Scott Coyle
@cellraiser.bsky.social
signaling systems and protein circuitry. reimagining what cells can be. fun posts only. Assistant Professor:
@uwbiochem | Postdoc: @stanford @prakashlab | Ph.D.:
@ucsf Wendell Lim @CDI_UCSF
@uwbiochem | Postdoc: @stanford @prakashlab | Ph.D.:
@ucsf Wendell Lim @CDI_UCSF
Pinned
Scott Coyle
@cellraiser.bsky.social
· Mar 4
Excited to share a new preprint! Wireless devices use FM modulation to transmit multiplexed noise-resistant data. Led by @born2raisecell.bsky.social, we create a biochemical analogue of this paradigm using genetically encoded oscillators (GEOs) for single-cell FM streaming tinyurl.com/nbs8rw42 🧵
Reposted by Scott Coyle
Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 9, 2026 at 8:03 PM
Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Scott Coyle
Thank you @mollyherring.bsky.social for the stunning showcase 😍
Like what you see? Come ExM with us! Let’s flood the internet with microbial marvels 🦠
#ProtistsOnSky #MicroEvoSky 🧪🔬🌍
@dudinlab.bsky.social @centriolelab.bsky.social @moorefound.bsky.social @embl.org @erc.europa.eu @embo.org
Like what you see? Come ExM with us! Let’s flood the internet with microbial marvels 🦠
#ProtistsOnSky #MicroEvoSky 🧪🔬🌍
@dudinlab.bsky.social @centriolelab.bsky.social @moorefound.bsky.social @embl.org @erc.europa.eu @embo.org
February 4, 2026 at 8:43 PM
Thank you @mollyherring.bsky.social for the stunning showcase 😍
Like what you see? Come ExM with us! Let’s flood the internet with microbial marvels 🦠
#ProtistsOnSky #MicroEvoSky 🧪🔬🌍
@dudinlab.bsky.social @centriolelab.bsky.social @moorefound.bsky.social @embl.org @erc.europa.eu @embo.org
Like what you see? Come ExM with us! Let’s flood the internet with microbial marvels 🦠
#ProtistsOnSky #MicroEvoSky 🧪🔬🌍
@dudinlab.bsky.social @centriolelab.bsky.social @moorefound.bsky.social @embl.org @erc.europa.eu @embo.org
Reposted by Scott Coyle
If you're interested in the regulation and/or evolution of complex cell behavior, this could serve as an opportunity to join our lab as a postdoc. I would be happy to consult on proposal development if we've got a good alignment of goals, skills, and interests. DMs or emails welcome.
Holy shit: it's an RFP for the NSF Postdoctoral Research Fellowship in Biology (PRFB). Hello old friend www.nsf.gov/funding/oppo...
Postdoctoral Research Fellowships in Biology (PRFB)
www.nsf.gov
February 6, 2026 at 6:23 PM
If you're interested in the regulation and/or evolution of complex cell behavior, this could serve as an opportunity to join our lab as a postdoc. I would be happy to consult on proposal development if we've got a good alignment of goals, skills, and interests. DMs or emails welcome.
Reposted by Scott Coyle
Thx for @mollyherring.bsky.social for featuring our recent work with @centriolelab.bsky.social and our quest with @gautamdey.bsky.social & the support of the @moorefound.bsky.social to look for the beauty in every #eukaryote out there using #Expansion #Microscopy #UExM
Even with the largest zoom on a classic compound optical system, scientists struggle to make sense of finer details. Microbiologists are turning to an unexpected source to clear things up: a moisture-absorbing material found in diapers. www.quantamagazine.org/expansion-mi...
Expansion Microscopy Has Transformed How We See the Cellular World | Quanta Magazine
How physically magnifying objects using a key ingredient in diapers has opened an unprecedented view of the microbial world.
www.quantamagazine.org
February 4, 2026 at 7:30 PM
Thx for @mollyherring.bsky.social for featuring our recent work with @centriolelab.bsky.social and our quest with @gautamdey.bsky.social & the support of the @moorefound.bsky.social to look for the beauty in every #eukaryote out there using #Expansion #Microscopy #UExM
Reposted by Scott Coyle
Now in print at ACS Synbio! Introducing Aviatar: a concept for inducible translocation to any cell compartment using only a 1-component probe
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
February 2, 2026 at 12:21 PM
Now in print at ACS Synbio! Introducing Aviatar: a concept for inducible translocation to any cell compartment using only a 1-component probe
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Scott Coyle
Our company has a new name, Eira Bio (www.eirabio.com) (formerly K2 Therapeutics), but the same important mission to apply our advanced synthetic biology, directed evolution, and protein design technologies to discover and develop next-generation antibody-based medicines for a range of diseases!
EiraBio
www.eirabio.com
February 1, 2026 at 12:43 PM
Our company has a new name, Eira Bio (www.eirabio.com) (formerly K2 Therapeutics), but the same important mission to apply our advanced synthetic biology, directed evolution, and protein design technologies to discover and develop next-generation antibody-based medicines for a range of diseases!
Reposted by Scott Coyle
Our new paper just out!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
January 31, 2026 at 1:53 PM
Our new paper just out!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Scott Coyle
#SynBYSS conference is scheduled on Jun 8-11, 2026 in Barcelona. Given the 100-year celebration of Architect Gaudi in Barcelona, we suggest early booking of hotels.
Details can be found: www.jcvi.org/events/synbyss (speakers, abstract submission & registration)
@jcvi.org @marcguellc.bsky.social
Details can be found: www.jcvi.org/events/synbyss (speakers, abstract submission & registration)
@jcvi.org @marcguellc.bsky.social
SynBYSS
The International SynBYSS Conference is focused on bringing together the synthetic biology community with the explicit goal of developing young...
www.jcvi.org
January 31, 2026 at 12:01 PM
#SynBYSS conference is scheduled on Jun 8-11, 2026 in Barcelona. Given the 100-year celebration of Architect Gaudi in Barcelona, we suggest early booking of hotels.
Details can be found: www.jcvi.org/events/synbyss (speakers, abstract submission & registration)
@jcvi.org @marcguellc.bsky.social
Details can be found: www.jcvi.org/events/synbyss (speakers, abstract submission & registration)
@jcvi.org @marcguellc.bsky.social
Reposted by Scott Coyle
Out in @physrevlett.bsky.social: @sfuphysics.bsky.social postdoc Antonio Patrón Castro (in tight collaboration with my colleague John Bechhoefer) pushes our information engine to higher dimensions!
doi.org/10.1103/xwjd...
doi.org/10.1103/xwjd...
Harnessing Higher-Dimensional Fluctuations in an Information Engine
We study the optimal performance of an information engine consisting of an overdamped Brownian bead confined in a controllable, $d$-dimensional harmonic trap and additionally subjected to gravity. The...
doi.org
January 28, 2026 at 5:19 PM
Out in @physrevlett.bsky.social: @sfuphysics.bsky.social postdoc Antonio Patrón Castro (in tight collaboration with my colleague John Bechhoefer) pushes our information engine to higher dimensions!
doi.org/10.1103/xwjd...
doi.org/10.1103/xwjd...
Reposted by Scott Coyle
We've got a new preprint posted, you can read all about it (and see a picture of our recently adopted lab mascot) here: eltinglab.github.io/news/taylorB...
The bottom line of this work is that we reveal new ways that S. pombe spindle biochemistry is regulated by force from the nuclear envelope.
The bottom line of this work is that we reveal new ways that S. pombe spindle biochemistry is regulated by force from the nuclear envelope.
January 27, 2026 at 11:09 PM
We've got a new preprint posted, you can read all about it (and see a picture of our recently adopted lab mascot) here: eltinglab.github.io/news/taylorB...
The bottom line of this work is that we reveal new ways that S. pombe spindle biochemistry is regulated by force from the nuclear envelope.
The bottom line of this work is that we reveal new ways that S. pombe spindle biochemistry is regulated by force from the nuclear envelope.
Reposted by Scott Coyle
Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...
January 26, 2026 at 8:50 PM
Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...
Reposted by Scott Coyle
Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him.
White. Hot. Rage.
White. Hot. Rage.
January 24, 2026 at 7:31 PM
Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him.
White. Hot. Rage.
White. Hot. Rage.
Reposted by Scott Coyle
"Use it or lose it." This is great advice for exercise, but when cells need to slow down or go dormant, they need to store ribosomes to recover growth in the future. They use hibernation factors to do this. Here is our latest story on how archaea hibernate ribosomes (1/7):
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org
January 20, 2026 at 3:53 PM
"Use it or lose it." This is great advice for exercise, but when cells need to slow down or go dormant, they need to store ribosomes to recover growth in the future. They use hibernation factors to do this. Here is our latest story on how archaea hibernate ribosomes (1/7):
doi.org/10.64898/202...
doi.org/10.64898/202...
Reposted by Scott Coyle
Latest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
www.nature.com/articles/s42...
Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production - Nature Metabolism
Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer mitochondrial membrane, co...
www.nature.com
January 18, 2026 at 12:36 PM
Latest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
www.nature.com/articles/s42...
Reposted by Scott Coyle
📢 Open faculty position – Origins of Life
We have an opening in our section at the University of Geneva! 🧬🚀
SPREAD THE WORD
Apply here: jobs.unige.ch/www/wd_porta...
We have an opening in our section at the University of Geneva! 🧬🚀
SPREAD THE WORD
Apply here: jobs.unige.ch/www/wd_porta...
a woman says " would you like to join us " with her eyes closed
ALT: a woman says " would you like to join us " with her eyes closed
media.tenor.com
January 16, 2026 at 5:49 PM
📢 Open faculty position – Origins of Life
We have an opening in our section at the University of Geneva! 🧬🚀
SPREAD THE WORD
Apply here: jobs.unige.ch/www/wd_porta...
We have an opening in our section at the University of Geneva! 🧬🚀
SPREAD THE WORD
Apply here: jobs.unige.ch/www/wd_porta...
Yet another fantastic study by my amazing colleague @jasonrcantor.bsky.social -- the spatiotemporal organization of glycolytic machinery / ATP production at play here is so interesting. Congrats to @thebiokimist.bsky.social and the team on a beautiful paper!
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
January 16, 2026 at 4:44 PM
Yet another fantastic study by my amazing colleague @jasonrcantor.bsky.social -- the spatiotemporal organization of glycolytic machinery / ATP production at play here is so interesting. Congrats to @thebiokimist.bsky.social and the team on a beautiful paper!
Reposted by Scott Coyle
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
January 16, 2026 at 4:27 PM
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
Reposted by Scott Coyle
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇
www.nature.com/articles/s41...
More info 👇
Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology
Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.
www.nature.com
January 7, 2026 at 2:59 PM
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇
www.nature.com/articles/s41...
More info 👇
Reposted by Scott Coyle
Thrilled that the lab's first @hhmijanelia.bsky.social project is up on bioRxiv! Story behind the story to follow. www.biorxiv.org/content/10.6...
Memory from variability: Heritable short-term cellular memory emerges from stochastic biochemical reaction networks
Cells exhibit a mysterious form of selective heritable short-term memory, influencing outcomes as diverse as cell fate decisions in embryos and environmental responses in cancer cells and bacteria. He...
www.biorxiv.org
January 2, 2026 at 8:54 PM
Thrilled that the lab's first @hhmijanelia.bsky.social project is up on bioRxiv! Story behind the story to follow. www.biorxiv.org/content/10.6...
Reposted by Scott Coyle
New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1
December 21, 2025 at 3:58 AM
New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
December 17, 2025 at 3:24 PM
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Reposted by Scott Coyle
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
December 16, 2025 at 12:05 PM
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Reposted by Scott Coyle
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
December 12, 2025 at 2:58 PM
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
Reposted by Scott Coyle
#Cellbio2025 come see the latest from the lab, including on opto/thermogenetics, condensates, RTK fusions, stress granules, biosensors of clustering. Talks and posters today and tomorrow!
December 8, 2025 at 12:12 PM
#Cellbio2025 come see the latest from the lab, including on opto/thermogenetics, condensates, RTK fusions, stress granules, biosensors of clustering. Talks and posters today and tomorrow!
Reposted by Scott Coyle
Come work with us! We are looking for a postdoc in #philbio or #philphysics to work on an interdisciplinary project that adopts the lens of self-organization & active matter to explore the boundary between living & nonliving systems www.kuleuven.be/personeel/jo... #academicsky #philjobs #HPS #evosky
December 8, 2025 at 11:21 AM
Come work with us! We are looking for a postdoc in #philbio or #philphysics to work on an interdisciplinary project that adopts the lens of self-organization & active matter to explore the boundary between living & nonliving systems www.kuleuven.be/personeel/jo... #academicsky #philjobs #HPS #evosky