Scott Coyle
@cellraiser.bsky.social
signaling systems and protein circuitry. reimagining what cells can be. fun posts only. Assistant Professor:
@uwbiochem | Postdoc: @stanford @prakashlab | Ph.D.:
@ucsf Wendell Lim @CDI_UCSF
@uwbiochem | Postdoc: @stanford @prakashlab | Ph.D.:
@ucsf Wendell Lim @CDI_UCSF
Pinned
Scott Coyle
@cellraiser.bsky.social
· Mar 4
Excited to share a new preprint! Wireless devices use FM modulation to transmit multiplexed noise-resistant data. Led by @born2raisecell.bsky.social, we create a biochemical analogue of this paradigm using genetically encoded oscillators (GEOs) for single-cell FM streaming tinyurl.com/nbs8rw42 🧵
Reposted by Scott Coyle
Wow! Remarkably complete story on the logic of phenotypic plasticity in a predatory protist - congrats @cellraiser.bsky.social et al!
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 8:52 PM
Wow! Remarkably complete story on the logic of phenotypic plasticity in a predatory protist - congrats @cellraiser.bsky.social et al!
Reposted by Scott Coyle
Thrilled to share our work on the 🔥 single-celled predator Podophrya collini, which rewires its cell morphology to hunt more efficiently. Huge thanks to our amazing team—Amy, Lauren, Omaya, Marine, Mari, and especially Scott—for making this shine! ✨
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 5:12 PM
Thrilled to share our work on the 🔥 single-celled predator Podophrya collini, which rewires its cell morphology to hunt more efficiently. Huge thanks to our amazing team—Amy, Lauren, Omaya, Marine, Mari, and especially Scott—for making this shine! ✨
Reposted by Scott Coyle
Very happy to see this out there ! Amazing work by @zjmaggiexu.bsky.social @amyweeks.bsky.social & @cellraiser.bsky.social!
All #ProtistsOnSky are amazing, but when I bumbed into @zjmaggiexu.bsky.social & her poster 2y ago at a #GRC conference, I got the urge to attempt #ExpnasionMicroscopy!
n/1
All #ProtistsOnSky are amazing, but when I bumbed into @zjmaggiexu.bsky.social & her poster 2y ago at a #GRC conference, I got the urge to attempt #ExpnasionMicroscopy!
n/1
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 5:19 PM
Very happy to see this out there ! Amazing work by @zjmaggiexu.bsky.social @amyweeks.bsky.social & @cellraiser.bsky.social!
All #ProtistsOnSky are amazing, but when I bumbed into @zjmaggiexu.bsky.social & her poster 2y ago at a #GRC conference, I got the urge to attempt #ExpnasionMicroscopy!
n/1
All #ProtistsOnSky are amazing, but when I bumbed into @zjmaggiexu.bsky.social & her poster 2y ago at a #GRC conference, I got the urge to attempt #ExpnasionMicroscopy!
n/1
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 4:15 PM
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
Reposted by Scott Coyle
We’re hiring! 🚨
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
November 8, 2025 at 5:54 PM
We’re hiring! 🚨
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
Reposted by Scott Coyle
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
October 31, 2025 at 2:42 PM
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
Reposted by Scott Coyle
What's creepy and chemistry? Look back at this gallium-based liquid metal that squirms due to an electron-transfer reaction that changes the surface tension of the alloy.⚡
Researchers are investigating the serpentine locomotion of liquid metals for potential applications in soft electronics. [1/2]
Researchers are investigating the serpentine locomotion of liquid metals for potential applications in soft electronics. [1/2]
Slithering liquid metal motivated by chemistry | Headline Science
Liquid metals can spontaneously bulge, protrude, branch and slither in response to certain ions in their environment. This happens due to the Marangoni effect, which starts with uneven changes in the…
www.youtube.com
October 31, 2025 at 2:02 PM
What's creepy and chemistry? Look back at this gallium-based liquid metal that squirms due to an electron-transfer reaction that changes the surface tension of the alloy.⚡
Researchers are investigating the serpentine locomotion of liquid metals for potential applications in soft electronics. [1/2]
Researchers are investigating the serpentine locomotion of liquid metals for potential applications in soft electronics. [1/2]
Reposted by Scott Coyle
An intimate conversation about what drives me every day in “sharing experience” of science by getting tools of science in hands of kids everywhere.
themicroscopists.bitesizebio.com/episodes/man...
themicroscopists.bitesizebio.com/episodes/man...
October 31, 2025 at 12:30 PM
An intimate conversation about what drives me every day in “sharing experience” of science by getting tools of science in hands of kids everywhere.
themicroscopists.bitesizebio.com/episodes/man...
themicroscopists.bitesizebio.com/episodes/man...
Reposted by Scott Coyle
Bacteria use paralog teamwork to survive stress.
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
Paralogs with distinct phase behaviors broaden the in vivo stress response range of condensates
Paralogs are widespread, but their physiological roles are often masked by redundancy. H-NS, a nucleoid-associated protein in Gram-negative bacteria, typically coexists with paralogs such as StpA, who...
www.biorxiv.org
October 20, 2025 at 7:55 PM
Bacteria use paralog teamwork to survive stress.
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
Reposted by Scott Coyle
Andrea A. Putnam, a UW School of Medicine and Public Health assistant professor of biomolecular chemistry, has been named a 2025 Packard Foundation Fellow in Science and Engineering. Congratulations, Dr. Putnam!
Andrea Putnam awarded 2025 Packard Fellowship - School of Medicine and Public Health
www.med.wisc.edu
October 16, 2025 at 7:12 PM
Andrea A. Putnam, a UW School of Medicine and Public Health assistant professor of biomolecular chemistry, has been named a 2025 Packard Foundation Fellow in Science and Engineering. Congratulations, Dr. Putnam!
Reposted by Scott Coyle
Final version of our paper on ciliary metachronal waves out now in Science Advances! doi.org/10.1126/scia...
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
October 15, 2025 at 8:53 PM
Final version of our paper on ciliary metachronal waves out now in Science Advances! doi.org/10.1126/scia...
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
Reposted by Scott Coyle
We have PhD and Postdoc positions open in our group. Join us in Lausanne to explore how cells pull off extreme shape changes and how cilia drive biological flows.
You can find more details on the projects available and how to apply in our website:
www.epfl.ch/labs/lpl/joi...
You can find more details on the projects available and how to apply in our website:
www.epfl.ch/labs/lpl/joi...
Join us !
We are looking for creative and motivated scientists at to join the group. We are recruiting candidates from various scientific backgrounds including, but not limited to: biophysics, physics, biochemi...
www.epfl.ch
October 15, 2025 at 11:20 AM
We have PhD and Postdoc positions open in our group. Join us in Lausanne to explore how cells pull off extreme shape changes and how cilia drive biological flows.
You can find more details on the projects available and how to apply in our website:
www.epfl.ch/labs/lpl/joi...
You can find more details on the projects available and how to apply in our website:
www.epfl.ch/labs/lpl/joi...
Reposted by Scott Coyle
The Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology (cryo-EM, cryo-ET, structural prediction methods, image analysis)!
More info here: apply.ista.ac.at/comp_structu...
More info here: apply.ista.ac.at/comp_structu...
GenApp
apply.ista.ac.at
October 15, 2025 at 10:10 AM
The Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology (cryo-EM, cryo-ET, structural prediction methods, image analysis)!
More info here: apply.ista.ac.at/comp_structu...
More info here: apply.ista.ac.at/comp_structu...
Reposted by Scott Coyle
MCDB Assistant Professor Faculty Search. Please Repost!
Applications Due Oct 15th (TOMORROW!)
We welcome applications from all areas of physiology and neuroscience - spanning molecular, cellular, systems, and organismal levels.
More information can be found HERE:
lsa.umich.edu/mcdb/news-ev...
Applications Due Oct 15th (TOMORROW!)
We welcome applications from all areas of physiology and neuroscience - spanning molecular, cellular, systems, and organismal levels.
More information can be found HERE:
lsa.umich.edu/mcdb/news-ev...
MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB)
MCDB welcomes applications at the Assistant Professor level from outstanding biological scientists in all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal le...
lsa.umich.edu
October 14, 2025 at 1:49 PM
MCDB Assistant Professor Faculty Search. Please Repost!
Applications Due Oct 15th (TOMORROW!)
We welcome applications from all areas of physiology and neuroscience - spanning molecular, cellular, systems, and organismal levels.
More information can be found HERE:
lsa.umich.edu/mcdb/news-ev...
Applications Due Oct 15th (TOMORROW!)
We welcome applications from all areas of physiology and neuroscience - spanning molecular, cellular, systems, and organismal levels.
More information can be found HERE:
lsa.umich.edu/mcdb/news-ev...
Reposted by Scott Coyle
#Expansion #Microscopy #Atlas of #Microbial #Eukaryotes is getting up to speed.
We will be at full speed soon, but we are lucky to have a welcoming #protistology #community. Thx
🙏 to @Marine @fmikus.bsky.social @Julius & @Galina
⏭️Stop: @ccapoban.bsky.social
#ExpandThemAll #ExAME #ProtistsOnSky
We will be at full speed soon, but we are lucky to have a welcoming #protistology #community. Thx
🙏 to @Marine @fmikus.bsky.social @Julius & @Galina
⏭️Stop: @ccapoban.bsky.social
#ExpandThemAll #ExAME #ProtistsOnSky
Trip 3 and past the 100 species count! Thank you for hosting us in České Budějovice Julius and Galina (and everyone providing samples!), for the prime support, and a fantastic selection of cultures!
#expandthemall @moorefound.bsky.social @dudinlab.bsky.social @gautamdey.bsky.social & T. Richards
#expandthemall @moorefound.bsky.social @dudinlab.bsky.social @gautamdey.bsky.social & T. Richards
October 9, 2025 at 1:00 PM
#Expansion #Microscopy #Atlas of #Microbial #Eukaryotes is getting up to speed.
We will be at full speed soon, but we are lucky to have a welcoming #protistology #community. Thx
🙏 to @Marine @fmikus.bsky.social @Julius & @Galina
⏭️Stop: @ccapoban.bsky.social
#ExpandThemAll #ExAME #ProtistsOnSky
We will be at full speed soon, but we are lucky to have a welcoming #protistology #community. Thx
🙏 to @Marine @fmikus.bsky.social @Julius & @Galina
⏭️Stop: @ccapoban.bsky.social
#ExpandThemAll #ExAME #ProtistsOnSky
Reposted by Scott Coyle
Extremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor!
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
The Thawani Lab at Columbia University
The Thawani Lab at Columbia University describing their research on mobile genome, cryo-electron microscopy and genome engineering
thawanilab.org
August 19, 2025 at 5:00 PM
Extremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor!
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
Reposted by Scott Coyle
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
October 1, 2025 at 6:21 PM
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
Reposted by Scott Coyle
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
September 29, 2025 at 7:09 PM
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Reposted by Scott Coyle
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
September 25, 2025 at 4:27 PM
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Reposted by Scott Coyle
Love #protists? Then you'd love this! Beautiful collection of hand-drawn critters represented here at the Oxford-Japan symposium on ethological dynamics in diorama environments sites.google.com/view/oxford-... #ciliates #testateamoeba #diatoms
September 24, 2025 at 3:14 PM
Love #protists? Then you'd love this! Beautiful collection of hand-drawn critters represented here at the Oxford-Japan symposium on ethological dynamics in diorama environments sites.google.com/view/oxford-... #ciliates #testateamoeba #diatoms
Reposted by Scott Coyle
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
September 23, 2025 at 5:08 PM
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
Reposted by Scott Coyle
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:27 PM
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Reposted by Scott Coyle
A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize
#KeioMedicalSciencePrize
Bioengineer Clifford Brangwynne wins Keio Medical Science Prize
Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell bi...
www.princeton.edu
September 20, 2025 at 6:16 PM
A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize
#KeioMedicalSciencePrize
Reposted by Scott Coyle
Looks like I am late to this party but have exciting news. I’ve been awarded an ERC Starting Grant to study #XtrmCells! Thankful to @erc.europa.eus for this opportunity, and to my collaborators, mentors, and group for their support. Looking forward to exploring the mechanics of these cells!
September 18, 2025 at 6:06 AM
Looks like I am late to this party but have exciting news. I’ve been awarded an ERC Starting Grant to study #XtrmCells! Thankful to @erc.europa.eus for this opportunity, and to my collaborators, mentors, and group for their support. Looking forward to exploring the mechanics of these cells!
Reposted by Scott Coyle
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
September 17, 2025 at 5:20 PM
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N