Life Science Alliance
@lsajournal.org
#OpenAccess community-driven journal for peer-reviewed research in all areas of the life sciences. By EMBO Press (@embopress.org), Rockefeller University Press (@rupress.org), and Cold Spring Harbor Laboratory Press (@cshlpress.bsky.social).
The Chameau gene helps flies survive starvation at lower temps, but a mere 2{degree sign}C rise makes it obsolete! This temperature-dependent role in metabolism and resilience has big implications for climate change biology.
@reviewcommons.org
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@reviewcommons.org
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November 7, 2025 at 4:04 PM
The Chameau gene helps flies survive starvation at lower temps, but a mere 2{degree sign}C rise makes it obsolete! This temperature-dependent role in metabolism and resilience has big implications for climate change biology.
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
This study presents an in vitro analysis of centriole and cilium formation during early mouse embryonic development, using 3D models to mimic implantation, tissue patterning, and axis elongation. @chribue.bsky.social @isabellavoelkl.bsky.social www.life-science-alliance.org/content/9/1/...
November 6, 2025 at 4:04 PM
This study presents an in vitro analysis of centriole and cilium formation during early mouse embryonic development, using 3D models to mimic implantation, tissue patterning, and axis elongation. @chribue.bsky.social @isabellavoelkl.bsky.social www.life-science-alliance.org/content/9/1/...
The study shows that NSUN1-mediated m5C RNA methylation drives TDP-43 cytoplasmic accumulation and neurotoxicity, revealing a new pathway contributing to ALS/FTD pathogenesis. #ALS #TDP-43
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www.life-science-alliance.org/content/9/1/...
November 5, 2025 at 4:04 PM
The study shows that NSUN1-mediated m5C RNA methylation drives TDP-43 cytoplasmic accumulation and neurotoxicity, revealing a new pathway contributing to ALS/FTD pathogenesis. #ALS #TDP-43
www.life-science-alliance.org/content/9/1/...
www.life-science-alliance.org/content/9/1/...
Using in vitro stimulation & CRISPR/Cas9-mediated gene editing, Abir et al. found that Th1 cell identity is anchored in glycolysis by fostering STAT1 O-glycosylation, STAT1 Ser727 phosphorylation & Th1 cell effector capacity.
@mielenzlab.bsky.social
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@mielenzlab.bsky.social
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November 4, 2025 at 9:34 PM
Using in vitro stimulation & CRISPR/Cas9-mediated gene editing, Abir et al. found that Th1 cell identity is anchored in glycolysis by fostering STAT1 O-glycosylation, STAT1 Ser727 phosphorylation & Th1 cell effector capacity.
@mielenzlab.bsky.social
www.life-science-alliance.org/content/9/1/...
@mielenzlab.bsky.social
www.life-science-alliance.org/content/9/1/...
BCL6 limits CD8 T cell responses to tumors by inhibiting Glut3 expression. Conditional deletion of Bcl6 in activated CD8 T cells or pharmacological inhibition of BCL6 in mice represses tumor growth. www.life-science-alliance.org/content/9/1/... @scripps.edu
November 4, 2025 at 4:05 PM
BCL6 limits CD8 T cell responses to tumors by inhibiting Glut3 expression. Conditional deletion of Bcl6 in activated CD8 T cells or pharmacological inhibition of BCL6 in mice represses tumor growth. www.life-science-alliance.org/content/9/1/... @scripps.edu
Our November issue is here! Two articles in this issue uncover amino acid sensing mechanisms and outcomes. Also, discover which T cell subset targets pediatric neuroblastoma, the evolutionary conservation of a meiotic protein, and much more! www.life-science-alliance.org/content/8/11
November 3, 2025 at 4:04 PM
Our November issue is here! Two articles in this issue uncover amino acid sensing mechanisms and outcomes. Also, discover which T cell subset targets pediatric neuroblastoma, the evolutionary conservation of a meiotic protein, and much more! www.life-science-alliance.org/content/8/11
Using HDX-MS, this study demonstrates that conformational flexibility in beetle luciferases governs bioluminescence color, revealing how active site dynamics and domain-specific mutations fine-tune red- and blue-shifted light emission. www.life-science-alliance.org/content/9/1/...
October 31, 2025 at 3:06 PM
Using HDX-MS, this study demonstrates that conformational flexibility in beetle luciferases governs bioluminescence color, revealing how active site dynamics and domain-specific mutations fine-tune red- and blue-shifted light emission. www.life-science-alliance.org/content/9/1/...
This exciting study by the Buecker lab @chribue.bsky.social & first author Isabella Voelkl @isabellavoelkl.bsky.social explores in vitro differentiation models for their usability in studying cilia and centriole formation in mouse embryonic development www.life-science-alliance.org/content/9/1/...
October 30, 2025 at 3:05 PM
This exciting study by the Buecker lab @chribue.bsky.social & first author Isabella Voelkl @isabellavoelkl.bsky.social explores in vitro differentiation models for their usability in studying cilia and centriole formation in mouse embryonic development www.life-science-alliance.org/content/9/1/...
DA-Raf efficiently associates with the plasma membrane phosphatidylserine via the RBD and CRD domains and thus predominates over Raf proteins in the binding to Ras, thereby preventing the ERK pathway. www.life-science-alliance.org/content/8/12...
October 29, 2025 at 3:09 PM
DA-Raf efficiently associates with the plasma membrane phosphatidylserine via the RBD and CRD domains and thus predominates over Raf proteins in the binding to Ras, thereby preventing the ERK pathway. www.life-science-alliance.org/content/8/12...
Reposted by Life Science Alliance
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Life Science Alliance @lsajournal.org is now on @researchgate.bsky.social 🥳
If you peruse ResearchGate, give us a follow!
Life Science Alliance @lsajournal.org is now on @researchgate.bsky.social 🥳
If you peruse ResearchGate, give us a follow!
October 15, 2025 at 6:41 PM
I've been claimed!
Life Science Alliance @lsajournal.org is now on @researchgate.bsky.social 🥳
If you peruse ResearchGate, give us a follow!
Life Science Alliance @lsajournal.org is now on @researchgate.bsky.social 🥳
If you peruse ResearchGate, give us a follow!
Luan & colleagues show that a lack of BCL6 expression in activated CD8 T cells or pharmacological BCL6 inhibition inhibits tumors. The findings suggest ways to improve the CD8 T cell function in cancer by changing their energy utilization @scripps.edu www.life-science-alliance.org/content/9/1/...
October 28, 2025 at 3:07 PM
Luan & colleagues show that a lack of BCL6 expression in activated CD8 T cells or pharmacological BCL6 inhibition inhibits tumors. The findings suggest ways to improve the CD8 T cell function in cancer by changing their energy utilization @scripps.edu www.life-science-alliance.org/content/9/1/...
Check out this research article:
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
October 27, 2025 at 3:07 PM
Check out this research article:
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
Why do some beetle luciferases glow red while others glow green? HDX-MS reveals a simple rule: motion sets the hue. Red variants stay more flexible; green ones are more rigid. Flexibility around the active site acts like a dial that shifts the spectrum. www.life-science-alliance.org/content/9/1/...
October 24, 2025 at 3:08 PM
Why do some beetle luciferases glow red while others glow green? HDX-MS reveals a simple rule: motion sets the hue. Red variants stay more flexible; green ones are more rigid. Flexibility around the active site acts like a dial that shifts the spectrum. www.life-science-alliance.org/content/9/1/...
This study shows that DA-Raf localizes to the plasma membrane, binds preferentially to phosphatidylserine and active Ras via its Ras-binding and cysteine-rich domains (RBD/CRD), and thereby inhibits Raf activation and the Ras-ERK pathway. www.life-science-alliance.org/content/8/12...
October 22, 2025 at 3:07 PM
This study shows that DA-Raf localizes to the plasma membrane, binds preferentially to phosphatidylserine and active Ras via its Ras-binding and cysteine-rich domains (RBD/CRD), and thereby inhibits Raf activation and the Ras-ERK pathway. www.life-science-alliance.org/content/8/12...
Mitochondria-generated reactive oxygen species influence centrosome replication, leading to microtubule reorganization and impacting endosomal transport. #CellBiology #Research www.life-science-alliance.org/content/9/1/...
October 21, 2025 at 3:06 PM
Mitochondria-generated reactive oxygen species influence centrosome replication, leading to microtubule reorganization and impacting endosomal transport. #CellBiology #Research www.life-science-alliance.org/content/9/1/...
This study investigates effects of increased POLRMT levels and reports stimulation of mtDNA transcription initiation and enhanced exercise capacity without an effect on steady-state mRNA levels. www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
@kuhl-lab.bsky.social
October 20, 2025 at 3:29 PM
This study investigates effects of increased POLRMT levels and reports stimulation of mtDNA transcription initiation and enhanced exercise capacity without an effect on steady-state mRNA levels. www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
@kuhl-lab.bsky.social
This review outlines the scientific utility and ethical imperatives of human brain slice cultures, calling for global ethical standards in ex vivo neuroscience research www.life-science-alliance.org/content/8/12...
October 17, 2025 at 8:34 PM
This review outlines the scientific utility and ethical imperatives of human brain slice cultures, calling for global ethical standards in ex vivo neuroscience research www.life-science-alliance.org/content/8/12...
Have you already seen this research article, recently published in LSA:
PARP10 is Critical for Stress Granule Initiation @leunglab.bsky.social www.life-science-alliance.org/content/8/12...
PARP10 is Critical for Stress Granule Initiation @leunglab.bsky.social www.life-science-alliance.org/content/8/12...
October 17, 2025 at 3:07 PM
Have you already seen this research article, recently published in LSA:
PARP10 is Critical for Stress Granule Initiation @leunglab.bsky.social www.life-science-alliance.org/content/8/12...
PARP10 is Critical for Stress Granule Initiation @leunglab.bsky.social www.life-science-alliance.org/content/8/12...
Exploring the pros and cons of AHR activation during gut infections: AHR can both aid in fighting off pathogens and potentially worsen inflammation. #GutHealth #AHRImpact www.life-science-alliance.org/content/8/12...
October 16, 2025 at 8:34 PM
Exploring the pros and cons of AHR activation during gut infections: AHR can both aid in fighting off pathogens and potentially worsen inflammation. #GutHealth #AHRImpact www.life-science-alliance.org/content/8/12...
Check out this recently published paper in LSA:
A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling @reviewcommons.org www.life-science-alliance.org/content/8/12...
A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling @reviewcommons.org www.life-science-alliance.org/content/8/12...
October 16, 2025 at 3:05 PM
Check out this recently published paper in LSA:
A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling @reviewcommons.org www.life-science-alliance.org/content/8/12...
A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling @reviewcommons.org www.life-science-alliance.org/content/8/12...
This study shows that reactive oxygen species produced by mitochondria alter centrosome duplication, causing microtubule rearrangements that alter endosomal trafficking. www.life-science-alliance.org/content/9/1/...
October 14, 2025 at 3:04 PM
This study shows that reactive oxygen species produced by mitochondria alter centrosome duplication, causing microtubule rearrangements that alter endosomal trafficking. www.life-science-alliance.org/content/9/1/...
KANSL3 is an epigenetic regulator of hepatocyte metabolism and differentiation, essential for liver development and key to maintaining liver health. @mwiese.bsky.social www.life-science-alliance.org/content/8/12...
October 13, 2025 at 4:56 PM
KANSL3 is an epigenetic regulator of hepatocyte metabolism and differentiation, essential for liver development and key to maintaining liver health. @mwiese.bsky.social www.life-science-alliance.org/content/8/12...
New in #neuroscience: Human brain slice cultures (HBSCs) are revolutionizing disease modeling, drug testing & neuroethics. Our latest work explores their translational promise-and the need for global ethical standards www.life-science-alliance.org/content/8/12...
October 10, 2025 at 10:21 AM
New in #neuroscience: Human brain slice cultures (HBSCs) are revolutionizing disease modeling, drug testing & neuroethics. Our latest work explores their translational promise-and the need for global ethical standards www.life-science-alliance.org/content/8/12...
This study identifies PARP10 as a key regulator of stress granule assembly by ADP-ribosylating G3BP1 and modulating eIF2α phosphorylation and translation factor recruitment @leunglab.bsky.social www.life-science-alliance.org/content/8/12...
October 10, 2025 at 10:15 AM
This study identifies PARP10 as a key regulator of stress granule assembly by ADP-ribosylating G3BP1 and modulating eIF2α phosphorylation and translation factor recruitment @leunglab.bsky.social www.life-science-alliance.org/content/8/12...
ADAMTS10 and ADAMTS17 regulate bone growth and extracellular matrix formation by promoting secretion and deposition of fibronectin, fibrillin-1, and collagen type VI www.life-science-alliance.org/content/8/12...
October 9, 2025 at 3:05 PM
ADAMTS10 and ADAMTS17 regulate bone growth and extracellular matrix formation by promoting secretion and deposition of fibronectin, fibrillin-1, and collagen type VI www.life-science-alliance.org/content/8/12...