NealeLab
@labneale.bsky.social
Recombination, Meiosis, Chromosomes, DNA Break Repair
https://twitter.com/LabNeale
https://twitter.com/LabNeale
Pinned
NealeLab
@labneale.bsky.social
· Nov 13
Mismatch repair disturbs meiotic crossover control in S. cerevisiae
Abstract. Crossover formation during meiosis generates genetic diversity. In many species most crossovers display interference, meaning they are spaced mor
academic.oup.com
Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers!
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
It’s a massive problem across the sector, and I’m not sure what is the solution is…
And that is: asking a student to do a literature review isn’t really about the output, the final product. It’s about learning the process - assessing the quality of the evidence as you read it, learning how your question may evolve as you engage with the literature, learning how to spot SALIENCE 1/2
January 19, 2026 at 9:01 AM
It’s a massive problem across the sector, and I’m not sure what is the solution is…
Reposted by NealeLab
Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility.
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
January 12, 2026 at 11:23 AM
Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility.
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
Skip to 1m 39s for my current coding hobby project 🙃
youtu.be/-qHwnO15YqA?... The Nextcade music is now available on streaming services. I also made a simple video to go with the music, featuring clips from all the Next games on the SD Card. #retrogame #zxspectrum #zxspectrumnext #indiedev #videogamemusic
Jamie Mallender - Nextcade
YouTube video by Jamie Mallender
youtu.be
January 7, 2026 at 11:07 PM
Skip to 1m 39s for my current coding hobby project 🙃
Reposted by NealeLab
30 years ago today, December 31st 1995, the last ever Calvin & Hobbes comic strip was published. Even now, I still find it so poignant & moving.
December 31, 2025 at 2:32 PM
30 years ago today, December 31st 1995, the last ever Calvin & Hobbes comic strip was published. Even now, I still find it so poignant & moving.
Reposted by NealeLab
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 6, 2026 at 6:58 AM
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by NealeLab
Do #hybrids handle heat, cold better? ❄️🔥 Over 140 generations at 5C and 31C, #yeast #F2 hybrids adapted fast, were ~4× fitter in cold, more resilient to sudden flips. #Hybridization could turbocharge #adaptation, impacting #conservation & #agriculture. #Evolution www.yeastgenome.org/reference/41...
January 6, 2026 at 3:41 PM
Do #hybrids handle heat, cold better? ❄️🔥 Over 140 generations at 5C and 31C, #yeast #F2 hybrids adapted fast, were ~4× fitter in cold, more resilient to sudden flips. #Hybridization could turbocharge #adaptation, impacting #conservation & #agriculture. #Evolution www.yeastgenome.org/reference/41...
Reposted by NealeLab
Large and intricate naturally occurring structures composed exclusively of RNA... ROOL!
More at Molecule of the Month: pdb101.rcsb.org/motm...
More at Molecule of the Month: pdb101.rcsb.org/motm...
January 5, 2026 at 6:05 PM
Large and intricate naturally occurring structures composed exclusively of RNA... ROOL!
More at Molecule of the Month: pdb101.rcsb.org/motm...
More at Molecule of the Month: pdb101.rcsb.org/motm...
Reposted by NealeLab
Leanna Owen, Margot Riggi , David Drubin, Janet Iwasa and Yidi Sun use molecular animation to depict the full progression of CME in budding yeast, with an accompanying Cell Science at a Glance article and poster.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
December 9, 2025 at 4:27 PM
Leanna Owen, Margot Riggi , David Drubin, Janet Iwasa and Yidi Sun use molecular animation to depict the full progression of CME in budding yeast, with an accompanying Cell Science at a Glance article and poster.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by NealeLab
While 𝘝. 𝘷𝘦𝘳𝘮𝘪𝘧𝘰𝘳𝘮𝘪𝘴 max temp is around 45°C, we found 𝘐. 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 grows up to 63°C with optimal growth at 55-57°C🥵. We showed cellular replication via Ultrastructure Expansion Microscopy at 63°C. The previous limit for euks is 60°C!
November 25, 2025 at 8:22 PM
While 𝘝. 𝘷𝘦𝘳𝘮𝘪𝘧𝘰𝘳𝘮𝘪𝘴 max temp is around 45°C, we found 𝘐. 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 grows up to 63°C with optimal growth at 55-57°C🥵. We showed cellular replication via Ultrastructure Expansion Microscopy at 63°C. The previous limit for euks is 60°C!
Bye bye Edinburgh - such a lovely trip! Thanks to @marstonlab.bsky.social @owendavi77.bsky.social !
November 25, 2025 at 5:29 PM
Bye bye Edinburgh - such a lovely trip! Thanks to @marstonlab.bsky.social @owendavi77.bsky.social !
Successful change at Euston. Train is standing room only though due to a prior cancellation 😱
Very glad I booked a seat and it is still reserved!
Very glad I booked a seat and it is still reserved!
November 23, 2025 at 3:28 PM
Successful change at Euston. Train is standing room only though due to a prior cancellation 😱
Very glad I booked a seat and it is still reserved!
Very glad I booked a seat and it is still reserved!
Departure: Brighton 13:40
(Due Edinburgh 20:24) 😁
(Due Edinburgh 20:24) 😁
November 23, 2025 at 1:38 PM
Departure: Brighton 13:40
(Due Edinburgh 20:24) 😁
(Due Edinburgh 20:24) 😁
New research from Valerie Garcia and colleagues:
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
November 22, 2025 at 5:03 PM
New research from Valerie Garcia and colleagues:
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
Reposted by NealeLab
Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
International Symposium on Chromosome Dynamics from Structure to Cellular Function
www.fbs.osaka-u.ac.jp
November 21, 2025 at 6:33 PM
Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
Reposted by NealeLab
Using #yeast, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability #CancerResearch #Genetics #DNARepair
www.yeastgenome.org/reference/39...
www.yeastgenome.org/reference/39...
November 13, 2025 at 8:57 PM
Using #yeast, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability #CancerResearch #Genetics #DNARepair
www.yeastgenome.org/reference/39...
www.yeastgenome.org/reference/39...
Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers!
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae
Abstract. Crossover formation during meiosis generates genetic diversity. In many species most crossovers display interference, meaning they are spaced mor
academic.oup.com
November 13, 2025 at 8:40 PM
Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers!
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Matching T-shirt and slide @gdsc-sussex.bsky.social from Sir Paul Nurse
November 7, 2025 at 4:13 PM
Matching T-shirt and slide @gdsc-sussex.bsky.social from Sir Paul Nurse
Fantastic celebration of Tony Carr’s scientific career at the @gdsc-sussex.bsky.social retreat 2025
November 7, 2025 at 3:08 PM
Fantastic celebration of Tony Carr’s scientific career at the @gdsc-sussex.bsky.social retreat 2025
Reposted by NealeLab
Vital piece of investigative reporting from Sky. They've uncovered the X algorithm which feeds users extremist right wing material from the moment they join the site. It is a far-right radicalisation engine, by design.
news.sky.com/story/the-x-...
news.sky.com/story/the-x-...
Elon Musk is boosting the British right - and this shows how
Elon Musk is boosting the British right - and this shows how
news.sky.com
November 6, 2025 at 7:23 AM
Vital piece of investigative reporting from Sky. They've uncovered the X algorithm which feeds users extremist right wing material from the moment they join the site. It is a far-right radicalisation engine, by design.
news.sky.com/story/the-x-...
news.sky.com/story/the-x-...
Reposted by NealeLab
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 30, 2025 at 8:41 PM
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Good old @nathanwpyle.bsky.social 😀
October 27, 2025 at 12:46 PM
Good old @nathanwpyle.bsky.social 😀
Reposted by NealeLab
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by NealeLab
I'm always reminded of Tim Hunt's description of going to the library: "flipping through tables of contents of all the latest issues, hoping there isn't something relevant to your work..." 3/n
September 30, 2025 at 11:29 AM
I'm always reminded of Tim Hunt's description of going to the library: "flipping through tables of contents of all the latest issues, hoping there isn't something relevant to your work..." 3/n
Reposted by NealeLab
Excited to announce that our PearlAI DependANT tool for identifying targeted treatments for patients with Cancer of Unknown Primary is one of the 48 projects funded by the UKRI Proof of Concept programme !!
www.ukri.org/news/48-proj...
www.ukri.org/news/48-proj...
48 projects backed to turn cutting-edge research into businesses
UKRI backs cutting-edge projects, from home tests for endometriosis to AI for accessible travel, to grow into market-leading products and services.
www.ukri.org
September 25, 2025 at 8:48 AM
Excited to announce that our PearlAI DependANT tool for identifying targeted treatments for patients with Cancer of Unknown Primary is one of the 48 projects funded by the UKRI Proof of Concept programme !!
www.ukri.org/news/48-proj...
www.ukri.org/news/48-proj...
Slowly recovering after just briefly visiting that "other" place we used to hang out in and Tweet. So much hate and misinformation...😔
September 15, 2025 at 12:02 PM
Slowly recovering after just briefly visiting that "other" place we used to hang out in and Tweet. So much hate and misinformation...😔