PomBase: The S. pombe knowledgebase
@pombase.bsky.social
https://www.pombase.org/ Knowledgebase for Schizosaccharomyces pombe (a fission yeast). Supporting scientific discovery for cell-level processes; #OpenScience, #FAIR data #CommunityCuration; Monitoring #UnknownProteins; Elixir and GBC Core Data Resource.
Pinned
PomBase introduces two new interactive views for GO-CAM pathway models: Summary Maps (high-level, visual overview) and Mega-Models (connected models). Check them out here: lnkd.in/gfxNRdua
Reposted by PomBase: The S. pombe knowledgebase
The first release of 2026 of the Rhea database is out! Release 140 (2026-01-28) contains 18,343 unique reactions and 15,125 unique reaction participants, with 25M protein sequence entries annotated with Rhea reactions in UniProtKB.
January 30, 2026 at 10:48 AM
The first release of 2026 of the Rhea database is out! Release 140 (2026-01-28) contains 18,343 unique reactions and 15,125 unique reaction participants, with 25M protein sequence entries annotated with Rhea reactions in UniProtKB.
Reposted by PomBase: The S. pombe knowledgebase
📣 NuQuest consortium update: Our first joint publication is out!
Review on quiescence—A milestone for our initiative laying out the scientific groundwork & collaborative vision for our MSCA-DN application coordinated by @jlugiessen.bsky.social 1/n
www.mdpi.com/3700996
#NuQuest #MSCA #DoctoralNetwork
Review on quiescence—A milestone for our initiative laying out the scientific groundwork & collaborative vision for our MSCA-DN application coordinated by @jlugiessen.bsky.social 1/n
www.mdpi.com/3700996
#NuQuest #MSCA #DoctoralNetwork
www.mdpi.com
January 30, 2026 at 8:58 AM
📣 NuQuest consortium update: Our first joint publication is out!
Review on quiescence—A milestone for our initiative laying out the scientific groundwork & collaborative vision for our MSCA-DN application coordinated by @jlugiessen.bsky.social 1/n
www.mdpi.com/3700996
#NuQuest #MSCA #DoctoralNetwork
Review on quiescence—A milestone for our initiative laying out the scientific groundwork & collaborative vision for our MSCA-DN application coordinated by @jlugiessen.bsky.social 1/n
www.mdpi.com/3700996
#NuQuest #MSCA #DoctoralNetwork
Another removal from the #UnknownProteins inventory!
This is pombe SPAC630.06c and human 'Custos' ortholog
-There are still plenty of broadly conserved eukaryotic proteins to study: www.pombase.org/status/prote... 144 in our high priority list (well 143 tomorrow)
This is pombe SPAC630.06c and human 'Custos' ortholog
-There are still plenty of broadly conserved eukaryotic proteins to study: www.pombase.org/status/prote... 144 in our high priority list (well 143 tomorrow)
January 30, 2026 at 9:03 AM
Another removal from the #UnknownProteins inventory!
This is pombe SPAC630.06c and human 'Custos' ortholog
-There are still plenty of broadly conserved eukaryotic proteins to study: www.pombase.org/status/prote... 144 in our high priority list (well 143 tomorrow)
This is pombe SPAC630.06c and human 'Custos' ortholog
-There are still plenty of broadly conserved eukaryotic proteins to study: www.pombase.org/status/prote... 144 in our high priority list (well 143 tomorrow)
Reposted by PomBase: The S. pombe knowledgebase
🧬 Meet Sni445, a newly discovered #Yeast ribosome assembly factor! Ynl050c/Sni445 recruits specialized snoRNPs (snR4 & snR45) that guide precise rRNA acetylation during ribosome synthesis. Another piece of the puzzle solved!
🧪 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...
🧪 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...
January 29, 2026 at 11:19 PM
🧬 Meet Sni445, a newly discovered #Yeast ribosome assembly factor! Ynl050c/Sni445 recruits specialized snoRNPs (snR4 & snR45) that guide precise rRNA acetylation during ribosome synthesis. Another piece of the puzzle solved!
🧪 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...
🧪 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...
Reposted by PomBase: The S. pombe knowledgebase
Structure of the adaptor protein 4 (AP-4) complex revealed! AP-4 exists in a dynamic equilibrium between closed and open conformations in solution. ARF1 does not shift this equilibrium but is required—together with cargo—for membrane recruitment. rdcu.be/e1ozM
January 29, 2026 at 9:53 PM
Structure of the adaptor protein 4 (AP-4) complex revealed! AP-4 exists in a dynamic equilibrium between closed and open conformations in solution. ARF1 does not shift this equilibrium but is required—together with cargo—for membrane recruitment. rdcu.be/e1ozM
Reposted by PomBase: The S. pombe knowledgebase
🚀 InterPro 108.0 is live!
✨ Updated to Pfam 38.1 and NCBIFam 18.0
✨ 1,911 InterPro entries
Explore the latest annotations and discover new protein insights.
Explore it now: www.ebi.ac.uk/interpro/
✨ Updated to Pfam 38.1 and NCBIFam 18.0
✨ 1,911 InterPro entries
Explore the latest annotations and discover new protein insights.
Explore it now: www.ebi.ac.uk/interpro/
January 30, 2026 at 7:10 AM
🚀 InterPro 108.0 is live!
✨ Updated to Pfam 38.1 and NCBIFam 18.0
✨ 1,911 InterPro entries
Explore the latest annotations and discover new protein insights.
Explore it now: www.ebi.ac.uk/interpro/
✨ Updated to Pfam 38.1 and NCBIFam 18.0
✨ 1,911 InterPro entries
Explore the latest annotations and discover new protein insights.
Explore it now: www.ebi.ac.uk/interpro/
Reposted by PomBase: The S. pombe knowledgebase
Micropublication @micropub7n.bsky.social is peer reviewed and PubMed indexed. A great way to get the data out in uncertain times
👇🏼
👇🏼
"Due to a variety of circumstances...many science projects will never be finished, despite years of invested resources and effort. By carefully and strategically documenting scientific work achieved, components of unfinished projects can be salvaged and preserved to benefit future researchers." 🧪
When goodbye comes too soon: How to wrap up science projects quickly
Science projects are designed and funded on the scale of years, so what happens when researchers need to finish prematurely? This Community Page discusses solutions for quickly documenting partially f...
journals.plos.org
October 28, 2025 at 12:50 PM
Micropublication @micropub7n.bsky.social is peer reviewed and PubMed indexed. A great way to get the data out in uncertain times
👇🏼
👇🏼
Reposted by PomBase: The S. pombe knowledgebase
As a final nod to 2025, #GeneOntology announces our latest paper in @narjournal.bsky.social! Updates include expanded #Ontology & annotations in #Metabolism, multi-org interactions, #chromatin remodeling, & more.
Also ft. #Functionome v2 and 1500+ GO-CAM pathway models! 🧬🧪
doi.org/10.1093/nar/...
Also ft. #Functionome v2 and 1500+ GO-CAM pathway models! 🧬🧪
doi.org/10.1093/nar/...
The Gene Ontology knowledgebase in 2026
Abstract. The Gene Ontology (GO) knowledgebase (https://geneontology.org) is a comprehensive resource describing the functions of genes. The GO knowledgeba
doi.org
December 19, 2025 at 11:41 PM
As a final nod to 2025, #GeneOntology announces our latest paper in @narjournal.bsky.social! Updates include expanded #Ontology & annotations in #Metabolism, multi-org interactions, #chromatin remodeling, & more.
Also ft. #Functionome v2 and 1500+ GO-CAM pathway models! 🧬🧪
doi.org/10.1093/nar/...
Also ft. #Functionome v2 and 1500+ GO-CAM pathway models! 🧬🧪
doi.org/10.1093/nar/...
Reposted by PomBase: The S. pombe knowledgebase
This week, Professor James Hansen and colleagues published projections that the global temperature record could reach +1.7°C by 2027.
And if that number lands in your gut the way it landed in mine, good. It should.
#climatecrisis #auspol www.lyrebirddreaming.com/post/two-yea...
And if that number lands in your gut the way it landed in mine, good. It should.
#climatecrisis #auspol www.lyrebirddreaming.com/post/two-yea...
Two Years to 1.7°C: the “Prediction Game” We Can’t Afford to Lose
Australia’s sweltering through another early-summer heatwave, and I’m trying to decide whether to write about the weather outside my window - or the bigger climate system we’re reengineering on this p...
www.lyrebirddreaming.com
December 20, 2025 at 12:29 PM
This week, Professor James Hansen and colleagues published projections that the global temperature record could reach +1.7°C by 2027.
And if that number lands in your gut the way it landed in mine, good. It should.
#climatecrisis #auspol www.lyrebirddreaming.com/post/two-yea...
And if that number lands in your gut the way it landed in mine, good. It should.
#climatecrisis #auspol www.lyrebirddreaming.com/post/two-yea...
Truly amazing knowledge synthesis. I will use this to demonstrate why biocuration is so difficult 😃
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
December 3, 2025 at 9:44 AM
Truly amazing knowledge synthesis. I will use this to demonstrate why biocuration is so difficult 😃
Reposted by PomBase: The S. pombe knowledgebase
#OpenCloning is a an Open Source alternative to SnapGene/Benchling that supports automation and integration with other software
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
November 24, 2025 at 4:57 PM
#OpenCloning is a an Open Source alternative to SnapGene/Benchling that supports automation and integration with other software
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨🔬 Built by a researcher — for researchers!
👉 Check it out at opencloning.org
Calling thesis advisors, department chairs, and supervisory committee members! 📣 Nominate an outstanding PhD/PhD candidate working with Drosophila for the Larry Sandler Award. They'll present at #Dros26. Learn more and submit a nomination: buff.ly/mtfDbBD
@peiferlabunc.bsky.social
@peiferlabunc.bsky.social
November 14, 2025 at 7:21 PM
Reposted by PomBase: The S. pombe knowledgebase
Congrats!
Thrilled to share that the first paper from the Miller Lab is out on bioRxiv! 🎉
Fission yeast use distinct size-sensing pathways to adapt their geometry under stress.
Now under peer review - proud of my amazing team!
www.biorxiv.org/content/10.1...
Fission yeast use distinct size-sensing pathways to adapt their geometry under stress.
Now under peer review - proud of my amazing team!
www.biorxiv.org/content/10.1...
Fission yeast cells use distinct cell size control mechanisms for size adaptation to osmotic, oxidative, or low glucose conditions
Cells maintain an appropriate size to function, yet the mechanisms that enable size adaptation to environmental stress remain poorly understood. Fission yeast cells enter mitosis and divide at a thres...
www.biorxiv.org
November 8, 2025 at 8:40 AM
Congrats!
Reposted by PomBase: The S. pombe knowledgebase
🧬 PomBase needs you! 🧬
If you PomBase on a regular basis, now it’s the time to show your support to the team behind this incredibly useful resource (and help them secure funding to keep up the amazing work). Fill out their short user survey, which they will use to support their grant application.
If you PomBase on a regular basis, now it’s the time to show your support to the team behind this incredibly useful resource (and help them secure funding to keep up the amazing work). Fill out their short user survey, which they will use to support their grant application.
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
November 12, 2025 at 8:55 PM
🧬 PomBase needs you! 🧬
If you PomBase on a regular basis, now it’s the time to show your support to the team behind this incredibly useful resource (and help them secure funding to keep up the amazing work). Fill out their short user survey, which they will use to support their grant application.
If you PomBase on a regular basis, now it’s the time to show your support to the team behind this incredibly useful resource (and help them secure funding to keep up the amazing work). Fill out their short user survey, which they will use to support their grant application.
Reposted by PomBase: The S. pombe knowledgebase
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:56 AM
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
Reposted by PomBase: The S. pombe knowledgebase
This is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
November 7, 2025 at 1:35 PM
This is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Congrats!
Thrilled to share that the first paper from the Miller Lab is out on bioRxiv! 🎉
Fission yeast use distinct size-sensing pathways to adapt their geometry under stress.
Now under peer review - proud of my amazing team!
www.biorxiv.org/content/10.1...
Fission yeast use distinct size-sensing pathways to adapt their geometry under stress.
Now under peer review - proud of my amazing team!
www.biorxiv.org/content/10.1...
Fission yeast cells use distinct cell size control mechanisms for size adaptation to osmotic, oxidative, or low glucose conditions
Cells maintain an appropriate size to function, yet the mechanisms that enable size adaptation to environmental stress remain poorly understood. Fission yeast cells enter mitosis and divide at a thres...
www.biorxiv.org
November 8, 2025 at 8:40 AM
Congrats!
Reposted by PomBase: The S. pombe knowledgebase
The new issue of #Yeast of 2025 (Volume 42, Issue 11, November 2025) is out! It includes papers about new yeast genomes, the biodiversity of yeasts in dough, polyphosphate accumulation and even a new #FantasticYeasts species 😃
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
Happy 40th birthday Yeast: Yeast: Vol 42, No 11
Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.
onlinelibrary.wiley.com
November 5, 2025 at 3:59 PM
The new issue of #Yeast of 2025 (Volume 42, Issue 11, November 2025) is out! It includes papers about new yeast genomes, the biodiversity of yeasts in dough, polyphosphate accumulation and even a new #FantasticYeasts species 😃
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
More great work on mitochondrial dynamics from @leeba.bsky.social
et al!
et al!
Grateful for this Current Biology highlight by Dr. Mikael Bjorklund, which places our recent paper on mitochondrial volume and cell-cycle timing in a broader context.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Size control: Tune the mitochondrial volume to time your cell division!
A new study links mitochondrial volume control with growth and cell division, suggesting that cells not only sense their mitochondrial content but als…
www.sciencedirect.com
November 8, 2025 at 8:33 AM
More great work on mitochondrial dynamics from @leeba.bsky.social
et al!
et al!
Reposted by PomBase: The S. pombe knowledgebase
Enjoyed three days at #EMBOMobileGenome —fantastic talks and inspiring discussions on TE regulation across diverse model systems, great community! Excited to share our recent work on solo LTR silencing in S. pombe via talk and poster by @vishnuss.bsky.social. @pombase.bsky.social @embo.org
November 7, 2025 at 3:37 PM
Enjoyed three days at #EMBOMobileGenome —fantastic talks and inspiring discussions on TE regulation across diverse model systems, great community! Excited to share our recent work on solo LTR silencing in S. pombe via talk and poster by @vishnuss.bsky.social. @pombase.bsky.social @embo.org
Reposted by PomBase: The S. pombe knowledgebase
Interesting to see new papers connecting Pol II stalling to heterochromatin formation.
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
The Piwi-piRNA complex initiates transposon silencing via transcription termination factors PNUTS and Senataxin
Wu et al. reveal that the SFiNX complex triggers transposon silencing through the
association of Sov with two transcription termination factors, PNUTS and Senataxin,
leading to RNA Pol II stalling. Th...
www.cell.com
October 29, 2025 at 3:47 PM
Interesting to see new papers connecting Pol II stalling to heterochromatin formation.
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
www.cell.com/molecular-ce...
Reminiscent of our work in S. pombe:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by PomBase: The S. pombe knowledgebase
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
October 30, 2025 at 11:44 AM
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
Reposted by PomBase: The S. pombe knowledgebase
How is #cytokinesis coordinated to ensure successful #CellDivision? Jian-Qiu Wu @sophiemartinlab.bsky.social &co show that the Ync13-Rga7-Rng10 module coordinates selective tethering & fusion of vesicles containing glucan synthases at the division site @plosbiology.org 🧪 plos.io/43zJ35Z
October 28, 2025 at 5:31 PM
How is #cytokinesis coordinated to ensure successful #CellDivision? Jian-Qiu Wu @sophiemartinlab.bsky.social &co show that the Ync13-Rga7-Rng10 module coordinates selective tethering & fusion of vesicles containing glucan synthases at the division site @plosbiology.org 🧪 plos.io/43zJ35Z
Every funder and policy-maker should take note, as we burn through our scientific capital, "the incandescent lamp did not emerge from the continuous improvement of candles”.
www.embopress.org/doi/full/10....
Here's an important and topical perspective from Nektarios Tavernarakis. Wise words!
Here's an important and topical perspective from Nektarios Tavernarakis. Wise words!
For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
October 27, 2025 at 6:44 AM
Every funder and policy-maker should take note, as we burn through our scientific capital, "the incandescent lamp did not emerge from the continuous improvement of candles”.