Stephan Wilmes
@stephanwilmes.bsky.social
PhD student in Kümmel-Lab @ University of Münster
Reposted by Stephan Wilmes
Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel Kümmel lab, Thomas Becker lab! www.cell.com/cell-reports...
The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility
Zhao et al. identify the molecular machinery for lipid droplet motility, consisting
of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor
Ldo16. They uncover a molecular l...
www.cell.com
November 7, 2025 at 2:06 PM
Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel Kümmel lab, Thomas Becker lab! www.cell.com/cell-reports...
Reposted by Stephan Wilmes
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
October 17, 2025 at 3:18 PM
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
Thrilled to share our newest publication in Science Advances!
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
The molecular comparison of related RabGEFs reveals adaptation mechanisms of a functional module for specific cellular tasks.
www.science.org
September 2, 2025 at 8:02 PM
Thrilled to share our newest publication in Science Advances!
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
Reposted by Stephan Wilmes
Check out our new preprint from the @landerlab.bsky.social, Stagg-Lab and Cianfrocco-Lab: CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection www.biorxiv.org/content/10.1...
Happy testing: cryosift.org #cryoEM #CNN
Happy testing: cryosift.org #cryoEM #CNN
August 1, 2025 at 3:20 PM
Check out our new preprint from the @landerlab.bsky.social, Stagg-Lab and Cianfrocco-Lab: CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection www.biorxiv.org/content/10.1...
Happy testing: cryosift.org #cryoEM #CNN
Happy testing: cryosift.org #cryoEM #CNN
Happy our preprint on the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned is out! doi.org/10.1101/2025...
Thanks to everyone involved! @jessetoenjes.bsky.social @jhschaef.bsky.social @djanuliene.bsky.social @arnemoeller.bsky.social @nartimsoole.bsky.social
Thanks to everyone involved! @jessetoenjes.bsky.social @jhschaef.bsky.social @djanuliene.bsky.social @arnemoeller.bsky.social @nartimsoole.bsky.social
Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
Rab GTPases organize intracellular trafficking and provide identity to organelles. Their spatiotemporal activation by guanine nucleotide exchange factors (GEFs) is tightly controlled to ensure fidelit...
doi.org
April 6, 2025 at 9:54 PM
Happy our preprint on the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned is out! doi.org/10.1101/2025...
Thanks to everyone involved! @jessetoenjes.bsky.social @jhschaef.bsky.social @djanuliene.bsky.social @arnemoeller.bsky.social @nartimsoole.bsky.social
Thanks to everyone involved! @jessetoenjes.bsky.social @jhschaef.bsky.social @djanuliene.bsky.social @arnemoeller.bsky.social @nartimsoole.bsky.social
Reposted by Stephan Wilmes
Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned https://www.biorxiv.org/content/10.1101/2025.03.27.645700v1
March 29, 2025 at 4:46 AM
Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned https://www.biorxiv.org/content/10.1101/2025.03.27.645700v1
Reposted by Stephan Wilmes
Structure and mechanism of the RalGAP tumor suppressor complex https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1
Structure and mechanism of the RalGAP tumor suppressor complex https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1
The RalGAP (GTPase activating protein) complexes are negative regulators of the Ral GTPases and thus
www.biorxiv.org
November 26, 2024 at 3:46 AM
Structure and mechanism of the RalGAP tumor suppressor complex https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1