@davidroper2.bsky.social
Professor of Biochemistry at U.Warwick, UK. bacterial cell walls, cell division, antibiotic discovery and resistance mechanisms. I’m on
here for science just like @davidroper2.
His name is Gus if you are wondering…
here for science just like @davidroper2.
His name is Gus if you are wondering…
Ah ha, as I suspect: there is an unequal distribution of the contents of a celebrations tub! Bluesky do your things and help in this scientific study!
December 25, 2025 at 8:00 PM
Ah ha, as I suspect: there is an unequal distribution of the contents of a celebrations tub! Bluesky do your things and help in this scientific study!
Reposted
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications
Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
www.nature.com
December 22, 2025 at 1:11 PM
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Well that’s another Christmas gift! Great collaboration between Tim Dafforn at Bhm Biosciences & Phil Ireland at DSTL and the wonderful student Adam (drive cruser) Evans dx.doi.org/10.1002/pro....
dx.doi.org
December 22, 2025 at 4:41 PM
Well that’s another Christmas gift! Great collaboration between Tim Dafforn at Bhm Biosciences & Phil Ireland at DSTL and the wonderful student Adam (drive cruser) Evans dx.doi.org/10.1002/pro....
Fantastic to be part of this which was published today, Dr Nic Briggs and newly minted Dr Jack Stone from my lab did the experimental works that contributed to the paper with Christophe Grangeasse and colleagues. @warwicklifesci.bsky.social
And check out the accompanying paper from the Grangeasse lab: www.nature.com/articles/s41...
Streptococcus pneumoniae S protein activates PBP1a to regulate peptidoglycan remodelling and cell division - Nature Microbiology
S protein interacts with and activates PBP1a during cell division, as part of a larger GpsB-associated multiprotein complex that coordinates peptidoglycan remodelling in Streptococcus pneumoniae.
www.nature.com
December 19, 2025 at 11:43 AM
Fantastic to be part of this which was published today, Dr Nic Briggs and newly minted Dr Jack Stone from my lab did the experimental works that contributed to the paper with Christophe Grangeasse and colleagues. @warwicklifesci.bsky.social
Reposted
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
December 12, 2025 at 2:58 PM
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
Reposted
Google at its peak was basically the best information retrieval system in human history and they and every competitor decided going from there to “you didn’t want answers you wanted half-assed auto-complete 80%-wrong hallucinations” in a few years was the right idea
November 25, 2025 at 1:57 AM
Google at its peak was basically the best information retrieval system in human history and they and every competitor decided going from there to “you didn’t want answers you wanted half-assed auto-complete 80%-wrong hallucinations” in a few years was the right idea
Reposted
A very - ahem - groovy talk by @georgiaisom.bsky.social: the protein YhdP spans the E. coli periplasm and transports phospholipids to the OM via a hydrophobic groove along its length. Impressive mix of computational & wet lab work www.sciencedirect.com/science/arti...
Phospholipid Transport Across the Bacterial Periplasm Through the Envelope-spanning Bridge YhdP
The outer membrane of Gram-negative bacteria provides a formidable barrier, essential for both pathogenesis and antimicrobial resistance. Biogenesis o…
www.sciencedirect.com
December 9, 2025 at 12:27 PM
A very - ahem - groovy talk by @georgiaisom.bsky.social: the protein YhdP spans the E. coli periplasm and transports phospholipids to the OM via a hydrophobic groove along its length. Impressive mix of computational & wet lab work www.sciencedirect.com/science/arti...
Kate Willett pass her viva yesterday, congrats Dr Willett! Huge thanks to @robfagan.bsky.social @ @jeremykeown.bsky.social
December 5, 2025 at 7:04 AM
Kate Willett pass her viva yesterday, congrats Dr Willett! Huge thanks to @robfagan.bsky.social @ @jeremykeown.bsky.social
I think young Professor Tame had a good time with us @warwicklifesci.bsky.social curtesy of an IAS professorial fellowship and is now of on the second leg in Rome. Thanks to my lab for making home feel so welcome. I may have to visit him in Rome, just to make sure he’s ok of course…
December 3, 2025 at 6:28 PM
I think young Professor Tame had a good time with us @warwicklifesci.bsky.social curtesy of an IAS professorial fellowship and is now of on the second leg in Rome. Thanks to my lab for making home feel so welcome. I may have to visit him in Rome, just to make sure he’s ok of course…
Reposted
JB Editor's Choice: Anderson, Khursigara et al. review the role of peptidoglycomics in understanding the structure and function of peptidoglycan.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
December 2, 2025 at 8:54 PM
JB Editor's Choice: Anderson, Khursigara et al. review the role of peptidoglycomics in understanding the structure and function of peptidoglycan.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted
Excited to share my latest postdoctoral work in the Shen Lab at Tufts! In this study, we follow up on an exciting finding by former grad student @shailab.bsky.social that C diff uses its Class A PBP (PBP1) to drive cell division (unlike previously studied bacteria)! journals.plos.org/plosgenetics...
Molecular dissection of Class A PBP function uncovers novel features of the non-canonical Clostridioides difficile divisome complex
Author summary Bacterial cell division is an ancient and essential process, but our molecular understanding of this process is primarily based on studies in a select few model systems. Recent work fou...
journals.plos.org
October 28, 2025 at 1:25 AM
Excited to share my latest postdoctoral work in the Shen Lab at Tufts! In this study, we follow up on an exciting finding by former grad student @shailab.bsky.social that C diff uses its Class A PBP (PBP1) to drive cell division (unlike previously studied bacteria)! journals.plos.org/plosgenetics...
30 years on since @YSBL_York who would have thought these two old gits would find themselves in a lab together again!
November 7, 2025 at 9:08 AM
30 years on since @YSBL_York who would have thought these two old gits would find themselves in a lab together again!
Reposted
Looking for a PhD? 🚀 MIBTP projects are out lots to explore!
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
Dr Melissa Webby
Dr Melissa Webby
warwick.ac.uk
October 23, 2025 at 5:56 PM
Looking for a PhD? 🚀 MIBTP projects are out lots to explore!
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
Reposted
Just in time for Becca’s thesis submission, their paper on MreB membrane interactions is published in @biophysj.bsky.social: www.cell.com/biophysj/ful... 🎉
October 4, 2025 at 1:34 PM
Just in time for Becca’s thesis submission, their paper on MreB membrane interactions is published in @biophysj.bsky.social: www.cell.com/biophysj/ful... 🎉
Reposted
I joined School of Life Sciences 3 months ago and these guys have been so welcoming. Gibbet Hill Rovers making it feel like being apart of a community instantly. Thanks to @davidroper2.bsky.social for helping me get involved. Looking forward to season 3!
October 2, 2025 at 6:59 PM
I joined School of Life Sciences 3 months ago and these guys have been so welcoming. Gibbet Hill Rovers making it feel like being apart of a community instantly. Thanks to @davidroper2.bsky.social for helping me get involved. Looking forward to season 3!
Reposted
People get special things engraved…. We got cryo-EM pucks engraved.
Now time to make some samples @jeremykeown.bsky.social
Now time to make some samples @jeremykeown.bsky.social
October 1, 2025 at 8:11 PM
People get special things engraved…. We got cryo-EM pucks engraved.
Now time to make some samples @jeremykeown.bsky.social
Now time to make some samples @jeremykeown.bsky.social
Reposted
Great opportunity to do a PhD with Giusy and co in Glasgow!
🚨PhD Opportunity Alert🚨 Join me, @suzieh.bsky.social and @walllabuoglasgow.bsky.social to investigate how environment shapes anti-phage defences & prophage–prophage conflict in Pseudomonas aeruginosa.
Apply here:
www.gla.ac.uk/postgraduate...
Apply here:
www.gla.ac.uk/postgraduate...
October 1, 2025 at 8:20 PM
Great opportunity to do a PhD with Giusy and co in Glasgow!
Anyone else had a circuit board blow on a Sorval ultracentrifuge in the recent past?
October 1, 2025 at 6:13 PM
Anyone else had a circuit board blow on a Sorval ultracentrifuge in the recent past?
Two PhD theses submitted to day from @warwicklifesci.bsky.social Kate Willett from my lab and Becca Bailey from @pstansfeld.bsky.social. Supervisor of one, internal examiner for another!
September 30, 2025 at 12:21 PM
Two PhD theses submitted to day from @warwicklifesci.bsky.social Kate Willett from my lab and Becca Bailey from @pstansfeld.bsky.social. Supervisor of one, internal examiner for another!
New from Chris Sham at NUS www.science.org/doi/10.1126/...
Dual transposon sequencing profiles the genetic interaction landscape in bacteria
Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform...
www.science.org
September 26, 2025 at 9:13 AM
New from Chris Sham at NUS www.science.org/doi/10.1126/...
Lovely trip back to @UniOfYork to the carbohydrate group meeting of the @RoySocChem. Old friends and familiar places
September 23, 2025 at 8:45 AM
Lovely trip back to @UniOfYork to the carbohydrate group meeting of the @RoySocChem. Old friends and familiar places
It’s been my honour and privilege to co-organise the Great Wall Symposium with @ivo-boneca.bsky.social for the past 14 years, roll on 2027 more news soon.
September 19, 2025 at 9:43 AM
It’s been my honour and privilege to co-organise the Great Wall Symposium with @ivo-boneca.bsky.social for the past 14 years, roll on 2027 more news soon.
And that’s a wrap on the Great Wall Symposium 2025!
Roll on 2027, venue to be confirmed shortly …
Roll on 2027, venue to be confirmed shortly …
September 17, 2025 at 6:29 PM
And that’s a wrap on the Great Wall Symposium 2025!
Roll on 2027, venue to be confirmed shortly …
Roll on 2027, venue to be confirmed shortly …
Reposted
Want to know what natural products are in clinical trials? Read this review! Great job from Mark Butler, Rob Capon, Mark Blaskovich! pubs.rsc.org/en/content/a...
#naturalproducts #antibiotic #amr #drugdiscovery #drug
#naturalproducts #antibiotic #amr #drugdiscovery #drug
Natural product-derived compounds in clinical trials and drug approvals
Covering: January 2014–June 2025. Previous review: Natural Product Reports, 2014, 31, 1612Natural products (NPs) have long been foundational in medicine, from ancient herbal remedies to the discovery ...
pubs.rsc.org
September 10, 2025 at 3:01 PM
Want to know what natural products are in clinical trials? Read this review! Great job from Mark Butler, Rob Capon, Mark Blaskovich! pubs.rsc.org/en/content/a...
#naturalproducts #antibiotic #amr #drugdiscovery #drug
#naturalproducts #antibiotic #amr #drugdiscovery #drug
Reposted
ICYMI: Simplifying access to MRC applicant-led funding #MRC #AcademicSky
Simplifying access to MRC applicant-led funding
We’re introducing a new flexible research grant and removing closing dates from our board funding opportunities.
www.ukri.org
September 9, 2025 at 8:33 AM
ICYMI: Simplifying access to MRC applicant-led funding #MRC #AcademicSky