Abby Buchwalter
@abbybuch.bsky.social
Associate professor at UCSF. Cell biologist at heart, research focus on the function and dynamic regulation of the nuclear periphery.
www.buchwalterlab.UCSF.edu.
www.buchwalterlab.UCSF.edu.
Personal good news alert: I’ve been promoted to associate professor and it’s time to update the ol’ bio! Launching my lab at UCSF has been a privilege + I’m so grateful to my team and community here. More exciting science ahead! 🚀
November 6, 2025 at 8:12 PM
Personal good news alert: I’ve been promoted to associate professor and it’s time to update the ol’ bio! Launching my lab at UCSF has been a privilege + I’m so grateful to my team and community here. More exciting science ahead! 🚀
Apple picking with the crew
October 21, 2025 at 7:00 PM
Apple picking with the crew
Reposted by Abby Buchwalter
Thrilled to announce the launch of my lab
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
We're growing! Our newest Investigator @henrydebelly.bsky.social will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henr... and 📌apply to research in his lab cri.utsw.edu/careers
October 16, 2025 at 10:00 PM
Thrilled to announce the launch of my lab
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
OK, an NIH grant question that I would normally ask my PO but can't because of shutdown 🫠...
Interested in applying for NIGMS RM1 team grant with colleagues. Several of us are NIGMS-funded. Are we eligible? Funds for lab but not our salary, or no more GM funds for us, full stop? (see screenshot)
Interested in applying for NIGMS RM1 team grant with colleagues. Several of us are NIGMS-funded. Are we eligible? Funds for lab but not our salary, or no more GM funds for us, full stop? (see screenshot)
October 13, 2025 at 4:36 PM
OK, an NIH grant question that I would normally ask my PO but can't because of shutdown 🫠...
Interested in applying for NIGMS RM1 team grant with colleagues. Several of us are NIGMS-funded. Are we eligible? Funds for lab but not our salary, or no more GM funds for us, full stop? (see screenshot)
Interested in applying for NIGMS RM1 team grant with colleagues. Several of us are NIGMS-funded. Are we eligible? Funds for lab but not our salary, or no more GM funds for us, full stop? (see screenshot)
Reposted by Abby Buchwalter
We're still accepting submissions for our next special issue:
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
September 30, 2025 at 9:26 AM
We're still accepting submissions for our next special issue:
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
Back-to-school vibes with new PhD class arriving at UCSF… @devjanee.bsky.social rocked my world the other day with “happy 20th anniversary of being friends” text! We were those incoming PhD students at WUSTL 20 years ago. Yikes. Looking at you too @rolyanharas.bsky.social @thelucalab.bsky.social!
September 4, 2025 at 8:01 PM
Back-to-school vibes with new PhD class arriving at UCSF… @devjanee.bsky.social rocked my world the other day with “happy 20th anniversary of being friends” text! We were those incoming PhD students at WUSTL 20 years ago. Yikes. Looking at you too @rolyanharas.bsky.social @thelucalab.bsky.social!
Reposted by Abby Buchwalter
Last day to submit abstracts! Nuclear cell biologists, mechanobiologists, et al. don’t miss out - amazing interdisciplinary line up: computational biology, biophysics, development, genomics - we will have it all!
Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...
August 31, 2025 at 5:06 PM
Last day to submit abstracts! Nuclear cell biologists, mechanobiologists, et al. don’t miss out - amazing interdisciplinary line up: computational biology, biophysics, development, genomics - we will have it all!
Reposted by Abby Buchwalter
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
August 28, 2025 at 8:47 PM
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
Truth.
Final year PhD students, I know you’re desperately trying to finish experiments/revisions/submissions/write a thesis & just survive - but please spare a few minutes to apply to your dream postdoc labs.
It easily takes A YEAR from first contact, even if everything goes to plan on both sides.
It easily takes A YEAR from first contact, even if everything goes to plan on both sides.
August 27, 2025 at 8:06 PM
Truth.
Reposted by Abby Buchwalter
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion
Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...
www.biorxiv.org
August 16, 2025 at 3:03 AM
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
The basic sciences are HIRING at UCSF: open recruitment in the Department of Biochemistry & Biophysics. Please share and please apply! aprecruit.ucsf.edu/JPF05702
Ladder Rank Faculty Position – Assistant Professor
University of California, San Francisco is hiring. Apply now!
aprecruit.ucsf.edu
August 14, 2025 at 8:49 PM
The basic sciences are HIRING at UCSF: open recruitment in the Department of Biochemistry & Biophysics. Please share and please apply! aprecruit.ucsf.edu/JPF05702
Just catching up to this - so many inspiring scientists among this year's ASCB awardees! Congrats, all. www.ascb.org/society-news...
ASCB Announces 2025 Honorific Award Winners - ASCB
Each year, the American Society for Cell Biology honors exceptional scientists whose research, mentorship, and leadership are shaping the future of cell biology. From groundbreaking discoveries to tir...
www.ascb.org
August 14, 2025 at 8:46 PM
Just catching up to this - so many inspiring scientists among this year's ASCB awardees! Congrats, all. www.ascb.org/society-news...
Reposted by Abby Buchwalter
Good news for NIH MIRA applicants. Grants.gov recently published the forecast notice for the reissuance of the EI/NI MIRA notice of funding opportunity. As indicated at the link, the estimated post date for the NOFO is Nov 3. www.grants.gov/search-resul...
Lock
www.grants.gov
August 5, 2025 at 5:51 PM
Good news for NIH MIRA applicants. Grants.gov recently published the forecast notice for the reissuance of the EI/NI MIRA notice of funding opportunity. As indicated at the link, the estimated post date for the NOFO is Nov 3. www.grants.gov/search-resul...
Reposted by Abby Buchwalter
Big congrats to UNC's @cohenlaboratory.bsky.social , winner of the @ascbiology.bsky.social's WICB Junior Award for Excellence in Research. Sarah's work on organelle contact sites has helped revolutionize the field. 🧪
www.ascb.org/society-news...
www.ascb.org/society-news...
August 4, 2025 at 11:09 PM
Big congrats to UNC's @cohenlaboratory.bsky.social , winner of the @ascbiology.bsky.social's WICB Junior Award for Excellence in Research. Sarah's work on organelle contact sites has helped revolutionize the field. 🧪
www.ascb.org/society-news...
www.ascb.org/society-news...
Congrats to Sandy Schmid , a scientific hero, winner of @ascbiology.bsky.social's E.B Wilson Medal. She shaped our understanding of molecular mechanisms & regulation of clathrin-mediated endocytosis, is a leader in the cell biology community & a remarkable mentor🧪
www.ascb.org/society-news...
www.ascb.org/society-news...
August 4, 2025 at 11:40 PM
Reposted by Abby Buchwalter
1/3 It's official, our grants from the NIH/NIEHS have all been suspended. We were aiming to understand how arsenic, a chemical that millions of Americans are exposed to at high levels, is disrupting the epigenetic machinery.
August 1, 2025 at 8:59 PM
1/3 It's official, our grants from the NIH/NIEHS have all been suspended. We were aiming to understand how arsenic, a chemical that millions of Americans are exposed to at high levels, is disrupting the epigenetic machinery.
Weekend reset in the Sierras - Lake Schmidell, Desolation Wilderness.
July 29, 2025 at 5:29 PM
Weekend reset in the Sierras - Lake Schmidell, Desolation Wilderness.
Reposted by Abby Buchwalter
1 month to abstract deadline for the first cell biology of the nucleus meeting at @embl.org in many years - organised by the stellar @luskinglab.bsky.social @sarawickstrom.bsky.social Tom Quail & Simone Koehler
Tons of open slots, invited and selected speakers all get 20 mins ❤️
#EESNucleus
Tons of open slots, invited and selected speakers all get 20 mins ❤️
#EESNucleus
July 23, 2025 at 10:49 AM
1 month to abstract deadline for the first cell biology of the nucleus meeting at @embl.org in many years - organised by the stellar @luskinglab.bsky.social @sarawickstrom.bsky.social Tom Quail & Simone Koehler
Tons of open slots, invited and selected speakers all get 20 mins ❤️
#EESNucleus
Tons of open slots, invited and selected speakers all get 20 mins ❤️
#EESNucleus
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 22, 2025 at 5:10 PM
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n)
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
Lamin B1 and LAP2β resist cytoskeletal force to maintain lamin A/C meshwork organization and preserve nuclear integrity | Molecular Biology of the Cell
The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. ...
www.molbiolcell.org
July 21, 2025 at 5:46 PM
The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n)
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
San Francisco summer is in full effect: a soggy bike ride through the fog this AM.
July 21, 2025 at 4:46 PM
San Francisco summer is in full effect: a soggy bike ride through the fog this AM.
Obviously, the nucleus is the best organelle. If you agree and have a story to share in the realm of nuclear cell biology, it may need a home in this upcoming special issue at @jcellsci.bsky.social. More details at the link below.
Call for papers: Cell Biology of the Nucleus
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
July 16, 2025 at 4:12 PM
Obviously, the nucleus is the best organelle. If you agree and have a story to share in the realm of nuclear cell biology, it may need a home in this upcoming special issue at @jcellsci.bsky.social. More details at the link below.
Reposted by Abby Buchwalter
🧪 BREAKING (good news): Senate subcommittee says NO! to Trump's proposed slashes to NASA & NSF funding.
Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24.
See 7:15 below. Full Senate appropriations committee meets tomorrow about it.
🧵 1/3
Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24.
See 7:15 below. Full Senate appropriations committee meets tomorrow about it.
🧵 1/3
Subcommittee Markup of the Commerce, Justice, Science, and Related Agencies Appropriations Act | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
www.appropriations.senate.gov
July 10, 2025 at 12:23 AM
🧪 BREAKING (good news): Senate subcommittee says NO! to Trump's proposed slashes to NASA & NSF funding.
Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24.
See 7:15 below. Full Senate appropriations committee meets tomorrow about it.
🧵 1/3
Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24.
See 7:15 below. Full Senate appropriations committee meets tomorrow about it.
🧵 1/3
Reposted by Abby Buchwalter
An actual good thing coming from this NIH nightmare? www.nih.gov/news-events/...
July 9, 2025 at 1:55 PM
An actual good thing coming from this NIH nightmare? www.nih.gov/news-events/...
Reposted by Abby Buchwalter
BREAKING: A federal judge in Massachusetts (the Reagan-appointed William Young) has declared the Trump administration's cuts to NIH grants — ostensibly over Trump's EOs on gender ideology and DEI — are "illegal" and "void." He's ordering many grants restored.
June 16, 2025 at 6:23 PM
BREAKING: A federal judge in Massachusetts (the Reagan-appointed William Young) has declared the Trump administration's cuts to NIH grants — ostensibly over Trump's EOs on gender ideology and DEI — are "illegal" and "void." He's ordering many grants restored.