Life Science Alliance
@lsajournal.org
#OpenAccess community-driven journal for peer-reviewed research in all areas of the life sciences. By EMBO Press (@embopress.org), Rockefeller University Press (@rupress.org), and Cold Spring Harbor Laboratory Press (@cshlpress.bsky.social).
Loss of the RB tumor suppressor drives centromere transcription, resulting in DNA damage and whole chromosome segregation errors. www.life-science-alliance.org/content/9/3/...
December 26, 2025 at 4:04 PM
Loss of the RB tumor suppressor drives centromere transcription, resulting in DNA damage and whole chromosome segregation errors. www.life-science-alliance.org/content/9/3/...
Reposted by Life Science Alliance
Scientific publishing has a bias against negative results and that hurts science, says Tim Fessenden, editor of @lsajournal.org, a publication of @rupress.org. Here’s how journal editors can help.
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
December 23, 2025 at 2:30 PM
Scientific publishing has a bias against negative results and that hurts science, says Tim Fessenden, editor of @lsajournal.org, a publication of @rupress.org. Here’s how journal editors can help.
The study shows how blood and lymphatic endothelial cells change their metabolism when they are growing and resting. It reveals different pathways that support their specific functions.
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
December 25, 2025 at 4:04 PM
The study shows how blood and lymphatic endothelial cells change their metabolism when they are growing and resting. It reveals different pathways that support their specific functions.
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
Reposted by Life Science Alliance
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
December 23, 2025 at 1:26 PM
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Enhancing lung tissue preservation during cold storage and ex vivo lung perfusion is possible by adding Cystatin C to the preservation solution. This approach boosts tissue protection and minimizes injury.
#LungHealth #MedicalInnovation
www.life-science-alliance.org/content/9/2/...
#LungHealth #MedicalInnovation
www.life-science-alliance.org/content/9/2/...
December 24, 2025 at 4:04 PM
Enhancing lung tissue preservation during cold storage and ex vivo lung perfusion is possible by adding Cystatin C to the preservation solution. This approach boosts tissue protection and minimizes injury.
#LungHealth #MedicalInnovation
www.life-science-alliance.org/content/9/2/...
#LungHealth #MedicalInnovation
www.life-science-alliance.org/content/9/2/...
Reposted by Life Science Alliance
Why do negative data, or null results, matter? @lsajournal.org's Tim Fessenden (@timisstuck.bsky.social) shares his insider perspective on why and how the scientific community should actively encourage the publication of negative results. From @rockefeller.edu 👉 www.rockefeller.edu/news/38829-t...
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies…
www.rockefeller.edu
December 23, 2025 at 4:00 PM
Why do negative data, or null results, matter? @lsajournal.org's Tim Fessenden (@timisstuck.bsky.social) shares his insider perspective on why and how the scientific community should actively encourage the publication of negative results. From @rockefeller.edu 👉 www.rockefeller.edu/news/38829-t...
CryoEM and biochemical analyses reveal that CENP-A/H4 octasomes form stable, flexible chromatin intermediates that may facilitate CCAN engagement and centromere organization.
@uio.no
www.life-science-alliance.org/content/9/3/...
@uio.no
www.life-science-alliance.org/content/9/3/...
December 23, 2025 at 9:34 PM
CryoEM and biochemical analyses reveal that CENP-A/H4 octasomes form stable, flexible chromatin intermediates that may facilitate CCAN engagement and centromere organization.
@uio.no
www.life-science-alliance.org/content/9/3/...
@uio.no
www.life-science-alliance.org/content/9/3/...
Take a look at this recently published research article in LSA:
A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration
www.life-science-alliance.org/content/9/3/...
A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration
www.life-science-alliance.org/content/9/3/...
December 23, 2025 at 4:04 PM
Take a look at this recently published research article in LSA:
A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration
www.life-science-alliance.org/content/9/3/...
A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration
www.life-science-alliance.org/content/9/3/...
A new paper from the Manning lab describes that loss of the RB tumor suppressor drives centromere transcription, resulting in DNA damage and whole chromosome segregation errors. www.life-science-alliance.org/content/9/3/...
December 19, 2025 at 9:34 PM
A new paper from the Manning lab describes that loss of the RB tumor suppressor drives centromere transcription, resulting in DNA damage and whole chromosome segregation errors. www.life-science-alliance.org/content/9/3/...
The study shows how blood and lymphatic endothelial cells reorganize metabolism in proliferating and quiescent states, revealing distinct pathway dependencies that sustain their specialized functions.
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
December 19, 2025 at 4:05 PM
The study shows how blood and lymphatic endothelial cells reorganize metabolism in proliferating and quiescent states, revealing distinct pathway dependencies that sustain their specialized functions.
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
Unknown driver mutations are enriched in Alzheimer's patients with Y chromosome loss, suggesting LOY-driven clonal myeloid expansion may contribute to distinct disease-associated mutational profiles.
Loss of Y chromosome in Alzheimer’s patients co-occurs with somatic mutations beyond CHIP drivers
Loss of Y chromosome (LOY) and clonal hematopoiesis of indeterminate potential (CHIP) are common age-related events with implications for aging and Alzheimer disease (AD). LOY is linked to increased…
www.life-science-alliance.org
December 18, 2025 at 9:34 PM
Unknown driver mutations are enriched in Alzheimer's patients with Y chromosome loss, suggesting LOY-driven clonal myeloid expansion may contribute to distinct disease-associated mutational profiles.
The authors present a detailed step-by-step protocol for preparing custom-made cell culture media and provide guidance on its use in cancer metabolism experiments.
@dkfz.bsky.social @mtprentzell.bsky.social
www.life-science-alliance.org/content/9/2/...
@dkfz.bsky.social @mtprentzell.bsky.social
www.life-science-alliance.org/content/9/2/...
December 18, 2025 at 4:04 PM
The authors present a detailed step-by-step protocol for preparing custom-made cell culture media and provide guidance on its use in cancer metabolism experiments.
@dkfz.bsky.social @mtprentzell.bsky.social
www.life-science-alliance.org/content/9/2/...
@dkfz.bsky.social @mtprentzell.bsky.social
www.life-science-alliance.org/content/9/2/...
Cystatin C added to the preservation solution during cold storage and ex vivo lung perfusion of donor lungs, results in improved tissue preservation and protection against lung tissue injury.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
December 17, 2025 at 4:05 PM
Cystatin C added to the preservation solution during cold storage and ex vivo lung perfusion of donor lungs, results in improved tissue preservation and protection against lung tissue injury.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
New study in @LSAjournal reveals that CENP-A/H4 octasomes form flexible chromatin intermediates that may guide centromere assembly via CCAN. @uio.no @NCMMnews
#chromatin #centromere #CENP-A #cryo-EM #nucleosome #octasome
www.life-science-alliance.org/content/9/3/...
#chromatin #centromere #CENP-A #cryo-EM #nucleosome #octasome
www.life-science-alliance.org/content/9/3/...
December 16, 2025 at 9:34 PM
New study in @LSAjournal reveals that CENP-A/H4 octasomes form flexible chromatin intermediates that may guide centromere assembly via CCAN. @uio.no @NCMMnews
#chromatin #centromere #CENP-A #cryo-EM #nucleosome #octasome
www.life-science-alliance.org/content/9/3/...
#chromatin #centromere #CENP-A #cryo-EM #nucleosome #octasome
www.life-science-alliance.org/content/9/3/...
ALS is a neurodegenerative disease commonly marked by disrupted RNA-binding protein function; this study investigates circadian regulation of RNA metabolism in spinal cord cholinergic neurons--the cell-type of ALS disease origin and fatality.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
December 16, 2025 at 4:04 PM
ALS is a neurodegenerative disease commonly marked by disrupted RNA-binding protein function; this study investigates circadian regulation of RNA metabolism in spinal cord cholinergic neurons--the cell-type of ALS disease origin and fatality.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
The authors found unusual DNA changes in immune cells of men with Alzheimer's who have lost the Y chromosome. These mutations may help explain how the immune system contributes to the disease, opening new paths to understanding the means of Alzheimer's. www.life-science-alliance.org/content/9/2/...
December 12, 2025 at 4:04 PM
The authors found unusual DNA changes in immune cells of men with Alzheimer's who have lost the Y chromosome. These mutations may help explain how the immune system contributes to the disease, opening new paths to understanding the means of Alzheimer's. www.life-science-alliance.org/content/9/2/...
A detailed protocol for preparing custom-made cell culture media, offering researchers step-by-step instructions and practical advice for its use in cancer metabolism studies. #cancermetabolism #cellculture
@dkfz.bsky.social @mtprentzell.bsky.social
www.life-science-alliance.org/content/9/2/...
@dkfz.bsky.social @mtprentzell.bsky.social
www.life-science-alliance.org/content/9/2/...
December 11, 2025 at 9:34 PM
A detailed protocol for preparing custom-made cell culture media, offering researchers step-by-step instructions and practical advice for its use in cancer metabolism studies. #cancermetabolism #cellculture
@dkfz.bsky.social @mtprentzell.bsky.social
www.life-science-alliance.org/content/9/2/...
@dkfz.bsky.social @mtprentzell.bsky.social
www.life-science-alliance.org/content/9/2/...
Have you already read this review?
Conserved 3D genome reorganization during DNA repair
www.life-science-alliance.org/content/9/2/...
Conserved 3D genome reorganization during DNA repair
www.life-science-alliance.org/content/9/2/...
December 11, 2025 at 4:04 PM
Have you already read this review?
Conserved 3D genome reorganization during DNA repair
www.life-science-alliance.org/content/9/2/...
Conserved 3D genome reorganization during DNA repair
www.life-science-alliance.org/content/9/2/...
This is the first demonstration of cell-type specific GPCR localization to primary cilia in vivo in intact brain tissue.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
December 10, 2025 at 9:34 PM
This is the first demonstration of cell-type specific GPCR localization to primary cilia in vivo in intact brain tissue.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
TRPM7 and magnesium coordinate the activation and differentiation of human CD4 T-cells. #Immunology #Biology
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
December 10, 2025 at 4:04 PM
TRPM7 and magnesium coordinate the activation and differentiation of human CD4 T-cells. #Immunology #Biology
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
Take a look at this recently published paper in LSA:
The unfolded protein response in progeria arteries originates from non-endothelial cell types @maxperutzlabs.ac.at @gekaragoz.bsky.social
www.life-science-alliance.org/content/9/2/...
The unfolded protein response in progeria arteries originates from non-endothelial cell types @maxperutzlabs.ac.at @gekaragoz.bsky.social
www.life-science-alliance.org/content/9/2/...
December 9, 2025 at 4:05 PM
Take a look at this recently published paper in LSA:
The unfolded protein response in progeria arteries originates from non-endothelial cell types @maxperutzlabs.ac.at @gekaragoz.bsky.social
www.life-science-alliance.org/content/9/2/...
The unfolded protein response in progeria arteries originates from non-endothelial cell types @maxperutzlabs.ac.at @gekaragoz.bsky.social
www.life-science-alliance.org/content/9/2/...
Our annual collection of exceptional papers in cell biology is here! These articles advance our understanding of the structures and processes at the core of diverse living systems and human disease.
www.life-science-alliance.org/content/cell...
www.life-science-alliance.org/content/cell...
December 5, 2025 at 4:05 PM
Our annual collection of exceptional papers in cell biology is here! These articles advance our understanding of the structures and processes at the core of diverse living systems and human disease.
www.life-science-alliance.org/content/cell...
www.life-science-alliance.org/content/cell...
This review synthesizes findings from genomic, molecular, and disease studies that chromatin organization dynamically shapes diverse DNA repair pathways, with translational potential for therapeutic intervention.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
December 4, 2025 at 9:34 PM
This review synthesizes findings from genomic, molecular, and disease studies that chromatin organization dynamically shapes diverse DNA repair pathways, with translational potential for therapeutic intervention.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
Li Guan et al., demonstrate that the striatal enriched orphan receptor GPR88 localizes to primary cilia in the striatum but not in the cortex. These findings demonstrate cell-type specific regulation of GPCR localization to primary cilia.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
December 4, 2025 at 4:04 PM
Li Guan et al., demonstrate that the striatal enriched orphan receptor GPR88 localizes to primary cilia in the striatum but not in the cortex. These findings demonstrate cell-type specific regulation of GPCR localization to primary cilia.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
The ion channel-kinase TRPM7 maintains intracellular Mg2+ homeostasis, affects early Ca2+ signals, influences downstream Ca2+-dependent signaling pathways and thus is crucial for T-cell activation and differentiation.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
December 3, 2025 at 9:34 PM
The ion channel-kinase TRPM7 maintains intracellular Mg2+ homeostasis, affects early Ca2+ signals, influences downstream Ca2+-dependent signaling pathways and thus is crucial for T-cell activation and differentiation.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...