Haselbach Lab
@haselbachlab.bsky.social
cryo EM enthusiasts with interest in molecular machines.
My this years Christmas chocolates ended up a little IMP branded ;)
December 16, 2025 at 3:37 PM
My this years Christmas chocolates ended up a little IMP branded ;)
Reposted by Haselbach Lab
Reposted by Haselbach Lab
so many grand gestures welcoming US researchers - neglecting the fact that funding in Canada, Australia, Europe and China is already fiercly competitive. This is not the solution. #standupforscience
December 10, 2025 at 3:04 PM
so many grand gestures welcoming US researchers - neglecting the fact that funding in Canada, Australia, Europe and China is already fiercly competitive. This is not the solution. #standupforscience
Reposted by Haselbach Lab
Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...
Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668
The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a Tenure Track Professors...
www.nature.com
December 10, 2025 at 2:14 PM
Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...
Reposted by Haselbach Lab
One month later and still thinking about the great science and conversations from the 8th Austrian Cryo-EM Symposium 🧊🔬
Huge thanks to all who joined - let’s make next year even bigger!
cryoem-symposium.pages.ist.ac.at/invited-spea...
Huge thanks to all who joined - let’s make next year even bigger!
cryoem-symposium.pages.ist.ac.at/invited-spea...
December 8, 2025 at 2:15 PM
One month later and still thinking about the great science and conversations from the 8th Austrian Cryo-EM Symposium 🧊🔬
Huge thanks to all who joined - let’s make next year even bigger!
cryoem-symposium.pages.ist.ac.at/invited-spea...
Huge thanks to all who joined - let’s make next year even bigger!
cryoem-symposium.pages.ist.ac.at/invited-spea...
Reposted by Haselbach Lab
SAVE THE DATE!
The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026.
Exciting line up of talks and an amazing location!
Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro.
Registration open soon.
The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026.
Exciting line up of talks and an amazing location!
Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro.
Registration open soon.
December 8, 2025 at 1:16 PM
SAVE THE DATE!
The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026.
Exciting line up of talks and an amazing location!
Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro.
Registration open soon.
The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026.
Exciting line up of talks and an amazing location!
Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro.
Registration open soon.
Oh if this isnt a very familiar molecule :)
A fired public-health official, a mosquito breeder and a baby with a smile seen around the world. These are just a few of the remarkable people chosen for Nature’s 10 2025
Check out the full list: go.nature.com/4rIQH8H
Check out the full list: go.nature.com/4rIQH8H
December 8, 2025 at 5:49 PM
Oh if this isnt a very familiar molecule :)
So now its official I will have to spend my christmas for a second time in a row with grant writing - but maybe third time is the charm ...
December 4, 2025 at 7:55 PM
So now its official I will have to spend my christmas for a second time in a row with grant writing - but maybe third time is the charm ...
Join us in a highly collaborative environment. At the IMP everything is possible.
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 11, 2025 at 9:56 AM
Join us in a highly collaborative environment. At the IMP everything is possible.
Reposted by Haselbach Lab
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Haselbach Lab
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
It was a great pleasure hosting @lindorfflarsen.bsky.social at the VBC today. Great talk and engaging discussions! Thanks for your visit!
October 30, 2025 at 10:22 PM
It was a great pleasure hosting @lindorfflarsen.bsky.social at the VBC today. Great talk and engaging discussions! Thanks for your visit!
Reposted by Haselbach Lab
Looking forward to visit colleagues in Vienna and Graz 🇦🇹
If you’re in Vienna I’m speaking on:
Prediction and Design of Intrinsically Disordered Proteins and Condensates (27/10 ISTA)
&
Understanding the Effects of Missense Variants Using Analyses of Protein Stability and Conservation (30/10 VBC)
If you’re in Vienna I’m speaking on:
Prediction and Design of Intrinsically Disordered Proteins and Condensates (27/10 ISTA)
&
Understanding the Effects of Missense Variants Using Analyses of Protein Stability and Conservation (30/10 VBC)
October 26, 2025 at 6:41 AM
Looking forward to visit colleagues in Vienna and Graz 🇦🇹
If you’re in Vienna I’m speaking on:
Prediction and Design of Intrinsically Disordered Proteins and Condensates (27/10 ISTA)
&
Understanding the Effects of Missense Variants Using Analyses of Protein Stability and Conservation (30/10 VBC)
If you’re in Vienna I’m speaking on:
Prediction and Design of Intrinsically Disordered Proteins and Condensates (27/10 ISTA)
&
Understanding the Effects of Missense Variants Using Analyses of Protein Stability and Conservation (30/10 VBC)
Reposted by Haselbach Lab
Join us for the Austrian Cryo-EM Symposium from Nov 11–12 at ISTA! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at/registration/
#cryoEM
#cryoEM
October 10, 2025 at 10:04 AM
Join us for the Austrian Cryo-EM Symposium from Nov 11–12 at ISTA! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at/registration/
#cryoEM
#cryoEM
Reposted by Haselbach Lab
✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv
Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo
🔗 www.biorxiv.org/content/10.1...
Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo
🔗 www.biorxiv.org/content/10.1...
October 8, 2025 at 3:59 PM
✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv
Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo
🔗 www.biorxiv.org/content/10.1...
Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo
🔗 www.biorxiv.org/content/10.1...
Reposted by Haselbach Lab
The Vienna BioCenter PhD Program application deadline is approaching: October 10!
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
October 5, 2025 at 9:35 AM
The Vienna BioCenter PhD Program application deadline is approaching: October 10!
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Reposted by Haselbach Lab
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
doi.org/10.1101/2025.09.24.678028 #proteindesign
September 28, 2025 at 9:16 PM
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
doi.org/10.1101/2025.09.24.678028 #proteindesign
Finally! This was really missing.
wwPDB has introducing the first 3DEM Model-Map percentile slider (based on Q-score) to validation reports
Introducing the first 3DEM Model-Map percentile slider to the wwPDB validation report
Introducing the latest wwPDB Percentile slider based on the Q-score model-map validation metric
www.rcsb.org
September 26, 2025 at 7:09 PM
Finally! This was really missing.
Reposted by Haselbach Lab
Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology
By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...
www.nature.com
September 19, 2025 at 1:52 PM
Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Haselbach Lab
Core achievement unlocked!! Congrats to Fabrizio amd all authors!!
Who knew that the perfect pasta sauce could lead to a Nobel Prize? Congrats to ISTA postdoc Fabrizio Olmeda and collaborators for winning the Ig Nobel Prize with their research on mastering Cacio e Pepe. Bravo! 🍝 🎉
Getting hungry? Here´s the recipe for delicious research: https://bit.ly/42vlpHm
Getting hungry? Here´s the recipe for delicious research: https://bit.ly/42vlpHm
September 19, 2025 at 7:32 AM
Core achievement unlocked!! Congrats to Fabrizio amd all authors!!
Reposted by Haselbach Lab
Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
September 15, 2025 at 9:37 AM
Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.
Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo
Reposted by Haselbach Lab
I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October.
More info: www.imb.de/students-pos...
More info: www.imb.de/students-pos...
Laura Lorenzo Orts
IMB Mainz
www.imb.de
September 15, 2025 at 12:13 PM
I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October.
More info: www.imb.de/students-pos...
More info: www.imb.de/students-pos...
Wow this seems to be a major breakthrough can’t wait to test it on all the small stuff we could never solve
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 5:59 AM
Wow this seems to be a major breakthrough can’t wait to test it on all the small stuff we could never solve
It was wonderful to be back in Göttingen and see so many friendly and familiar faces. Still a city of vibrant science.
September 12, 2025 at 10:03 AM
It was wonderful to be back in Göttingen and see so many friendly and familiar faces. Still a city of vibrant science.
Reposted by Haselbach Lab
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22 pubmed.ncbi.nlm.nih.gov/40909644/ #cryoem
September 6, 2025 at 9:14 PM
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22 pubmed.ncbi.nlm.nih.gov/40909644/ #cryoem