Martin Loose
@nartimsoole.bsky.social
Interested in protein self-organization. We rebuild the bacterial cell division machinery and small GTPase networks in vitro. https://looselab.ist.ac.at
Pinned
Martin Loose
@nartimsoole.bsky.social
· Jul 2
Evolutionary repurposing of a DNA segregation machinery into a cytoskeletal system controlling cyanobacterial cell shape
Bacteria, despite their diversity, use conserved cytoskeletal systems for their intracellular organization. In unicellular bacteria, the ParMRC DNA partitioning apparatus is well known for forming act...
www.biorxiv.org
One of the most exciting discoveries from our lab so far is now online as a preprint!
Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria:
www.biorxiv.org/content/10.1...
Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria:
www.biorxiv.org/content/10.1...
Happy to share a new preprint from the lab: Marko became interested in whether the disordered linker of FtsZ might influence how the protein organizes into the Z-ring. And this led to some surprising findings!
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
Charge segregation in the C-terminal linker of FtsZ enables Z-ring scaling with prokaryotic cell width
Bacterial cytokinesis is orchestrated by the Z-ring, a cytoskeletal structure formed by treadmilling filaments of the tubulin-like GTPase FtsZ. During assembly, filament curvature must match the cell ...
www.biorxiv.org
November 26, 2025 at 9:29 PM
Happy to share a new preprint from the lab: Marko became interested in whether the disordered linker of FtsZ might influence how the protein organizes into the Z-ring. And this led to some surprising findings!
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
Reposted by Martin Loose
Our fully-funded PhD program is open for applications!
Join us to conduct cutting-edge research at top facilities with guidance from world-class faculty. Through our interdisciplinary training, you can tailor your PhD experience to match your interests and curiosity.
Apply now: phd.ista.ac.at
Join us to conduct cutting-edge research at top facilities with guidance from world-class faculty. Through our interdisciplinary training, you can tailor your PhD experience to match your interests and curiosity.
Apply now: phd.ista.ac.at
October 27, 2025 at 2:35 PM
Our fully-funded PhD program is open for applications!
Join us to conduct cutting-edge research at top facilities with guidance from world-class faculty. Through our interdisciplinary training, you can tailor your PhD experience to match your interests and curiosity.
Apply now: phd.ista.ac.at
Join us to conduct cutting-edge research at top facilities with guidance from world-class faculty. Through our interdisciplinary training, you can tailor your PhD experience to match your interests and curiosity.
Apply now: phd.ista.ac.at
The Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology (cryo-EM, cryo-ET, structural prediction methods, image analysis)!
More info here: apply.ista.ac.at/comp_structu...
More info here: apply.ista.ac.at/comp_structu...
GenApp
apply.ista.ac.at
October 15, 2025 at 10:10 AM
The Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology (cryo-EM, cryo-ET, structural prediction methods, image analysis)!
More info here: apply.ista.ac.at/comp_structu...
More info here: apply.ista.ac.at/comp_structu...
Reposted by Martin Loose
Thrilled to share our newest publication in Science Advances!
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
The molecular comparison of related RabGEFs reveals adaptation mechanisms of a functional module for specific cellular tasks.
www.science.org
September 2, 2025 at 8:02 PM
Thrilled to share our newest publication in Science Advances!
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
We are looking for a Master’s student to join a project on in vitro reconstitution of signaling networks in pathogen–host interactions: combine protein biochemistry, fluorescence microscopy & image analysis. Deadline: September 15.
Find out more and apply here: ist.ac.at/en/job/maste...
Find out more and apply here: ist.ac.at/en/job/maste...
Master Thesis Position – Loose Research Group
Our Group
The Loose lab at the Institute of Science and Technology Austria (ISTA) is looking for a highly motivated Master student to join our research on the in vitro reconstitution of signaling n...
ist.ac.at
September 1, 2025 at 9:15 AM
We are looking for a Master’s student to join a project on in vitro reconstitution of signaling networks in pathogen–host interactions: combine protein biochemistry, fluorescence microscopy & image analysis. Deadline: September 15.
Find out more and apply here: ist.ac.at/en/job/maste...
Find out more and apply here: ist.ac.at/en/job/maste...
Reposted by Martin Loose
We're hiring a postdoc!
Join our ActinID project to explore an uncharacterized actin-binding protein.
- Background in cell and/or structural biology?
- Eager to bridge both fields?
Get in touch if you're curious or have questions!
#cellbiology #cryoEM #cryoET #actin
ista.ac.at/en/job/postd...
Join our ActinID project to explore an uncharacterized actin-binding protein.
- Background in cell and/or structural biology?
- Eager to bridge both fields?
Get in touch if you're curious or have questions!
#cellbiology #cryoEM #cryoET #actin
ista.ac.at/en/job/postd...
Postdoc Research Group Schur
The Schur lab at the Institute of Science and Technology Austria (ISTA) has an open postdoc position for a highly motivated candidate to be part of our ERC-funded project ActinID.
Our Group
...
ista.ac.at
July 7, 2025 at 9:21 AM
We're hiring a postdoc!
Join our ActinID project to explore an uncharacterized actin-binding protein.
- Background in cell and/or structural biology?
- Eager to bridge both fields?
Get in touch if you're curious or have questions!
#cellbiology #cryoEM #cryoET #actin
ista.ac.at/en/job/postd...
Join our ActinID project to explore an uncharacterized actin-binding protein.
- Background in cell and/or structural biology?
- Eager to bridge both fields?
Get in touch if you're curious or have questions!
#cellbiology #cryoEM #cryoET #actin
ista.ac.at/en/job/postd...
One of the most exciting discoveries from our lab so far is now online as a preprint!
Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria:
www.biorxiv.org/content/10.1...
Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria:
www.biorxiv.org/content/10.1...
Evolutionary repurposing of a DNA segregation machinery into a cytoskeletal system controlling cyanobacterial cell shape
Bacteria, despite their diversity, use conserved cytoskeletal systems for their intracellular organization. In unicellular bacteria, the ParMRC DNA partitioning apparatus is well known for forming act...
www.biorxiv.org
July 2, 2025 at 11:35 AM
One of the most exciting discoveries from our lab so far is now online as a preprint!
Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria:
www.biorxiv.org/content/10.1...
Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria:
www.biorxiv.org/content/10.1...
Looking for a student or postdoc!
Want to combine evolutionary analysis + structural modeling with in vitro biochemistry & fluorescence microscopy?
Help us uncover new protein-protein interactions — from in silico to in vitro.
Join us at @istaresearch.bsky.social 👉 looselab.org
🧬💡🔬🎡
Want to combine evolutionary analysis + structural modeling with in vitro biochemistry & fluorescence microscopy?
Help us uncover new protein-protein interactions — from in silico to in vitro.
Join us at @istaresearch.bsky.social 👉 looselab.org
🧬💡🔬🎡
looselab.org
April 10, 2025 at 9:28 AM
Looking for a student or postdoc!
Want to combine evolutionary analysis + structural modeling with in vitro biochemistry & fluorescence microscopy?
Help us uncover new protein-protein interactions — from in silico to in vitro.
Join us at @istaresearch.bsky.social 👉 looselab.org
🧬💡🔬🎡
Want to combine evolutionary analysis + structural modeling with in vitro biochemistry & fluorescence microscopy?
Help us uncover new protein-protein interactions — from in silico to in vitro.
Join us at @istaresearch.bsky.social 👉 looselab.org
🧬💡🔬🎡
Very cool findings from Paula, Andrea et al.! Excited that my student Roman could contribute! See Andrea’s thread below for more details:
It has been coming a long way... happy to share our latest work with you: www.biorxiv.org/content/10.1...
Here, we show the importance of septal fortification by the Class A Penicillin Binding Protein, PBP1b, in E. coli and provide a molecular mechanism for this function. (1/12).
Here, we show the importance of septal fortification by the Class A Penicillin Binding Protein, PBP1b, in E. coli and provide a molecular mechanism for this function. (1/12).
The aPBP-type cell wall synthase PBP1b plays a specialized role in fortifying the Escherichia coli division site against osmotic rupture
A multi-protein system called the divisome promotes bacterial division. This apparatus synthesizes the peptidoglycan (PG) cell wall layer that forms the daughter cell poles and protects them from osmo...
www.biorxiv.org
April 4, 2025 at 6:41 AM
Very cool findings from Paula, Andrea et al.! Excited that my student Roman could contribute! See Andrea’s thread below for more details:
Reposted by Martin Loose
🚨👉 Please check our recent work on bacterial cell division. In situ Cryo-ET reveals the cellular function of the penicillin binding protein 1b supported by AFM, live-cell imaging, in silico AlphaFold proteome screen and TIRFM. Hope you enjoy the read! #teamtomo #cryo-ET ❄️🔬🐎 big thanks to the team!
The aPBP-type cell wall synthase PBP1b plays a specialized role in fortifying the Escherichia coli division site against osmotic rupture https://www.biorxiv.org/content/10.1101/2025.04.02.646830v1
April 3, 2025 at 9:08 AM
Reposted by Martin Loose
who doesn't enjoy some beautiful FtsZ rings on a sunday evening? these from 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴, from all angles, by the @jwveening.bsky.social, posted earlier on 𝕏, on may 6, 2021
Movie S2 from journals.plos.org/plospathogen...
#MicroSky
Movie S2 from journals.plos.org/plospathogen...
#MicroSky
March 23, 2025 at 6:19 PM
who doesn't enjoy some beautiful FtsZ rings on a sunday evening? these from 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴, from all angles, by the @jwveening.bsky.social, posted earlier on 𝕏, on may 6, 2021
Movie S2 from journals.plos.org/plospathogen...
#MicroSky
Movie S2 from journals.plos.org/plospathogen...
#MicroSky
Excited about protein biochemistry, fluorescence microscopy, and image analysis? Curious how proteins drive bacterial division or define organelle identity? Join us at ISTA! Apply to the PhD program by Jan 8th: gradschool.ist.ac.at
gradschool.ist.ac.at
December 20, 2024 at 9:02 AM
Excited about protein biochemistry, fluorescence microscopy, and image analysis? Curious how proteins drive bacterial division or define organelle identity? Join us at ISTA! Apply to the PhD program by Jan 8th: gradschool.ist.ac.at
Input needed: What is your favourite amphipathic helix?
I am looking for looots of sequences to train a ML model to find even more.
Please tell me! Thanks! :)
I am looking for looots of sequences to train a ML model to find even more.
Please tell me! Thanks! :)
December 18, 2024 at 4:32 PM
Input needed: What is your favourite amphipathic helix?
I am looking for looots of sequences to train a ML model to find even more.
Please tell me! Thanks! :)
I am looking for looots of sequences to train a ML model to find even more.
Please tell me! Thanks! :)