Scott Coyle
@cellraiser.bsky.social
signaling systems and protein circuitry. reimagining what cells can be. fun posts only. Assistant Professor:
@uwbiochem | Postdoc: @stanford @prakashlab | Ph.D.:
@ucsf Wendell Lim @CDI_UCSF
@uwbiochem | Postdoc: @stanford @prakashlab | Ph.D.:
@ucsf Wendell Lim @CDI_UCSF
Pinned
Scott Coyle
@cellraiser.bsky.social
· Mar 4
Excited to share a new preprint! Wireless devices use FM modulation to transmit multiplexed noise-resistant data. Led by @born2raisecell.bsky.social, we create a biochemical analogue of this paradigm using genetically encoded oscillators (GEOs) for single-cell FM streaming tinyurl.com/nbs8rw42 🧵
Reposted by Scott Coyle
New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1
December 21, 2025 at 3:58 AM
New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
December 17, 2025 at 3:24 PM
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Reposted by Scott Coyle
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
December 16, 2025 at 12:05 PM
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Reposted by Scott Coyle
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
December 12, 2025 at 2:58 PM
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
Reposted by Scott Coyle
#Cellbio2025 come see the latest from the lab, including on opto/thermogenetics, condensates, RTK fusions, stress granules, biosensors of clustering. Talks and posters today and tomorrow!
December 8, 2025 at 12:12 PM
#Cellbio2025 come see the latest from the lab, including on opto/thermogenetics, condensates, RTK fusions, stress granules, biosensors of clustering. Talks and posters today and tomorrow!
Reposted by Scott Coyle
Come work with us! We are looking for a postdoc in #philbio or #philphysics to work on an interdisciplinary project that adopts the lens of self-organization & active matter to explore the boundary between living & nonliving systems www.kuleuven.be/personeel/jo... #academicsky #philjobs #HPS #evosky
December 8, 2025 at 11:21 AM
Come work with us! We are looking for a postdoc in #philbio or #philphysics to work on an interdisciplinary project that adopts the lens of self-organization & active matter to explore the boundary between living & nonliving systems www.kuleuven.be/personeel/jo... #academicsky #philjobs #HPS #evosky
Reposted by Scott Coyle
Cells can hunt prey, solve mazes, and learn from past experience. Does this mean they can think, at some level? Find out more at our upcoming session on "Cell Behavior and Cognition" at the ASCB/EMBO #cellbio2025 meeting, Saturday 1-3 pm rm 115.
December 5, 2025 at 2:36 PM
Cells can hunt prey, solve mazes, and learn from past experience. Does this mean they can think, at some level? Find out more at our upcoming session on "Cell Behavior and Cognition" at the ASCB/EMBO #cellbio2025 meeting, Saturday 1-3 pm rm 115.
Reposted by Scott Coyle
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
November 25, 2025 at 8:41 PM
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
Reposted by Scott Coyle
Our new preprint describes Plasmodium NEK4 as a key regulator coupling meiotic initiation and morphogenesis—a critical step for malaria transmission. This involves MTOC-driven nuclear movement strikingly analogous to "horsetail" movement in fission yeast.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 24, 2025 at 4:08 PM
Our new preprint describes Plasmodium NEK4 as a key regulator coupling meiotic initiation and morphogenesis—a critical step for malaria transmission. This involves MTOC-driven nuclear movement strikingly analogous to "horsetail" movement in fission yeast.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Scott Coyle
Wow! Remarkably complete story on the logic of phenotypic plasticity in a predatory protist - congrats @cellraiser.bsky.social et al!
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 8:52 PM
Wow! Remarkably complete story on the logic of phenotypic plasticity in a predatory protist - congrats @cellraiser.bsky.social et al!
Reposted by Scott Coyle
Thrilled to share our work on the 🔥 single-celled predator Podophrya collini, which rewires its cell morphology to hunt more efficiently. Huge thanks to our amazing team—Amy, Lauren, Omaya, Marine, Mari, and especially Scott—for making this shine! ✨
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 5:12 PM
Thrilled to share our work on the 🔥 single-celled predator Podophrya collini, which rewires its cell morphology to hunt more efficiently. Huge thanks to our amazing team—Amy, Lauren, Omaya, Marine, Mari, and especially Scott—for making this shine! ✨
Reposted by Scott Coyle
Very happy to see this out there ! Amazing work by @zjmaggiexu.bsky.social @amyweeks.bsky.social & @cellraiser.bsky.social!
All #ProtistsOnSky are amazing, but when I bumbed into @zjmaggiexu.bsky.social & her poster 2y ago at a #GRC conference, I got the urge to attempt #ExpnasionMicroscopy!
n/1
All #ProtistsOnSky are amazing, but when I bumbed into @zjmaggiexu.bsky.social & her poster 2y ago at a #GRC conference, I got the urge to attempt #ExpnasionMicroscopy!
n/1
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 5:19 PM
Very happy to see this out there ! Amazing work by @zjmaggiexu.bsky.social @amyweeks.bsky.social & @cellraiser.bsky.social!
All #ProtistsOnSky are amazing, but when I bumbed into @zjmaggiexu.bsky.social & her poster 2y ago at a #GRC conference, I got the urge to attempt #ExpnasionMicroscopy!
n/1
All #ProtistsOnSky are amazing, but when I bumbed into @zjmaggiexu.bsky.social & her poster 2y ago at a #GRC conference, I got the urge to attempt #ExpnasionMicroscopy!
n/1
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 4:15 PM
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
Reposted by Scott Coyle
We’re hiring! 🚨
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
November 8, 2025 at 5:54 PM
We’re hiring! 🚨
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
Reposted by Scott Coyle
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
October 31, 2025 at 2:42 PM
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
Reposted by Scott Coyle
What's creepy and chemistry? Look back at this gallium-based liquid metal that squirms due to an electron-transfer reaction that changes the surface tension of the alloy.⚡
Researchers are investigating the serpentine locomotion of liquid metals for potential applications in soft electronics. [1/2]
Researchers are investigating the serpentine locomotion of liquid metals for potential applications in soft electronics. [1/2]
Slithering liquid metal motivated by chemistry | Headline Science
Liquid metals can spontaneously bulge, protrude, branch and slither in response to certain ions in their environment. This happens due to the Marangoni effect, which starts with uneven changes in the…
www.youtube.com
October 31, 2025 at 2:02 PM
What's creepy and chemistry? Look back at this gallium-based liquid metal that squirms due to an electron-transfer reaction that changes the surface tension of the alloy.⚡
Researchers are investigating the serpentine locomotion of liquid metals for potential applications in soft electronics. [1/2]
Researchers are investigating the serpentine locomotion of liquid metals for potential applications in soft electronics. [1/2]
Reposted by Scott Coyle
An intimate conversation about what drives me every day in “sharing experience” of science by getting tools of science in hands of kids everywhere.
themicroscopists.bitesizebio.com/episodes/man...
themicroscopists.bitesizebio.com/episodes/man...
October 31, 2025 at 12:30 PM
An intimate conversation about what drives me every day in “sharing experience” of science by getting tools of science in hands of kids everywhere.
themicroscopists.bitesizebio.com/episodes/man...
themicroscopists.bitesizebio.com/episodes/man...
Reposted by Scott Coyle
Bacteria use paralog teamwork to survive stress.
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
Paralogs with distinct phase behaviors broaden the in vivo stress response range of condensates
Paralogs are widespread, but their physiological roles are often masked by redundancy. H-NS, a nucleoid-associated protein in Gram-negative bacteria, typically coexists with paralogs such as StpA, who...
www.biorxiv.org
October 20, 2025 at 7:55 PM
Bacteria use paralog teamwork to survive stress.
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
Reposted by Scott Coyle
Andrea A. Putnam, a UW School of Medicine and Public Health assistant professor of biomolecular chemistry, has been named a 2025 Packard Foundation Fellow in Science and Engineering. Congratulations, Dr. Putnam!
Andrea Putnam awarded 2025 Packard Fellowship - School of Medicine and Public Health
www.med.wisc.edu
October 16, 2025 at 7:12 PM
Andrea A. Putnam, a UW School of Medicine and Public Health assistant professor of biomolecular chemistry, has been named a 2025 Packard Foundation Fellow in Science and Engineering. Congratulations, Dr. Putnam!
Reposted by Scott Coyle
Final version of our paper on ciliary metachronal waves out now in Science Advances! doi.org/10.1126/scia...
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
October 15, 2025 at 8:53 PM
Final version of our paper on ciliary metachronal waves out now in Science Advances! doi.org/10.1126/scia...
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
Reposted by Scott Coyle
We have PhD and Postdoc positions open in our group. Join us in Lausanne to explore how cells pull off extreme shape changes and how cilia drive biological flows.
You can find more details on the projects available and how to apply in our website:
www.epfl.ch/labs/lpl/joi...
You can find more details on the projects available and how to apply in our website:
www.epfl.ch/labs/lpl/joi...
Join us !
We are looking for creative and motivated scientists at to join the group. We are recruiting candidates from various scientific backgrounds including, but not limited to: biophysics, physics, biochemi...
www.epfl.ch
October 15, 2025 at 11:20 AM
We have PhD and Postdoc positions open in our group. Join us in Lausanne to explore how cells pull off extreme shape changes and how cilia drive biological flows.
You can find more details on the projects available and how to apply in our website:
www.epfl.ch/labs/lpl/joi...
You can find more details on the projects available and how to apply in our website:
www.epfl.ch/labs/lpl/joi...
Reposted by Scott Coyle
The Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology (cryo-EM, cryo-ET, structural prediction methods, image analysis)!
More info here: apply.ista.ac.at/comp_structu...
More info here: apply.ista.ac.at/comp_structu...
GenApp
apply.ista.ac.at
October 15, 2025 at 10:10 AM
The Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology (cryo-EM, cryo-ET, structural prediction methods, image analysis)!
More info here: apply.ista.ac.at/comp_structu...
More info here: apply.ista.ac.at/comp_structu...
Reposted by Scott Coyle
MCDB Assistant Professor Faculty Search. Please Repost!
Applications Due Oct 15th (TOMORROW!)
We welcome applications from all areas of physiology and neuroscience - spanning molecular, cellular, systems, and organismal levels.
More information can be found HERE:
lsa.umich.edu/mcdb/news-ev...
Applications Due Oct 15th (TOMORROW!)
We welcome applications from all areas of physiology and neuroscience - spanning molecular, cellular, systems, and organismal levels.
More information can be found HERE:
lsa.umich.edu/mcdb/news-ev...
MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB)
MCDB welcomes applications at the Assistant Professor level from outstanding biological scientists in all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal le...
lsa.umich.edu
October 14, 2025 at 1:49 PM
MCDB Assistant Professor Faculty Search. Please Repost!
Applications Due Oct 15th (TOMORROW!)
We welcome applications from all areas of physiology and neuroscience - spanning molecular, cellular, systems, and organismal levels.
More information can be found HERE:
lsa.umich.edu/mcdb/news-ev...
Applications Due Oct 15th (TOMORROW!)
We welcome applications from all areas of physiology and neuroscience - spanning molecular, cellular, systems, and organismal levels.
More information can be found HERE:
lsa.umich.edu/mcdb/news-ev...
Reposted by Scott Coyle
#Expansion #Microscopy #Atlas of #Microbial #Eukaryotes is getting up to speed.
We will be at full speed soon, but we are lucky to have a welcoming #protistology #community. Thx
🙏 to @Marine @fmikus.bsky.social @Julius & @Galina
⏭️Stop: @ccapoban.bsky.social
#ExpandThemAll #ExAME #ProtistsOnSky
We will be at full speed soon, but we are lucky to have a welcoming #protistology #community. Thx
🙏 to @Marine @fmikus.bsky.social @Julius & @Galina
⏭️Stop: @ccapoban.bsky.social
#ExpandThemAll #ExAME #ProtistsOnSky
Trip 3 and past the 100 species count! Thank you for hosting us in České Budějovice Julius and Galina (and everyone providing samples!), for the prime support, and a fantastic selection of cultures!
#expandthemall @moorefound.bsky.social @dudinlab.bsky.social @gautamdey.bsky.social & T. Richards
#expandthemall @moorefound.bsky.social @dudinlab.bsky.social @gautamdey.bsky.social & T. Richards
October 9, 2025 at 1:00 PM
#Expansion #Microscopy #Atlas of #Microbial #Eukaryotes is getting up to speed.
We will be at full speed soon, but we are lucky to have a welcoming #protistology #community. Thx
🙏 to @Marine @fmikus.bsky.social @Julius & @Galina
⏭️Stop: @ccapoban.bsky.social
#ExpandThemAll #ExAME #ProtistsOnSky
We will be at full speed soon, but we are lucky to have a welcoming #protistology #community. Thx
🙏 to @Marine @fmikus.bsky.social @Julius & @Galina
⏭️Stop: @ccapoban.bsky.social
#ExpandThemAll #ExAME #ProtistsOnSky
Reposted by Scott Coyle
Extremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor!
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
The Thawani Lab at Columbia University
The Thawani Lab at Columbia University describing their research on mobile genome, cryo-electron microscopy and genome engineering
thawanilab.org
August 19, 2025 at 5:00 PM
Extremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor!
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org