Rob Fagan
@robfagan.bsky.social
Lead for Molecular Microbiology @sheffielduni.bsky.social
@molmicrosheffield.bsky.social
#SEN parent, #AngelmanSyndrome
Clostridial cell biology, AMR & bacteriophage structure and function
He/Him
https://sites.google.com/sheffield.ac.uk/fagan-lab/
@molmicrosheffield.bsky.social
#SEN parent, #AngelmanSyndrome
Clostridial cell biology, AMR & bacteriophage structure and function
He/Him
https://sites.google.com/sheffield.ac.uk/fagan-lab/
Pinned
Rob Fagan
@robfagan.bsky.social
· Aug 22
A novel two-component system controls vancomycin resistance in epidemic Clostridioides difficile
The glycopeptide antibiotic vancomycin is the frontline treatment for C. difficile infection in the UK. There have been only sporadic reports of resistance in the clinic but testing is rare so the tru...
www.biorxiv.org
New preprint from us! The latest part of our C. difficile vancomycin resistance story. We identified a new two-component system (VnrRS) that can control expression of the vanG pathway - just needs one amino acid change
@buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social
@buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social
Reposted by Rob Fagan
Absolutely delighted (and proud) that @freyaallen.bsky.social passed her viva with minor corrections today.
Thanks very much @jessicamablair.bsky.social @robfagan.bsky.social for examining!
Thanks very much @jessicamablair.bsky.social @robfagan.bsky.social for examining!
November 6, 2025 at 10:09 PM
Absolutely delighted (and proud) that @freyaallen.bsky.social passed her viva with minor corrections today.
Thanks very much @jessicamablair.bsky.social @robfagan.bsky.social for examining!
Thanks very much @jessicamablair.bsky.social @robfagan.bsky.social for examining!
Reposted by Rob Fagan
Thrilled to present the findings from my 2025 #SUREscheme project - 'Investigating the influence of latent bacteriophages on healthcare-associated C. difficile lysogens' - at the showcase yesterday evening. Huge thanks to @funnirudh.bsky.social and @robfagan.bsky.social for making this possible!
November 7, 2025 at 12:49 PM
Thrilled to present the findings from my 2025 #SUREscheme project - 'Investigating the influence of latent bacteriophages on healthcare-associated C. difficile lysogens' - at the showcase yesterday evening. Huge thanks to @funnirudh.bsky.social and @robfagan.bsky.social for making this possible!
Reposted by Rob Fagan
🚨 Fully funded PhD studentships 🚨
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
Clostridial Cell Biology Group
We are the Clostridial Cell Biology Group at the University of Sheffield. We study all aspects of cell biology, including the architecture and biogenesis of surface structures on both vegetative cells...
sites.google.com
October 31, 2025 at 3:44 PM
🚨 Fully funded PhD studentships 🚨
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
🚨 Fully funded PhD studentships 🚨
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
Clostridial Cell Biology Group
We are the Clostridial Cell Biology Group at the University of Sheffield. We study all aspects of cell biology, including the architecture and biogenesis of surface structures on both vegetative cells...
sites.google.com
October 31, 2025 at 3:44 PM
🚨 Fully funded PhD studentships 🚨
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
And just like that PhD student number 9 has finished! Congratulations Dr @anneswilliams.bsky.social and huge thanks to @claireyt.bsky.social and Laurence Wilson for acting as examiners. In the chaos yesterday I didn't get a photo so instead here's a drawing of our puppy by multi-talented Dr Williams
October 23, 2025 at 8:47 AM
And just like that PhD student number 9 has finished! Congratulations Dr @anneswilliams.bsky.social and huge thanks to @claireyt.bsky.social and Laurence Wilson for acting as examiners. In the chaos yesterday I didn't get a photo so instead here's a drawing of our puppy by multi-talented Dr Williams
The UK needs to be "culturally coherent" apparently - it's incredibly concerning when these disgusting racists feel comfortable enough to say this kind of garbage in public
Tory MP criticised after demanding legally settled families be deported
Katie Lam said move would make UK ‘culturally coherent’ and that a large number of people ‘need to go home’
www.theguardian.com
October 22, 2025 at 12:20 PM
The UK needs to be "culturally coherent" apparently - it's incredibly concerning when these disgusting racists feel comfortable enough to say this kind of garbage in public
Nesting habits of a 60lb Labrador puppy. So well camouflaged I almost didn't see her....
October 21, 2025 at 1:14 PM
Nesting habits of a 60lb Labrador puppy. So well camouflaged I almost didn't see her....
Who says TV isn't educational? I just had our 4 year old explain coastal erosion to me - courtesy of the Octonauts apparently
October 18, 2025 at 6:41 PM
Who says TV isn't educational? I just had our 4 year old explain coastal erosion to me - courtesy of the Octonauts apparently
Reposted by Rob Fagan
Beautiful CryoEM work by our University of Sheffield colleagues @molmicrosheffield.bsky.social
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum url: academic.oup.com/nar/article/...
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum url: academic.oup.com/nar/article/...
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum
Abstract. Plasmodium falciparum is a eukaryotic pathogen responsible for the majority of malaria-related fatalities. Plasmodium belongs to the phylum Apico
academic.oup.com
October 17, 2025 at 9:53 AM
Beautiful CryoEM work by our University of Sheffield colleagues @molmicrosheffield.bsky.social
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum url: academic.oup.com/nar/article/...
Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum url: academic.oup.com/nar/article/...
Starting the day with news of a fire in our office early this morning. Thankfully no one hurt and no lasting damage but an unpleasant start to the day!
October 8, 2025 at 9:26 AM
Starting the day with news of a fire in our office early this morning. Thankfully no one hurt and no lasting damage but an unpleasant start to the day!
Reposted by Rob Fagan
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
October 2, 2025 at 9:04 AM
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
Making the most of a few days off before I have to get back to the day job! I think I've finally found the puppy's limit
September 24, 2025 at 12:23 PM
Making the most of a few days off before I have to get back to the day job! I think I've finally found the puppy's limit
There are definite benefits to living on the edge of the Peak District. 5 min walk from our front door we reach the edge of the woods and after that the only limit is my legs. Today's mission was to clear my head and tire out the puppy
September 18, 2025 at 12:12 PM
There are definite benefits to living on the edge of the Peak District. 5 min walk from our front door we reach the edge of the woods and after that the only limit is my legs. Today's mission was to clear my head and tire out the puppy
Having a few days off to recover from a really full on summer & to get some DIY jobs done so we can sell our house. Was all going well until I got the carpet cleaner out. Managed to do half of one room before the magic white smoke escaped. Now two upset dogs and all the windows open. House stinks 😩
September 16, 2025 at 10:22 AM
Having a few days off to recover from a really full on summer & to get some DIY jobs done so we can sell our house. Was all going well until I got the carpet cleaner out. Managed to do half of one room before the magic white smoke escaped. Now two upset dogs and all the windows open. House stinks 😩
Reposted by Rob Fagan
Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...
September 8, 2025 at 8:56 AM
Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...
Reposted by Rob Fagan
Saturday morning Lego fun with Mr4!
September 6, 2025 at 9:33 AM
Saturday morning Lego fun with Mr4!
Our French hosts really outdid themselves with the venue for last night's #ClostPath2025 congress dinner. A fantastic night, a fantastic week of science and now just two years to wait to do it all again in Rio
September 5, 2025 at 10:45 AM
Our French hosts really outdid themselves with the venue for last night's #ClostPath2025 congress dinner. A fantastic night, a fantastic week of science and now just two years to wait to do it all again in Rio
Reposted by Rob Fagan
Looking back at a great #clostpath2025, and ahead to #icds2026 (Bled) and #clostpath2027 (Rio de Janeiro).
September 5, 2025 at 10:15 AM
Looking back at a great #clostpath2025, and ahead to #icds2026 (Bled) and #clostpath2027 (Rio de Janeiro).
Delighted to see some excellent work on C. diff vancomycin resistance at ClostPath. The evidence for emerging resistance is mounting and it's becoming clear that even fairly low level resistance causes treatment failure
September 4, 2025 at 6:29 AM
Delighted to see some excellent work on C. diff vancomycin resistance at ClostPath. The evidence for emerging resistance is mounting and it's becoming clear that even fairly low level resistance causes treatment failure
Lab on tour - the wonderful #ClostPath2025 organisers have arranged great walking tours. Guess where we are?
September 3, 2025 at 5:23 PM
Lab on tour - the wonderful #ClostPath2025 organisers have arranged great walking tours. Guess where we are?
Reposted by Rob Fagan
Our RW media are sharks. Labour spent the summer feeding them buckets of raw chum.
76 anti-immigration tweets in August 2025 from Starmer's Twitter account, the Home Office, and the official Number 10 account.
I compiled them all into a 10-minute Youtube video.
www.youtube.com/watch?v=naaj...
76 anti-immigration tweets in August 2025 from Starmer's Twitter account, the Home Office, and the official Number 10 account.
I compiled them all into a 10-minute Youtube video.
www.youtube.com/watch?v=naaj...
The Death of Labour's Soul (August 2025)
YouTube video by Edwin Hayward
www.youtube.com
September 2, 2025 at 10:37 AM
Our RW media are sharks. Labour spent the summer feeding them buckets of raw chum.
76 anti-immigration tweets in August 2025 from Starmer's Twitter account, the Home Office, and the official Number 10 account.
I compiled them all into a 10-minute Youtube video.
www.youtube.com/watch?v=naaj...
76 anti-immigration tweets in August 2025 from Starmer's Twitter account, the Home Office, and the official Number 10 account.
I compiled them all into a 10-minute Youtube video.
www.youtube.com/watch?v=naaj...
Reposted by Rob Fagan
net immigration fell by more than half last year and the politics has gone in the complete opposite direction. It's not really about the numbers
September 3, 2025 at 10:15 AM
net immigration fell by more than half last year and the politics has gone in the complete opposite direction. It's not really about the numbers
I'm tempting fate here but the transpennine express hasn't let me down yet - first stage of journey to #ClostPath2025 underway
September 1, 2025 at 7:19 AM
I'm tempting fate here but the transpennine express hasn't let me down yet - first stage of journey to #ClostPath2025 underway