Boris Sieber
@borissieber.bsky.social
Postdoc @SophieMartinLab.bsky.social studying #GPCR and #MAPK signalling in fission yeast. Alumnus of @mjafreeman.bsky.social and @jordanraff.bsky.social
Pinned
Boris Sieber
@borissieber.bsky.social
· Sep 25
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Reposted by Boris Sieber
Open Postdoc position in our lab!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.
ista.ac.at/en/job/postd...
Please share and feel free to reach out if there are questions!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.
ista.ac.at/en/job/postd...
Please share and feel free to reach out if there are questions!
Postdoc Research Group Schur
The Schur lab at the Institute of Science and Technology Austria (ISTA) has an open postdoc position for a highly motivated candidate to be part of our ERC-funded project ActinID.
Our Group
...
ista.ac.at
February 13, 2026 at 3:50 PM
Open Postdoc position in our lab!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.
ista.ac.at/en/job/postd...
Please share and feel free to reach out if there are questions!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.
ista.ac.at/en/job/postd...
Please share and feel free to reach out if there are questions!
Reposted by Boris Sieber
Join us at the @crick.ac.uk for the 2026 meeting of the UK proteostasis community!
We especially encourage students and postdocs to attend and share their work. All talks (except the keynotes) will be selected from abstracts.
We especially encourage students and postdocs to attend and share their work. All talks (except the keynotes) will be selected from abstracts.
📣 UK Proteostasis Meeting 2026 – Registration Now Open!
I’m delighted to share that registration is now open for the UK Proteostasis Meeting 2026, hosted by The Francis Crick Institute on 20–21 July 2026 .
Please register here(lnkd.in/ervXMzWN) and through Eventbrite for payment (lnkd.in/eTxqjnQy)
I’m delighted to share that registration is now open for the UK Proteostasis Meeting 2026, hosted by The Francis Crick Institute on 20–21 July 2026 .
Please register here(lnkd.in/ervXMzWN) and through Eventbrite for payment (lnkd.in/eTxqjnQy)
February 13, 2026 at 1:55 PM
Join us at the @crick.ac.uk for the 2026 meeting of the UK proteostasis community!
We especially encourage students and postdocs to attend and share their work. All talks (except the keynotes) will be selected from abstracts.
We especially encourage students and postdocs to attend and share their work. All talks (except the keynotes) will be selected from abstracts.
Reposted by Boris Sieber
It took a while but it’s finally published!
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
New online: Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
Nature Structural & Molecular Biology, Published online: 12 February 2026; doi:10.1038/s41594-026-01746-2Tafur et al. determined the cryo-electron microscopy structure of the SEA complex (GATOR) bound to its substrate, the EGO complex (Ragulator–Rag), and showed that its GAP activity is essential for both rapid inactivation and reactivation of TORC1.
dlvr.it
February 13, 2026 at 12:56 PM
It took a while but it’s finally published!
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
Reposted by Boris Sieber
JOB ALERT!
We are excited to announce that we are recruiting three new academics at lecturer level!
Click the link below for more info on how to apply, and don’t forget to explore our research themes too!
We look forward to receiving your applications!
www.bristol.ac.uk/jobs/find/de...
We are excited to announce that we are recruiting three new academics at lecturer level!
Click the link below for more info on how to apply, and don’t forget to explore our research themes too!
We look forward to receiving your applications!
www.bristol.ac.uk/jobs/find/de...
February 12, 2026 at 9:14 AM
JOB ALERT!
We are excited to announce that we are recruiting three new academics at lecturer level!
Click the link below for more info on how to apply, and don’t forget to explore our research themes too!
We look forward to receiving your applications!
www.bristol.ac.uk/jobs/find/de...
We are excited to announce that we are recruiting three new academics at lecturer level!
Click the link below for more info on how to apply, and don’t forget to explore our research themes too!
We look forward to receiving your applications!
www.bristol.ac.uk/jobs/find/de...
Reposted by Boris Sieber
🚨 New preprint!
Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria
Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬
Check it out: doi.org/10.64898/202...
Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria
Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬
Check it out: doi.org/10.64898/202...
February 12, 2026 at 10:30 AM
🚨 New preprint!
Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria
Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬
Check it out: doi.org/10.64898/202...
Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria
Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬
Check it out: doi.org/10.64898/202...
Reposted by Boris Sieber
The FMI cryo-EM team is looking for a new team member. Join us in Basel!
🚀 We’re hiring! The Structural Biology Platform is seeking a Project Leader to advance cryo-electron tomography and expand capabilities at the FMI. Join a vibrant research community at the interface of structural biology, cell biology & disease mechanisms. Apply at: www.fmi.ch/education-ca...
February 12, 2026 at 7:12 AM
The FMI cryo-EM team is looking for a new team member. Join us in Basel!
Reposted by Boris Sieber
Yeast ubiquilin Dsk2 scaffolds proteasome-containing condensates under stress via multivalent interactions – @castanedalab.bsky.social et al show how dynamic interactions among its STI1 domain & transient helices in its disordered region promote its phase-separation
link.springer.com/article/10.1...
link.springer.com/article/10.1...
STI1 domain engages transient helices to mediate Dsk2 phase separation and proteasome condensation - The EMBO Journal
Ubiquitin-binding shuttle proteins are important components of stress-induced biomolecular condensates in cells. Yeast Dsk2 scaffolds proteasome-containing condensates via multivalent interactions wit...
link.springer.com
February 11, 2026 at 2:53 PM
Yeast ubiquilin Dsk2 scaffolds proteasome-containing condensates under stress via multivalent interactions – @castanedalab.bsky.social et al show how dynamic interactions among its STI1 domain & transient helices in its disordered region promote its phase-separation
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Boris Sieber
Junior PI position in cancer research open at the IRCM. Apply below 👇🏽 #PIposition #assistantprofessor #cancer #openposition #ircm
Principal investigator job alert @ircm.bsky.social! We are recruiting a new junior faculty member working in the field of cancer. Apply before February 22nd. Contact me if you have more questions.
www.ircm.qc.ca/en/position-...
www.ircm.qc.ca/en/position-...
Research Unit Director – IRCM Cancer Research Center
Job reference code: IRCM-Cancer
www.ircm.qc.ca
February 10, 2026 at 12:04 PM
Junior PI position in cancer research open at the IRCM. Apply below 👇🏽 #PIposition #assistantprofessor #cancer #openposition #ircm
Reposted by Boris Sieber
We need to teach PhD students how to write a great cover letter - one that links their research to a future lab’s goals, shows genuine enthusiasm, and clearly explains fit. It’s not a CV summary or a formality; it’s their first real conversation with future colleagues.
February 10, 2026 at 8:06 PM
We need to teach PhD students how to write a great cover letter - one that links their research to a future lab’s goals, shows genuine enthusiasm, and clearly explains fit. It’s not a CV summary or a formality; it’s their first real conversation with future colleagues.
Reposted by Boris Sieber
Amazing science on beautiful Spetses 🤩
EMBO-FEBS Lecture Course – Membranes in Organelle Biogenesis
📍 Spetses, Greece | 🗓️ 10–16 May 2026
A week with leading experts on organelle biology, membranes, lipids, and dynamics.
⏰ Deadline: 1 March 2026
🔗 Info: network.febs.org/videos/membr...
📝 Register: spetses2026.sites.uu.nl
📍 Spetses, Greece | 🗓️ 10–16 May 2026
A week with leading experts on organelle biology, membranes, lipids, and dynamics.
⏰ Deadline: 1 March 2026
🔗 Info: network.febs.org/videos/membr...
📝 Register: spetses2026.sites.uu.nl
Membranes and their lipids and proteins in organelle biogenesis
The Joint FEBS/EMBO Lecture Course 'Membranes and their lipids and proteins in organelle biogenesis' will take place in Spetses Island, Greece, from 10–16 May 2026. Registration is open (deadline 1 Ma...
network.febs.org
February 10, 2026 at 2:45 PM
Amazing science on beautiful Spetses 🤩
Reposted by Boris Sieber
A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration: Current Biology www.cell.com/current-biol...
A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration
Iu et al. uncover a Ca2+ signaling pathway promoting cell migration by facilitating
actin assembly in protrusions. Ca2+ influx through TRPV4 channel activates RhoA in
lamellipodia via CaMKII and TEM4,...
www.cell.com
February 8, 2026 at 2:45 PM
A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration: Current Biology www.cell.com/current-biol...
Reposted by Boris Sieber
Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - Poste de chercheur postdoctoral en trafic membranaire fondamental et sécrétion du collagène (H/F)
Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler
emploi.cnrs.fr
February 6, 2026 at 10:12 AM
Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...
Reposted by Boris Sieber
2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...
crick.ac.uk/WayPostdoc20...
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab
crick.ac.uk
February 6, 2026 at 8:29 AM
2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...
crick.ac.uk/WayPostdoc20...
Reposted by Boris Sieber
Postdoc job alert in the Crick Institute in London. Are you interested in the actin cytoskeleton? I am looking for a postdoc to examine the cellular, developmental or physiological role of Arp2/3 iso-complex driven actin polymerisation. Multiple aspects available.
crick.ac.uk/WayPostdoc2026
crick.ac.uk/WayPostdoc2026
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab
crick.ac.uk
February 6, 2026 at 8:22 AM
Postdoc job alert in the Crick Institute in London. Are you interested in the actin cytoskeleton? I am looking for a postdoc to examine the cellular, developmental or physiological role of Arp2/3 iso-complex driven actin polymerisation. Multiple aspects available.
crick.ac.uk/WayPostdoc2026
crick.ac.uk/WayPostdoc2026
Reposted by Boris Sieber
Do you have experience in bioinformatics and are looking for a new challenge? To immerse yourself in a group and institute doing highly diverse research?
Then come and join our group !
Then come and join our group !
🚨We are hiring a Bioinformatician who will be embedded in our lab and work with members of the NCCR Microbiomes at ETH Zurich, as well as the Institute of Microbiology.🚨
nccr-microbiomes.ch
jobs.ethz.ch/job/view/JOP...
nccr-microbiomes.ch
jobs.ethz.ch/job/view/JOP...
Bioinformatician in Microbiome Research
jobs.ethz.ch
January 23, 2026 at 6:18 PM
Do you have experience in bioinformatics and are looking for a new challenge? To immerse yourself in a group and institute doing highly diverse research?
Then come and join our group !
Then come and join our group !
Reposted by Boris Sieber
New paper out! Here's a puzzle: phototrophy, the ability to use light for energy, is one of life's great innovations. It evolved early and transformed the biosphere. But it evolved 2x. Why not just once, why not more? Our work suggests the answer is priority effects.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Priority effects inhibit the repeated evolution of phototrophy - npj Complexity
npj Complexity - Priority effects inhibit the repeated evolution of phototrophy
www.nature.com
February 3, 2026 at 9:37 PM
New paper out! Here's a puzzle: phototrophy, the ability to use light for energy, is one of life's great innovations. It evolved early and transformed the biosphere. But it evolved 2x. Why not just once, why not more? Our work suggests the answer is priority effects.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by Boris Sieber
Great to see this officially out: An mTurquoise2-Based Glucose Biosensor - works in yeast & mammalian cells and is compatible with FLIM: pubs.acs.org/doi/10.1021/...
An mTurquoise2-Based Glucose Biosensor
Glucose is an important substrate for organisms to acquire energy needed for cellular growth. Despite the importance of this metabolite, single-cell information at a fast time-scale about the dynamics...
pubs.acs.org
February 3, 2026 at 9:10 PM
Great to see this officially out: An mTurquoise2-Based Glucose Biosensor - works in yeast & mammalian cells and is compatible with FLIM: pubs.acs.org/doi/10.1021/...
Reposted by Boris Sieber
After 15 years as Editor-in-chief (EiC), Michael Way @drmichaelway.bsky.social will be stepping down at the end of 2026 & we are seeking feedback from the cell biology community as part of the consultation process for appointing a new EiC.
We'd love to hear from you: www.surveymonkey.com/r/GZCC9F9
We'd love to hear from you: www.surveymonkey.com/r/GZCC9F9
February 3, 2026 at 1:36 PM
After 15 years as Editor-in-chief (EiC), Michael Way @drmichaelway.bsky.social will be stepping down at the end of 2026 & we are seeking feedback from the cell biology community as part of the consultation process for appointing a new EiC.
We'd love to hear from you: www.surveymonkey.com/r/GZCC9F9
We'd love to hear from you: www.surveymonkey.com/r/GZCC9F9
Reposted by Boris Sieber
Beginning 2026 with a flipping good paper🚀 OSCA/TMEM63 proteins do double duty: they’re ion channels and mechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. 👏 @yiechanglin.bsky.social @charlesdcox.bsky.social doi.org/10.1038/s414...
February 2, 2026 at 10:30 PM
Beginning 2026 with a flipping good paper🚀 OSCA/TMEM63 proteins do double duty: they’re ion channels and mechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. 👏 @yiechanglin.bsky.social @charlesdcox.bsky.social doi.org/10.1038/s414...
Reposted by Boris Sieber
Check out our new review in Nature Reviews Genetics on de novo emerged genes and proteins. How they emerge, are lost and persist - and how de novo emerged proteins relate to randomized proteins! @bornberglab.bsky.social www.nature.com/articles/s41...
January 28, 2026 at 6:23 PM
Check out our new review in Nature Reviews Genetics on de novo emerged genes and proteins. How they emerge, are lost and persist - and how de novo emerged proteins relate to randomized proteins! @bornberglab.bsky.social www.nature.com/articles/s41...
Reposted by Boris Sieber
Another day, another great story out !
Don't miss the latest work from @guallar-garrido.bsky.social on calcium as a "chef d'orchestre" coordinating the mycobacterial vacuole damage repair response !! ⤵️
Don't miss the latest work from @guallar-garrido.bsky.social on calcium as a "chef d'orchestre" coordinating the mycobacterial vacuole damage repair response !! ⤵️
🚨 Preprint alert 🚨
In this study, we reveal how a calcium-sensing protein coordinates membrane damage sensing with repair pathways in response to damage from intracellular mycobacteria
Huge congrats to @guallar-garrido.bsky.social for leading this project! 🤩👏
www.biorxiv.org/content/10.6...
In this study, we reveal how a calcium-sensing protein coordinates membrane damage sensing with repair pathways in response to damage from intracellular mycobacteria
Huge congrats to @guallar-garrido.bsky.social for leading this project! 🤩👏
www.biorxiv.org/content/10.6...
February 2, 2026 at 4:55 PM
Another day, another great story out !
Don't miss the latest work from @guallar-garrido.bsky.social on calcium as a "chef d'orchestre" coordinating the mycobacterial vacuole damage repair response !! ⤵️
Don't miss the latest work from @guallar-garrido.bsky.social on calcium as a "chef d'orchestre" coordinating the mycobacterial vacuole damage repair response !! ⤵️
Reposted by Boris Sieber
Mitosis lovers, get ready for Dubrovnik! 🔬🎉
I’m super excited to be organizing the 4th Mitotic Spindle Conference with Nenad Pavin, and we can’t wait to see you there!
Want your abstract to be selected for a talk? Submit by Feb 8!
www.phy.pmf.unizg.hr/~mitosis/
#SpindleCroatia2026
I’m super excited to be organizing the 4th Mitotic Spindle Conference with Nenad Pavin, and we can’t wait to see you there!
Want your abstract to be selected for a talk? Submit by Feb 8!
www.phy.pmf.unizg.hr/~mitosis/
#SpindleCroatia2026
February 2, 2026 at 8:22 AM
Mitosis lovers, get ready for Dubrovnik! 🔬🎉
I’m super excited to be organizing the 4th Mitotic Spindle Conference with Nenad Pavin, and we can’t wait to see you there!
Want your abstract to be selected for a talk? Submit by Feb 8!
www.phy.pmf.unizg.hr/~mitosis/
#SpindleCroatia2026
I’m super excited to be organizing the 4th Mitotic Spindle Conference with Nenad Pavin, and we can’t wait to see you there!
Want your abstract to be selected for a talk? Submit by Feb 8!
www.phy.pmf.unizg.hr/~mitosis/
#SpindleCroatia2026
Reposted by Boris Sieber
The Federal Council is proposing the dissolution of the Swiss Science Council.
Independent fact-based, scientific advice should be available for policy decisions.
Independent fact-based, scientific advice should be available for policy decisions.
January 30, 2026 at 7:53 PM
The Federal Council is proposing the dissolution of the Swiss Science Council.
Independent fact-based, scientific advice should be available for policy decisions.
Independent fact-based, scientific advice should be available for policy decisions.
Reposted by Boris Sieber
Amazing opportunity, two 5-year Research Professor positions opened at the Finnish Cancer Institute www.syopainstituutti.com/researcher-p...
January 31, 2026 at 12:05 PM
Amazing opportunity, two 5-year Research Professor positions opened at the Finnish Cancer Institute www.syopainstituutti.com/researcher-p...