Andrew Bowman
@bowchro.bsky.social
Scientist and serial hobbyist. Warwick Uni. How does chromatin move, and is it important? Contrary to my profile picture, I am ambivalent towards cats. Chickens however....
Potato or DNA polymerase?
September 19, 2025 at 4:34 PM
Potato or DNA polymerase?
Reposted by Andrew Bowman
Oh ffs. No, I do not want to "Chat with the PDF" of this interesting looking academic journal article I just came across.
I would like to read it. With my own eyeballs. And think about it. You know, with that grey matter sitting between my ears.
Just make it stop.
#AcademicChatter
I would like to read it. With my own eyeballs. And think about it. You know, with that grey matter sitting between my ears.
Just make it stop.
#AcademicChatter
September 19, 2025 at 5:06 AM
Oh ffs. No, I do not want to "Chat with the PDF" of this interesting looking academic journal article I just came across.
I would like to read it. With my own eyeballs. And think about it. You know, with that grey matter sitting between my ears.
Just make it stop.
#AcademicChatter
I would like to read it. With my own eyeballs. And think about it. You know, with that grey matter sitting between my ears.
Just make it stop.
#AcademicChatter
“To consult the statistician after an experiment is finished is often merely to ask him to conduct a post mortem examination. He can perhaps say what the experiment died of.” – Ronald A. Fisher
Yeah, but, I just wanted a quick look...
share.google/jo0NIT24BKmS...
Yeah, but, I just wanted a quick look...
share.google/jo0NIT24BKmS...
How thoughtful experimental design can empower biologists in the omics era - Nature Communications
Here, the authors discuss principles of experimental design that are relevant for all biology research, along with special considerations for projects using -omics approaches, highlighting common expe...
share.google
August 7, 2025 at 8:03 PM
“To consult the statistician after an experiment is finished is often merely to ask him to conduct a post mortem examination. He can perhaps say what the experiment died of.” – Ronald A. Fisher
Yeah, but, I just wanted a quick look...
share.google/jo0NIT24BKmS...
Yeah, but, I just wanted a quick look...
share.google/jo0NIT24BKmS...
Reposted by Andrew Bowman
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
June 16, 2025 at 3:14 PM
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Reposted by Andrew Bowman
ggplot2 is turning 18! 🎂
For nearly two decades, it’s helped data scientists turn complex data into clear, beautiful insights.
We’re throwing a birthday party at Data+AI Summit, with treats and limited-edition swag. Come celebrate with us and @hadley.nz!
📍 Posit Lounge (402)
📅 June 10, 6–8pm
For nearly two decades, it’s helped data scientists turn complex data into clear, beautiful insights.
We’re throwing a birthday party at Data+AI Summit, with treats and limited-edition swag. Come celebrate with us and @hadley.nz!
📍 Posit Lounge (402)
📅 June 10, 6–8pm
June 9, 2025 at 9:58 PM
ggplot2 is turning 18! 🎂
For nearly two decades, it’s helped data scientists turn complex data into clear, beautiful insights.
We’re throwing a birthday party at Data+AI Summit, with treats and limited-edition swag. Come celebrate with us and @hadley.nz!
📍 Posit Lounge (402)
📅 June 10, 6–8pm
For nearly two decades, it’s helped data scientists turn complex data into clear, beautiful insights.
We’re throwing a birthday party at Data+AI Summit, with treats and limited-edition swag. Come celebrate with us and @hadley.nz!
📍 Posit Lounge (402)
📅 June 10, 6–8pm
Reposted by Andrew Bowman
We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
'
my.corehr.com
June 6, 2025 at 4:48 AM
We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
Reposted by Andrew Bowman
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...
May 30, 2025 at 11:37 AM
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...
Reposted by Andrew Bowman
Just published the new edition of “Principles of Development’ from now called “Wolpert’s Principles of Development’ to honour his memory and the origin of this textbooks that aims at distilling the, sometimes elusive, principles underlying animal and plant development shorturl.at/LrOxn
May 4, 2025 at 4:31 PM
Just published the new edition of “Principles of Development’ from now called “Wolpert’s Principles of Development’ to honour his memory and the origin of this textbooks that aims at distilling the, sometimes elusive, principles underlying animal and plant development shorturl.at/LrOxn
Reposted by Andrew Bowman
I do not think enough people know about the Campaign for Real Ale
(1/2)
(1/2)
In the 1960s/70s there was a big corporate push to replace local ales & diverse styles of beer in the UK w/ mass produced lagers & slop. In response, the Campaign for Real Ale, started by beer fans, has been one of the most successful consumer campaign ever.
camra.org.uk/about/who-we...
camra.org.uk/about/who-we...
About the Campaign for Real Ale
CAMRA is considered one of the most successful consumer organisations across Europe. Founded by four real ale enthusiasts back in 1971, today we represent beer drinkers and pub-goers across the UK.
camra.org.uk
May 4, 2025 at 4:11 AM
I do not think enough people know about the Campaign for Real Ale
(1/2)
(1/2)
Very good
April 4, 2025 at 8:42 PM
Very good
Spring has arrived and yes, the two bunnies we got in Autumn were a boy and a girl.
April 3, 2025 at 2:44 PM
Spring has arrived and yes, the two bunnies we got in Autumn were a boy and a girl.
Step aside AlphaFold. www.nature.com/articles/d41...
AI masters Minecraft: DeepMind program finds diamonds without being taught
The Dreamer system reached the milestone by ‘imagining’ the future impact of possible decisions.
www.nature.com
April 3, 2025 at 1:06 PM
Step aside AlphaFold. www.nature.com/articles/d41...
Alejandro came to Warwick last year and gave an excellent talk on life as a scientific editor. Highly recommend.
But you do!
Which is why it's important to organize career seminars, so trainees know what's out there.
If you think some of the students/postdocs at your institution may feel this way, I'd be happy to visit and give a talk about careers in publishing, particularly as a journal editor!
Which is why it's important to organize career seminars, so trainees know what's out there.
If you think some of the students/postdocs at your institution may feel this way, I'd be happy to visit and give a talk about careers in publishing, particularly as a journal editor!
"why don't you leave academia then?"
March 28, 2025 at 12:47 PM
Alejandro came to Warwick last year and gave an excellent talk on life as a scientific editor. Highly recommend.
They say life becomes boring in middle age, but I recorded both a Eurasian Green Woodpecker AND a Rose-ringed Parakeet on my lunch break today. So there.
March 28, 2025 at 12:27 PM
They say life becomes boring in middle age, but I recorded both a Eurasian Green Woodpecker AND a Rose-ringed Parakeet on my lunch break today. So there.
Seeds in a PCR tube? This is combining work and play.
March 21, 2025 at 5:30 PM
Seeds in a PCR tube? This is combining work and play.
Reposted by Andrew Bowman
Epigenetics Folks, Science must go on! Please consider joining us for the Epigenetics Gordon Research Conference to be held August 10-15 in Barcelona. Please spread the word and apply early, as this meeting always oversubscribes! www.grc.org/epigenetics-...
2025 Epigenetics Conference GRC
The 2025 Gordon Research Conference on Epigenetics will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
www.grc.org
February 25, 2025 at 3:17 PM
Epigenetics Folks, Science must go on! Please consider joining us for the Epigenetics Gordon Research Conference to be held August 10-15 in Barcelona. Please spread the word and apply early, as this meeting always oversubscribes! www.grc.org/epigenetics-...
www.theguardian.com/technology/2...
"Henceforth, they could speak to machines like the Duke of Devonshire spoke to his gardener, and the machines would do their bidding."
"Henceforth, they could speak to machines like the Duke of Devonshire spoke to his gardener, and the machines would do their bidding."
You don't need code to be a programmer. But you do need expertise | John Naughton
AI is so good at writing software that one father asked it to organise his kids’ school lunches. But that doesn’t mean it’s taking over
www.theguardian.com
March 17, 2025 at 4:53 PM
www.theguardian.com/technology/2...
"Henceforth, they could speak to machines like the Duke of Devonshire spoke to his gardener, and the machines would do their bidding."
"Henceforth, they could speak to machines like the Duke of Devonshire spoke to his gardener, and the machines would do their bidding."
Polyclonal>monoclonal>phage display>AlphaFold
The evolution of antobodies.
www.biorxiv.org/content/10.1...
The evolution of antobodies.
www.biorxiv.org/content/10.1...
In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer
Antibodies are central mediators of the adaptive immune response, and they are powerful research tools and therapeutics. Antibody discovery requires substantial experimental effort, such as immunization campaigns or in vitro library screening. Predicting antibody-antigen binding a priori remains challenging. However, recent machine learning methods raise the possibility of in silico antibody discovery, bypassing or reducing initial experimental bottlenecks. Here, we report a virtual screen using AlphaFold-Multimer (AF-M) that prospectively identified nanobody binders to MRGPRX2, a G protein-coupled receptor (GPCR) and therapeutic target for the treatment of pseudoallergic inflammation and itch. Using previously reported nanobody-GPCR structures, we identified a set of AF-M outputs that effectively discriminate between interacting and non-interacting nanobody-GPCR pairs. We used these outputs to perform a prospective in silico screen, identified nanobodies that bind MRGPRX2 with high affinity, and confirmed activity in signaling and functional cellular assays. Our results provide a proof of concept for fully computational antibody discovery pipelines that can circumvent laboratory experiments. ### Competing Interest Statement E.P.H., J.S.S., J.D.H., K.J.S., and A.C.K. are co-inventors on a patent application for MRGPRX2 antagonist nanobodies. D.S.M. is an advisor for Dyno Therapeutics, Octant, Jura Bio, Tectonic Therapeutic, and Genentech, and is a co-founder of Seismic Therapeutic. J.C.W. is a co-founder of MOMA therapeutics, a company in which he has a financial interest. A.C.K. is a co-founder and consultant for biotechnology companies Tectonic Therapeutic and Seismic Therapeutic, and for the Institute for Protein Innovation, a non-profit research institute. J.S.S. is an advisor / investigator for Biogen. The remaining authors declare no competing interests.
www.biorxiv.org
March 10, 2025 at 10:58 PM
Polyclonal>monoclonal>phage display>AlphaFold
The evolution of antobodies.
www.biorxiv.org/content/10.1...
The evolution of antobodies.
www.biorxiv.org/content/10.1...
Mendel vibes in the greenhouse this morning.
March 4, 2025 at 4:37 PM
Mendel vibes in the greenhouse this morning.
Reposted by Andrew Bowman
We are so proud of how Thalia has handled the past two years and continues to approach every day! Brain tumours are devastating and we desperately need more treatments to provide options for families!
March 2, 2025 at 5:21 PM
We are so proud of how Thalia has handled the past two years and continues to approach every day! Brain tumours are devastating and we desperately need more treatments to provide options for families!
Reposted by Andrew Bowman
For whatever reason it was hard to find the original letter of Lech Walesa, the Polish president.
(And I’m increasingly fond of full context and “zero moderation” raw materials and videos… almost like I want to form MY OWN opinion… 😉)
If you are in a similar situation, here you go…
(And I’m increasingly fond of full context and “zero moderation” raw materials and videos… almost like I want to form MY OWN opinion… 😉)
If you are in a similar situation, here you go…
March 4, 2025 at 6:28 AM
For whatever reason it was hard to find the original letter of Lech Walesa, the Polish president.
(And I’m increasingly fond of full context and “zero moderation” raw materials and videos… almost like I want to form MY OWN opinion… 😉)
If you are in a similar situation, here you go…
(And I’m increasingly fond of full context and “zero moderation” raw materials and videos… almost like I want to form MY OWN opinion… 😉)
If you are in a similar situation, here you go…
Reposted by Andrew Bowman
February 26, 2025 at 4:06 PM
“They dance around the subject,” said one student. “It’s not banned but not advised, it’s academic misconduct if you use it, but lecturers tell us they use it. Very mixed messages.”
www.theguardian.com/education/20...
www.theguardian.com/education/20...
UK universities warned to ‘stress-test’ assessments as 92% of students use AI
Survey of 1,000 students shows ‘explosive increase’ in use of generative AI in particular over past 12 months
www.theguardian.com
February 26, 2025 at 7:20 AM
“They dance around the subject,” said one student. “It’s not banned but not advised, it’s academic misconduct if you use it, but lecturers tell us they use it. Very mixed messages.”
www.theguardian.com/education/20...
www.theguardian.com/education/20...
Reposted by Andrew Bowman
