Saccharomyces Genome Database
@yeastgenome.bsky.social
The Saccharomyces Genome Database (SGD) provides comprehensive biological information for the budding yeast Saccharomyces cerevisiae along with search and analysis tools to explore these data, enabling scientific discovery.
Do #hybrids handle heat, cold better? ❄️🔥 Over 140 generations at 5C and 31C, #yeast #F2 hybrids adapted fast, were ~4× fitter in cold, more resilient to sudden flips. #Hybridization could turbocharge #adaptation, impacting #conservation & #agriculture. #Evolution www.yeastgenome.org/reference/41...
January 6, 2026 at 3:41 PM
Do #hybrids handle heat, cold better? ❄️🔥 Over 140 generations at 5C and 31C, #yeast #F2 hybrids adapted fast, were ~4× fitter in cold, more resilient to sudden flips. #Hybridization could turbocharge #adaptation, impacting #conservation & #agriculture. #Evolution www.yeastgenome.org/reference/41...
Although the SGD website will be available over the next few weeks, SGD staff will be on winter break until Jan 5, 2026.
SGD wishes all of you, your colleagues, and your families a safe and restful holiday season. May your yeast grow robustly and your experiments be reproducible! 🧬🍻☃️
SGD wishes all of you, your colleagues, and your families a safe and restful holiday season. May your yeast grow robustly and your experiments be reproducible! 🧬🍻☃️
December 19, 2025 at 10:20 PM
Although the SGD website will be available over the next few weeks, SGD staff will be on winter break until Jan 5, 2026.
SGD wishes all of you, your colleagues, and your families a safe and restful holiday season. May your yeast grow robustly and your experiments be reproducible! 🧬🍻☃️
SGD wishes all of you, your colleagues, and your families a safe and restful holiday season. May your yeast grow robustly and your experiments be reproducible! 🧬🍻☃️
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
December 19, 2025 at 7:27 PM
Some absolutely beautiful artwork here! Really love to see #yeast #cerevisae representing so well in yet another category: #fineart
🍻🥖🩺🔬🧪🧬🎨
#YeastResearch
🍻🥖🩺🔬🧪🧬🎨
#YeastResearch
The 2025 Agar Art Contest winners have been selected! This year’s theme, “Microbes Make the World Go Round,” inspired 557 global entries—from food fermentation to antibiotic production. See the masterpieces and finalists! asm.org/press-releas... #agarart
December 19, 2025 at 12:41 AM
Some absolutely beautiful artwork here! Really love to see #yeast #cerevisae representing so well in yet another category: #fineart
🍻🥖🩺🔬🧪🧬🎨
#YeastResearch
🍻🥖🩺🔬🧪🧬🎨
#YeastResearch
🔬How do single amino acid changes cause severe diseases? New #Structure study uses #Yeast to reveal the structural basis of PRoteasome-Associated Autoinflammatory Syndromes; 15 crystal structures show PRAAS-linked mutations
🔗 www.yeastgenome.org/reference/S1...
#Proteasome #YeastResearch
🔗 www.yeastgenome.org/reference/S1...
#Proteasome #YeastResearch
December 18, 2025 at 2:17 AM
🔬How do single amino acid changes cause severe diseases? New #Structure study uses #Yeast to reveal the structural basis of PRoteasome-Associated Autoinflammatory Syndromes; 15 crystal structures show PRAAS-linked mutations
🔗 www.yeastgenome.org/reference/S1...
#Proteasome #YeastResearch
🔗 www.yeastgenome.org/reference/S1...
#Proteasome #YeastResearch
🧬 Researchers have developed a microfluidic protocol to continuously observe ENTIRE microbial life cycles in real-time, including transitions! 🔬 #Yeast #YeastResearch #Microfluidics #CellBiology #Science #AgScience #Biomed
www.yeastgenome.org/reference/S1...
www.yeastgenome.org/reference/S1...
December 17, 2025 at 12:16 AM
🧬 Researchers have developed a microfluidic protocol to continuously observe ENTIRE microbial life cycles in real-time, including transitions! 🔬 #Yeast #YeastResearch #Microfluidics #CellBiology #Science #AgScience #Biomed
www.yeastgenome.org/reference/S1...
www.yeastgenome.org/reference/S1...
Don't wait to book your stay at Fungal 2026!
The reservation site for Asilomar Hotel and Conference Grounds is open until January 13, 2026, but spots are filling up fast #Fungal26
genetics-gsa.org/fungal-2026/...
The reservation site for Asilomar Hotel and Conference Grounds is open until January 13, 2026, but spots are filling up fast #Fungal26
genetics-gsa.org/fungal-2026/...
December 15, 2025 at 7:09 PM
Don't wait to book your stay at Fungal 2026!
The reservation site for Asilomar Hotel and Conference Grounds is open until January 13, 2026, but spots are filling up fast #Fungal26
genetics-gsa.org/fungal-2026/...
The reservation site for Asilomar Hotel and Conference Grounds is open until January 13, 2026, but spots are filling up fast #Fungal26
genetics-gsa.org/fungal-2026/...
As many of us 🎁 things up for the year, make sure all your ℹ️'s are dotted- and all your #yeast emojis are downloaded! If you haven't yet, make sure to add the emojyeast collection to all your 📱💻🖥️⌚️
mayaschuldiner.wixsite.com/schuldinerla...
Thanks to the amazing Schuldiner lab for these!
mayaschuldiner.wixsite.com/schuldinerla...
Thanks to the amazing Schuldiner lab for these!
December 12, 2025 at 11:20 PM
As many of us 🎁 things up for the year, make sure all your ℹ️'s are dotted- and all your #yeast emojis are downloaded! If you haven't yet, make sure to add the emojyeast collection to all your 📱💻🖥️⌚️
mayaschuldiner.wixsite.com/schuldinerla...
Thanks to the amazing Schuldiner lab for these!
mayaschuldiner.wixsite.com/schuldinerla...
Thanks to the amazing Schuldiner lab for these!
How’s the #yeast community closing out 2025? SGD is saying a heartfelt farewell, revealing new Resource links, announcing a simple way to support the #Database you rely on, and more. Read our December newsletter: www.yeastgenome.org/blog/sgd-new... #SGD #science
December 12, 2025 at 1:34 AM
How’s the #yeast community closing out 2025? SGD is saying a heartfelt farewell, revealing new Resource links, announcing a simple way to support the #Database you rely on, and more. Read our December newsletter: www.yeastgenome.org/blog/sgd-new... #SGD #science
Calling all #YeastResearch -ers! Who would like to work in beautiful Barcelona? 🌴🌊 And even better, work on #cerevisiae?
#ScienceJobs #EarlyScienceCareer #ResearchOpportunities #STEMCareers #CareerInScience #Yeast
#ScienceJobs #EarlyScienceCareer #ResearchOpportunities #STEMCareers #CareerInScience #Yeast
🚨We are hiring!
Looking for a Laboratory Technician to join Mar Albà's research group
🔬 Bachelor’s or Master’s degree in Molecular Biology, Genetics, Biotechnology
🌍 Research group focused on yeast functional genomics
📍 Hospital del Mar Research Institute
👉 albagroup.researchmar.net/positions
Looking for a Laboratory Technician to join Mar Albà's research group
🔬 Bachelor’s or Master’s degree in Molecular Biology, Genetics, Biotechnology
🌍 Research group focused on yeast functional genomics
📍 Hospital del Mar Research Institute
👉 albagroup.researchmar.net/positions
December 11, 2025 at 1:32 AM
Calling all #YeastResearch -ers! Who would like to work in beautiful Barcelona? 🌴🌊 And even better, work on #cerevisiae?
#ScienceJobs #EarlyScienceCareer #ResearchOpportunities #STEMCareers #CareerInScience #Yeast
#ScienceJobs #EarlyScienceCareer #ResearchOpportunities #STEMCareers #CareerInScience #Yeast
Enhanced #Yeast for better #ethanol production:
After 144 days of #evolution on ⬆️EtOH, a new strain produced 94.5 g/L vs. non-evolved strain @ 78.5 g/L. Key genetic mutations boosted growth & EtOH tolerance.
🍷 🍺 🧬 #Biotech #YeastResearch
www.yeastgenome.org/reference/S1...
After 144 days of #evolution on ⬆️EtOH, a new strain produced 94.5 g/L vs. non-evolved strain @ 78.5 g/L. Key genetic mutations boosted growth & EtOH tolerance.
🍷 🍺 🧬 #Biotech #YeastResearch
www.yeastgenome.org/reference/S1...
December 9, 2025 at 11:56 PM
Enhanced #Yeast for better #ethanol production:
After 144 days of #evolution on ⬆️EtOH, a new strain produced 94.5 g/L vs. non-evolved strain @ 78.5 g/L. Key genetic mutations boosted growth & EtOH tolerance.
🍷 🍺 🧬 #Biotech #YeastResearch
www.yeastgenome.org/reference/S1...
After 144 days of #evolution on ⬆️EtOH, a new strain produced 94.5 g/L vs. non-evolved strain @ 78.5 g/L. Key genetic mutations boosted growth & EtOH tolerance.
🍷 🍺 🧬 #Biotech #YeastResearch
www.yeastgenome.org/reference/S1...
COQ5-related primary #CoQ10 deficiency: #RareDisease of #mitochondria. S.cerevisiae #complementation tests #COQ5 variants, revealing CoQ intermediate buildup and impaired biosynthesis, speeding variant interpretation, informing CoQ10 therapy. #Yeast #modelOrganism www.yeastgenome.org/reference/41...
December 9, 2025 at 6:21 PM
COQ5-related primary #CoQ10 deficiency: #RareDisease of #mitochondria. S.cerevisiae #complementation tests #COQ5 variants, revealing CoQ intermediate buildup and impaired biosynthesis, speeding variant interpretation, informing CoQ10 therapy. #Yeast #modelOrganism www.yeastgenome.org/reference/41...
#Yeast biodiversity + #MachineLearning enable strain/pathway design in other yeasts #MetabolicEngineering
S. cerevisiae
✅genetic tractability
✅robust growth
❌industrial biotech
Y. lipolytica/O. polymorpha
✅thermo/acid resistance
✅amass lipids
❌ genetic tools
www.yeastgenome.org/reference/S1...
S. cerevisiae
✅genetic tractability
✅robust growth
❌industrial biotech
Y. lipolytica/O. polymorpha
✅thermo/acid resistance
✅amass lipids
❌ genetic tools
www.yeastgenome.org/reference/S1...
December 5, 2025 at 7:02 PM
#Yeast biodiversity + #MachineLearning enable strain/pathway design in other yeasts #MetabolicEngineering
S. cerevisiae
✅genetic tractability
✅robust growth
❌industrial biotech
Y. lipolytica/O. polymorpha
✅thermo/acid resistance
✅amass lipids
❌ genetic tools
www.yeastgenome.org/reference/S1...
S. cerevisiae
✅genetic tractability
✅robust growth
❌industrial biotech
Y. lipolytica/O. polymorpha
✅thermo/acid resistance
✅amass lipids
❌ genetic tools
www.yeastgenome.org/reference/S1...
#Yeast RNase H1 responds to unscheduled, stress-inducing #RNA-DNAhybrids. Overexpressed Rnh1 leaves wt cells unaffected, but clears dysregulated RNA–DNA hybrids in mutants and promotes #DNAreplication at transcription-replication conflict sites. Read more:
www.yeastgenome.org/reference/S1...
www.yeastgenome.org/reference/S1...
December 5, 2025 at 12:58 AM
#Yeast RNase H1 responds to unscheduled, stress-inducing #RNA-DNAhybrids. Overexpressed Rnh1 leaves wt cells unaffected, but clears dysregulated RNA–DNA hybrids in mutants and promotes #DNAreplication at transcription-replication conflict sites. Read more:
www.yeastgenome.org/reference/S1...
www.yeastgenome.org/reference/S1...
Targeted changes in interaction of Nab3p with low-abundant #mRNA of highly conserved #mitochondrial #transporter PIC2 alters its stability and can trigger significant system-wide defects and profoundly impact cellular #fitness
www.yeastgenome.org/reference/41... #yeast #regulation
www.yeastgenome.org/reference/41... #yeast #regulation
December 4, 2025 at 10:19 AM
Targeted changes in interaction of Nab3p with low-abundant #mRNA of highly conserved #mitochondrial #transporter PIC2 alters its stability and can trigger significant system-wide defects and profoundly impact cellular #fitness
www.yeastgenome.org/reference/41... #yeast #regulation
www.yeastgenome.org/reference/41... #yeast #regulation
And wine, and beer, and the list of uses for this versatile little organism goes on and on! There is evidence that humans domesticated yeast >7000 years ago! Read a short summary here, including what "shmooing" has to do with yeast: sites.google.com/view/yeastge...
#YeastBiology #ScienceIsFun
#YeastBiology #ScienceIsFun
November 25, 2025 at 6:41 PM
And wine, and beer, and the list of uses for this versatile little organism goes on and on! There is evidence that humans domesticated yeast >7000 years ago! Read a short summary here, including what "shmooing" has to do with yeast: sites.google.com/view/yeastge...
#YeastBiology #ScienceIsFun
#YeastBiology #ScienceIsFun
Reposted by Saccharomyces Genome Database
The European Drosophila Society #flyEDS extends the condolences on the passing of Antonio García-Bellido, considered the founder of the Spanish school of #Drosophila genetics and an influential figure in developmental biology research worldwide. May he rest in peace.
November 11, 2025 at 2:15 PM
The European Drosophila Society #flyEDS extends the condolences on the passing of Antonio García-Bellido, considered the founder of the Spanish school of #Drosophila genetics and an influential figure in developmental biology research worldwide. May he rest in peace.
Using #yeast, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability #CancerResearch #Genetics #DNARepair
www.yeastgenome.org/reference/39...
www.yeastgenome.org/reference/39...
November 13, 2025 at 8:57 PM
Using #yeast, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability #CancerResearch #Genetics #DNARepair
www.yeastgenome.org/reference/39...
www.yeastgenome.org/reference/39...
New insights into #meiosisI reveal distinct roles of spindle checkpoint proteins. Mad2p drives transition to #metaphase, Mad3p ensures microtubule-dependent #chromosome capture on spindle, safeguarding fidelity of segregation #Yeast #CellBiology #Genetics www.yeastgenome.org/reference/39...
November 12, 2025 at 10:57 PM
New insights into #meiosisI reveal distinct roles of spindle checkpoint proteins. Mad2p drives transition to #metaphase, Mad3p ensures microtubule-dependent #chromosome capture on spindle, safeguarding fidelity of segregation #Yeast #CellBiology #Genetics www.yeastgenome.org/reference/39...
Researchers have identified cullin E3 ubiquitin ligase Rtt101p as key player in repairing DNA−protein crosslinks (DPCs) during #DNA #replication. Rtt101p's role is crucial across #cellCycle phases, ensuring genomic integrity. #Yeast #Genetics #CellBiology www.yeastgenome.org/reference/39...
November 12, 2025 at 10:16 PM
Researchers have identified cullin E3 ubiquitin ligase Rtt101p as key player in repairing DNA−protein crosslinks (DPCs) during #DNA #replication. Rtt101p's role is crucial across #cellCycle phases, ensuring genomic integrity. #Yeast #Genetics #CellBiology www.yeastgenome.org/reference/39...
Reposted by Saccharomyces Genome Database
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
October 14, 2025 at 5:57 AM
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
Reposted by Saccharomyces Genome Database
In the latest #Yeast research article, Miguel A. Rocha, Gowda Bhavani and Jacob Fleischmann investigate the role of exonuclease-resistant ribosomal RNAs in Saccharomyces cerevisiae, their relationship with nutritional status and the TOR signalling pathway.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
18S and 25S Exonuclease Resistant Ribosomal RNA Molecules Are Produced by 5′‐End Modification During TOR Inhibition.
Saccharomyces cerevisiae produces exonuclease-resistant rRNA molecules upon TOR inhibition. This phenomenon occurs when cells enter the diauxic phase, upon addition of rapamycin to the culture, or wh...
onlinelibrary.wiley.com
November 10, 2025 at 2:10 PM
In the latest #Yeast research article, Miguel A. Rocha, Gowda Bhavani and Jacob Fleischmann investigate the role of exonuclease-resistant ribosomal RNAs in Saccharomyces cerevisiae, their relationship with nutritional status and the TOR signalling pathway.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Unlocking secrets of #meiosis! Wei et al. reveal how Mei5-Sae3 complex enhances Dmc1p assembly by stabilizing Dmc1p clusters on ssDNA, altering RPA dynamics, paving way for successful interhomolog recombination. Fascinating proteins in action! #yeast #Genetics www.yeastgenome.org/reference/39...
November 7, 2025 at 11:45 PM
Unlocking secrets of #meiosis! Wei et al. reveal how Mei5-Sae3 complex enhances Dmc1p assembly by stabilizing Dmc1p clusters on ssDNA, altering RPA dynamics, paving way for successful interhomolog recombination. Fascinating proteins in action! #yeast #Genetics www.yeastgenome.org/reference/39...
Insights into mitochondrial #ribosome reveal mL44 mutations linked to childhood #cardiomyopathy, neuro issues. Box et al. study #yeast homolog MRPL3, show evolutionary divergence, translation hierarchy in mitochondrial protein synthesis #Mitochondria #Genetics www.yeastgenome.org/reference/38...
November 7, 2025 at 11:14 PM
Insights into mitochondrial #ribosome reveal mL44 mutations linked to childhood #cardiomyopathy, neuro issues. Box et al. study #yeast homolog MRPL3, show evolutionary divergence, translation hierarchy in mitochondrial protein synthesis #Mitochondria #Genetics www.yeastgenome.org/reference/38...
Cap-binding protein eIF4E links protein synthesis to metabolic regulation. When depleted, cells adapt by upregulating amino acid catabolism and biosynthesis. Read how this regulation helps maintain balance during stress. #CellBiology #ProteinSynthesis #yeast www.yeastgenome.org/reference/38...
November 7, 2025 at 5:18 PM
Cap-binding protein eIF4E links protein synthesis to metabolic regulation. When depleted, cells adapt by upregulating amino acid catabolism and biosynthesis. Read how this regulation helps maintain balance during stress. #CellBiology #ProteinSynthesis #yeast www.yeastgenome.org/reference/38...