoniae in neonatal sepsis, and how the work she leads is quantifying the impact of AMR on neonatal sepsis in LMICs: www.ineosoxford.ox.ac.uk/barnards
BARNARDS
Causes and impacts of sepsis in new-born babies
www.ineosoxford.ox.ac.uk
November 27, 2025 at 3:18 PM
Now at @bsacandjac.bsky.social #AntibioticResistance & mechanisms workshop, Kirsty Sands @ineosoxford.bsky.social stresses the dominance of Kleb pneumoniae in neonatal sepsis, and how the work she leads is quantifying the impact of AMR on neonatal sepsis in LMICs: www.ineosoxford.ox.ac.uk/barnards
Reposted by Alasdair Hubbard
OMG no-one has every explained what "MD simulations" actually means before and I think @sykhalid.bsky.social has given me a sufficient understanding in about two minutes - amazing!
November 27, 2025 at 4:05 PM
OMG no-one has every explained what "MD simulations" actually means before and I think @sykhalid.bsky.social has given me a sufficient understanding in about two minutes - amazing!
Reposted by Alasdair Hubbard
Now at @bsacandjac.bsky.social, @sykhalid.bsky.social explains that, while the outer leaflet of the Gram- OM is a calm sea anchored by OmpA to the cell wall, the phospholipids of the inner leaflet are paddling about madly beneath the surface. #MicroSky khalidlab.web.ox.ac.uk/publications
Publications
khalidlab.web.ox.ac.uk
November 27, 2025 at 4:20 PM
Now at @bsacandjac.bsky.social, @sykhalid.bsky.social explains that, while the outer leaflet of the Gram- OM is a calm sea anchored by OmpA to the cell wall, the phospholipids of the inner leaflet are paddling about madly beneath the surface. #MicroSky khalidlab.web.ox.ac.uk/publications
Reposted by Alasdair Hubbard
Synthetic teixobactin development: Ishwar Singh is telling @bsacandjac.bsky.social #antibioticResistance & mechanisms meeting about the long and winding road to promising new molecules with good bioactivity www.liverpool.ac.uk/people/ishwa... #MicroSky
Dr Ishwar Singh | Our people | University of Liverpool
www.liverpool.ac.uk
November 27, 2025 at 4:42 PM
Synthetic teixobactin development: Ishwar Singh is telling @bsacandjac.bsky.social #antibioticResistance & mechanisms meeting about the long and winding road to promising new molecules with good bioactivity www.liverpool.ac.uk/people/ishwa... #MicroSky
Reposted by Alasdair Hubbard
'Bacterial dietitian' @danybeste.bsky.social is telling @bsacandjac.bsky.social #AntibioticResistance & mechanisms workshop how switching C sources affects Tb antibiotic tolerance - can we use this info to design adjuvants that increase sensitivity? www.surrey.ac.uk/people/dany-... #MicroSky
Dr Dany Beste | University of Surrey
https://www.surrey.ac.uk/people/dany-beste#research#MicroSky
November 27, 2025 at 5:00 PM
'Bacterial dietitian' @danybeste.bsky.social is telling @bsacandjac.bsky.social #AntibioticResistance & mechanisms workshop how switching C sources affects Tb antibiotic tolerance - can we use this info to design adjuvants that increase sensitivity? www.surrey.ac.uk/people/dany-... #MicroSky
Reposted by Alasdair Hubbard
Flash talk 1 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! Ahmed Alomar selected E. coli for colistin resistance: clinical isolates evolved higher MIC than MG1655, associated with mutations in pmrA/B, many of those in pmrA not previously described. @imibirmingham.bsky.social #MicroSky
November 27, 2025 at 5:18 PM
Flash talk 1 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! Ahmed Alomar selected E. coli for colistin resistance: clinical isolates evolved higher MIC than MG1655, associated with mutations in pmrA/B, many of those in pmrA not previously described. @imibirmingham.bsky.social #MicroSky
Reposted by Alasdair Hubbard
Flash talk 2 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! @taylorwr.bsky.social found that E. coli damaged but not killed by b-lactams die when they try to divide on abx-free solid medium, but not in liquid - so do plate count assays overestimate b-lactam killing? #MicroSky
November 27, 2025 at 5:31 PM
Flash talk 2 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! @taylorwr.bsky.social found that E. coli damaged but not killed by b-lactams die when they try to divide on abx-free solid medium, but not in liquid - so do plate count assays overestimate b-lactam killing? #MicroSky
Reposted by Alasdair Hubbard
Flash talk 4 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! Caleb Marsh is designing dual efflux inhibitor-abx molecules, then testing them in @ukhsa.bsky.social's open innovation platform for abx development. Very promising drops in MIC & spontaneous resistance rates. #MicroSky
November 27, 2025 at 5:55 PM
Flash talk 4 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! Caleb Marsh is designing dual efflux inhibitor-abx molecules, then testing them in @ukhsa.bsky.social's open innovation platform for abx development. Very promising drops in MIC & spontaneous resistance rates. #MicroSky
Reposted by Alasdair Hubbard
Flash talk 3 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! @mwilde.bsky.social on AMR gene silencing via mutation & reversion: engineering in SNP in a carbapenemase alters AST profile, but effect depends on genetic background. #MicroSky
November 27, 2025 at 5:46 PM
Flash talk 3 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! @mwilde.bsky.social on AMR gene silencing via mutation & reversion: engineering in SNP in a carbapenemase alters AST profile, but effect depends on genetic background. #MicroSky
Reposted by Alasdair Hubbard
gggenomes: A Grammar of Graphics for Comparative Genomics thackl.github.io/gggenomes/ #Rstats
A Grammar of Graphics for Comparative Genomics
An extension of ggplot2 for creating complex genomic maps. It builds on the power of ggplot2 and tidyverse adding new ggplot2-style geoms & positions and dplyr-style verbs to manipulate the…
thackl.github.io
November 18, 2025 at 7:02 PM
gggenomes: A Grammar of Graphics for Comparative Genomics thackl.github.io/gggenomes/ #Rstats
Reposted by Alasdair Hubbard
New paper out of the lab this week. Looking at the genomic diversity in isolates from outbreaks of Lactococcosis, and potential virulence mechanisms of the emerging causative pathogen L. pertauri.
doi.org/10.1002/mbo3...
doi.org/10.1002/mbo3...
Comparative Genomics of Lactococcus spp. From Global Aquaculture Outbreaks Reveals Virulence Determinants, Antibiotic Resistance, and Phage Defence Mechanisms
Lactococcus petauri predominated in isolates from outbreaks of lactococcosis, suggesting a shift in disease aetiology. Genomic analysis revealed diverse virulence factors, prophage and resistance gen...
doi.org
November 15, 2025 at 11:07 AM
New paper out of the lab this week. Looking at the genomic diversity in isolates from outbreaks of Lactococcosis, and potential virulence mechanisms of the emerging causative pathogen L. pertauri.
doi.org/10.1002/mbo3...
doi.org/10.1002/mbo3...
Reposted by Alasdair Hubbard
Reposted by Alasdair Hubbard
Very pleased to plug our latest preprint, lead author @microberamon.bsky.social - fantastic collaboration with labs of Dario Carugo (Oxford) and Martha Clokie (Leicester) https:// - and others #UTISKy #UTI #IDSky #MicroSky www.biorxiv.org/content/10.1101/2025.11.12.688052v1 more below👇🧵
Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli
Urinary tract infections (UTI) remain a major global health burden, with high recurrence despite antibiotic treatment. The escalating prevalence of antimicrobial resistance further compromises therape...
www.biorxiv.org
November 13, 2025 at 9:20 AM
Very pleased to plug our latest preprint, lead author @microberamon.bsky.social - fantastic collaboration with labs of Dario Carugo (Oxford) and Martha Clokie (Leicester) https:// - and others #UTISKy #UTI #IDSky #MicroSky www.biorxiv.org/content/10.1101/2025.11.12.688052v1 more below👇🧵
Reposted by Alasdair Hubbard
What Rosalind Franklin truly contributed to the discovery of DNA’s structure. A really informative article, perfect for a weekend coffee read. www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 8, 2025 at 9:21 AM
What Rosalind Franklin truly contributed to the discovery of DNA’s structure. A really informative article, perfect for a weekend coffee read. www.nature.com/articles/d41...