Thomas Gorochowski
@chofski.bsky.social
Synthetic biologist, programmer of cells, and lover of all things visual. Wakes up in the morning to learn some of natures secrets and do a spot of fly fishing.
Reposted by Thomas Gorochowski
So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli?
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...
Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation
Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...
doi.org
December 17, 2025 at 8:19 AM
So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli?
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...
Reposted by Thomas Gorochowski
Emerging trends in genome integration tools for precision engineering of diverse bacterial species
doi.org/10.1093/synb...
doi.org/10.1093/synb...
Emerging trends in genome integration tools for precision engineering of diverse bacterial species
Abstract. The ability to precisely insert DNA payloads into a genome enables the comprehensive engineering of cellular phenotypes and the creation of new b
doi.org
December 15, 2025 at 1:27 PM
Emerging trends in genome integration tools for precision engineering of diverse bacterial species
doi.org/10.1093/synb...
doi.org/10.1093/synb...
🚨 Last call for the 'AI, Engineering Biology and Beyond' conference taking place in Bristol on the 15-16 January 2026. There is a limited capacity and some places are still left, but worth signing up soon before the 19th December deadline! Register at: aiebab.github.io
December 10, 2025 at 8:49 PM
🚨 Last call for the 'AI, Engineering Biology and Beyond' conference taking place in Bristol on the 15-16 January 2026. There is a limited capacity and some places are still left, but worth signing up soon before the 19th December deadline! Register at: aiebab.github.io
📕My review for Jane Calvert's latest book, 'A Place for Science and Technology Studies' is out in Interdisciplinary Science Reviews! I really enjoyed the stories and learnt so mcuh. Well worth a read if you are interested in the ways that that study of science works: doi.org/10.1177/0308...
December 10, 2025 at 1:27 PM
📕My review for Jane Calvert's latest book, 'A Place for Science and Technology Studies' is out in Interdisciplinary Science Reviews! I really enjoyed the stories and learnt so mcuh. Well worth a read if you are interested in the ways that that study of science works: doi.org/10.1177/0308...
End of year Science Bonanza is always something I look forward to, not only for hearing about what the team has been up to all year, but also for the amazing food everyone brings. Christmas has started proper now 🎅
December 9, 2025 at 7:44 PM
End of year Science Bonanza is always something I look forward to, not only for hearing about what the team has been up to all year, but also for the amazing food everyone brings. Christmas has started proper now 🎅
Very excited for this project with @pierrebuscaill.bsky.social! Will bring together a lot of exciting tools we have up and running in the lab for working with diverse biology and put them to use in building new technologies to trace gene expression across plants. 🧬 🔍 Applications open!
🚀 PhD opportunity!
Join us (@pierrebuscaill.bsky.social & @chofski.bsky.social) in Bristol 🌱✨ Design, test & model synthetic promoters in Nicotiana benthamiana, focusing on plant immunity. Apply now!
🔗 www.findaphd.com/phds/project...
#PlantSci #SyntheticBiology #PhD #PlantBioDesign #BristolUni
Join us (@pierrebuscaill.bsky.social & @chofski.bsky.social) in Bristol 🌱✨ Design, test & model synthetic promoters in Nicotiana benthamiana, focusing on plant immunity. Apply now!
🔗 www.findaphd.com/phds/project...
#PlantSci #SyntheticBiology #PhD #PlantBioDesign #BristolUni
SynProm: Fast, Modular Spatio-Temporal Transcriptional Reporters for Plants (Plant BioDesign Bristol project) at University of York on FindAPhD.com
PhD Project - SynProm: Fast, Modular Spatio-Temporal Transcriptional Reporters for Plants (Plant BioDesign Bristol project) at University of York, listed on FindAPhD.com
www.findaphd.com
December 2, 2025 at 5:59 PM
Very excited for this project with @pierrebuscaill.bsky.social! Will bring together a lot of exciting tools we have up and running in the lab for working with diverse biology and put them to use in building new technologies to trace gene expression across plants. 🧬 🔍 Applications open!
The initial lineup of keynotes and spotlight talks is finalised, with 10 contributed talks still up for grabs! Come join us in Bristol on 15-16 Jan 2026 for AI, Engineering Biology and Beyond to shape the future of these fields🤖🧬🦠Register now at: aiebab.github.io
November 20, 2025 at 9:52 AM
The initial lineup of keynotes and spotlight talks is finalised, with 10 contributed talks still up for grabs! Come join us in Bristol on 15-16 Jan 2026 for AI, Engineering Biology and Beyond to shape the future of these fields🤖🧬🦠Register now at: aiebab.github.io
🚨Interested in the intersection of AI and Engineering Biology? 🤖🧬 If so, come join us in Bristol, UK from 15-16 Jan 2026 for the latest instalment of the "AI, Engineering Biology and Beyond" conference! It's going to be a "banger" and registration is open NOW! #synbio #ai aiebab.github.io
October 22, 2025 at 10:03 AM
🚨Interested in the intersection of AI and Engineering Biology? 🤖🧬 If so, come join us in Bristol, UK from 15-16 Jan 2026 for the latest instalment of the "AI, Engineering Biology and Beyond" conference! It's going to be a "banger" and registration is open NOW! #synbio #ai aiebab.github.io
Reposted by Thomas Gorochowski
Université Grenoble Alpes opens a full professorship in microbiology in 2026. The selected candidate will develop their research program on quantitative approaches in microbiology in the Laboratoire Interdisciplinaire de Physique. More info: liphy.univ-grenoble-alpes.fr/en/join-us/r...
Professorship (tenure) in 'Quantitative approaches in microbiology' (CNU Sections 64/65) | LIPhy - Université Grenoble Alpes
liphy.univ-grenoble-alpes.fr
October 7, 2025 at 1:19 PM
Université Grenoble Alpes opens a full professorship in microbiology in 2026. The selected candidate will develop their research program on quantitative approaches in microbiology in the Laboratoire Interdisciplinaire de Physique. More info: liphy.univ-grenoble-alpes.fr/en/join-us/r...
Reposted by Thomas Gorochowski
SHARK: a specialized host for assembling R6K plasmids https://www.biorxiv.org/content/10.1101/2025.10.06.680659v1
October 7, 2025 at 4:11 AM
SHARK: a specialized host for assembling R6K plasmids https://www.biorxiv.org/content/10.1101/2025.10.06.680659v1
Reposted by Thomas Gorochowski
SHARK: a specialized host for assembling R6K plasmids
doi.org/10.1101/2025...
doi.org/10.1101/2025...
October 7, 2025 at 7:02 AM
SHARK: a specialized host for assembling R6K plasmids
doi.org/10.1101/2025...
doi.org/10.1101/2025...
🛠️New tool from the lab! #SHARK🦈: a new strain to support complex cloning of transient R6K expression plasmids – perfect for genome engineering. Work led by the talented Shivang Joshi and all strains and strain assembly tools enroute to Addgene. #synbio doi.org/10.1101/2025...
October 7, 2025 at 8:31 AM
🛠️New tool from the lab! #SHARK🦈: a new strain to support complex cloning of transient R6K expression plasmids – perfect for genome engineering. Work led by the talented Shivang Joshi and all strains and strain assembly tools enroute to Addgene. #synbio doi.org/10.1101/2025...
🥳Excited to share our latest collaborative work using whole-cell models and #AI to design genomes!🦠🧬 What a time to be alive! Project led by Ioana Gherman, with Kieren Sharma, Joshua Rees-Garbutt, Claire Grierson, Lucia Marucci, Wei Pang & Zahraa Abdallah #synbio authors.elsevier.com/sd/article/S...
September 24, 2025 at 5:25 PM
🥳Excited to share our latest collaborative work using whole-cell models and #AI to design genomes!🦠🧬 What a time to be alive! Project led by Ioana Gherman, with Kieren Sharma, Joshua Rees-Garbutt, Claire Grierson, Lucia Marucci, Wei Pang & Zahraa Abdallah #synbio authors.elsevier.com/sd/article/S...
Very excited to attend and speak at this years #UKOMAIN Multimodal AI workshop at the Barbican. Already learning a lot about emulators and generative models for novel materials.
September 16, 2025 at 9:24 AM
Very excited to attend and speak at this years #UKOMAIN Multimodal AI workshop at the Barbican. Already learning a lot about emulators and generative models for novel materials.
🚨I have a fully funded 4-year #PhD opportunity in my lab on 'Tuneable multi-input genetic logic circuits for designer probiotics'.🦠 We'll be throwing all the tech we have at this one to make reliable engineering of diverse microbes a reality. Applicants must be UK national...
September 3, 2025 at 9:00 AM
🚨I have a fully funded 4-year #PhD opportunity in my lab on 'Tuneable multi-input genetic logic circuits for designer probiotics'.🦠 We'll be throwing all the tech we have at this one to make reliable engineering of diverse microbes a reality. Applicants must be UK national...
Come and join us at a free complementary Japan-UK Engineering Biology meeting after the main ESSL conference (essl2025.org/). A few spaces left to some see some of the up and coming superstars of #synbio in the UK!
September 1, 2025 at 8:31 PM
Come and join us at a free complementary Japan-UK Engineering Biology meeting after the main ESSL conference (essl2025.org/). A few spaces left to some see some of the up and coming superstars of #synbio in the UK!
Standard day in Bristol... balloons!
August 12, 2025 at 12:27 PM
Standard day in Bristol... balloons!
Reading some wonderful old Russian mathematics on automata theory and love this comment that just popped up! Coming from the rural countryside of Somerset, I'm not sure the people quite match this analysis! 🤠
August 7, 2025 at 6:19 PM
Reading some wonderful old Russian mathematics on automata theory and love this comment that just popped up! Coming from the rural countryside of Somerset, I'm not sure the people quite match this analysis! 🤠
I've become obsessed by the idea of "design" in all aspects of synthetic biology. How do we discover good bio-design? How will it make me feel? Does it even matter? This awesome post by iA is the first that resonates in terms of how we might get there... ia.net/topics/maker...
Maker’s Knowledge
Giambattista Vico's Design of Philosophy
ia.net
July 22, 2025 at 9:16 PM
I've become obsessed by the idea of "design" in all aspects of synthetic biology. How do we discover good bio-design? How will it make me feel? Does it even matter? This awesome post by iA is the first that resonates in terms of how we might get there... ia.net/topics/maker...
Although I've now taken a back seat, it is great to see the growing adoption of SBOL Visual in the synthetic and engineering biology literature and even more awesome to see so many current and visiting students to my lab on the author list😍 Roll on 2035! arxiv.org/abs/2507.04601
July 8, 2025 at 12:53 PM
Although I've now taken a back seat, it is great to see the growing adoption of SBOL Visual in the synthetic and engineering biology literature and even more awesome to see so many current and visiting students to my lab on the author list😍 Roll on 2035! arxiv.org/abs/2507.04601
What to agument your favourite protein with new functionalities? 🛠️ We've got a #biodesign workflow to help with that! In work led by @georgiehs.bsky.social we present SIMPLIFE that blends biophyscial and #ML models to extend biology in useful ways. #synbio doi.org/10.1101/2025...
June 23, 2025 at 8:43 AM
What to agument your favourite protein with new functionalities? 🛠️ We've got a #biodesign workflow to help with that! In work led by @georgiehs.bsky.social we present SIMPLIFE that blends biophyscial and #ML models to extend biology in useful ways. #synbio doi.org/10.1101/2025...
What to learn a bit about some of the topics explored at the Japan-UK Synthetic Biology Conference earlier this year? Then, check out our meeting report now out in ACS Synthetic Biology. Big thanks to all the authors and Patrick Cai and Masato Kanemaki for organising! #synbio doi.org/10.1021/acss...
The Japan-UK Synthetic Biology Conference, Spring 2025: Strengthening Global Links to Engineer Biology
Both Japan and the UK have recognized the growing importance of synthetic and engineering biology for transforming life science research and transitioning toward a sustainable biobased economy. Such a...
doi.org
June 20, 2025 at 8:05 AM
What to learn a bit about some of the topics explored at the Japan-UK Synthetic Biology Conference earlier this year? Then, check out our meeting report now out in ACS Synthetic Biology. Big thanks to all the authors and Patrick Cai and Masato Kanemaki for organising! #synbio doi.org/10.1021/acss...
Great to see this report out from the UK Government Office for Science on 'Mirror Life'. Was nice to contribute to the discussions and thoughts on this topic with other UK colleagues. #synbio www.gov.uk/government/p...
Mirror life
www.gov.uk
June 12, 2025 at 9:42 AM
Great to see this report out from the UK Government Office for Science on 'Mirror Life'. Was nice to contribute to the discussions and thoughts on this topic with other UK colleagues. #synbio www.gov.uk/government/p...
Some days I’m reminded of why working in research can be so exciting. Imaging DNA at the sub-nanometre scale on this beast! High-speed scanning #AFM for the win.
June 4, 2025 at 3:52 PM
Some days I’m reminded of why working in research can be so exciting. Imaging DNA at the sub-nanometre scale on this beast! High-speed scanning #AFM for the win.