Simon Bullock
@simonbullock11.bsky.social
Molecular motors, mRNA localisation, microscopes4schools, MRC-LMB (Cambridge, UK)
Lots of exciting PhD projects on offer at the LMB, including in our group 😊
Considering the LMB for your PhD?
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
November 10, 2025 at 2:30 PM
Lots of exciting PhD projects on offer at the LMB, including in our group 😊
Reposted by Simon Bullock
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Simon Bullock
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
October 23, 2025 at 5:25 PM
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Reposted by Simon Bullock
How can we see the cells that make up a living organism? Membrane-localising tags can drive fluorescent proteins to the cell's outer membrane, making their outlines visible. But the tags don't work well in all organisms. How do you find one for your species of interest? 🧵
Check our latest preprint
Check our latest preprint
A toolkit for testing membrane-localising tags across species
Transgenic markers and tools have revolutionised how we study cells and developing organisms. Some of the elements needed to construct those tools are universally applicable (e.g. fluorescent proteins...
www.biorxiv.org
October 23, 2025 at 8:16 AM
How can we see the cells that make up a living organism? Membrane-localising tags can drive fluorescent proteins to the cell's outer membrane, making their outlines visible. But the tags don't work well in all organisms. How do you find one for your species of interest? 🧵
Check our latest preprint
Check our latest preprint
Reposted by Simon Bullock
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
October 14, 2025 at 1:50 PM
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
Reposted by Simon Bullock
📣 Two week left to apply! 👇
Apply in the link below or, if you have specific questions, reach out!
Apply in the link below or, if you have specific questions, reach out!
Job alert in neuro-immunology!
In case the internal link I shared last week does not work for some, here is an external link to apply for our postdoc position at the @mrclmb.bsky.social PNAC Division.
www.nature.com/naturecareer...
In case the internal link I shared last week does not work for some, here is an external link to apply for our postdoc position at the @mrclmb.bsky.social PNAC Division.
www.nature.com/naturecareer...
Postdoctoral Scientist - PNAC - Dr Noe Rodriguez - LMB 2717 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12845398
Postdoctoral Scientist Salary £41,344 per annum pro rata (for PD/CDF) MRC Laboratory of Molecular Biology, Cambridge, UK We are looking for a motiv...
www.nature.com
October 14, 2025 at 9:06 AM
📣 Two week left to apply! 👇
Apply in the link below or, if you have specific questions, reach out!
Apply in the link below or, if you have specific questions, reach out!
Reposted by Simon Bullock
Are you thinking on an exciting PHD project at the interface of translation control and innate immunity? @rnanomad.bsky.social and I have a project that might interest you!
@alf-castello.bsky.social & I are inviting applications for a competitive PhD studentship to study the mechanisms of translational regulation of the host response to RNA virus infections. The student will be based at Uni. Glasgow. Please spread the word. #RNASky
www.gla.ac.uk/postgraduate...
www.gla.ac.uk/postgraduate...
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Understanding Pathogens, from Molecules to Phenotypes - Alfredo Castello
www.gla.ac.uk
October 3, 2025 at 1:38 PM
Are you thinking on an exciting PHD project at the interface of translation control and innate immunity? @rnanomad.bsky.social and I have a project that might interest you!
Reposted by Simon Bullock
Start independent research at the JIC with us 👇.
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
VACANCY - Independent research fellowships leading to tenured positions
We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.
APPLICATION DEADLINE: 10 November 2025
Click here to apply: jic.link/Fellows
We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.
APPLICATION DEADLINE: 10 November 2025
Click here to apply: jic.link/Fellows
October 3, 2025 at 6:36 PM
Start independent research at the JIC with us 👇.
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
Reposted by Simon Bullock
BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...
Bioimage Analysis Specialist | King's College London
www.kcl.ac.uk
September 29, 2025 at 9:48 AM
BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...
Reposted by Simon Bullock
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
September 15, 2025 at 5:26 PM
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
Reposted by Simon Bullock
And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4
Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers
Nature Structural & Molecular Biology - Liu et al. show that SPIN90 dimerizes and binds two Arp2/3 complexes to nucleate two bidirectional actin filaments and the dimerization domain is...
rdcu.be
September 16, 2025 at 6:09 AM
And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4
Reposted by Simon Bullock
🚨Publication alert🚨
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...
Multispectral live-cell imaging with uncompromised spatiotemporal resolution - Nature Photonics
A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with...
www.nature.com
September 16, 2025 at 10:20 AM
🚨Publication alert🚨
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...
Reposted by Simon Bullock
Are you ready for a symposium dedicated to microtubule dynamics, function, and structure? 🙌
#EESMicrotubules will bring together researchers who share an interest in microtubule biology and its relevance to health and disease 🩺
💻 s.embl.org/ees26-09-bl
✒️ Submit your abstract by 11 March
#EESMicrotubules will bring together researchers who share an interest in microtubule biology and its relevance to health and disease 🩺
💻 s.embl.org/ees26-09-bl
✒️ Submit your abstract by 11 March
September 11, 2025 at 2:13 PM
Are you ready for a symposium dedicated to microtubule dynamics, function, and structure? 🙌
#EESMicrotubules will bring together researchers who share an interest in microtubule biology and its relevance to health and disease 🩺
💻 s.embl.org/ees26-09-bl
✒️ Submit your abstract by 11 March
#EESMicrotubules will bring together researchers who share an interest in microtubule biology and its relevance to health and disease 🩺
💻 s.embl.org/ees26-09-bl
✒️ Submit your abstract by 11 March
Reposted by Simon Bullock
A 6-month postdoc position is currently available in our group. The project involves the use of hPSC-based models to dissect the links between chromosomal copy number alterations, DNA damage and tumour initiation-please spread the word-closing date=29th Sept: www.jobs.ac.uk/job/DON353/r...
Research Associate (Stem Cell/Cancer Biology)
Research Associate (Stem Cell/Cancer Biology)
jobsite.sheffield.ac.uk
September 11, 2025 at 10:32 AM
A 6-month postdoc position is currently available in our group. The project involves the use of hPSC-based models to dissect the links between chromosomal copy number alterations, DNA damage and tumour initiation-please spread the word-closing date=29th Sept: www.jobs.ac.uk/job/DON353/r...
The winners of our schools microscopy competition have been announced 👇!
🔬 Over 900 pupils from 22 schools across Cambridge, Peterborough & Bedfordshire took part in this year’s #Microscopes4Schools competition.
From insect wings to iridescent feathers, kids used microscopes to explore the hidden beauty of nature: www2.mrc-lmb.cam.ac.uk/microscopes-...
#LMBNews
From insect wings to iridescent feathers, kids used microscopes to explore the hidden beauty of nature: www2.mrc-lmb.cam.ac.uk/microscopes-...
#LMBNews
September 10, 2025 at 1:33 PM
The winners of our schools microscopy competition have been announced 👇!
Reposted by Simon Bullock
ICYMI: Simplifying access to MRC applicant-led funding #MRC #AcademicSky
Simplifying access to MRC applicant-led funding
We’re introducing a new flexible research grant and removing closing dates from our board funding opportunities.
www.ukri.org
September 9, 2025 at 8:33 AM
ICYMI: Simplifying access to MRC applicant-led funding #MRC #AcademicSky
Reposted by Simon Bullock
EMBO meeting on "Molecular and Developmental Biology of Drosophila" 21 – 27 June 2026
Registration is now open!
Deadline next November 3rd!
meetings.embo.org/event/26-dro...
Registration is now open!
Deadline next November 3rd!
meetings.embo.org/event/26-dro...
Molecular and Developmental Biology of Drosophila
The principal theme of the EMBO Workshop is the Molecular and Developmental Biology of Drosophila. Supported by EMBO over four decades, this will be the 24th biennial “Crete meeting”.
With the a…
meetings.embo.org
September 4, 2025 at 8:01 AM
EMBO meeting on "Molecular and Developmental Biology of Drosophila" 21 – 27 June 2026
Registration is now open!
Deadline next November 3rd!
meetings.embo.org/event/26-dro...
Registration is now open!
Deadline next November 3rd!
meetings.embo.org/event/26-dro...
Reposted by Simon Bullock
If you love cytoskeleton and tissue morphogenesis, have a read!
Supracellular actomyosin assemblies: master coordinators of development
In this Review, Katja Röper @katjaroeper.bsky.social discusses supracellular actomyosin structures, tissues where they function, their known roles as well as potential properties
journals.biologists.com/dev/article/...
In this Review, Katja Röper @katjaroeper.bsky.social discusses supracellular actomyosin structures, tissues where they function, their known roles as well as potential properties
journals.biologists.com/dev/article/...
September 3, 2025 at 11:53 AM
If you love cytoskeleton and tissue morphogenesis, have a read!
Reposted by Simon Bullock
Are you a postdoc interested in the mechanisms of disease?
Do you have a great record and an exciting vision?
Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.
Deadline 30th September...pass it on!
www.path.ox.ac.uk/work-with-us...
Do you have a great record and an exciting vision?
Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.
Deadline 30th September...pass it on!
www.path.ox.ac.uk/work-with-us...
Group Leader Career Development Fellowships - Dunn School
Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?
www.path.ox.ac.uk
September 1, 2025 at 2:39 PM
Are you a postdoc interested in the mechanisms of disease?
Do you have a great record and an exciting vision?
Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.
Deadline 30th September...pass it on!
www.path.ox.ac.uk/work-with-us...
Do you have a great record and an exciting vision?
Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.
Deadline 30th September...pass it on!
www.path.ox.ac.uk/work-with-us...
Reposted by Simon Bullock
Dear GenZ members of the #Drosophila community! You are needed to make cool fly research viral in your social media world! As a boomer I do not understand that sphere, but I can consult and contribute our enormous fund of outreach resources: droso4public.wordpress.com. Please, get in contact!
(no title)
droso4public is a central resource store supporting science communication and advocacy for Drosophila
droso4public.wordpress.com
August 25, 2025 at 10:02 AM
Dear GenZ members of the #Drosophila community! You are needed to make cool fly research viral in your social media world! As a boomer I do not understand that sphere, but I can consult and contribute our enormous fund of outreach resources: droso4public.wordpress.com. Please, get in contact!
Reposted by Simon Bullock
New paper on DYRK kinases and primary cilium!
This project began with our interest in DYRK3’s relationship to centriolar satellites. But what started as a CS-focused story soon evolved into studying DYRK kinase activity during ciliogenesis.
nature.com/articles/s42...
This project began with our interest in DYRK3’s relationship to centriolar satellites. But what started as a CS-focused story soon evolved into studying DYRK kinase activity during ciliogenesis.
nature.com/articles/s42...
Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology - Communications Biology
DYRK3 kinase interacts with multiple centriolar satellites and ciliary components to regulate axoneme length dynamics in cooperation with DYRK2.
nature.com
August 26, 2025 at 9:29 AM
New paper on DYRK kinases and primary cilium!
This project began with our interest in DYRK3’s relationship to centriolar satellites. But what started as a CS-focused story soon evolved into studying DYRK kinase activity during ciliogenesis.
nature.com/articles/s42...
This project began with our interest in DYRK3’s relationship to centriolar satellites. But what started as a CS-focused story soon evolved into studying DYRK kinase activity during ciliogenesis.
nature.com/articles/s42...
Reposted by Simon Bullock
💥 Another Cryo-ET study from the Way lab by @miguel-virus-cells.bsky.social in collaboration with Rosenthal lab @crick.ac.uk examining Vaccinia virus egress 😀👇 www.biorxiv.org/content/10.1...
In situ cryo-electron tomography of vaccinia virus exit from infected cells
Poxvirus-infected cells release newly assembled virions via Golgi-mediated envelopment and subsequent exocytosis at the plasma membrane, prior to cell lysis. Here, we used cryo-electron tomography and...
www.biorxiv.org
August 20, 2025 at 11:32 AM
💥 Another Cryo-ET study from the Way lab by @miguel-virus-cells.bsky.social in collaboration with Rosenthal lab @crick.ac.uk examining Vaccinia virus egress 😀👇 www.biorxiv.org/content/10.1...
Reposted by Simon Bullock
We’re looking for a #postdoc to join Michael Hastings’ group, studying diet-induced neuroinflammation in the hypothalamus and its modulation by circadian clock mechanisms, in collaboration with John O'Neill's group.
www.nature.com/naturecareer...
Closes 08 SEP
#ScienceJobs #PostdocJobs
www.nature.com/naturecareer...
Closes 08 SEP
#ScienceJobs #PostdocJobs
August 20, 2025 at 10:38 AM
We’re looking for a #postdoc to join Michael Hastings’ group, studying diet-induced neuroinflammation in the hypothalamus and its modulation by circadian clock mechanisms, in collaboration with John O'Neill's group.
www.nature.com/naturecareer...
Closes 08 SEP
#ScienceJobs #PostdocJobs
www.nature.com/naturecareer...
Closes 08 SEP
#ScienceJobs #PostdocJobs
Reposted by Simon Bullock
A beautiful model of an mRNA transport complex that looks like a Texas congressional district
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 6, 2025 at 7:54 AM
A beautiful model of an mRNA transport complex that looks like a Texas congressional district
Reposted by Simon Bullock
Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...
In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️
In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️
August 4, 2025 at 7:31 PM
Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...
In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️
In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️