Xuebing Wu
@xuebingwu.bsky.social
Assistant Professor @Columbia University | Ribosome, translation, RNA, CRISPR, genomics | alum @MIT @WhiteheadInst @Tsinghua_Uni | #hiringNow
xuebingwu.github.io
xuebingwu.github.io
Reposted by Xuebing Wu
Check out the latest study from our lab, led by @mhall98.bsky.social :
www.biorxiv.org/content/10.1... (1/2)
www.biorxiv.org/content/10.1... (1/2)
March 15, 2025 at 12:36 AM
Check out the latest study from our lab, led by @mhall98.bsky.social :
www.biorxiv.org/content/10.1... (1/2)
www.biorxiv.org/content/10.1... (1/2)
Reposted by Xuebing Wu
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
very interesting work on ribosome cooperativity
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
February 3, 2025 at 4:24 PM
very interesting work on ribosome cooperativity
Glad to be in the "conversation" about microproteins and other non-canonical proteins arising from noncoding translation. I look forward to continuing the discussion at the upcoming keystone symposium on microproteins
“The leaders of the Human Genome Project always knew they were just starting a conversation”
The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do
https://go.nature.com/3CupmSS
The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do
https://go.nature.com/3CupmSS
‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases
The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.
go.nature.com
January 29, 2025 at 3:31 PM
Glad to be in the "conversation" about microproteins and other non-canonical proteins arising from noncoding translation. I look forward to continuing the discussion at the upcoming keystone symposium on microproteins
congratulations! @nadavahituv.bsky.social and @vagar.bsky.social
Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by @vagar.bsky.social, Fumitaka Inoue, @jshendure.bsky.social and many others as part of ENCODE.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Massively parallel characterization of transcriptional regulatory elements - Nature
Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.
www.nature.com
January 15, 2025 at 5:50 PM
congratulations! @nadavahituv.bsky.social and @vagar.bsky.social
Reposted by Xuebing Wu
Dear meeting organizers:
Picking the same senior PIs to keynote/give talks at meetings, who's talks I've seen a dozen times already, is not a great use of everyone's time. Nor does it highlight all of the rich talent in your field from more junior folks and peeps not at "elite" institutions.
Picking the same senior PIs to keynote/give talks at meetings, who's talks I've seen a dozen times already, is not a great use of everyone's time. Nor does it highlight all of the rich talent in your field from more junior folks and peeps not at "elite" institutions.
January 13, 2025 at 11:00 PM
Dear meeting organizers:
Picking the same senior PIs to keynote/give talks at meetings, who's talks I've seen a dozen times already, is not a great use of everyone's time. Nor does it highlight all of the rich talent in your field from more junior folks and peeps not at "elite" institutions.
Picking the same senior PIs to keynote/give talks at meetings, who's talks I've seen a dozen times already, is not a great use of everyone's time. Nor does it highlight all of the rich talent in your field from more junior folks and peeps not at "elite" institutions.
who said scientists are smart?
January 6, 2025 at 6:57 PM
who said scientists are smart?
Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...
January 2, 2025 at 9:55 PM
Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...
somehow this was the first thing came to my mind:
Interviewer: Can you explain this gap in your resume?
Me: I was updating my biosketch to the new format
Interviewer: Can you explain this gap in your resume?
Me: I was updating my biosketch to the new format
Interviewer: Can you explain this gap in your resume?
Me: It’s an in-frame deletion.
Me: It’s an in-frame deletion.
Interviewer: Can you explain this gap in your resume?
Me: I was thinking . . .
Me: I was thinking . . .
December 21, 2024 at 10:04 PM
somehow this was the first thing came to my mind:
Interviewer: Can you explain this gap in your resume?
Me: I was updating my biosketch to the new format
Interviewer: Can you explain this gap in your resume?
Me: I was updating my biosketch to the new format
I also believe that the current system of peer review and journal publishing is not working. I hope to witness and experience a system without those in my lifetime
In a world where publishing is a button and peer review can be carried out far more rapidly and effectively on public forums, our refusal to let go of a system that is slow, expensive and ineffective is causing substantive damage to science and society.
December 20, 2024 at 3:40 AM
I also believe that the current system of peer review and journal publishing is not working. I hope to witness and experience a system without those in my lifetime
Reposted by Xuebing Wu
The total length of human DNA on the planet right now is thus: (3.4x10^-10) • (2 x 3.055x10^9) • (3x10^13) • (8.2x10^9) = 5.11 x 10^23 meters
Time to call in NASA!
1 *light-year* – the distance light travels in one year – is 9.46x10^15 meters...
So: 54 million light-years of human DNA!
Time to call in NASA!
1 *light-year* – the distance light travels in one year – is 9.46x10^15 meters...
So: 54 million light-years of human DNA!
December 8, 2024 at 9:52 PM
The total length of human DNA on the planet right now is thus: (3.4x10^-10) • (2 x 3.055x10^9) • (3x10^13) • (8.2x10^9) = 5.11 x 10^23 meters
Time to call in NASA!
1 *light-year* – the distance light travels in one year – is 9.46x10^15 meters...
So: 54 million light-years of human DNA!
Time to call in NASA!
1 *light-year* – the distance light travels in one year – is 9.46x10^15 meters...
So: 54 million light-years of human DNA!
We are hiring a technician to help with CRISPR screens. Prior experience with CRISPR screens and large-scale cell culture is preferred but not required. Please feel free to share: jobrxiv.org/job/columbia...
Technician in Xuebing Wu lab at Columbia University in New York
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
December 6, 2024 at 7:21 PM
We are hiring a technician to help with CRISPR screens. Prior experience with CRISPR screens and large-scale cell culture is preferred but not required. Please feel free to share: jobrxiv.org/job/columbia...
Question for faculty interviewing students for PhD admission: do you give feedback at the end to help them do better in future interviews? eg things they should change/clarify in personal statement/CV, that they need to prepare better/more questions for faculty, their weakness compared to peers, etc
December 4, 2024 at 3:42 AM
Question for faculty interviewing students for PhD admission: do you give feedback at the end to help them do better in future interviews? eg things they should change/clarify in personal statement/CV, that they need to prepare better/more questions for faculty, their weakness compared to peers, etc
Honored to receive the inaugural Glenn Foundation Discovery Award from @AFARorg! Also congrats to the other awardee Dr. Ya-Chieh Hsu @HSCRB. Come work with us if you are interested in testing new ideas in aging biology! www.afar.org/news/announc...
September 21, 2023 at 4:28 PM
Honored to receive the inaugural Glenn Foundation Discovery Award from @AFARorg! Also congrats to the other awardee Dr. Ya-Chieh Hsu @HSCRB. Come work with us if you are interested in testing new ideas in aging biology! www.afar.org/news/announc...
This has to be a great conference, just look at the speaker list! - Katalin Karikó, David Liu, John Maraganore, Chuan He, Melissa Moore, Georg Seelig, and of course my favorite, Phillip Sharp!
Cracking the Code: The Dawn of Nucleic Acid Medicines
conferences.nature.com/event/27e02c...
Cracking the Code: The Dawn of Nucleic Acid Medicines
conferences.nature.com/event/27e02c...
September 20, 2023 at 2:50 AM
This has to be a great conference, just look at the speaker list! - Katalin Karikó, David Liu, John Maraganore, Chuan He, Melissa Moore, Georg Seelig, and of course my favorite, Phillip Sharp!
Cracking the Code: The Dawn of Nucleic Acid Medicines
conferences.nature.com/event/27e02c...
Cracking the Code: The Dawn of Nucleic Acid Medicines
conferences.nature.com/event/27e02c...