The Braun Lab
@thebraunlab.bsky.social
We work on nuclear organization and silent chromatin using the powerful fission yeast model.
Pinned
The Braun Lab
@thebraunlab.bsky.social
· Sep 27
Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin
Subtelomeres are imperfect repeats adjacent to telomeres that are repressed by heterochromatin. Although essential for genome integrity, their repetitive nature has thwarted dissection of local hetero...
www.biorxiv.org
This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
Reposted by The Braun Lab
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
October 30, 2025 at 11:44 AM
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
Enjoyed three days at #EMBOMobileGenome —fantastic talks and inspiring discussions on TE regulation across diverse model systems, great community! Excited to share our recent work on solo LTR silencing in S. pombe via talk and poster by @vishnuss.bsky.social. @pombase.bsky.social @embo.org
November 7, 2025 at 3:37 PM
Enjoyed three days at #EMBOMobileGenome —fantastic talks and inspiring discussions on TE regulation across diverse model systems, great community! Excited to share our recent work on solo LTR silencing in S. pombe via talk and poster by @vishnuss.bsky.social. @pombase.bsky.social @embo.org
Impressive study and great talk at #EMBOMobileGenome! Enjoyed it a lot!
Having a lot of fun at #EMBOMobileGenome 😃
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice - Nature Communications
KRAB-zinc finger proteins repress retrotransposons and rapidly evolve in mammals. Here, the authors show that ERV insertions drive the emergence and diversification of new KZFP genes in mice, revealin...
www.nature.com
November 7, 2025 at 7:07 AM
Impressive study and great talk at #EMBOMobileGenome! Enjoyed it a lot!
Reposted by The Braun Lab
Having a lot of fun at #EMBOMobileGenome 😃
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice - Nature Communications
KRAB-zinc finger proteins repress retrotransposons and rapidly evolve in mammals. Here, the authors show that ERV insertions drive the emergence and diversification of new KZFP genes in mice, revealin...
www.nature.com
November 6, 2025 at 9:40 AM
Having a lot of fun at #EMBOMobileGenome 😃
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!
…and I’m currently on the job market looking for a new scientific home!
www.nature.com/articles/s41...
Reposted by The Braun Lab
Reposted by The Braun Lab
Excited to share our new @narjournal.bsky.social paper!
Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity.
academic.oup.com/nar/article/...
Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity.
academic.oup.com/nar/article/...
October 18, 2025 at 6:59 AM
Excited to share our new @narjournal.bsky.social paper!
Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity.
academic.oup.com/nar/article/...
Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity.
academic.oup.com/nar/article/...
Reposted by The Braun Lab
Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium
Abstract. To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms
academic.oup.com
October 17, 2025 at 11:58 AM
Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
Reposted by The Braun Lab
Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!
jobs.jic.ac.uk/Details.asp?...
Please repost!
jobs.jic.ac.uk/Details.asp?...
John Innes Centre
jobs.jic.ac.uk
October 8, 2025 at 9:04 AM
Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!
jobs.jic.ac.uk/Details.asp?...
Please repost!
jobs.jic.ac.uk/Details.asp?...
Reposted by The Braun Lab
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College
Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.
www.magd.cam.ac.uk
October 7, 2025 at 4:02 PM
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Reposted by The Braun Lab
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes
Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...
www.science.org
October 2, 2025 at 10:55 PM
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin
Subtelomeres are imperfect repeats adjacent to telomeres that are repressed by heterochromatin. Although essential for genome integrity, their repetitive nature has thwarted dissection of local hetero...
www.biorxiv.org
September 27, 2025 at 6:55 AM
This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
Reposted by The Braun Lab
Amazing 2. day at the GfG ‘Epigenetics & Chromatin’ symposium. Fantastic flash talks, a great first poster session and many memorable talks: among others @erhardtlab.bsky.social, @rodvilla.bsky.social, @thebraunlab.bsky.social, @flurylab.bsky.social, Ehrenhofer-Murray, Liefke, Heun, Imhof & Brehm.
September 25, 2025 at 9:56 PM
Amazing 2. day at the GfG ‘Epigenetics & Chromatin’ symposium. Fantastic flash talks, a great first poster session and many memorable talks: among others @erhardtlab.bsky.social, @rodvilla.bsky.social, @thebraunlab.bsky.social, @flurylab.bsky.social, Ehrenhofer-Murray, Liefke, Heun, Imhof & Brehm.
Reposted by The Braun Lab
What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!
Looking forward to exciting talks at the GfG Symposium in Gießen.
Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud
#epigenomics @diagenode.bsky.social @gfgenetik.bsky.social
Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud
#epigenomics @diagenode.bsky.social @gfgenetik.bsky.social
September 24, 2025 at 7:23 PM
What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!
Reposted by The Braun Lab
We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
August 28, 2025 at 5:35 PM
We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Reposted by The Braun Lab
Excited to share our newest results on ZNF512B: It not only regulates chromatin organization, binds NuRD and H2A.Z, and acts as transcriptional repressor (Wunderlich et al., NAR, 2024), it also participates in mitosis and is crucial for stem cell differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ZNF512B associates with mitotic spindles, regulates metaphase exit and is crucial for stem cell differentiation
Zinc finger proteins are a large family of DNA-binding factors that play key roles in diverse cellular processes including gene regulation, RNA metabolism and cell cycle control. The zinc finger prote...
www.biorxiv.org
August 25, 2025 at 8:05 AM
Excited to share our newest results on ZNF512B: It not only regulates chromatin organization, binds NuRD and H2A.Z, and acts as transcriptional repressor (Wunderlich et al., NAR, 2024), it also participates in mitosis and is crucial for stem cell differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by The Braun Lab
Congratulations, Dr. Kalita!!!
Dr. Agata Kalita wins the prestigious GfG Elisabeth-Gateff Prize 2025 for her amazing work on sex chromosome dosage compensation in insects!
Dr. Kalita will receive the award at the upcoming GfG Symposium “Epigenetics & Chromatin” on September 26th, 2025 (express.converia.de/frontend/ind...).
Dr. Kalita will receive the award at the upcoming GfG Symposium “Epigenetics & Chromatin” on September 26th, 2025 (express.converia.de/frontend/ind...).
August 19, 2025 at 1:35 PM
Congratulations, Dr. Kalita!!!
Farewell to guest student Rosario Brockhausen (Constructor Univ. Bremen) 🎉 . In just 2 months she made big strides, key manuscript contributions & was a wonderful colleague. Hope to see her back soon! 👋
August 16, 2025 at 9:43 AM
Farewell to guest student Rosario Brockhausen (Constructor Univ. Bremen) 🎉 . In just 2 months she made big strides, key manuscript contributions & was a wonderful colleague. Hope to see her back soon! 👋
Reposted by The Braun Lab
Epigenetics Update - The molecular basis of lamin-specific chromatin interactions go.nature.com/3GRXydB
Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB
#Epigenetics #Chromatin #Lamin
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Gain deeper insights into gene regulation; epigenometech.com
Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB
#Epigenetics #Chromatin #Lamin
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Gain deeper insights into gene regulation; epigenometech.com
The molecular basis of lamin-specific chromatin interactions - Nature Structural & Molecular Biology
Wang, Kronenberg-Tenga, Rosti and colleagues use several structural approaches to analyze the distribution of nucleosomes at the lamin–chromatin interface, test the impact of lamins on nucleosome dens...
go.nature.com
August 4, 2025 at 1:11 PM
Epigenetics Update - The molecular basis of lamin-specific chromatin interactions go.nature.com/3GRXydB
Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB
#Epigenetics #Chromatin #Lamin
---
Gain deeper insights into gene regulation; epigenometech.com
Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB
#Epigenetics #Chromatin #Lamin
---
Gain deeper insights into gene regulation; epigenometech.com
Reposted by The Braun Lab
New paper out by RTG2355 members Jennifer Kothe, Theresa Dietz, Robina Scheuer & Elena Evguenieva-Hackenberg, identifying a new attenuation mechanism that apparently monitors ribosome availability and translation efficiency in the soil bacterium Sinorhizobium meliloti
Early posttranscriptional response to tetracycline exposure in a gram-negative soil bacterium reveals unexpected attenuation mechanism of a DUF1127 gene
The gram-negative, soil-dwelling plant symbiont Sinorhizobium meliloti shares its free-living habitat with antibiotic producers. To learn about early steps of its adaptation to antibiotics, we anal...
www.tandfonline.com
July 21, 2025 at 6:34 AM
New paper out by RTG2355 members Jennifer Kothe, Theresa Dietz, Robina Scheuer & Elena Evguenieva-Hackenberg, identifying a new attenuation mechanism that apparently monitors ribosome availability and translation efficiency in the soil bacterium Sinorhizobium meliloti
Reposted by The Braun Lab
The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n)
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
Lamin B1 and LAP2β resist cytoskeletal force to maintain lamin A/C meshwork organization and preserve nuclear integrity | Molecular Biology of the Cell
The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. ...
www.molbiolcell.org
July 21, 2025 at 5:46 PM
The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n)
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
Reposted by The Braun Lab
Exciting paper on how the nuclear envelope talks to chromatin!
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 24, 2025 at 7:36 AM
Exciting paper on how the nuclear envelope talks to chromatin!
Reposted by The Braun Lab
Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events*
*should be specific to gene regulation
*should be specific to gene regulation
Conferences & Schools – 2025 – Gene Regulation – Teif Lab
generegulation.org
January 14, 2025 at 7:14 PM
Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events*
*should be specific to gene regulation
*should be specific to gene regulation
Reposted by The Braun Lab
🧪 Open PhD or Postdoc position 🧪
The project is in collaboration with my new collegue Miha Modic. If you are interesed in RNA modification, centromeres and bioinformatics this is for you!
Miha has more positions to fill, infos on his linkedin: linkedin.com/in/miha-modic-9aa8a752.
The project is in collaboration with my new collegue Miha Modic. If you are interesed in RNA modification, centromeres and bioinformatics this is for you!
Miha has more positions to fill, infos on his linkedin: linkedin.com/in/miha-modic-9aa8a752.
July 23, 2025 at 7:56 PM
🧪 Open PhD or Postdoc position 🧪
The project is in collaboration with my new collegue Miha Modic. If you are interesed in RNA modification, centromeres and bioinformatics this is for you!
Miha has more positions to fill, infos on his linkedin: linkedin.com/in/miha-modic-9aa8a752.
The project is in collaboration with my new collegue Miha Modic. If you are interesed in RNA modification, centromeres and bioinformatics this is for you!
Miha has more positions to fill, infos on his linkedin: linkedin.com/in/miha-modic-9aa8a752.
We're looking forward to the GfG “Epigenetics & Chromatin” Symposium in Giessen, Sept 24–26! Fantastic chance to learn from leading experts, connect with fellow researchers, and compete for €300 poster and talk prizes (plus free membership!). Hope to see you there! #Epigenetics #ChromatinCommunity
🎉 Join us at the upcoming GfG Symposium "Epigenetics & Chromatin" in Giessen, Sept 24–26, 2025!
Amazing speakers, low registration fee, € 300 prizes for best poster & short talk, + free GfG membership for non-members.
Please RT!
express.converia.de/frontend/ind...
Amazing speakers, low registration fee, € 300 prizes for best poster & short talk, + free GfG membership for non-members.
Please RT!
express.converia.de/frontend/ind...
July 18, 2025 at 5:12 AM
We're looking forward to the GfG “Epigenetics & Chromatin” Symposium in Giessen, Sept 24–26! Fantastic chance to learn from leading experts, connect with fellow researchers, and compete for €300 poster and talk prizes (plus free membership!). Hope to see you there! #Epigenetics #ChromatinCommunity