This Review describes leukocyte migration through various types of extracellular matrix (ECM) during inflammation, as well as the changes to the ECM that occur in chronic inflammation and tumours. It ...

Drop the race and gender material from your course and the Plato readings, or teach a different course. You have a day to decide. That's a paraphrase of what Martin Peterson, professor of philosophy a...

The first vaccine was a lucky accident. Now we can design new vaccines in weeks, atom by atom.

Using quantitative brain imaging, the authors show opposite fMRI BOLD signal to metabolic activity due to variable oxygen extraction across the human cortex. This questions the canonical interpretatio...

Animal vocalizations contain distinct elements, but it is not clear whether they convey combined meanings in the same way as human speech. Here, Suzuki et al.show that Japanese great tits can combine ...

If there is no boundary between real and unreal, good and evil, life and death, then nothing means anything, and we face a nihilist abyss.

Lung development generates a complex tree-like architecture through proximal-distal patterning and branching morphogenesis. However, the gene regulatory programs governing embryonic lung development remain poorly understood. Here, we present a comprehensive single-cell multi-omics atlas of mouse embryonic lungs, integrating gene expression and chromatin accessibility profiles. Through systematic analysis, we identify 13 distinct cell types and map cis-regulatory elements, peak-to-gene linkages, and transcription factors underlying lung development. Leveraging this multi-modal dataset, we uncover lineage-determining transcription factors driving cell differentiation, including the Activated Protein-1 complex. We further delineate gene regulatory networks involving diverse transcription regulators, including CCCTC-binding factor (CTCF). Using the Ctcf conditional knockout mouse, coupled with histological and multi-omics analyses, we demonstrate that CTCF orchestrates lung progenitor main