Matthew Taliaferro
@jmtali.bsky.social
RNA biologist at University of Colorado Anschutz Medical Campus http://www.taliaferrolab.com
Excited to share that this work is now published in its final form!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
December 15, 2025 at 2:37 PM
Excited to share that this work is now published in its final form!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Matthew Taliaferro
A mechanism for controlling mRNA localization to neuronal projections:
Daniel Dominguez, Matthew Taliaferro @jmtali.bsky.social and collaborators implicated ALS-linked TDP-43 as inhibitor of mRNA accumulation in neurites, possibly by promoting their decay
link.springer.com/article/10.1...
Daniel Dominguez, Matthew Taliaferro @jmtali.bsky.social and collaborators implicated ALS-linked TDP-43 as inhibitor of mRNA accumulation in neurites, possibly by promoting their decay
link.springer.com/article/10.1...
TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability - The EMBO Journal
The subcellular localization of many mRNAs to neuronal projections allows neurons to efficiently and rapidly react to spatially restricted external cues. However, for most of these RNAs, the mechanism...
link.springer.com
December 15, 2025 at 1:00 PM
A mechanism for controlling mRNA localization to neuronal projections:
Daniel Dominguez, Matthew Taliaferro @jmtali.bsky.social and collaborators implicated ALS-linked TDP-43 as inhibitor of mRNA accumulation in neurites, possibly by promoting their decay
link.springer.com/article/10.1...
Daniel Dominguez, Matthew Taliaferro @jmtali.bsky.social and collaborators implicated ALS-linked TDP-43 as inhibitor of mRNA accumulation in neurites, possibly by promoting their decay
link.springer.com/article/10.1...
Reposted by Matthew Taliaferro
Join us in Porto for the forefront of RNA localization & local translation research! Registration is live!
Registrations are due March 10, and both travel grants and dependent care grants are available. We look forward to seeing you in Portugal next summer!
meetings.embo.org/event/26-rna...
meetings.embo.org/event/26-rna...
RNA localization and local translation
Gene expression is regulated through a series of complex, coordinated events, including the localization of specific RNA molecules to distinct subcellular locations. This subcellular organization of …
meetings.embo.org
December 8, 2025 at 9:46 PM
Join us in Porto for the forefront of RNA localization & local translation research! Registration is live!
Reposted by Matthew Taliaferro
My favourite meeting! Highly recommend registering for this one...
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
December 8, 2025 at 5:08 PM
My favourite meeting! Highly recommend registering for this one...
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
December 8, 2025 at 4:40 PM
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
How does one review his paper if he’s infallible?
May 9, 2025 at 12:20 AM
How does one review his paper if he’s infallible?
Reposted by Matthew Taliaferro
New @prelights.bsky.social post ! I'm happy to highlight @jmtali.bsky.social lab latest preprint prelights.biologists.com/highlights/t...
TDP-43 directly inhibits RNA accumulation in neurites through modulation of RNA stability - preLights
An intriguing twist! TDP-43 (linked to ALS) keeps RNAs out of neuronal projections by making them unstable preventing RNA buildup in neurites
prelights.biologists.com
April 10, 2025 at 12:44 PM
New @prelights.bsky.social post ! I'm happy to highlight @jmtali.bsky.social lab latest preprint prelights.biologists.com/highlights/t...
We received notice that two F31s were terminated and submitted another F31 application two hours later. We keep on trucking, I guess.
April 2, 2025 at 8:40 PM
We received notice that two F31s were terminated and submitted another F31 application two hours later. We keep on trucking, I guess.
Two updates with this project! First, this work is now published here: academic.oup.com/nar/article/...
Second, our software for identifying 8-oxoguanosine via RNAseq, PIGPEN, is now installable via bioconda: anaconda.org/bioconda/pig...
Second, our software for identifying 8-oxoguanosine via RNAseq, PIGPEN, is now installable via bioconda: anaconda.org/bioconda/pig...
March 21, 2025 at 3:25 PM
Two updates with this project! First, this work is now published here: academic.oup.com/nar/article/...
Second, our software for identifying 8-oxoguanosine via RNAseq, PIGPEN, is now installable via bioconda: anaconda.org/bioconda/pig...
Second, our software for identifying 8-oxoguanosine via RNAseq, PIGPEN, is now installable via bioconda: anaconda.org/bioconda/pig...
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
March 3, 2025 at 3:55 PM
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
Save the date for the next edition of this wonderful meeting. We look forward to seeing you in Portugal!!
February 28, 2025 at 3:53 PM
Save the date for the next edition of this wonderful meeting. We look forward to seeing you in Portugal!!
From this we can conclude that I am:
A. extremely arrogant about my own writing
B. an idiot
C. both
A. extremely arrogant about my own writing
B. an idiot
C. both
February 1, 2025 at 5:33 PM
From this we can conclude that I am:
A. extremely arrogant about my own writing
B. an idiot
C. both
A. extremely arrogant about my own writing
B. an idiot
C. both
Come be our colleague! @cu-bmg.bsky.social is running an open rank search for a structural biologist specializing in cryo-EM/ET. This is a great opportunity in a highly collegial and collaborative department.
Apply here: cu.taleo.net/careersectio...
Apply here: cu.taleo.net/careersectio...
January 27, 2025 at 4:36 PM
Come be our colleague! @cu-bmg.bsky.social is running an open rank search for a structural biologist specializing in cryo-EM/ET. This is a great opportunity in a highly collegial and collaborative department.
Apply here: cu.taleo.net/careersectio...
Apply here: cu.taleo.net/careersectio...
Start PCR. Ski. Purify PCR product. @molbcu.bsky.social
January 4, 2025 at 2:25 AM
Start PCR. Ski. Purify PCR product. @molbcu.bsky.social
@triggerloop.bsky.social ok seriously is a&m refusing to share the film or what is going on here
January 1, 2025 at 8:20 PM
@triggerloop.bsky.social ok seriously is a&m refusing to share the film or what is going on here
@triggerloop.bsky.social good for you. Got your win for the day. No need to worry about anything else.
November 30, 2024 at 8:54 PM
@triggerloop.bsky.social good for you. Got your win for the day. No need to worry about anything else.
Reposted by Matthew Taliaferro
Interested in doing your postdoc with the Department of Pharmacology at @CUAnschutz? Join us for our Postdoctoral Education & Knowledge Summit with @cuanschutz_dpb and the Department of Biochemistry & Molecular Genetics!
Applications close December 1st. bit.ly/CU-PEAKS
Applications close December 1st. bit.ly/CU-PEAKS
CU PEAKS
bit.ly
November 23, 2024 at 10:42 PM
Interested in doing your postdoc with the Department of Pharmacology at @CUAnschutz? Join us for our Postdoctoral Education & Knowledge Summit with @cuanschutz_dpb and the Department of Biochemistry & Molecular Genetics!
Applications close December 1st. bit.ly/CU-PEAKS
Applications close December 1st. bit.ly/CU-PEAKS
Reposted by Matthew Taliaferro
Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705
https://www.rug.nl/about-ug/work-with-us/job-opportunities/?details=00347-02S000B06P
t.co
November 15, 2024 at 9:13 PM
Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705
Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation. biorxiv.org/cgi/content/...
November 13, 2024 at 4:46 PM
Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation. biorxiv.org/cgi/content/...
Reposted by Matthew Taliaferro
New preprint from my group! We used SHAPE-MaP to measure RNA structure of DDX3X-sensitive mRNAs, developed a colorimetric translation reporter for DDX3X activity, and identified amino acids in DDX3X that mediate interaction with the translation machinery:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Determinants of DDX3X sensitivity uncovered using a helicase activity in translation reporter
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
September 18, 2023 at 5:16 PM
New preprint from my group! We used SHAPE-MaP to measure RNA structure of DDX3X-sensitive mRNAs, developed a colorimetric translation reporter for DDX3X activity, and identified amino acids in DDX3X that mediate interaction with the translation machinery:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...