Simon Bullock
@simonbullock11.bsky.social
Molecular motors, mRNA localisation, microscopes4schools, MRC-LMB (Cambridge, UK)
Reposted by Simon Bullock
thanks @lucksmith.bsky.social
15 years after your key paper with Nelson Lau showing the abundance & widespread nature of piRNAs from 3' UTRs, we now start to get the logic.
dissecting how the Yb protein reads out U-content, and talks to the Upf1-related SF2 helicase Armitage, will be interesting.
15 years after your key paper with Nelson Lau showing the abundance & widespread nature of piRNAs from 3' UTRs, we now start to get the logic.
dissecting how the Yb protein reads out U-content, and talks to the Upf1-related SF2 helicase Armitage, will be interesting.
as always, beautiful mechanistic dissection by @86dominik.bsky.social @juliusbrennecke.bsky.social lab, taking advantage of genetics and genomics to get decisive insights into piRNAs! surprising how instructive U content is for piRNA biogenesis, but it makes total sense, the system is very clever! 🪰
How does the piRNA pathway solve the self vs. non-self problem? 🧬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
February 18, 2026 at 7:30 AM
thanks @lucksmith.bsky.social
15 years after your key paper with Nelson Lau showing the abundance & widespread nature of piRNAs from 3' UTRs, we now start to get the logic.
dissecting how the Yb protein reads out U-content, and talks to the Upf1-related SF2 helicase Armitage, will be interesting.
15 years after your key paper with Nelson Lau showing the abundance & widespread nature of piRNAs from 3' UTRs, we now start to get the logic.
dissecting how the Yb protein reads out U-content, and talks to the Upf1-related SF2 helicase Armitage, will be interesting.
Reposted by Simon Bullock
Reem Abouward, Giampietro Schiavo & team find that LAMP1 and LAMP2A localise to distinct axonal organelles with differential transport dynamics, but share overlapping total protein compositions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
February 17, 2026 at 10:31 AM
Reem Abouward, Giampietro Schiavo & team find that LAMP1 and LAMP2A localise to distinct axonal organelles with differential transport dynamics, but share overlapping total protein compositions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Reposted by Simon Bullock
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
mrc.tal.net
February 16, 2026 at 12:09 PM
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Reposted by Simon Bullock
🚨 Postdoc opportunity to study memory or nutrition in #Drosophila 🪰
I am looking for a candidate to support for a 3 year Addison Wheeler Fellowship application lnkd.in/e2rvNf5x
Interested? Please send a CV & cover letter with brief research outline by 20th February to vincent.croset@durham.ac.uk
I am looking for a candidate to support for a 3 year Addison Wheeler Fellowship application lnkd.in/e2rvNf5x
Interested? Please send a CV & cover letter with brief research outline by 20th February to vincent.croset@durham.ac.uk
addison-wheeler-fellowship - Durham University
www.dur.ac.uk
February 12, 2026 at 3:31 PM
🚨 Postdoc opportunity to study memory or nutrition in #Drosophila 🪰
I am looking for a candidate to support for a 3 year Addison Wheeler Fellowship application lnkd.in/e2rvNf5x
Interested? Please send a CV & cover letter with brief research outline by 20th February to vincent.croset@durham.ac.uk
I am looking for a candidate to support for a 3 year Addison Wheeler Fellowship application lnkd.in/e2rvNf5x
Interested? Please send a CV & cover letter with brief research outline by 20th February to vincent.croset@durham.ac.uk
Reposted by Simon Bullock
Out now in Cell Systems: We develop a technique to visualize influenza A virus in live cells with single viral RNA resolution. Combined with precise readouts of viral transcription, we map the whole influenza A viral life cycle and identify key bottlenecks in infection.
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Live-cell single-vRNP imaging identifies viral gene expression signatures that shape influenza infection heterogeneity
In this study, an imaging technology, “VISUN,” is developed that allows live-cell
visualization of unmodified influenza virus during infection with single-vRNP resolution.
Combining VISUN with multipl...
www.cell.com
February 12, 2026 at 7:45 AM
Out now in Cell Systems: We develop a technique to visualize influenza A virus in live cells with single viral RNA resolution. Combined with precise readouts of viral transcription, we map the whole influenza A viral life cycle and identify key bottlenecks in infection.
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Reposted by Simon Bullock
Thanks @michaelboutros.bsky.social and @crisprflydesign.bsky.social for sharing! 🧪🧬✂️🔬🪰
Multiplexed Cas12a editing plasmids here: www.addgene.org/browse/artic...
Multiplexed Cas12a editing plasmids here: www.addgene.org/browse/artic...
February 10, 2026 at 5:43 PM
Thanks @michaelboutros.bsky.social and @crisprflydesign.bsky.social for sharing! 🧪🧬✂️🔬🪰
Multiplexed Cas12a editing plasmids here: www.addgene.org/browse/artic...
Multiplexed Cas12a editing plasmids here: www.addgene.org/browse/artic...
Reposted by Simon Bullock
One week left to apply for the postdoc position at MRC-LMB in Cambridge. Join our team for an exciting project on transcription-coupled splicing to understand human gene regulation 🧬 Feel free to get in touch directly
#postdoc #cryoEM #biochemistry
#postdoc #cryoEM #biochemistry
February 5, 2026 at 12:06 PM
One week left to apply for the postdoc position at MRC-LMB in Cambridge. Join our team for an exciting project on transcription-coupled splicing to understand human gene regulation 🧬 Feel free to get in touch directly
#postdoc #cryoEM #biochemistry
#postdoc #cryoEM #biochemistry
Reposted by Simon Bullock
Searching for a human neural cell line with greater differentiation potential than SH-SY5Y cells? Check out the human #neural #stem_cell line HNSC.100. Differentiates into astrocytes, neurons & oligodendrocytes. On #BioRxiv, we provide protocols, markers, ABs, karyotyping & RNAseq: shorturl.at/y0aJG
February 9, 2026 at 2:10 PM
Searching for a human neural cell line with greater differentiation potential than SH-SY5Y cells? Check out the human #neural #stem_cell line HNSC.100. Differentiates into astrocytes, neurons & oligodendrocytes. On #BioRxiv, we provide protocols, markers, ABs, karyotyping & RNAseq: shorturl.at/y0aJG
Reposted by Simon Bullock
Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
www.biorxiv.org
February 6, 2026 at 11:20 AM
Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
Reposted by Simon Bullock
Postdoc job alert in the Crick Institute in London. Are you interested in the actin cytoskeleton? I am looking for a postdoc to examine the cellular, developmental or physiological role of Arp2/3 iso-complex driven actin polymerisation. Multiple aspects available.
crick.ac.uk/WayPostdoc2026
crick.ac.uk/WayPostdoc2026
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab
crick.ac.uk
February 6, 2026 at 8:22 AM
Postdoc job alert in the Crick Institute in London. Are you interested in the actin cytoskeleton? I am looking for a postdoc to examine the cellular, developmental or physiological role of Arp2/3 iso-complex driven actin polymerisation. Multiple aspects available.
crick.ac.uk/WayPostdoc2026
crick.ac.uk/WayPostdoc2026
Reposted by Simon Bullock
2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...
crick.ac.uk/WayPostdoc20...
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab
crick.ac.uk
February 6, 2026 at 8:29 AM
2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...
crick.ac.uk/WayPostdoc20...
Reposted by Simon Bullock
The registration deadline for this wonderful meeting is approaching! Be sure to reserve your spot before March 10!
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
February 4, 2026 at 6:10 PM
The registration deadline for this wonderful meeting is approaching! Be sure to reserve your spot before March 10!
Reposted by Simon Bullock
This is for you – and a great opportunity – if you are establishing a group in Croatia, Czechia, Estonia, Hungary, Lithuania, Luxembourg, Poland, Portugal and Türkiye...
Apply now! The 2026 call for the EMBO Installation Grants Programme is now open with a deadline of 15 April 12:00 midday CEST. 🧪
More information can be found here:
https://www.embo.org/funding/fellowships-grants-and-career-support/installation-grants/
#LifeSciences #research #funding
More information can be found here:
https://www.embo.org/funding/fellowships-grants-and-career-support/installation-grants/
#LifeSciences #research #funding
February 4, 2026 at 8:42 AM
This is for you – and a great opportunity – if you are establishing a group in Croatia, Czechia, Estonia, Hungary, Lithuania, Luxembourg, Poland, Portugal and Türkiye...
Reposted by Simon Bullock
Job alert! 📣 I’m looking for a research assistant to join my new team @idrm.ox.ac.uk
Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️🩹
Full info below, and please share! 🫶🏻
bit.ly/467TO0M
Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️🩹
Full info below, and please share! 🫶🏻
bit.ly/467TO0M
February 2, 2026 at 2:01 PM
Job alert! 📣 I’m looking for a research assistant to join my new team @idrm.ox.ac.uk
Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️🩹
Full info below, and please share! 🫶🏻
bit.ly/467TO0M
Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️🩹
Full info below, and please share! 🫶🏻
bit.ly/467TO0M
Reposted by Simon Bullock
The IGNITION PhD Programme is now open! We’re offering 13 fully funded PhD positions across 10 institutions in 8 EU countries to study immune mediated neurodegeneration.
If you're passionate about research, innovation & international collaboration, this is for you.
ignition-consortium.eu/home/
If you're passionate about research, innovation & international collaboration, this is for you.
ignition-consortium.eu/home/
February 2, 2026 at 9:31 AM
The IGNITION PhD Programme is now open! We’re offering 13 fully funded PhD positions across 10 institutions in 8 EU countries to study immune mediated neurodegeneration.
If you're passionate about research, innovation & international collaboration, this is for you.
ignition-consortium.eu/home/
If you're passionate about research, innovation & international collaboration, this is for you.
ignition-consortium.eu/home/
This is another tour de force from @crisprflydesign.bsky.social and colleagues with consideration of utility for the community at its heart. Great work!
Make your gene knockouts more efficient with multiplexed Cas12a sgRNAs. Our new paper is out now, with tools available from @addgene.bsky.social , www.plasmids.eu and @vdrc-flies.bsky.social.
www.nature.com/articles/s41...
#CRISPR #geneediting #Drosophila 🧪🧬✂️🔬🪰
Summary 🧵 below.
www.nature.com/articles/s41...
#CRISPR #geneediting #Drosophila 🧪🧬✂️🔬🪰
Summary 🧵 below.
January 29, 2026 at 4:51 PM
This is another tour de force from @crisprflydesign.bsky.social and colleagues with consideration of utility for the community at its heart. Great work!
Reposted by Simon Bullock
More efficient CRISPR targeting in Drosophila, via Cas12a and easier synthesis of multiplexed gRNAs
Make your gene knockouts more efficient with multiplexed Cas12a sgRNAs. Our new paper is out now, with tools available from @addgene.bsky.social , www.plasmids.eu and @vdrc-flies.bsky.social.
www.nature.com/articles/s41...
#CRISPR #geneediting #Drosophila 🧪🧬✂️🔬🪰
Summary 🧵 below.
www.nature.com/articles/s41...
#CRISPR #geneediting #Drosophila 🧪🧬✂️🔬🪰
Summary 🧵 below.
January 29, 2026 at 9:49 AM
More efficient CRISPR targeting in Drosophila, via Cas12a and easier synthesis of multiplexed gRNAs
Reposted by Simon Bullock
Just out @natrevimmunol.nature.com
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity - Nature Reviews Immunology
RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...
www.nature.com
January 27, 2026 at 7:32 AM
Just out @natrevimmunol.nature.com
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
Reposted by Simon Bullock
Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry.
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
January 27, 2026 at 9:40 AM
Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry.
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
Reposted by Simon Bullock
I’m happy to share the main result of my PhD, which you can find on bioRxiv www.biorxiv.org/content/10.6.... If you are interested in learning about a new way to perform DNA-PAINT multiplexing, which we call Combi-PAINT, or if you are interested in the study of mRNA conformation, keep reading! 1/10
January 26, 2026 at 11:31 AM
I’m happy to share the main result of my PhD, which you can find on bioRxiv www.biorxiv.org/content/10.6.... If you are interested in learning about a new way to perform DNA-PAINT multiplexing, which we call Combi-PAINT, or if you are interested in the study of mRNA conformation, keep reading! 1/10
Reposted by Simon Bullock
Hitting the postdoc search? Consider applying to be part of the Winship postdoc recruitment cohort @winshipcancer.emory.edu
apps.winshipcancer.emory.edu/admin/Event/...
Eligibility requirements and participating faculty are listed in the link✅
apps.winshipcancer.emory.edu/admin/Event/...
Eligibility requirements and participating faculty are listed in the link✅
Winship Postdoctoral Fellow Recruitment Event
apps.winshipcancer.emory.edu
January 26, 2026 at 3:25 PM
Hitting the postdoc search? Consider applying to be part of the Winship postdoc recruitment cohort @winshipcancer.emory.edu
apps.winshipcancer.emory.edu/admin/Event/...
Eligibility requirements and participating faculty are listed in the link✅
apps.winshipcancer.emory.edu/admin/Event/...
Eligibility requirements and participating faculty are listed in the link✅
Reposted by Simon Bullock
Tom Cech on RNA research in Davos (video): www.weforum.org/meetings/wor...
January 21, 2026 at 9:24 PM
Tom Cech on RNA research in Davos (video): www.weforum.org/meetings/wor...
Reposted by Simon Bullock
Join us in Warwick for a fun two-day symposium and celebrate the career of Prof Rob Cross!
January 22, 2026 at 9:42 AM
Join us in Warwick for a fun two-day symposium and celebrate the career of Prof Rob Cross!
Reposted by Simon Bullock
Postdocs wanted - Please spread the word! We are looking for one bioinformatician and 1-2 cell biologists with different expertise! See the job ad below for more information and links to the job descriptions!
January 20, 2026 at 12:48 PM
Postdocs wanted - Please spread the word! We are looking for one bioinformatician and 1-2 cell biologists with different expertise! See the job ad below for more information and links to the job descriptions!