Henry De Belly
@henrydebelly.bsky.social
Postdoc in Orion Weiner's lab at UCSF. I work at the interface of Cell Biology and Biophysics.
I am into: #Actin, #Membrane, #CellMigration, #Polarity, #Cats, #Mechanobiology #Cheese #CellBiology
I am into: #Actin, #Membrane, #CellMigration, #Polarity, #Cats, #Mechanobiology #Cheese #CellBiology
Pinned
Henry De Belly
@henrydebelly.bsky.social
· Nov 11
Sharing my latest preprint as a re-introduction to bsky!
biorxiv.org/content/10.1...
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Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
biorxiv.org/content/10.1...
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Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
Reposted by Henry De Belly
🚨NEW PI ALERT🚨 @henrydebelly.bsky.social is in the house, and look at that *fresh* new office. Clean slate for his next #relentlessdiscovery in CRI's Tissue Regeneration Program (TRP). Onward! Read more about his new lab 👉 cri.utsw.edu/faculty/henr...
🧪 @haozhulab.bsky.social
🧪 @haozhulab.bsky.social
January 29, 2026 at 6:23 PM
🚨NEW PI ALERT🚨 @henrydebelly.bsky.social is in the house, and look at that *fresh* new office. Clean slate for his next #relentlessdiscovery in CRI's Tissue Regeneration Program (TRP). Onward! Read more about his new lab 👉 cri.utsw.edu/faculty/henr...
🧪 @haozhulab.bsky.social
🧪 @haozhulab.bsky.social
Today marks the end of my postdoctoral training at @oweinerlab.bsky.social at UCSF and the beginning of a new chapter @cri-utsw.bsky.social
January 14, 2026 at 5:15 PM
Today marks the end of my postdoctoral training at @oweinerlab.bsky.social at UCSF and the beginning of a new chapter @cri-utsw.bsky.social
Reposted by Henry De Belly
Super excited to share that I will be starting my lab at UT Southwestern Medical Center this January!
We will explore how lysosomes drive cellular metabolism and signaling to better understand disease to develop new therapies for cancer and neurodegeneration. More info here: aakritijainlab.com
We will explore how lysosomes drive cellular metabolism and signaling to better understand disease to develop new therapies for cancer and neurodegeneration. More info here: aakritijainlab.com
Jain Lab @ UTSW
aakritijainlab.com
December 5, 2025 at 5:20 PM
Super excited to share that I will be starting my lab at UT Southwestern Medical Center this January!
We will explore how lysosomes drive cellular metabolism and signaling to better understand disease to develop new therapies for cancer and neurodegeneration. More info here: aakritijainlab.com
We will explore how lysosomes drive cellular metabolism and signaling to better understand disease to develop new therapies for cancer and neurodegeneration. More info here: aakritijainlab.com
Privileged to have been involved in this great story led by Franklin from the Burkhardt's lab, showing the role of S1P in controlling naive T cell motility! www.biorxiv.org/content/10.1...
S1P induces bleb-based T cell motility via S1PR1-dependent activation of RhoA and WNK1
In vivo, the chemokine CCL19 and its receptor CCR7 control T cell retention in lymph nodes, while the lipid chemoattractant spingosine-1-phosphate (S1P) drives T cell egress from lymphoid organs. CCL1...
www.biorxiv.org
October 22, 2025 at 5:20 PM
Privileged to have been involved in this great story led by Franklin from the Burkhardt's lab, showing the role of S1P in controlling naive T cell motility! www.biorxiv.org/content/10.1...
Thrilled to announce the launch of my lab
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
We're growing! Our newest Investigator @henrydebelly.bsky.social will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henr... and 📌apply to research in his lab cri.utsw.edu/careers
October 16, 2025 at 10:00 PM
Thrilled to announce the launch of my lab
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
Reposted by Henry De Belly
@henrydebelly.bsky.social @oweinerlab.bsky.social elegantly showed how migrating cells exhibit a long-range mutual activation and partitioning of GTPases at both the front and back of the cell, functioning as an integrated mechano-chemical system. He’s also recruiting for his new lab!🧑🔬#MBIMPG2025
September 10, 2025 at 9:13 AM
@henrydebelly.bsky.social @oweinerlab.bsky.social elegantly showed how migrating cells exhibit a long-range mutual activation and partitioning of GTPases at both the front and back of the cell, functioning as an integrated mechano-chemical system. He’s also recruiting for his new lab!🧑🔬#MBIMPG2025
Reposted by Henry De Belly
Ever wished to become an actin star? 😎
Then try getting suspended above a non-adhesive substrate.
www.nature.com/articles/s41...
Then try getting suspended above a non-adhesive substrate.
www.nature.com/articles/s41...
A multicellular star-shaped actin network underpins epithelial organization and connectivity - Nature Communications
The combined role of cellular junctions and actomyosin networks in tissues remains unclear. Here, the authors identify a tissue-scale star-shaped network of actomyosin that preserves cell shape, limit...
www.nature.com
July 8, 2025 at 12:46 PM
Ever wished to become an actin star? 😎
Then try getting suspended above a non-adhesive substrate.
www.nature.com/articles/s41...
Then try getting suspended above a non-adhesive substrate.
www.nature.com/articles/s41...
Reposted by Henry De Belly
I'm thrilled to announce that my lab is opening this August in the Department of Cell & Tissue Biology @ UCSF!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
June 5, 2025 at 2:30 PM
I'm thrilled to announce that my lab is opening this August in the Department of Cell & Tissue Biology @ UCSF!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
Reposted by Henry De Belly
CTB welcomes new Assistant Professor Semil Choksi @semilc.bsky.social to the department! The Choksi Lab will study how airway stem cells generate multiciliated cells - and how this process goes wrong in respiratory disease. His lab is opening this August. Visit choksilab.org to learn more!
June 5, 2025 at 11:07 PM
CTB welcomes new Assistant Professor Semil Choksi @semilc.bsky.social to the department! The Choksi Lab will study how airway stem cells generate multiciliated cells - and how this process goes wrong in respiratory disease. His lab is opening this August. Visit choksilab.org to learn more!
Reposted by Henry De Belly
#Science Bluesky, do your thing:
We're organising the International Symposium on Mechanobiology (ISMB) 2026 in #Glasgow & we're looking for research groups in Latin America & Africa who are doing great work in #Mechanobiology or adjacent areas.
Can you indicate some names to me?
We're organising the International Symposium on Mechanobiology (ISMB) 2026 in #Glasgow & we're looking for research groups in Latin America & Africa who are doing great work in #Mechanobiology or adjacent areas.
Can you indicate some names to me?
May 30, 2025 at 8:24 PM
#Science Bluesky, do your thing:
We're organising the International Symposium on Mechanobiology (ISMB) 2026 in #Glasgow & we're looking for research groups in Latin America & Africa who are doing great work in #Mechanobiology or adjacent areas.
Can you indicate some names to me?
We're organising the International Symposium on Mechanobiology (ISMB) 2026 in #Glasgow & we're looking for research groups in Latin America & Africa who are doing great work in #Mechanobiology or adjacent areas.
Can you indicate some names to me?
Reposted by Henry De Belly
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
May 23, 2025 at 5:56 PM
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
Reposted by Henry De Belly
I am a proud HHMI Gilliam Fellow alumn. The HHMI funded me at a critical time in my career - a real inflection point that made me realize that I had a place and future in science. I always looked to the HHMI as a safety net to those historically excluded by academia, 1/4
May 16, 2025 at 4:55 PM
I am a proud HHMI Gilliam Fellow alumn. The HHMI funded me at a critical time in my career - a real inflection point that made me realize that I had a place and future in science. I always looked to the HHMI as a safety net to those historically excluded by academia, 1/4
Reposted by Henry De Belly
🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis
Despite progress in probing tissue mechanics, direct long-term measurements in live embryonic epithelia are lacking. This limits our understanding of amniote embryonic morphogenesis, which takes place...
www.biorxiv.org
May 12, 2025 at 2:01 PM
🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Reposted by Henry De Belly
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
March 27, 2025 at 7:45 PM
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Reposted by Henry De Belly
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
March 21, 2025 at 4:18 PM
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
Reposted by Henry De Belly
born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze
March 10, 2025 at 4:32 PM
born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze
Reposted by Henry De Belly
As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration
Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...
www.biorxiv.org
March 10, 2025 at 3:36 AM
As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Henry De Belly
Huge crowds in SF today for #standupforscience. inspiring stories, not only from scientists like @carolynbertozzi.bskyverified.social, but also people who have lived through life-saving/changing experiences as a direct consequence of federally-funded scientific research 💪🏽
March 8, 2025 at 3:43 AM
Huge crowds in SF today for #standupforscience. inspiring stories, not only from scientists like @carolynbertozzi.bskyverified.social, but also people who have lived through life-saving/changing experiences as a direct consequence of federally-funded scientific research 💪🏽
Reposted by Henry De Belly
Reposted by Henry De Belly
Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required.
Please Repost 🙏 thanks !
Please Repost 🙏 thanks !
March 5, 2025 at 5:20 PM
Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required.
Please Repost 🙏 thanks !
Please Repost 🙏 thanks !
Reposted by Henry De Belly
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
January 3, 2025 at 3:33 PM
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
The lanyards at ASCB this year are comically loud. It's like everyone is wearing little bells around their necks 🔔.
December 14, 2024 at 8:05 PM
The lanyards at ASCB this year are comically loud. It's like everyone is wearing little bells around their necks 🔔.
Reposted by Henry De Belly
Hi! Thought I'd mosey on down to bsky as well with the rest of the science peeps! I love combining old-school biochemistry with all the 'omics' to discover new things about organelle function and cellular metabolism in health and disease.
December 9, 2024 at 11:39 PM
Hi! Thought I'd mosey on down to bsky as well with the rest of the science peeps! I love combining old-school biochemistry with all the 'omics' to discover new things about organelle function and cellular metabolism in health and disease.
Reposted by Henry De Belly
Excited for some cool science at #CellBio2024 this year! Come by my poster (Sun. Dec 15, 1.30-3pm Board B136) and stay for my talk (Sun. Dec 15, 4 pm Rm 33B) where I'll tell you about our work on a lysosomal mechanism for membrane protein degradation!
December 9, 2024 at 11:41 PM
Excited for some cool science at #CellBio2024 this year! Come by my poster (Sun. Dec 15, 1.30-3pm Board B136) and stay for my talk (Sun. Dec 15, 4 pm Rm 33B) where I'll tell you about our work on a lysosomal mechanism for membrane protein degradation!
Reposted by Henry De Belly
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
December 3, 2024 at 9:18 AM
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1