PomBase: The S. pombe knowledgebase
@pombase.bsky.social
https://www.pombase.org/ Knowledgebase for Schizosaccharomyces pombe (a fission yeast). Supporting scientific discovery for cell-level processes; #OpenScience, #FAIR data #CommunityCuration; Monitoring #UnknownProteins; Elixir and GBC Core Data Resource.
Pinned
PomBase introduces two new interactive views for GO-CAM pathway models: Summary Maps (high-level, visual overview) and Mega-Models (connected models). Check them out here: lnkd.in/gfxNRdua
Calling thesis advisors, department chairs, and supervisory committee members! 📣 Nominate an outstanding PhD/PhD candidate working with Drosophila for the Larry Sandler Award. They'll present at #Dros26. Learn more and submit a nomination: buff.ly/mtfDbBD
@peiferlabunc.bsky.social
@peiferlabunc.bsky.social
November 14, 2025 at 7:21 PM
Reposted by PomBase: The S. pombe knowledgebase
Congrats!
Thrilled to share that the first paper from the Miller Lab is out on bioRxiv! 🎉
Fission yeast use distinct size-sensing pathways to adapt their geometry under stress.
Now under peer review - proud of my amazing team!
www.biorxiv.org/content/10.1...
Fission yeast use distinct size-sensing pathways to adapt their geometry under stress.
Now under peer review - proud of my amazing team!
www.biorxiv.org/content/10.1...
Fission yeast cells use distinct cell size control mechanisms for size adaptation to osmotic, oxidative, or low glucose conditions
Cells maintain an appropriate size to function, yet the mechanisms that enable size adaptation to environmental stress remain poorly understood. Fission yeast cells enter mitosis and divide at a thres...
www.biorxiv.org
November 8, 2025 at 8:40 AM
Congrats!
Reposted by PomBase: The S. pombe knowledgebase
🧬 PomBase needs you! 🧬
If you PomBase on a regular basis, now it’s the time to show your support to the team behind this incredibly useful resource (and help them secure funding to keep up the amazing work). Fill out their short user survey, which they will use to support their grant application.
If you PomBase on a regular basis, now it’s the time to show your support to the team behind this incredibly useful resource (and help them secure funding to keep up the amazing work). Fill out their short user survey, which they will use to support their grant application.
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
November 12, 2025 at 8:55 PM
🧬 PomBase needs you! 🧬
If you PomBase on a regular basis, now it’s the time to show your support to the team behind this incredibly useful resource (and help them secure funding to keep up the amazing work). Fill out their short user survey, which they will use to support their grant application.
If you PomBase on a regular basis, now it’s the time to show your support to the team behind this incredibly useful resource (and help them secure funding to keep up the amazing work). Fill out their short user survey, which they will use to support their grant application.
Reposted by PomBase: The S. pombe knowledgebase
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:56 AM
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
Reposted by PomBase: The S. pombe knowledgebase
This is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
November 7, 2025 at 1:35 PM
This is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Congrats!
Thrilled to share that the first paper from the Miller Lab is out on bioRxiv! 🎉
Fission yeast use distinct size-sensing pathways to adapt their geometry under stress.
Now under peer review - proud of my amazing team!
www.biorxiv.org/content/10.1...
Fission yeast use distinct size-sensing pathways to adapt their geometry under stress.
Now under peer review - proud of my amazing team!
www.biorxiv.org/content/10.1...
Fission yeast cells use distinct cell size control mechanisms for size adaptation to osmotic, oxidative, or low glucose conditions
Cells maintain an appropriate size to function, yet the mechanisms that enable size adaptation to environmental stress remain poorly understood. Fission yeast cells enter mitosis and divide at a thres...
www.biorxiv.org
November 8, 2025 at 8:40 AM
Congrats!
Reposted by PomBase: The S. pombe knowledgebase
The new issue of #Yeast of 2025 (Volume 42, Issue 11, November 2025) is out! It includes papers about new yeast genomes, the biodiversity of yeasts in dough, polyphosphate accumulation and even a new #FantasticYeasts species 😃
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
Happy 40th birthday Yeast: Yeast: Vol 42, No 11
Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.
onlinelibrary.wiley.com
November 5, 2025 at 3:59 PM
The new issue of #Yeast of 2025 (Volume 42, Issue 11, November 2025) is out! It includes papers about new yeast genomes, the biodiversity of yeasts in dough, polyphosphate accumulation and even a new #FantasticYeasts species 😃
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
More great work on mitochondrial dynamics from @leeba.bsky.social
et al!
et al!
Grateful for this Current Biology highlight by Dr. Mikael Bjorklund, which places our recent paper on mitochondrial volume and cell-cycle timing in a broader context.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Size control: Tune the mitochondrial volume to time your cell division!
A new study links mitochondrial volume control with growth and cell division, suggesting that cells not only sense their mitochondrial content but als…
www.sciencedirect.com
November 8, 2025 at 8:33 AM
More great work on mitochondrial dynamics from @leeba.bsky.social
et al!
et al!
Reposted by PomBase: The S. pombe knowledgebase
Enjoyed three days at #EMBOMobileGenome —fantastic talks and inspiring discussions on TE regulation across diverse model systems, great community! Excited to share our recent work on solo LTR silencing in S. pombe via talk and poster by @vishnuss.bsky.social. @pombase.bsky.social @embo.org
November 7, 2025 at 3:37 PM
Enjoyed three days at #EMBOMobileGenome —fantastic talks and inspiring discussions on TE regulation across diverse model systems, great community! Excited to share our recent work on solo LTR silencing in S. pombe via talk and poster by @vishnuss.bsky.social. @pombase.bsky.social @embo.org
Reposted by PomBase: The S. pombe knowledgebase
Interesting to see new papers connecting Pol II stalling to heterochromatin formation.
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
The Piwi-piRNA complex initiates transposon silencing via transcription termination factors PNUTS and Senataxin
Wu et al. reveal that the SFiNX complex triggers transposon silencing through the
association of Sov with two transcription termination factors, PNUTS and Senataxin,
leading to RNA Pol II stalling. Th...
www.cell.com
October 29, 2025 at 3:47 PM
Interesting to see new papers connecting Pol II stalling to heterochromatin formation.
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by PomBase: The S. pombe knowledgebase
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
October 30, 2025 at 11:44 AM
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
Reposted by PomBase: The S. pombe knowledgebase
How is #cytokinesis coordinated to ensure successful #CellDivision? Jian-Qiu Wu @sophiemartinlab.bsky.social &co show that the Ync13-Rga7-Rng10 module coordinates selective tethering & fusion of vesicles containing glucan synthases at the division site @plosbiology.org 🧪 plos.io/43zJ35Z
October 28, 2025 at 5:31 PM
How is #cytokinesis coordinated to ensure successful #CellDivision? Jian-Qiu Wu @sophiemartinlab.bsky.social &co show that the Ync13-Rga7-Rng10 module coordinates selective tethering & fusion of vesicles containing glucan synthases at the division site @plosbiology.org 🧪 plos.io/43zJ35Z
Every funder and policy-maker should take note, as we burn through our scientific capital, "the incandescent lamp did not emerge from the continuous improvement of candles”.
www.embopress.org/doi/full/10....
Here's an important and topical perspective from Nektarios Tavernarakis. Wise words!
Here's an important and topical perspective from Nektarios Tavernarakis. Wise words!
For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
October 27, 2025 at 6:44 AM
Every funder and policy-maker should take note, as we burn through our scientific capital, "the incandescent lamp did not emerge from the continuous improvement of candles”.
Reposted by PomBase: The S. pombe knowledgebase
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
October 13, 2025 at 9:04 AM
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
Reposted by PomBase: The S. pombe knowledgebase
This article captures the critical need for deliberate, coordinated support of scientific databases such as #BHL @biodivlibrary.bsky.social. Scientific information must be recognized as core infrastructure, not a peripheral project. 🧪
Article: www.biorxiv.org/content/10.1...
Article: www.biorxiv.org/content/10.1...
Sustainability During Instability: Long-Lived Life Science Databases and Science Funding Outlook in the United States
For decades, life science researchers have had cost-free, unrestricted access to data through online databases. However, the sustainability of even well-established resources was already tenuous, and ...
www.biorxiv.org
October 14, 2025 at 5:07 PM
This article captures the critical need for deliberate, coordinated support of scientific databases such as #BHL @biodivlibrary.bsky.social. Scientific information must be recognized as core infrastructure, not a peripheral project. 🧪
Article: www.biorxiv.org/content/10.1...
Article: www.biorxiv.org/content/10.1...
Reposted by PomBase: The S. pombe knowledgebase
Reposted by PomBase: The S. pombe knowledgebase
Proud to be an MIT alum today.
October 10, 2025 at 6:26 PM
Proud to be an MIT alum today.
Reposted by PomBase: The S. pombe knowledgebase
Nature has published an article on the crisis facing MODs
Model organism databases face budget cuts and closures www.nature.com/articles/d41...
@zfinmod.bsky.social @xenbase.bsky.social @yeastgenome.bsky.social @mousegenome.bsky.social @ratgenome.bsky.social @geneontology.bsky.social @nature.com
Model organism databases face budget cuts and closures www.nature.com/articles/d41...
@zfinmod.bsky.social @xenbase.bsky.social @yeastgenome.bsky.social @mousegenome.bsky.social @ratgenome.bsky.social @geneontology.bsky.social @nature.com
Model organism databases face budget cuts and closures
Beyond the crucial data they contain, these digital archives have provided an important space for academic communities to exchange ideas and resources.
www.nature.com
October 3, 2025 at 6:52 PM
Nature has published an article on the crisis facing MODs
Model organism databases face budget cuts and closures www.nature.com/articles/d41...
@zfinmod.bsky.social @xenbase.bsky.social @yeastgenome.bsky.social @mousegenome.bsky.social @ratgenome.bsky.social @geneontology.bsky.social @nature.com
Model organism databases face budget cuts and closures www.nature.com/articles/d41...
@zfinmod.bsky.social @xenbase.bsky.social @yeastgenome.bsky.social @mousegenome.bsky.social @ratgenome.bsky.social @geneontology.bsky.social @nature.com
An important new item on the status of model organism databases: these resources, built and refined over decades, are at risk. www.nature.com/articles/d41...
Model organism databases face budget cuts and closures
Beyond the crucial data they contain, these digital archives have provided an important space for academic communities to exchange ideas and resources.
www.nature.com
October 3, 2025 at 3:26 PM
An important new item on the status of model organism databases: these resources, built and refined over decades, are at risk. www.nature.com/articles/d41...
Reposted by PomBase: The S. pombe knowledgebase
Super excited that this story by @borissieber.bsky.social is now on BioRxiv!
For decades, we thought there was no MAPK scaffold for the ERK-like cascade that promotes sexual reproduction in fission yeast ... until Boris found it !
See the thread 👇 and enjoy the paper!
doi.org/10.1101/2025...
For decades, we thought there was no MAPK scaffold for the ERK-like cascade that promotes sexual reproduction in fission yeast ... until Boris found it !
See the thread 👇 and enjoy the paper!
doi.org/10.1101/2025...
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
September 25, 2025 at 7:48 PM
Super excited that this story by @borissieber.bsky.social is now on BioRxiv!
For decades, we thought there was no MAPK scaffold for the ERK-like cascade that promotes sexual reproduction in fission yeast ... until Boris found it !
See the thread 👇 and enjoy the paper!
doi.org/10.1101/2025...
For decades, we thought there was no MAPK scaffold for the ERK-like cascade that promotes sexual reproduction in fission yeast ... until Boris found it !
See the thread 👇 and enjoy the paper!
doi.org/10.1101/2025...
Reposted by PomBase: The S. pombe knowledgebase
This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin
Subtelomeres are imperfect repeats adjacent to telomeres that are repressed by heterochromatin. Although essential for genome integrity, their repetitive nature has thwarted dissection of local hetero...
www.biorxiv.org
September 27, 2025 at 6:55 AM
This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
Reposted by PomBase: The S. pombe knowledgebase
So for >30y, it was thought that #MAPK cascade in #fission #yeast lacked a scaffold ! Like in #animals, or #budding yeast.
Well this changes today !
All hail #Sms1
Congrats @borissieber.bsky.social @sophiemartinlab.bsky.social and Team !!
Well this changes today !
All hail #Sms1
Congrats @borissieber.bsky.social @sophiemartinlab.bsky.social and Team !!
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
September 27, 2025 at 2:01 PM
So for >30y, it was thought that #MAPK cascade in #fission #yeast lacked a scaffold ! Like in #animals, or #budding yeast.
Well this changes today !
All hail #Sms1
Congrats @borissieber.bsky.social @sophiemartinlab.bsky.social and Team !!
Well this changes today !
All hail #Sms1
Congrats @borissieber.bsky.social @sophiemartinlab.bsky.social and Team !!
Reposted by PomBase: The S. pombe knowledgebase
Reposted by PomBase: The S. pombe knowledgebase
Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nuclear mechanics as a determinant of nuclear pore complex plasticity - Nature Cell Biology
In this Review, Lusk et al. discuss emerging insights into nuclear pore complex variability with regard to composition and dilation state, and propose nuclear mechanics as a key determinant of driving...
www.nature.com
September 19, 2025 at 3:50 PM
Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction.
www.nature.com/articles/s41...
www.nature.com/articles/s41...