Molly Gale (Gale-Hammell Lab)
@mollygale.bsky.social
Jumping Genomics!
I run a lab in NYC that studies transposons 🧬in the brain 🧠
Opinions are all mine
mghlab.org
I run a lab in NYC that studies transposons 🧬in the brain 🧠
Opinions are all mine
mghlab.org
Pinned
ALS molecular subtypes are a combination of cellular and pathological features learned by deep multiomics classifiers
O’Neill et al. present a deep exploration of molecular subtypes in ALS postmortem
tissues from the NYGC ALS Consortium. Matched bulk and single-cell profiles demonstrate
that ALS subtypes are a combin...
www.cell.com
Super happy to announce the latest work from my lab together with Hemali Phatnani @nygenome.org & NYGC ALS Consortium!
We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes
#NIHfundedResearch
www.cell.com/cell-reports...
We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes
#NIHfundedResearch
www.cell.com/cell-reports...
I was still faculty at CSHL when Watson’s remaining titles were stripped in 2018. Duncan Watson wrote a sad/angry email to everyone living on Bungtown road. Me included. He told us we were no longer allowed to use the too “intimate” name Jim
The psychology of descendants of famous men fascinates me
The psychology of descendants of famous men fascinates me
November 8, 2025 at 7:38 PM
I was still faculty at CSHL when Watson’s remaining titles were stripped in 2018. Duncan Watson wrote a sad/angry email to everyone living on Bungtown road. Me included. He told us we were no longer allowed to use the too “intimate” name Jim
The psychology of descendants of famous men fascinates me
The psychology of descendants of famous men fascinates me
Reposted by Molly Gale (Gale-Hammell Lab)
I'm so excited to see this Perspective with @jasonsynaptic.bsky.social out in Neuron! About 8% of our genome is made up of the remnants of LTR-containing retroelements - here, Jason and I explore the activities of retroTEs in neurological health and disease!
authors.elsevier.com/c/1lzTx3BtfH...
authors.elsevier.com/c/1lzTx3BtfH...
authors.elsevier.com
October 23, 2025 at 3:15 PM
I'm so excited to see this Perspective with @jasonsynaptic.bsky.social out in Neuron! About 8% of our genome is made up of the remnants of LTR-containing retroelements - here, Jason and I explore the activities of retroTEs in neurological health and disease!
authors.elsevier.com/c/1lzTx3BtfH...
authors.elsevier.com/c/1lzTx3BtfH...
Of all the hot takes on Rosalind Franklin, I'm truly baffled by the argument that acknowledging harm done to women somehow removes their agency. And thus, it's more "feminist" to pretend that women were not wronged by the men who tormented and harassed them
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...
November 8, 2025 at 3:59 PM
Of all the hot takes on Rosalind Franklin, I'm truly baffled by the argument that acknowledging harm done to women somehow removes their agency. And thus, it's more "feminist" to pretend that women were not wronged by the men who tormented and harassed them
Reposted by Molly Gale (Gale-Hammell Lab)
VOTE!
VOTE!
VOTE!
VOTE!
VOTE!
VOTE!
VOTE!
VOTE!
VOTE!
a kermit the frog is holding a sign that says vote .
Alt: a kermit the frog is holding a sign that says vote .
media.tenor.com
November 4, 2025 at 11:00 AM
VOTE!
VOTE!
VOTE!
VOTE!
VOTE!
VOTE!
VOTE!
VOTE!
VOTE!
Reposted by Molly Gale (Gale-Hammell Lab)
Finally read the paper and it's worth the buzz.
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
October 25, 2025 at 1:42 PM
Finally read the paper and it's worth the buzz.
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time.
www.nature.com/articles/s41...
Reposted by Molly Gale (Gale-Hammell Lab)
Do you research endogenous retroviruses (ERVs) or want to learn more about them? 🧬🤔
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
AussiERV 2025
AussiERV: Australia’s first symposium dedicated to endogenous retroviruses. Join us for this one-day virtual event on November 7th!
events.humanitix.com
September 27, 2025 at 7:28 AM
Do you research endogenous retroviruses (ERVs) or want to learn more about them? 🧬🤔
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Reposted by Molly Gale (Gale-Hammell Lab)
Disease prevalence in US states before & after vaccine introduction 🧪
From Edward Tufte & graphics.wsj.com/infectious-d...
From Edward Tufte & graphics.wsj.com/infectious-d...
September 4, 2025 at 6:01 PM
Disease prevalence in US states before & after vaccine introduction 🧪
From Edward Tufte & graphics.wsj.com/infectious-d...
From Edward Tufte & graphics.wsj.com/infectious-d...
Reposted by Molly Gale (Gale-Hammell Lab)
Filmmaker Pamela Green is planning a movie about the late Ben Barres, transgender neuroscientist, world expert on glial cells, and an inspirational advocate for women and minorities in science. Pamela is seeking funds to finish her research and script – see fundraising trailer below.
AskTheQuestionMovie.com – An inspiring portrait of a rebel scientist with boundless curiosity, who, despit
askthequestionmovie.com
September 3, 2025 at 11:42 PM
Filmmaker Pamela Green is planning a movie about the late Ben Barres, transgender neuroscientist, world expert on glial cells, and an inspirational advocate for women and minorities in science. Pamela is seeking funds to finish her research and script – see fundraising trailer below.
Reposted by Molly Gale (Gale-Hammell Lab)
are you a PD in the glia (or neuroscience) space? Do you want to come to NYC and give a lecture and meet some amazing faculty here at @nyumedpostdocs.bsky.social?
LAST WEEK TO APPLY to be a SPiNES speaker for our next season.
Details and apply here: med.nyu.edu/departments-...
COME AND WOW US!
LAST WEEK TO APPLY to be a SPiNES speaker for our next season.
Details and apply here: med.nyu.edu/departments-...
COME AND WOW US!
a black and white photo of a crowd of people standing and sitting in chairs .
ALT: a black and white photo of a crowd of people standing and sitting in chairs .
media.tenor.com
August 15, 2025 at 7:57 PM
are you a PD in the glia (or neuroscience) space? Do you want to come to NYC and give a lecture and meet some amazing faculty here at @nyumedpostdocs.bsky.social?
LAST WEEK TO APPLY to be a SPiNES speaker for our next season.
Details and apply here: med.nyu.edu/departments-...
COME AND WOW US!
LAST WEEK TO APPLY to be a SPiNES speaker for our next season.
Details and apply here: med.nyu.edu/departments-...
COME AND WOW US!
Reposted by Molly Gale (Gale-Hammell Lab)
For ESIs dealing with grants being rescinded: if an investigator’s 1st substantial independent research award is terminated within the first 3 years of the project period (not due to scientific misconduct ) they can request the reinstatement of ESI status
grants.nih.gov/news-events/...
grants.nih.gov/news-events/...
July 2, 2025 at 7:27 PM
For ESIs dealing with grants being rescinded: if an investigator’s 1st substantial independent research award is terminated within the first 3 years of the project period (not due to scientific misconduct ) they can request the reinstatement of ESI status
grants.nih.gov/news-events/...
grants.nih.gov/news-events/...
Reposted by Molly Gale (Gale-Hammell Lab)
TIL that one of the books removed from the Armed Forces Library because it "had DEI" in it is Ben Barres' autobiography. Remember that you can buy and should read this book because Ben was badass and an amazing scientist mitpress.mit.edu/978026253954...
June 27, 2025 at 8:55 AM
TIL that one of the books removed from the Armed Forces Library because it "had DEI" in it is Ben Barres' autobiography. Remember that you can buy and should read this book because Ben was badass and an amazing scientist mitpress.mit.edu/978026253954...
Reposted by Molly Gale (Gale-Hammell Lab)
Tomorrow, 6/24, NINDS is celebrating 75 years with a special congressional briefing spotlighting scientific advancements made possible from #NINDS over the past 75 years—from foundational discoveries in brain function to life-changing therapies for neurological diseases. #neurosociety #brainresearch
Celebrating 75 Years of Scientific Discovery and Innovation: NINDS 75th Anniversary Congressional Neuroscience Caucus Briefing & Reception
Event Timing: Tuesday, June 24, 2025 - 3:30-5:00pm ET
Event Address: Longworth House Office Building Room 1539, Capitol Hill, Washington, DC
Snacks and refreshments will be provided
docs.google.com
June 23, 2025 at 3:58 PM
Tomorrow, 6/24, NINDS is celebrating 75 years with a special congressional briefing spotlighting scientific advancements made possible from #NINDS over the past 75 years—from foundational discoveries in brain function to life-changing therapies for neurological diseases. #neurosociety #brainresearch
Reposted by Molly Gale (Gale-Hammell Lab)
The image offers a stunning variety of objects — from bright stars ranging from blue to red in color, to nearby blue spiral galaxies, to distant red galaxy groups — demonstrating the broad range of science made possible by Rubin data ✨🔭🧪
June 23, 2025 at 3:46 PM
The image offers a stunning variety of objects — from bright stars ranging from blue to red in color, to nearby blue spiral galaxies, to distant red galaxy groups — demonstrating the broad range of science made possible by Rubin data ✨🔭🧪
Reposted by Molly Gale (Gale-Hammell Lab)
Dear Mobile DNA Researchers,
The 8th Woods Hole Mobile Genetic Elements meeting will be held Aug 28 to Aug 30, 2025, at the MBL in Woods Hole, Massachusetts.
Info, registration, and abstract submission: www.eventsquid.com/event/28372
#MobileDNA #MobileGeneticElements
The 8th Woods Hole Mobile Genetic Elements meeting will be held Aug 28 to Aug 30, 2025, at the MBL in Woods Hole, Massachusetts.
Info, registration, and abstract submission: www.eventsquid.com/event/28372
#MobileDNA #MobileGeneticElements
June 18, 2025 at 9:58 PM
Dear Mobile DNA Researchers,
The 8th Woods Hole Mobile Genetic Elements meeting will be held Aug 28 to Aug 30, 2025, at the MBL in Woods Hole, Massachusetts.
Info, registration, and abstract submission: www.eventsquid.com/event/28372
#MobileDNA #MobileGeneticElements
The 8th Woods Hole Mobile Genetic Elements meeting will be held Aug 28 to Aug 30, 2025, at the MBL in Woods Hole, Massachusetts.
Info, registration, and abstract submission: www.eventsquid.com/event/28372
#MobileDNA #MobileGeneticElements
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
June 16, 2025 at 3:14 PM
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Reposted by Molly Gale (Gale-Hammell Lab)
We hate that this t-shirt has to exist but we love the creativity behind it. Our friend Ed created it as he works to bring about change for all battling ALS.
Now please follow the alien's request and complete an ALS Clinic Survey today. bit.ly/448GkkF
Now please follow the alien's request and complete an ALS Clinic Survey today. bit.ly/448GkkF
June 10, 2025 at 8:17 PM
We hate that this t-shirt has to exist but we love the creativity behind it. Our friend Ed created it as he works to bring about change for all battling ALS.
Now please follow the alien's request and complete an ALS Clinic Survey today. bit.ly/448GkkF
Now please follow the alien's request and complete an ALS Clinic Survey today. bit.ly/448GkkF
Reposted by Molly Gale (Gale-Hammell Lab)
*URGENT* please support NIH research and the NIH employees who are standing up for science at the risk of losing their jobs! Sign *TODAY* in support of the Bethesda Declaration. The senate appropriations committee is reviewing the NIH budget Tuesday at 10 am. SHARE widely! 🧪
ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff
Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.
actionnetwork.org
June 9, 2025 at 2:04 PM
*URGENT* please support NIH research and the NIH employees who are standing up for science at the risk of losing their jobs! Sign *TODAY* in support of the Bethesda Declaration. The senate appropriations committee is reviewing the NIH budget Tuesday at 10 am. SHARE widely! 🧪
Reposted by Molly Gale (Gale-Hammell Lab)
If you burn down a forest, you don't miss out on lumber for just that season. You have to replant all the trees, nurture them, and wait for them to grow.
The science and research budget cuts happening now are wanton, senseless arson. Recovery, if it ever happens, will take generations.
The science and research budget cuts happening now are wanton, senseless arson. Recovery, if it ever happens, will take generations.
June 3, 2025 at 9:02 PM
If you burn down a forest, you don't miss out on lumber for just that season. You have to replant all the trees, nurture them, and wait for them to grow.
The science and research budget cuts happening now are wanton, senseless arson. Recovery, if it ever happens, will take generations.
The science and research budget cuts happening now are wanton, senseless arson. Recovery, if it ever happens, will take generations.
Reposted by Molly Gale (Gale-Hammell Lab)
Stop for a second and try to imagine this: a heat shock protein relocalizes to the cell surface and mediates dsRNA binding and internalization!
Intrigued? Read our newly minted paper in Science Advances www.science.org/doi/10.1126/...
Congrats to all the authors and thanks to reviewers and editor!
Intrigued? Read our newly minted paper in Science Advances www.science.org/doi/10.1126/...
Congrats to all the authors and thanks to reviewers and editor!
Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila
Hsc70-4 localizes to the cell surface of Drosophila cells, binds to exogenous dsRNA, and mediates its internalization.
www.science.org
May 20, 2025 at 2:47 PM
Stop for a second and try to imagine this: a heat shock protein relocalizes to the cell surface and mediates dsRNA binding and internalization!
Intrigued? Read our newly minted paper in Science Advances www.science.org/doi/10.1126/...
Congrats to all the authors and thanks to reviewers and editor!
Intrigued? Read our newly minted paper in Science Advances www.science.org/doi/10.1126/...
Congrats to all the authors and thanks to reviewers and editor!
Reposted by Molly Gale (Gale-Hammell Lab)
Our paper describing the results of the MIROCALS trial of low-dose interleukin-2 in #ALS #MND is out in the Lancet @thelancet.bsky.social
Open access
Read it here:
www.thelancet.com/journals/lan...
Open access
Read it here:
www.thelancet.com/journals/lan...
Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial
With this treatment schedule, IL-2LD resulted in a non-significant reduction in mortality
in the primary unadjusted analysis. However, the difference between the results of
unadjusted and adjusted ana...
www.thelancet.com
May 9, 2025 at 11:07 PM
Our paper describing the results of the MIROCALS trial of low-dose interleukin-2 in #ALS #MND is out in the Lancet @thelancet.bsky.social
Open access
Read it here:
www.thelancet.com/journals/lan...
Open access
Read it here:
www.thelancet.com/journals/lan...
Reposted by Molly Gale (Gale-Hammell Lab)
My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...
May 2, 2025 at 3:20 PM
My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...
Reposted by Molly Gale (Gale-Hammell Lab)
My lab at NYU is hiring a postdoc interested in RNA biology and local translation in neurons following axonal injury/neurodegenerative diseases!! Apply here: apply.interfolio.com/165681
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
April 30, 2025 at 5:01 PM
My lab at NYU is hiring a postdoc interested in RNA biology and local translation in neurons following axonal injury/neurodegenerative diseases!! Apply here: apply.interfolio.com/165681
Reposted by Molly Gale (Gale-Hammell Lab)
If using Bloomigton #Drosophila Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the @bdsc.bsky.social & they need our support in these dire times! @flybase.bsky.social @fly-eds.bsky.social
April 10, 2025 at 6:06 AM
If using Bloomigton #Drosophila Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the @bdsc.bsky.social & they need our support in these dire times! @flybase.bsky.social @fly-eds.bsky.social
Reposted by Molly Gale (Gale-Hammell Lab)
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...
www.training.nih.gov
April 10, 2025 at 1:22 AM
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...