Tim
@timisstuck.bsky.social
Executive Editor at Life Science Alliance. I help decide how biology thinks 🤔
Views are my own and do not reflect editorial policy.
www.timfessenden.com
Views are my own and do not reflect editorial policy.
www.timfessenden.com
Pinned
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Neat!
CRC cells pulling on Collagen I show increased calcium fluctuations, visualized with the calcium reporter K-GECO1
December 27, 2025 at 4:21 PM
Neat!
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
December 23, 2025 at 1:26 PM
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Reposted by Tim
Vote for JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and pick a favorite. Voting closes on Wednesday, December 31! 👉 www.surveymonkey.com/r/JCB2025Cov...
#ScienceArt
#ScienceArt
December 22, 2025 at 7:30 PM
Vote for JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and pick a favorite. Voting closes on Wednesday, December 31! 👉 www.surveymonkey.com/r/JCB2025Cov...
#ScienceArt
#ScienceArt
Reposted by Tim
I just finished my 28th yr of teaching grad compbio.
Following the inevitable trend, a 3rd of the course is now Deep Learning (DL).
One activity we did was a deep dive into the AlphaGenome pre-print (www.biorxiv.org/content/10.1...).
Question is, how do we evaluate it as a science paper?
1/n
Following the inevitable trend, a 3rd of the course is now Deep Learning (DL).
One activity we did was a deep dive into the AlphaGenome pre-print (www.biorxiv.org/content/10.1...).
Question is, how do we evaluate it as a science paper?
1/n
AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence model
Deep learning models that predict functional genomic measurements from DNA sequence are powerful tools for deciphering the genetic regulatory code. Existing methods trade off between input sequence le...
www.biorxiv.org
December 22, 2025 at 7:10 PM
I just finished my 28th yr of teaching grad compbio.
Following the inevitable trend, a 3rd of the course is now Deep Learning (DL).
One activity we did was a deep dive into the AlphaGenome pre-print (www.biorxiv.org/content/10.1...).
Question is, how do we evaluate it as a science paper?
1/n
Following the inevitable trend, a 3rd of the course is now Deep Learning (DL).
One activity we did was a deep dive into the AlphaGenome pre-print (www.biorxiv.org/content/10.1...).
Question is, how do we evaluate it as a science paper?
1/n
With a smaller, somewhat fraught #cellbio2025 behind us I am nevertheless still inspired and amazed at this community.
Curious to hear others’ impressions!!
Curious to hear others’ impressions!!
December 10, 2025 at 7:12 PM
With a smaller, somewhat fraught #cellbio2025 behind us I am nevertheless still inspired and amazed at this community.
Curious to hear others’ impressions!!
Curious to hear others’ impressions!!
Reposted by Tim
Don't miss out on the last "Meet the Editors" session at #CellBio2025! Join us at booth 825 from 14:00–15:00 EST to chat with editors Poonam (Molecular Systems Biology), Sara Monaco (Review Commons) and Tim (Life Science Alliance) to talk about #publishing, life as an editor and more! 🧪 EMBO Press
December 9, 2025 at 4:25 PM
Don't miss out on the last "Meet the Editors" session at #CellBio2025! Join us at booth 825 from 14:00–15:00 EST to chat with editors Poonam (Molecular Systems Biology), Sara Monaco (Review Commons) and Tim (Life Science Alliance) to talk about #publishing, life as an editor and more! 🧪 EMBO Press
Lovely work on the origins of vascular pathologies in progeria. Check out the nice video made by the authors describing their findings 👇
Take a look at this recently published paper in LSA:
The unfolded protein response in progeria arteries originates from non-endothelial cell types @maxperutzlabs.ac.at @gekaragoz.bsky.social
www.life-science-alliance.org/content/9/2/...
The unfolded protein response in progeria arteries originates from non-endothelial cell types @maxperutzlabs.ac.at @gekaragoz.bsky.social
www.life-science-alliance.org/content/9/2/...
December 9, 2025 at 4:25 PM
Lovely work on the origins of vascular pathologies in progeria. Check out the nice video made by the authors describing their findings 👇
Flyers for @lsajournal.org with our cell bio collection:
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
December 8, 2025 at 3:20 PM
Flyers for @lsajournal.org with our cell bio collection:
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
Reposted by Tim
G&D Executive Editor, Dr. Eric Sawey is at #cellbio2025!
If you’d like to share your work with us or learn about the journal, drop by the CSHL Press booth or reach out at sawey@cshl.edu
#genesdev Cold Spring Harbor Laboratory Press
If you’d like to share your work with us or learn about the journal, drop by the CSHL Press booth or reach out at sawey@cshl.edu
#genesdev Cold Spring Harbor Laboratory Press
December 8, 2025 at 1:55 PM
G&D Executive Editor, Dr. Eric Sawey is at #cellbio2025!
If you’d like to share your work with us or learn about the journal, drop by the CSHL Press booth or reach out at sawey@cshl.edu
#genesdev Cold Spring Harbor Laboratory Press
If you’d like to share your work with us or learn about the journal, drop by the CSHL Press booth or reach out at sawey@cshl.edu
#genesdev Cold Spring Harbor Laboratory Press
Reposted by Tim
Join us at booth 825 from 14–15:00 EST on Sun, Mon and Tues to chat with editors Poonam (Molecular Systems Biology), Sara Monaco (Review Commons) and Tim (Life Science Alliance), whether that is to discuss a paper you are writing, talk about publishing or life as an editor. See you! 🧪 #CellBio2025
December 7, 2025 at 3:15 PM
Join us at booth 825 from 14–15:00 EST on Sun, Mon and Tues to chat with editors Poonam (Molecular Systems Biology), Sara Monaco (Review Commons) and Tim (Life Science Alliance), whether that is to discuss a paper you are writing, talk about publishing or life as an editor. See you! 🧪 #CellBio2025
Reposted by Tim
Attending the ASCB/EMBO Cell Bio #cellbio2025 in Philadelphia? Check out the posters from our lab on nuclear mechanobiology, lamins, and mechanotransduction today and on Tuesday. I will be there too and look forward to catching up!
December 7, 2025 at 3:31 PM
Attending the ASCB/EMBO Cell Bio #cellbio2025 in Philadelphia? Check out the posters from our lab on nuclear mechanobiology, lamins, and mechanotransduction today and on Tuesday. I will be there too and look forward to catching up!
Today and every day at #cellbio2025
💥 find me and chat about @lsajournal.org
💥 take a gorgeous flyer
💥 get a free t-shirt 🥳
💥 find me and chat about @lsajournal.org
💥 take a gorgeous flyer
💥 get a free t-shirt 🥳
December 7, 2025 at 2:09 PM
Today and every day at #cellbio2025
💥 find me and chat about @lsajournal.org
💥 take a gorgeous flyer
💥 get a free t-shirt 🥳
💥 find me and chat about @lsajournal.org
💥 take a gorgeous flyer
💥 get a free t-shirt 🥳
Reposted by Tim
If you're at #cellbio2025, @atmolines.bsky.social Hernan Garcia and I invite you to attend our Minisymposium “Physical Cell Biology from Molecules to Organisms” for incredible talks on epigenetic mechanical memory, viscoelasticity, cortical flows, morphogenesis, tissue wetting, size scaling, et al!
December 5, 2025 at 11:13 PM
If you're at #cellbio2025, @atmolines.bsky.social Hernan Garcia and I invite you to attend our Minisymposium “Physical Cell Biology from Molecules to Organisms” for incredible talks on epigenetic mechanical memory, viscoelasticity, cortical flows, morphogenesis, tissue wetting, size scaling, et al!
Reposted by Tim
openRxiv is heading to Cell Bio 2025 in Philadelphia 🔬
See us at Booth 1134 with Cold Spring Harbor Laboratory Press from December 6-10. We’re excited to meet the community, share what we’re building, and talk about the future of open science. We hope to see you there.
See us at Booth 1134 with Cold Spring Harbor Laboratory Press from December 6-10. We’re excited to meet the community, share what we’re building, and talk about the future of open science. We hope to see you there.
December 5, 2025 at 9:46 PM
openRxiv is heading to Cell Bio 2025 in Philadelphia 🔬
See us at Booth 1134 with Cold Spring Harbor Laboratory Press from December 6-10. We’re excited to meet the community, share what we’re building, and talk about the future of open science. We hope to see you there.
See us at Booth 1134 with Cold Spring Harbor Laboratory Press from December 6-10. We’re excited to meet the community, share what we’re building, and talk about the future of open science. We hope to see you there.
Reposted by Tim
📣 Help choose @jcb.org's cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Voting closes on Wednesday, December 31 👉 www.surveymonkey.com/r/JCB2025Cov...
#CellBio2025 #ScienceArt
#CellBio2025 #ScienceArt
December 5, 2025 at 4:15 PM
📣 Help choose @jcb.org's cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Voting closes on Wednesday, December 31 👉 www.surveymonkey.com/r/JCB2025Cov...
#CellBio2025 #ScienceArt
#CellBio2025 #ScienceArt
I recall the first time you did this!! A fabulous demonstration of biology’s beauty.
#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
December 5, 2025 at 5:07 PM
I recall the first time you did this!! A fabulous demonstration of biology’s beauty.
Although the original thread from @andrea-musacchio.bsky.social was deleted, he was correct to bring his concerns to editors who are key players in how/where/when controversial papers are published.
Appreciate Richard's points on the larger issue (not, as he notes, the specifics of LLPS).
Appreciate Richard's points on the larger issue (not, as he notes, the specifics of LLPS).
Interesting 🧵. IANAE so won’t comment on the science beyond noting that phase separation (in biology) is highly contentious (see e.g. genesdev.cshlp.org/content/33/2...). But it does bring up issues around publishing and editorial decisions 1/n
December 4, 2025 at 3:26 PM
Although the original thread from @andrea-musacchio.bsky.social was deleted, he was correct to bring his concerns to editors who are key players in how/where/when controversial papers are published.
Appreciate Richard's points on the larger issue (not, as he notes, the specifics of LLPS).
Appreciate Richard's points on the larger issue (not, as he notes, the specifics of LLPS).
I imagine a triage mechanism that accelerates decisions on obviously low quality applications. More involvement than that seems dicey.
Interested to learn the outcome of this testing either way though.
Interested to learn the outcome of this testing either way though.
UKRI exploring use of AI in grant review - this will prompt debate but interested to know if people think it’d encourage novelty or the opposite? www.chemistryworld.com/news/ukri-op...
UKRI opens up grant proposal data to explore using AI to smooth peer review
Surging applications has led the UK's main funder to look at ways to reduce the burden on reviewers
www.chemistryworld.com
December 4, 2025 at 2:45 PM
I imagine a triage mechanism that accelerates decisions on obviously low quality applications. More involvement than that seems dicey.
Interested to learn the outcome of this testing either way though.
Interested to learn the outcome of this testing either way though.
Has anyone seen this executive order establishing "Genesis Mission" at the DOE?
In particular the provision that this initiative will be provided with "scientific datasets" and "experimental and production tools" to further its mission.
www.whitehouse.gov/presidential...
In particular the provision that this initiative will be provided with "scientific datasets" and "experimental and production tools" to further its mission.
www.whitehouse.gov/presidential...
December 3, 2025 at 7:36 PM
Has anyone seen this executive order establishing "Genesis Mission" at the DOE?
In particular the provision that this initiative will be provided with "scientific datasets" and "experimental and production tools" to further its mission.
www.whitehouse.gov/presidential...
In particular the provision that this initiative will be provided with "scientific datasets" and "experimental and production tools" to further its mission.
www.whitehouse.gov/presidential...
Read our top papers in cell bio from the past year, then come find me at #CellBio2025 and tell me what you thought!
Our annual collection of exceptional papers in cell biology is here! These articles advance our understanding of the structures and processes at the core of diverse living systems and human disease.
www.life-science-alliance.org/content/cell...
www.life-science-alliance.org/content/cell...
December 3, 2025 at 4:13 PM
Read our top papers in cell bio from the past year, then come find me at #CellBio2025 and tell me what you thought!
Beautiful!
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
December 2, 2025 at 11:11 PM
Beautiful!
Get pumped!! My first CellBio as executive editor at LSA!
💪💪💪🥳🥳🥳
💪💪💪🥳🥳🥳
We're packing our bags for Philadelphia! If you're attending #CellBio2025 be sure to stop by the EMBO booth #825. Three of our editors are attending and available to discuss your latest work! @molsystbiol.org @lsajournal.org @reviewcommons.org
One week to go until #CellBio2025! From 6–10 December, the American Society for Cell Biology and EMBO will bring together the global #CellBiology community in #Philadelphia for a meeting dedicated to cutting-edge #research, meaningful discussion and collaborative exchange. See you soon! #conference
December 2, 2025 at 3:04 PM
Get pumped!! My first CellBio as executive editor at LSA!
💪💪💪🥳🥳🥳
💪💪💪🥳🥳🥳
The assumed link between conceptual advance and journal impact factor is alive and well 😔
December 1, 2025 at 2:01 PM
The assumed link between conceptual advance and journal impact factor is alive and well 😔
The latest AI slop published by @springernature.com (great work!) has me wondering if, unlike the rat testicle one, this could be explained by English illiteracy? The graphics are not obviously wrong. Does anyone know?
November 30, 2025 at 1:02 PM
The latest AI slop published by @springernature.com (great work!) has me wondering if, unlike the rat testicle one, this could be explained by English illiteracy? The graphics are not obviously wrong. Does anyone know?
November 30, 2025 at 12:56 PM