Getting Sure to get the Proteins 😁
November 13, 2025 at 12:28 AM
Getting Sure to get the Proteins 😁
1) This study from Cornell University tested more than 6000 proteins before and after two exercise tests.
It found altered patterns in ME/CFS patients compared to controls, particularly in proteins involved in the immune system, signal transduction, and muscle contraction.
It found altered patterns in ME/CFS patients compared to controls, particularly in proteins involved in the immune system, signal transduction, and muscle contraction.
November 15, 2025 at 8:21 AM
1) This study from Cornell University tested more than 6000 proteins before and after two exercise tests.
It found altered patterns in ME/CFS patients compared to controls, particularly in proteins involved in the immune system, signal transduction, and muscle contraction.
It found altered patterns in ME/CFS patients compared to controls, particularly in proteins involved in the immune system, signal transduction, and muscle contraction.
Filling up small holes with healthy proteins
November 13, 2025 at 8:55 AM
Filling up small holes with healthy proteins
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize Type IX secretion signals and target effectors to their final destinations in Flavobacterium johnsoniae
Communications Biology - Bacteroidota use the Type IX secretion system to secrete proteins with a conserved C-terminal domain (CTD) secretion signal domain. Type B CTDs require specific shuttle...
www.nature.com
November 15, 2025 at 3:55 PM
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
messenger RNA -molecules that transmit genetic codes for building proteins- can be used to activate the immune system. Dr. Elias Sayour, a UF Health pediatric oncologist and Stop Children's Cancer/Bonnie R. Freeman Professor for Pediatric Oncology Research, has spent years developing mRNA-based
November 14, 2025 at 5:05 PM
messenger RNA -molecules that transmit genetic codes for building proteins- can be used to activate the immune system. Dr. Elias Sayour, a UF Health pediatric oncologist and Stop Children's Cancer/Bonnie R. Freeman Professor for Pediatric Oncology Research, has spent years developing mRNA-based
Nature research paper: Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis
go.nature.com/3JKJofG
go.nature.com/3JKJofG
Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis - Nature
Viral NblA accelerates the cyanophage infection cycle, directs degradation of the host phycobilisome and other proteins, and reduces host photosynthetic light-harvesting efficiency.
go.nature.com
November 13, 2025 at 6:49 PM
Nature research paper: Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis
go.nature.com/3JKJofG
go.nature.com/3JKJofG
New online! The type VI secretion system and associated effector proteins
The type VI secretion system and associated effector proteins
Nature Reviews Microbiology, Published online: 14 November 2025; doi:10.1038/s41579-025-01256-wIn this Review, Basler and colleagues examine the type VI secretion system (T6SS), focusing on the diversity of antibacterial T6SS effectors and the evolutionary forces that shape them. They explain how effectors diversify and highlight interbacterial antagonism as a key driver of this process.
www.nature.com
November 14, 2025 at 9:29 PM
New online! The type VI secretion system and associated effector proteins
New HRT just dropped: purchasing my gender whey-proteins from Jim on the black market, affordable and way faster and more polite than the NHS😌
He's milking gender, he's curdling gender, he's separating the gender curds from the gender whey, he's draining and pressing gender, he's ripening gender over long periods of time to produce subtle complexities of gender flavour. No one is doing it like him.
November 16, 2025 at 11:06 PM
New HRT just dropped: purchasing my gender whey-proteins from Jim on the black market, affordable and way faster and more polite than the NHS😌
It is! It's so cool! What do you mean we can hijack cell mechanisms to make specific proteins that we want you to have or defend against? Wizard level stuff
November 15, 2025 at 12:05 AM
It is! It's so cool! What do you mean we can hijack cell mechanisms to make specific proteins that we want you to have or defend against? Wizard level stuff
Natural beef flavour is beef extracts, that I'm allergic to.
Fats are fats, and proteins are proteins.. I have an allergic reaction to proteins found in red meat.
I'm basically a Lacto/vegetarian, and not by choice.
I do eat cheese and dairy products, but I don't react to those.
Fats are fats, and proteins are proteins.. I have an allergic reaction to proteins found in red meat.
I'm basically a Lacto/vegetarian, and not by choice.
I do eat cheese and dairy products, but I don't react to those.
November 13, 2025 at 3:57 PM
Natural beef flavour is beef extracts, that I'm allergic to.
Fats are fats, and proteins are proteins.. I have an allergic reaction to proteins found in red meat.
I'm basically a Lacto/vegetarian, and not by choice.
I do eat cheese and dairy products, but I don't react to those.
Fats are fats, and proteins are proteins.. I have an allergic reaction to proteins found in red meat.
I'm basically a Lacto/vegetarian, and not by choice.
I do eat cheese and dairy products, but I don't react to those.
9) Proteins were measured with the SomaScan assay, which uses DNA-based reagents.
Link to the paper:
Germain et al. 2025. Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/ CFS following exertion.
Link to the paper:
Germain et al. 2025. Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/ CFS following exertion.
Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/CFS following exertion
The overarching symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is post-exertional malaise (PEM), an exacerbation of symptoms f…
www.sciencedirect.com
November 15, 2025 at 8:21 AM
9) Proteins were measured with the SomaScan assay, which uses DNA-based reagents.
Link to the paper:
Germain et al. 2025. Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/ CFS following exertion.
Link to the paper:
Germain et al. 2025. Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/ CFS following exertion.
Im trying to get more veggies and varied proteins in so I've been into just tossing some edamame and corn into the rice cooker before cooking my rice...
November 17, 2025 at 12:57 AM
Im trying to get more veggies and varied proteins in so I've been into just tossing some edamame and corn into the rice cooker before cooking my rice...
In #ScienceSignaling, researchers present a method to predict whether proteins are sensitive to pH and to identify which amino acids in the protein are responsible for its pH sensitivity. https://scim.ag/47VgIIG
Ionizable networks mediate pH-dependent allostery in the SH2 domain–containing signaling proteins SHP2 and SRC
The pH-dependent activities of SHP2 and SRC depend on interactions at the SH2-catalytic domain interface.
scim.ag
November 14, 2025 at 3:49 PM
In #ScienceSignaling, researchers present a method to predict whether proteins are sensitive to pH and to identify which amino acids in the protein are responsible for its pH sensitivity. https://scim.ag/47VgIIG
The assigned program officer was following attempts to adapt mass spectrometry techniques to peptides and proteins. Little progress was being made.
He thought this applicant knew a lot about gas phase ion chemistry, a key to moving this field forward.
9/13
He thought this applicant knew a lot about gas phase ion chemistry, a key to moving this field forward.
9/13
November 14, 2025 at 3:31 PM
The assigned program officer was following attempts to adapt mass spectrometry techniques to peptides and proteins. Little progress was being made.
He thought this applicant knew a lot about gas phase ion chemistry, a key to moving this field forward.
9/13
He thought this applicant knew a lot about gas phase ion chemistry, a key to moving this field forward.
9/13
Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis www.nature.com/articles/s41...
this project was led by @omernadel.bsky.social and is a joint work between the labs of @bejalab.bsky.social, Debbie Lindell and Oded Kleifeld from @biologytechnion.bsky.social
this project was led by @omernadel.bsky.social and is a joint work between the labs of @bejalab.bsky.social, Debbie Lindell and Oded Kleifeld from @biologytechnion.bsky.social
the sun is shining through the clouds in the sky above the ocean
ALT: the sun is shining through the clouds in the sky above the ocean
media.tenor.com
November 12, 2025 at 4:00 PM
Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis www.nature.com/articles/s41...
this project was led by @omernadel.bsky.social and is a joint work between the labs of @bejalab.bsky.social, Debbie Lindell and Oded Kleifeld from @biologytechnion.bsky.social
this project was led by @omernadel.bsky.social and is a joint work between the labs of @bejalab.bsky.social, Debbie Lindell and Oded Kleifeld from @biologytechnion.bsky.social
In the world of proteins that drive cancer, Ras proteins and PI3Kα are major players. Several companies are developing molecules that break up this protein power couple. My latest short news feature for @cenmag.bsky.social
cen.acs.org/biological-c...
cen.acs.org/biological-c...
A breakup strategy that’s inspiring clinical candidates for cancer
Scientists seek molecules that will disrupt the Ras-PI3Kα interaction
cen.acs.org
November 12, 2025 at 8:36 PM
In the world of proteins that drive cancer, Ras proteins and PI3Kα are major players. Several companies are developing molecules that break up this protein power couple. My latest short news feature for @cenmag.bsky.social
cen.acs.org/biological-c...
cen.acs.org/biological-c...
Protein: Ignore marketing hype.
How much protein do you really need? www.nature.com/articles/d41... via @nature.com
"...the protein craze has been driven mostly by aggressive marketing of high-protein foods and supplements..."
"...most Americans already eat more than enough proteins."
How much protein do you really need? www.nature.com/articles/d41... via @nature.com
"...the protein craze has been driven mostly by aggressive marketing of high-protein foods and supplements..."
"...most Americans already eat more than enough proteins."
How much protein do you really need? What the science says
Fitness influencers promote super-high-protein diets, but studies show there’s only so much the body can use.
www.nature.com
November 12, 2025 at 5:15 PM
Protein: Ignore marketing hype.
How much protein do you really need? www.nature.com/articles/d41... via @nature.com
"...the protein craze has been driven mostly by aggressive marketing of high-protein foods and supplements..."
"...most Americans already eat more than enough proteins."
How much protein do you really need? www.nature.com/articles/d41... via @nature.com
"...the protein craze has been driven mostly by aggressive marketing of high-protein foods and supplements..."
"...most Americans already eat more than enough proteins."
There are some ways machine learning could be genuinely useful in the sciences, like running through huge amounts of hypothetical combinations of chemicals based on what we know to flag ones that might be useful to test experimentally, or learning about how proteins fold to help cure some conditions
November 16, 2025 at 8:16 PM
There are some ways machine learning could be genuinely useful in the sciences, like running through huge amounts of hypothetical combinations of chemicals based on what we know to flag ones that might be useful to test experimentally, or learning about how proteins fold to help cure some conditions
It’ll be interesting to explore whether there are interacting proteins specifically recognizing sialate OAc moieties, or how specific gangliosides cluster with different membrane proteins on cell surface or organelles.
November 15, 2025 at 11:32 AM
It’ll be interesting to explore whether there are interacting proteins specifically recognizing sialate OAc moieties, or how specific gangliosides cluster with different membrane proteins on cell surface or organelles.
… For Bolg origins, as they would have been unlikely to have evolved to process milk proteins.
So if we are going to gatekeep who can & who can’t be Irish, I’m taking over the gate & racists aren’t getting in.
I have spoken! 😉❤️☘️
So if we are going to gatekeep who can & who can’t be Irish, I’m taking over the gate & racists aren’t getting in.
I have spoken! 😉❤️☘️
November 13, 2025 at 1:22 PM
… For Bolg origins, as they would have been unlikely to have evolved to process milk proteins.
So if we are going to gatekeep who can & who can’t be Irish, I’m taking over the gate & racists aren’t getting in.
I have spoken! 😉❤️☘️
So if we are going to gatekeep who can & who can’t be Irish, I’m taking over the gate & racists aren’t getting in.
I have spoken! 😉❤️☘️
6) Instead of simply comparing individual proteins, the authors also looked at changing patterns in biological pathways using gene set enrichment analysis (GSEA).
The graph below gives an overview of abnormal pathways. We'll highlight a few interesting ones.
The graph below gives an overview of abnormal pathways. We'll highlight a few interesting ones.
November 15, 2025 at 8:21 AM
6) Instead of simply comparing individual proteins, the authors also looked at changing patterns in biological pathways using gene set enrichment analysis (GSEA).
The graph below gives an overview of abnormal pathways. We'll highlight a few interesting ones.
The graph below gives an overview of abnormal pathways. We'll highlight a few interesting ones.
What Crick proposed with the Central Dogma gets at understanding structure/function relationships, the underlying chemistry.
Watson's textbook simplification was memorization of the typical flow in the cells to make proteins.
Our students deserve better. #ChemChat #MolBio #Biochem
Watson's textbook simplification was memorization of the typical flow in the cells to make proteins.
Our students deserve better. #ChemChat #MolBio #Biochem
With Watson's death can we stop teaching his simplified version of the Central Dogma (DNA-RNA-protein) & instead teach what Crick actually proposed? It promotes understanding & critical thinking. wellcomecollection.org/works/xmscu3...
November 13, 2025 at 11:25 PM
You know what. Fuck you (misfolds your proteins)
November 13, 2025 at 9:44 PM
You know what. Fuck you (misfolds your proteins)
in a way yes but usually meat and fish are more expensive than vegan proteins like beans
November 14, 2025 at 8:52 PM
in a way yes but usually meat and fish are more expensive than vegan proteins like beans