Tom Ellis
@proftomellis.bsky.social
Synthetic Biology & Synthetic Genomics @ Imperial College London and the Sanger Institute. Bilingual in English and DNA. Views are either my own or my microbes'
Pinned
A new review paper from our lab courtesy of @jazzsynbio.bsky.social is published in Trends in Biotechnology
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
Was interesting to hear today about the annual “SynBio Challenges” competition that has got going in China as a cheaper/free alternative to iGEM - m.synbiochallenges.com/application/...
November 11, 2025 at 3:43 PM
Was interesting to hear today about the annual “SynBio Challenges” competition that has got going in China as a cheaper/free alternative to iGEM - m.synbiochallenges.com/application/...
Reposted by Tom Ellis
Share your synthetic based-biology insights at #SynBio26!
We welcome contributions from experts in biotech, genomics, computational, plant, or medical sciences to showcase the impact of advances in engineering biology on agriculture, personalised medicine, and diagnostics.
📎 bit.ly/3ZaYdwH
We welcome contributions from experts in biotech, genomics, computational, plant, or medical sciences to showcase the impact of advances in engineering biology on agriculture, personalised medicine, and diagnostics.
📎 bit.ly/3ZaYdwH
September 18, 2025 at 7:38 AM
Share your synthetic based-biology insights at #SynBio26!
We welcome contributions from experts in biotech, genomics, computational, plant, or medical sciences to showcase the impact of advances in engineering biology on agriculture, personalised medicine, and diagnostics.
📎 bit.ly/3ZaYdwH
We welcome contributions from experts in biotech, genomics, computational, plant, or medical sciences to showcase the impact of advances in engineering biology on agriculture, personalised medicine, and diagnostics.
📎 bit.ly/3ZaYdwH
Reposted by Tom Ellis
Meet our speakers for #SynBio26 🌟
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
October 15, 2025 at 10:00 AM
Meet our speakers for #SynBio26 🌟
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
Why is George Pig carrying a bacteria?
November 4, 2025 at 10:38 AM
Why is George Pig carrying a bacteria?
Reposted by Tom Ellis
A comprehensive genetic toolkit for Zymomonas mobilis; allowing rapid, high-resolution, combinatorial engineering of metabolic pathways. https://www.biorxiv.org/content/10.1101/2025.10.29.685439v1
October 31, 2025 at 2:04 AM
A comprehensive genetic toolkit for Zymomonas mobilis; allowing rapid, high-resolution, combinatorial engineering of metabolic pathways. https://www.biorxiv.org/content/10.1101/2025.10.29.685439v1
DISCARD - The aim is to combine gene segments to create a new genome, but recombination events will cause localised or system-wide death.
October 28, 2025 at 10:28 AM
DISCARD - The aim is to combine gene segments to create a new genome, but recombination events will cause localised or system-wide death.
Reposted by Tom Ellis
TRANCERs: Engineering enhancers into autonomous tissue-specific expression cassettes https://www.biorxiv.org/content/10.1101/2025.10.27.684763v1
October 27, 2025 at 9:05 PM
TRANCERs: Engineering enhancers into autonomous tissue-specific expression cassettes https://www.biorxiv.org/content/10.1101/2025.10.27.684763v1
Reposted by Tom Ellis
New Tuesday (Oct 28) in Heidelberg and online: kick off event of the Center for Synthetic Genomics: program and link to zoom: www.syn-gen.de/kick-off
Center Kick-Off Event | Center SynGen
www.syn-gen.de
October 24, 2025 at 11:19 AM
New Tuesday (Oct 28) in Heidelberg and online: kick off event of the Center for Synthetic Genomics: program and link to zoom: www.syn-gen.de/kick-off
A new review paper from our lab courtesy of @jazzsynbio.bsky.social is published in Trends in Biotechnology
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
October 23, 2025 at 10:09 AM
A new review paper from our lab courtesy of @jazzsynbio.bsky.social is published in Trends in Biotechnology
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
Reposted by Tom Ellis
Please RP! A 4-day synbio and tissue engineering conference #MASSIV to transform biology and medicine together.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
October 18, 2025 at 5:50 PM
Please RP! A 4-day synbio and tissue engineering conference #MASSIV to transform biology and medicine together.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
Reposted by Tom Ellis
Predicting sequence-specific amplification efficiency in multi-template PCR with deep learning
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Predicting sequence-specific amplification efficiency in multi-template PCR with deep learning - Nature Communications
Multi-template PCR enables parallel DNA amplification but suffers from sequence-specific biases. Here, the authors develop a 1D-CNN model predicting amplification efficiency directly from the DNA sequ...
doi.org
October 16, 2025 at 7:34 PM
Predicting sequence-specific amplification efficiency in multi-template PCR with deep learning
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Tom Ellis
Assembly and cell-free expression of a partial genome for the synthetic cell https://www.biorxiv.org/content/10.1101/2025.10.16.682769v1
October 16, 2025 at 9:04 PM
Assembly and cell-free expression of a partial genome for the synthetic cell https://www.biorxiv.org/content/10.1101/2025.10.16.682769v1
Reposted by Tom Ellis
Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation https://www.biorxiv.org/content/10.1101/2025.10.12.681955v1
October 14, 2025 at 3:04 AM
Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation https://www.biorxiv.org/content/10.1101/2025.10.12.681955v1
Reposted by Tom Ellis
Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: boolean logic-gated protein presentation (h/t @coledeforest.bsky.social), bacterial grown living materials (h/t @proftomellis.bsky.social) & more 🧪
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: boolean logic-gated protein presentation (h/t @coledeforest.bsky.social), bacterial grown living materials (h/t @proftomellis.bsky.social) & more 🧪
Boolean logic-gated protein presentation through autonomously compiled molecular topology - Nature Chemical Biology
Programming stimulus responsiveness into living systems enables advanced biocomputation. Here, the authors autonomously compile proteins with defined topology that can be site-specifically tethered to and conditionally released from biomaterials and cells following user-specified Boolean logic.
www.nature.com
October 12, 2025 at 9:39 AM
Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: boolean logic-gated protein presentation (h/t @coledeforest.bsky.social), bacterial grown living materials (h/t @proftomellis.bsky.social) & more 🧪
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: boolean logic-gated protein presentation (h/t @coledeforest.bsky.social), bacterial grown living materials (h/t @proftomellis.bsky.social) & more 🧪
Reposted by Tom Ellis
Reposted by Tom Ellis
Intracellularly Coupled Oscillators for Synthetic Biology https://www.biorxiv.org/content/10.1101/2025.09.23.678067v1
September 24, 2025 at 4:08 AM
Intracellularly Coupled Oscillators for Synthetic Biology https://www.biorxiv.org/content/10.1101/2025.09.23.678067v1
Yesterday was the first day of autumn and guess what appeared in the window of the Peninsula hotel in London.
September 23, 2025 at 9:09 PM
Yesterday was the first day of autumn and guess what appeared in the window of the Peninsula hotel in London.
Reposted by Tom Ellis
Reposted by Tom Ellis
Another new paper from our lab - this time from Anastasiya Kishkevich who has developed "YTK Display-and-Secrete" a library-based method to identifying genetic designs good for protein secretion from S.cerevisiae yeast. Online now at ACS SynBio - pubs.acs.org/doi/10.1021/...
August 19, 2025 at 7:30 PM
Another new paper from our lab - this time from Anastasiya Kishkevich who has developed "YTK Display-and-Secrete" a library-based method to identifying genetic designs good for protein secretion from S.cerevisiae yeast. Online now at ACS SynBio - pubs.acs.org/doi/10.1021/...
Reposted by Tom Ellis
Genetic entanglement enables ultra-stable biocontainment in the mammalian gut https://www.biorxiv.org/content/10.1101/2025.08.13.670093v1
August 13, 2025 at 11:04 PM
Genetic entanglement enables ultra-stable biocontainment in the mammalian gut https://www.biorxiv.org/content/10.1101/2025.08.13.670093v1
Reposted by Tom Ellis
We are hiring a scientist to lead our 'Build' team at the Seattle Hub for Synthetic Biology. @alleninstitute.org
Job posting below:
alleninstitute.org/careers/jobs...
Please reach out if you have any questions!
Job posting below:
alleninstitute.org/careers/jobs...
Please reach out if you have any questions!
Jobs
We are working to solve the biggest mysteries in bioscience.
alleninstitute.org
August 13, 2025 at 7:03 PM
We are hiring a scientist to lead our 'Build' team at the Seattle Hub for Synthetic Biology. @alleninstitute.org
Job posting below:
alleninstitute.org/careers/jobs...
Please reach out if you have any questions!
Job posting below:
alleninstitute.org/careers/jobs...
Please reach out if you have any questions!
New paper from our lab on synthetic genome work in yeast is out - Iterative SCRaMbLE for Engineering Synthetic Genome Modules and Chromosomes. Exciting project led by Jane (Xinyu) Lu in our group, now online. t.co/0LuGwgAWlA
https://www.nature.com/articles/s41467-025-62356-y
t.co
August 11, 2025 at 12:36 PM
New paper from our lab on synthetic genome work in yeast is out - Iterative SCRaMbLE for Engineering Synthetic Genome Modules and Chromosomes. Exciting project led by Jane (Xinyu) Lu in our group, now online. t.co/0LuGwgAWlA
Reposted by Tom Ellis
Unlock new organisms quickly with a genetic methods “cheat-sheet”🔬
Our Portal’s new Reported Methods section streamlines access to established genetic tools and related literature.
Read more here: tinyurl.com/yj33bnyr
Our Portal’s new Reported Methods section streamlines access to established genetic tools and related literature.
Read more here: tinyurl.com/yj33bnyr
Empowering Microbial Discovery: Your Guide to Genetic Tractability — Cultivarium — Cultivarium
Rapidly identify reported genetic methods and papers for your organism, including electroporation, transposon mutagenesis, and CRISPRi.
tinyurl.com
January 28, 2025 at 3:10 PM
Unlock new organisms quickly with a genetic methods “cheat-sheet”🔬
Our Portal’s new Reported Methods section streamlines access to established genetic tools and related literature.
Read more here: tinyurl.com/yj33bnyr
Our Portal’s new Reported Methods section streamlines access to established genetic tools and related literature.
Read more here: tinyurl.com/yj33bnyr
Reposted by Tom Ellis
200 engineering/life science/medical grants, including my lab's NIH MIRA, have been suspended. In case you are wondering, this means immediately stop spending = stop paying salaries for students & postdocs. www.latimes.com/california/s...
Trump freezes $200 million in UCLA science and medical research funding, citing antisemitism
The Trump administration has frozen roughly $200 million in National Science Foundation, National Institutes of Health and other federal agency-funded research at UCLA, citing allegations the school d...
www.latimes.com
August 1, 2025 at 9:01 PM
200 engineering/life science/medical grants, including my lab's NIH MIRA, have been suspended. In case you are wondering, this means immediately stop spending = stop paying salaries for students & postdocs. www.latimes.com/california/s...