Bruce Appel
@bruceappel.bsky.social
Developmental neurobiologist in the Section of Developmental Biology, Department of Pediatrics, at University of Colorado Anschutz Medical Campus. Zebrafish, neural cell fate specification, glia, myelin, and the great Colorado outdoors.
Immensely proud of our CU Pediatrics Dev Bio colleagues!
@cupediatrics.bsky.social
@cupediatrics.bsky.social
Congratulations to our very own @jenmckey.bsky.social for winning the Outstanding Mentorship Award and Lily Folts for winning the Outstanding Community Service Award at the Annual WiSTEM Symposium! @cuanschutz.bsky.social @cudevbio.bsky.social 🤩⭐🔬 We're s'proud of all their hard work!
March 31, 2025 at 4:27 PM
Immensely proud of our CU Pediatrics Dev Bio colleagues!
@cupediatrics.bsky.social
@cupediatrics.bsky.social
We've had a great collaboration with Dr. Elena Alberdi's group at the Achurcarro Basque Center for Neuroscience for which we got to host two terrific grad students, Adhara and Uxue, for 4 months each. Our first joint publication is now out!
onlinelibrary.wiley.com/doi/epdf/10....
onlinelibrary.wiley.com/doi/epdf/10....
Amyloid‐β Dysregulates Oligodendroglial Lineage Cell Dynamics and Myelination via PKC in the Zebrafish Spinal Cord
You have to enable JavaScript in your browser's settings in order to use the eReader.
onlinelibrary.wiley.com
March 15, 2025 at 1:51 PM
We've had a great collaboration with Dr. Elena Alberdi's group at the Achurcarro Basque Center for Neuroscience for which we got to host two terrific grad students, Adhara and Uxue, for 4 months each. Our first joint publication is now out!
onlinelibrary.wiley.com/doi/epdf/10....
onlinelibrary.wiley.com/doi/epdf/10....
Luuli has been a terrific colleague and friend. It was a true pleasure and privilege to serve on her thesis committee!
One of our stars defended today! Dr. @luulitran.bsky.social from the @thefrancolab.bsky.social lab gave a stellar seminar describing her deep, insightful, and highly productive investigations of the neuron-glia switch.
#devbio @cupediatrics.bsky.social @cuanschutz.bsky.social
#devbio @cupediatrics.bsky.social @cuanschutz.bsky.social
March 14, 2025 at 11:07 PM
Luuli has been a terrific colleague and friend. It was a true pleasure and privilege to serve on her thesis committee!
This has the most information I have been able to learn about the situation at NIH. Unfortunately, the chaos, worry, and hold-up on grant reviewing and awards seems even worse than I had thought.
I talked to NIH officials, current and former, about what's been happening inside the agency since the Trump administration shut down their grantmaking pipeline in January. Their stories showed just how willing our new leaders are to break the law: www.theatlantic.com/health/archi...
Inside the Collapse at NIH
Administration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
www.theatlantic.com
February 28, 2025 at 3:05 AM
This has the most information I have been able to learn about the situation at NIH. Unfortunately, the chaos, worry, and hold-up on grant reviewing and awards seems even worse than I had thought.
Reposted by Bruce Appel
Big congrats to this year's awardees!
Basic science matters more than ever - the awardees represent key aspects of what makes #devbio a central biomedical research endeavor of widespread impact. Applause!
Basic science matters more than ever - the awardees represent key aspects of what makes #devbio a central biomedical research endeavor of widespread impact. Applause!
Congrats to the 2025 SDB Award Winners!
Conklin Medal: Blanche Capel
DB-SDB Lifetime Achievement Award: Billie Swalla
Hamburger Outstanding Educator Prize: Erica Crespi
Hay New Investigator Award: Mubarak Syed
SDB Trainee Science Communication Award: Joaquin Navajas Acedo
bit.ly/4bcrFap
Conklin Medal: Blanche Capel
DB-SDB Lifetime Achievement Award: Billie Swalla
Hamburger Outstanding Educator Prize: Erica Crespi
Hay New Investigator Award: Mubarak Syed
SDB Trainee Science Communication Award: Joaquin Navajas Acedo
bit.ly/4bcrFap
February 11, 2025 at 5:49 PM
Big congrats to this year's awardees!
Basic science matters more than ever - the awardees represent key aspects of what makes #devbio a central biomedical research endeavor of widespread impact. Applause!
Basic science matters more than ever - the awardees represent key aspects of what makes #devbio a central biomedical research endeavor of widespread impact. Applause!
Reposted by Bruce Appel
Great to see collaborations such as this "develop" between the Section of Developmental Biology @cupediatrics.bsky.social @cuanschutz.bsky.social and our friends @colorado.edu. Looking forward to many more!
Congrats to Justin @brumbaugh-lab.bsky.social and his his team and Peter Dempsey and our colleagues in @cudevbio.bsky.social for this great paper in Nature Cell Biology on epigenetic regulation of intestinal stem cell fate specification! #weCUdevbio
🥂Congrats to @brumbaugh-lab.bsky.social & co for their new study in @naturecellbiology.bsky.social showing that H3K36 methylation maintains #intestinal epithelial fate commitment and is involved in #regeneration.
rdcu.be/d8awu
www.nature.com/articles/s41...
rdcu.be/d8awu
www.nature.com/articles/s41...
January 31, 2025 at 2:51 PM
Great to see collaborations such as this "develop" between the Section of Developmental Biology @cupediatrics.bsky.social @cuanschutz.bsky.social and our friends @colorado.edu. Looking forward to many more!
Reposted by Bruce Appel
Congratulations to Dr. Peter Dempsey, Professor in the Section of Developmental Biology, for recieving the 2025 Pediatric Gastroenterology & Developmental Biology Section Research Mentor Award from the American Gastroenterological Association! #devbio 🧪
January 15, 2025 at 2:41 PM
Congratulations to Dr. Peter Dempsey, Professor in the Section of Developmental Biology, for recieving the 2025 Pediatric Gastroenterology & Developmental Biology Section Research Mentor Award from the American Gastroenterological Association! #devbio 🧪
Our first manuscript on maternal nutrition and development, which was driven entirely by postdoc Katie Ranard, is now out. @cudevbio.bsky.social #devbio doi.org/10.1016/j.jl...
December 30, 2024 at 6:15 PM
Our first manuscript on maternal nutrition and development, which was driven entirely by postdoc Katie Ranard, is now out. @cudevbio.bsky.social #devbio doi.org/10.1016/j.jl...
Love the super creative work from my Dev Bio colleagues JP and Santos. I would never be able to master IU electroporation, but, wow, the things people who have skills can do with it! #devbio 🧪
JP Martin, grad student in @thefrancolab.bsky.social lab, is about to tell us how he proposes to discover mechanisms that drove human brain evolution for his thesis research! Stay tuned for the answer- in about 3 years when he defends!
December 13, 2024 at 9:27 PM
Love the super creative work from my Dev Bio colleagues JP and Santos. I would never be able to master IU electroporation, but, wow, the things people who have skills can do with it! #devbio 🧪
Reposted by Bruce Appel
Postdoc Austin Adkins noticed that mutant zebrafish he had inherited behaved oddly in their tanks. So he turned them into a new research project. Great demonstration of serendipity and creativity at today's Dev Bio Section meeting. #devbio #zebrafish 🧪
December 13, 2024 at 4:32 AM
Postdoc Austin Adkins noticed that mutant zebrafish he had inherited behaved oddly in their tanks. So he turned them into a new research project. Great demonstration of serendipity and creativity at today's Dev Bio Section meeting. #devbio #zebrafish 🧪
Thanks! It’s been awhile since we had a cover!
New issue of Differentiation out now! Congratulations to Samantha Bromley-Coolidge and co-authors, Diego Iruegas and @bruceappel.bsky.social for getting the cover of the journal! www.sciencedirect.com/journal/diff...
December 10, 2024 at 8:53 PM
Thanks! It’s been awhile since we had a cover!
Reposted by Bruce Appel
Looking for place to do PhD studies? Molecular Biology Graduate Program is a great place for that. Check it out. Deadline is December 1st.
November 20, 2024 at 10:26 PM
Looking for place to do PhD studies? Molecular Biology Graduate Program is a great place for that. Check it out. Deadline is December 1st.
This just out from grad student Samantha Bromley-Coolidge with help from Regis University undergrad Diego Iruegas. By the way, Regis has an awesome neuroscience program. If one of their students applies to your grad program, give them a close look!
authors.elsevier.com/a/1k7nr14Yy4...
authors.elsevier.com/a/1k7nr14Yy4...
authors.elsevier.com
November 20, 2024 at 1:35 PM
This just out from grad student Samantha Bromley-Coolidge with help from Regis University undergrad Diego Iruegas. By the way, Regis has an awesome neuroscience program. If one of their students applies to your grad program, give them a close look!
authors.elsevier.com/a/1k7nr14Yy4...
authors.elsevier.com/a/1k7nr14Yy4...
Sure, study section can be a be a grind but there is a huge perk - the chance to connect with special former students who have relocated to DC. Here with the incomparable Alex Hughes and Nick George. #myelin 🧠🧪
November 20, 2024 at 2:16 AM
Sure, study section can be a be a grind but there is a huge perk - the chance to connect with special former students who have relocated to DC. Here with the incomparable Alex Hughes and Nick George. #myelin 🧠🧪
Love to see the results of great collaborations between my wonderful colleagues (and hoping I might get picked for the team next time….)!
Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation. biorxiv.org/cgi/content/...
November 13, 2024 at 9:56 PM
Love to see the results of great collaborations between my wonderful colleagues (and hoping I might get picked for the team next time….)!
Hey, I think I see some myelin on that lineup! 🧠
This is your way-too-early notice that JCB is sponsoring its first-ever scientific session at CellBio2024!! Hosted by yours truly and one of our beloved leaders, Arshad Desai.
Check it out + our presence at the meeting: t.co/79Ceo3PAFd
Check it out + our presence at the meeting: t.co/79Ceo3PAFd
November 13, 2024 at 8:51 PM
Hey, I think I see some myelin on that lineup! 🧠
Not sure how this Bluesky thing is gonna work out for me. I could easily ignore that other platform - now I have a new diversion from grant reviewing….🧪
November 13, 2024 at 4:15 PM
Not sure how this Bluesky thing is gonna work out for me. I could easily ignore that other platform - now I have a new diversion from grant reviewing….🧪
For any of you aiming to advance your biomedical scientific training or pursue your research career among fabulous colleagues in a wonderful part of the world, check us out! 🧪
The largest academic health center in the Rocky Mountain region is excited to officially be on Bluesky! Follow us for the latest #healthscience news and breakthroughs straight from #CUAnschutz experts.
Learn more about who we are, here: cuanschutz.edu
Learn more about who we are, here: cuanschutz.edu
November 13, 2024 at 4:09 PM
For any of you aiming to advance your biomedical scientific training or pursue your research career among fabulous colleagues in a wonderful part of the world, check us out! 🧪
I encourage y’all to check out this work from @emilybateslab.bsky.social. I still remember the first time I heard Emily talk about her fly work that led to this - at a regional SDB meeting in Salt Lake City about 12 years when she was still at BYU. It’s been great to watch the story unfold.
We discovered that mouse embryonic palate mesenchymal cells are electrically active and send out BMP when they depolarize. We are excited to announce this work is published in Nature Communications. #womeninstem #devbio rdcu.be/dZX7V
Depolarization induces calcium-dependent BMP4 release from mouse embryonic palate mesenchymal cells
Nature Communications - BMP signaling is important for multiple process, including craniofacial development, but relatively little is known about how BMP ligands are secreted. Here they show that...
rdcu.be
November 13, 2024 at 2:20 PM
I encourage y’all to check out this work from @emilybateslab.bsky.social. I still remember the first time I heard Emily talk about her fly work that led to this - at a regional SDB meeting in Salt Lake City about 12 years when she was still at BYU. It’s been great to watch the story unfold.
Here is an enthusiastic plug for the journal Differentiation, edited by Drs. Crystal Rogers (@rogerslabucd.bsky.social), Rosa Uribe, and Loydie Jerome-Majewska. We just had a very pleasant and unusually (for these days) quick reviewing and proofs experience.
November 12, 2024 at 10:58 PM
Here is an enthusiastic plug for the journal Differentiation, edited by Drs. Crystal Rogers (@rogerslabucd.bsky.social), Rosa Uribe, and Loydie Jerome-Majewska. We just had a very pleasant and unusually (for these days) quick reviewing and proofs experience.
Just encouraged a publicity person to get our department on Bluesky, and we will be working to get our Section and grad programs on, too. Shout out to @cuhmggp.bsky.social and @kellydsullivan.bsky.social for leading the way. Please consider doing the same at your institutions if you haven’t already.
November 11, 2024 at 3:27 PM
Just encouraged a publicity person to get our department on Bluesky, and we will be working to get our Section and grad programs on, too. Shout out to @cuhmggp.bsky.social and @kellydsullivan.bsky.social for leading the way. Please consider doing the same at your institutions if you haven’t already.
A big unknown of developmental biology is how environmental exposures and maternal health affect development. Postdoc Katie Ranard is attempting to help fill that gap. Here is our first report on developing a zebrafish model of a maternal nutritional deficiency. www.biorxiv.org/content/10.1...
Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment
Docosahexaenoic acid (DHA), a dietary omega-3 fatty acid, is a major building block of brain cell membranes. Offspring rely on maternal DHA transfer to meet their neurodevelopmental needs, but DHA sou...
www.biorxiv.org
November 9, 2024 at 3:57 PM
A big unknown of developmental biology is how environmental exposures and maternal health affect development. Postdoc Katie Ranard is attempting to help fill that gap. Here is our first report on developing a zebrafish model of a maternal nutritional deficiency. www.biorxiv.org/content/10.1...
Please check out our new preprint, which describes a new mechanism by which oligodenrocytes recognize specific classes of axons for myelination. Stellar work by graduate student Natalie Carey with important contributions from Dr. Caleb Doll (and I made 2 plasmids!). www.biorxiv.org/content/10.1...
Oligodendrocytes use post-synaptic proteins to coordinate myelin formation on axons of distinct neurotransmitter classes
Axon myelination is a powerful method to tune neuronal circuit output through deposition of different patterns, lengths, and thicknesses of sheaths on many axon types. Yet the molecular mechanisms of ...
www.biorxiv.org
November 9, 2024 at 3:40 PM
Please check out our new preprint, which describes a new mechanism by which oligodenrocytes recognize specific classes of axons for myelination. Stellar work by graduate student Natalie Carey with important contributions from Dr. Caleb Doll (and I made 2 plasmids!). www.biorxiv.org/content/10.1...
ok, Bluesky, I just quit that other platform. If you are a developmental biologist, glia person, zebrafish person, etc., let me know you are out there.
November 9, 2024 at 3:12 PM
ok, Bluesky, I just quit that other platform. If you are a developmental biologist, glia person, zebrafish person, etc., let me know you are out there.