Semil Choksi
@semilc.bsky.social
Assistant Professor @UCSF studying cell differentiation, transcription factors and motile cilia. Food and dog take up the rest of my time. choksilab.org
Pinned
Semil Choksi
@semilc.bsky.social
· Jun 5
I'm thrilled to announce that my lab is opening this August in the Department of Cell & Tissue Biology @ UCSF!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
Reposted by Semil Choksi
New work from stellar scientists Jeremy Williams and Roman Camarda. Many contributors including the amazing Zena Werb and Atul Butte
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis
Nature Communications - Breast cancer cells interact with neighbouring adipocytes, but the mechanisms are not fully understood. Here, the authors show that triple-negative breast cancer (TNBC)...
www.nature.com
August 20, 2025 at 10:19 AM
New work from stellar scientists Jeremy Williams and Roman Camarda. Many contributors including the amazing Zena Werb and Atul Butte
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Reposted by Semil Choksi
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 22, 2025 at 5:10 PM
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
Reposted by Semil Choksi
I'm happy people can read the final version of this paper! See what happens when we detach heterochromatin from the nuclear periphery in mouse stem cells:
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology
Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...
www.nature.com
July 23, 2025 at 1:21 AM
I'm happy people can read the final version of this paper! See what happens when we detach heterochromatin from the nuclear periphery in mouse stem cells:
Reposted by Semil Choksi
‼️🚨Preprint alert! 🚨‼️
Excited to have some of my first works as a postdoc, and first corresponding author (!!), on biorxiv! This was a fun side quest of a project marrying a few things I deeply love, development, cilia, and hormones in the pituitary! Happy reading!
www.biorxiv.org/content/10.1...
Excited to have some of my first works as a postdoc, and first corresponding author (!!), on biorxiv! This was a fun side quest of a project marrying a few things I deeply love, development, cilia, and hormones in the pituitary! Happy reading!
www.biorxiv.org/content/10.1...
Primary cilia and BBS4 are required for postnatal pituitary development
Primary cilia orchestrate several signaling pathways, and their disruption results in pleiotropic disorders called ciliopathies. Bardet Beidl syndrome (BBS), one such ciliopathy, provides insights int...
www.biorxiv.org
July 19, 2025 at 5:58 PM
‼️🚨Preprint alert! 🚨‼️
Excited to have some of my first works as a postdoc, and first corresponding author (!!), on biorxiv! This was a fun side quest of a project marrying a few things I deeply love, development, cilia, and hormones in the pituitary! Happy reading!
www.biorxiv.org/content/10.1...
Excited to have some of my first works as a postdoc, and first corresponding author (!!), on biorxiv! This was a fun side quest of a project marrying a few things I deeply love, development, cilia, and hormones in the pituitary! Happy reading!
www.biorxiv.org/content/10.1...
Reposted by Semil Choksi
Congratulations, @semilc.bsky.social! Are you interested in the fascinating world of motile cilia? Consider coming to this lab to explore this awesome biology!
I'm thrilled to announce that my lab is opening this August in the Department of Cell & Tissue Biology @ UCSF!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
June 6, 2025 at 5:35 PM
Congratulations, @semilc.bsky.social! Are you interested in the fascinating world of motile cilia? Consider coming to this lab to explore this awesome biology!
Reposted by Semil Choksi
CTB welcomes new Assistant Professor Semil Choksi @semilc.bsky.social to the department! The Choksi Lab will study how airway stem cells generate multiciliated cells - and how this process goes wrong in respiratory disease. His lab is opening this August. Visit choksilab.org to learn more!
June 5, 2025 at 11:07 PM
CTB welcomes new Assistant Professor Semil Choksi @semilc.bsky.social to the department! The Choksi Lab will study how airway stem cells generate multiciliated cells - and how this process goes wrong in respiratory disease. His lab is opening this August. Visit choksilab.org to learn more!
Reposted by Semil Choksi
We are thrilled that @semilc.bsky.social and the Choksi Lab will be part of our RMB community! 🎉
I'm thrilled to announce that my lab is opening this August in the Department of Cell & Tissue Biology @ UCSF!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
June 5, 2025 at 2:59 PM
We are thrilled that @semilc.bsky.social and the Choksi Lab will be part of our RMB community! 🎉
I'm thrilled to announce that my lab is opening this August in the Department of Cell & Tissue Biology @ UCSF!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
June 5, 2025 at 2:30 PM
I'm thrilled to announce that my lab is opening this August in the Department of Cell & Tissue Biology @ UCSF!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!
Reposted by Semil Choksi
I'm thrilled to share that CTB faculty Fred Chang has been elected as a AAAS fellow! Congratulations to Fred on this well-deserved honor. @fredchanglab.bsky.social @ctbatucsf.bsky.social
www.ucsf.edu/news/2025/03/429681/ucsfs-fred-chang-honored-election-aaas
www.ucsf.edu/news/2025/03/429681/ucsfs-fred-chang-honored-election-aaas
UCSF’s Fred Chang Is Honored with Election to AAAS
Cell biologist Fred Chang, MD, PhD, has been named a fellow in the American Association for the Advancement of Science (AAAS), a highly esteemed lifetime honor within the scientific community.
www.ucsf.edu
March 28, 2025 at 3:26 PM
I'm thrilled to share that CTB faculty Fred Chang has been elected as a AAAS fellow! Congratulations to Fred on this well-deserved honor. @fredchanglab.bsky.social @ctbatucsf.bsky.social
www.ucsf.edu/news/2025/03/429681/ucsfs-fred-chang-honored-election-aaas
www.ucsf.edu/news/2025/03/429681/ucsfs-fred-chang-honored-election-aaas
Reposted by Semil Choksi
UCSF, like all UC campuses, announced an immediate hiring freeze today. UCSF is the second largest employer in the city. There will be wide ripple effects in the Bay Area and beyond, including the future of biotech and pharma in the area. 🧪
March 20, 2025 at 4:07 AM
UCSF, like all UC campuses, announced an immediate hiring freeze today. UCSF is the second largest employer in the city. There will be wide ripple effects in the Bay Area and beyond, including the future of biotech and pharma in the area. 🧪
Reposted by Semil Choksi
A reminder to colleagues interested in Cell-Matrix adhesion & anything ECM related that registration is now open for the Fibronectin, Integrins & related molecules Gordon Research Conference. Incredible list speakers! incredible location! it will 🔥 🔥 🔥 Please join us! www.grc.org/fibronectin-...
2025 Fibronectin, Integrins and Related Molecules Conference GRC
The 2025 Gordon Research Conference on Fibronectin, Integrins and Related Molecules will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 22, 2025 at 4:54 AM
A reminder to colleagues interested in Cell-Matrix adhesion & anything ECM related that registration is now open for the Fibronectin, Integrins & related molecules Gordon Research Conference. Incredible list speakers! incredible location! it will 🔥 🔥 🔥 Please join us! www.grc.org/fibronectin-...
Reposted by Semil Choksi
Are you a trainee interested in cilia? Or mucus? Or mucocliloary interactions? Register for the GRS (www.grc.org/cilia-mucus-...)! We are selecting talks for the cilia session soon, so submit your abstracts asap to be considered!
2025 Cilia, Mucus and Mucociliary Interactions (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Cilia, Mucus and Mucociliary Interactions (GRS) will be held in Pomona, California. Apply today to reserve your spot.
www.grc.org
January 3, 2025 at 11:17 PM
Are you a trainee interested in cilia? Or mucus? Or mucocliloary interactions? Register for the GRS (www.grc.org/cilia-mucus-...)! We are selecting talks for the cilia session soon, so submit your abstracts asap to be considered!
Are you a trainee interested in cilia? Or mucus? Or mucocliloary interactions? Register for the GRS (www.grc.org/cilia-mucus-...)! We are selecting talks for the cilia session soon, so submit your abstracts asap to be considered!
2025 Cilia, Mucus and Mucociliary Interactions (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Cilia, Mucus and Mucociliary Interactions (GRS) will be held in Pomona, California. Apply today to reserve your spot.
www.grc.org
January 3, 2025 at 11:17 PM
Are you a trainee interested in cilia? Or mucus? Or mucocliloary interactions? Register for the GRS (www.grc.org/cilia-mucus-...)! We are selecting talks for the cilia session soon, so submit your abstracts asap to be considered!
Reposted by Semil Choksi
Delighted to share our new preprint on the cell biology and genome of Stentor pyriformis, a giant ciliate that maintains Chlorella endosymbionts in surface-associated microtubule baskets.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 21, 2024 at 8:26 PM
Delighted to share our new preprint on the cell biology and genome of Stentor pyriformis, a giant ciliate that maintains Chlorella endosymbionts in surface-associated microtubule baskets.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Semil Choksi
Cilia alert! Stoked for our new paper in Dev. Cell! Our cross-linking mass spec interactome for motile cilia provides some cool new insights into motile ciliopathy. Helmed by @computingcaitie.bsky.social, read her fantastic Bluetorial below (👇)!
www.cell.com/developmenta...
www.cell.com/developmenta...
December 16, 2024 at 4:10 PM
Cilia alert! Stoked for our new paper in Dev. Cell! Our cross-linking mass spec interactome for motile cilia provides some cool new insights into motile ciliopathy. Helmed by @computingcaitie.bsky.social, read her fantastic Bluetorial below (👇)!
www.cell.com/developmenta...
www.cell.com/developmenta...
Reposted by Semil Choksi
I am excited to share some of my PhD work on the motile cilia interactome revealed by XL/MS with @jbwallingford.bsky.social @edwardmarcotte.bsky.social Ophelia Papoulas, Chanjae Lee, David Taylor, and @builab.bsky.social www.cell.com/developmenta...
December 16, 2024 at 2:44 PM
I am excited to share some of my PhD work on the motile cilia interactome revealed by XL/MS with @jbwallingford.bsky.social @edwardmarcotte.bsky.social Ophelia Papoulas, Chanjae Lee, David Taylor, and @builab.bsky.social www.cell.com/developmenta...
Reposted by Semil Choksi
Super excited to announce my new lab at the University of Michigan opening Jan 2025! 🎉We’ll study how cells work together to shape the GI tract, with ties to regeneration & disease.
Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org
#DevBio #CellBio #Hiring
Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org
#DevBio #CellBio #Hiring
December 13, 2024 at 5:09 PM
Super excited to announce my new lab at the University of Michigan opening Jan 2025! 🎉We’ll study how cells work together to shape the GI tract, with ties to regeneration & disease.
Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org
#DevBio #CellBio #Hiring
Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org
#DevBio #CellBio #Hiring
Reposted by Semil Choksi
Check out our new ✨preprint ✨📝 describing extraordinary convergence of autism proteins at the cilium, a 🧵
www.biorxiv.org/content/10.1... (1/ )
www.biorxiv.org/content/10.1... (1/ )
Convergence of autism proteins at the cilium
Hundreds of high confidence autism genes have been identified, yet the relevant etiological mechanisms remain unclear. Gene ontology analyses have repeatedly identified enrichment of proteins with ann...
www.biorxiv.org
December 9, 2024 at 11:24 PM
Check out our new ✨preprint ✨📝 describing extraordinary convergence of autism proteins at the cilium, a 🧵
www.biorxiv.org/content/10.1... (1/ )
www.biorxiv.org/content/10.1... (1/ )
Reposted by Semil Choksi
Out today, our newest paper in Nature Cardiovascular Research! A Herculean effort by an amazing grad student Joanna Wong. In short, we demonstrate pulmonary veins sprout and differentiate into capillary cells after severe lung injury. www.nature.com/articles/s44...
Dynamic behavior and lineage plasticity of the pulmonary venous endothelium - Nature Cardiovascular Research
Wong et al. identify Slc6a2 as a marker of pulmonary venous endothelial cells and demonstrate that these cells differentiate into capillary endothelial cells during vascular regeneration after lung in...
www.nature.com
December 9, 2024 at 12:08 PM
Out today, our newest paper in Nature Cardiovascular Research! A Herculean effort by an amazing grad student Joanna Wong. In short, we demonstrate pulmonary veins sprout and differentiate into capillary cells after severe lung injury. www.nature.com/articles/s44...
Reposted by Semil Choksi
My first post on Bluesky.
Check out the paper with my colleague Moe Mahjoub on expansion microscopy in kidneys
dx.doi.org/10.1002/cm.2...
Check out the paper with my colleague Moe Mahjoub on expansion microscopy in kidneys
dx.doi.org/10.1002/cm.2...
Ultrastructure expansion microscopy (U‐ExM) of mouse and human kidneys for analysis of subcellular structures
Ultrastructure expansion microscopy (U-ExM) involves the physical magnification of specimens embedded in hydrogels, which allows for super-resolution imaging of subcellular structures using a convent...
dx.doi.org
November 19, 2024 at 8:26 PM
My first post on Bluesky.
Check out the paper with my colleague Moe Mahjoub on expansion microscopy in kidneys
dx.doi.org/10.1002/cm.2...
Check out the paper with my colleague Moe Mahjoub on expansion microscopy in kidneys
dx.doi.org/10.1002/cm.2...
Reposted by Semil Choksi
🧪 Lab's latest!! Work by PD (and now PI) Alison Philbrook.
C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more!
#neuroscience
journals.plos.org/plosbiology/...
C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more!
#neuroscience
journals.plos.org/plosbiology/...
Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons
The relative contributions of intraflagellar transport (IFT) and cilia structure to sensory neuron responses remains unclear. This study reveals unexpected complexity in the contribution of IFT and ci...
journals.plos.org
November 26, 2024 at 11:38 PM
🧪 Lab's latest!! Work by PD (and now PI) Alison Philbrook.
C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more!
#neuroscience
journals.plos.org/plosbiology/...
C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more!
#neuroscience
journals.plos.org/plosbiology/...
Reposted by Semil Choksi
Out now in Dev Cell! scRNAseq trajectories describe the cascade of gene expression as cells differentiate, but turning them into a clear understanding of the underlying biology of a cell type's development remains challenging. authors.elsevier.com/c/1k9qj5Sx5g... (1/)
November 26, 2024 at 3:49 PM
Out now in Dev Cell! scRNAseq trajectories describe the cascade of gene expression as cells differentiate, but turning them into a clear understanding of the underlying biology of a cell type's development remains challenging. authors.elsevier.com/c/1k9qj5Sx5g... (1/)
Reposted by Semil Choksi
This just out from grad student Samantha Bromley-Coolidge with help from Regis University undergrad Diego Iruegas. By the way, Regis has an awesome neuroscience program. If one of their students applies to your grad program, give them a close look!
authors.elsevier.com/a/1k7nr14Yy4...
authors.elsevier.com/a/1k7nr14Yy4...
authors.elsevier.com
November 20, 2024 at 1:35 PM
This just out from grad student Samantha Bromley-Coolidge with help from Regis University undergrad Diego Iruegas. By the way, Regis has an awesome neuroscience program. If one of their students applies to your grad program, give them a close look!
authors.elsevier.com/a/1k7nr14Yy4...
authors.elsevier.com/a/1k7nr14Yy4...
Reposted by Semil Choksi
For anything stem cell and pluripotency-related: go.bsky.app/UTW4d7b
November 20, 2024 at 5:44 AM
For anything stem cell and pluripotency-related: go.bsky.app/UTW4d7b