Life Science Alliance
@lsajournal.org
#OpenAccess community-driven journal for peer-reviewed research in all areas of the life sciences. By EMBO Press (@embopress.org), Rockefeller University Press (@rupress.org), and Cold Spring Harbor Laboratory Press (@cshlpress.bsky.social).
Distinct genomic uracil patterns and APOBEC3 activation differentiate cellular responses to TS inhibitors, connecting uracil metabolism to mutagenesis and drug tolerance in colon cancer cells.
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
February 9, 2026 at 9:34 PM
Distinct genomic uracil patterns and APOBEC3 activation differentiate cellular responses to TS inhibitors, connecting uracil metabolism to mutagenesis and drug tolerance in colon cancer cells.
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
Join the #EMBL conference "Cellular mechanisms driven by phase separation" 🗓️ May 19-22! Register now for in-person @embl.org Heidelberg or Virtual 👉 www.embl.org/about/info/c...
#EESPhaseSeparation
@events.embl.org
#EESPhaseSeparation
@events.embl.org
February 9, 2026 at 4:05 PM
Join the #EMBL conference "Cellular mechanisms driven by phase separation" 🗓️ May 19-22! Register now for in-person @embl.org Heidelberg or Virtual 👉 www.embl.org/about/info/c...
#EESPhaseSeparation
@events.embl.org
#EESPhaseSeparation
@events.embl.org
Reposted by Life Science Alliance
Recently published work lead by the very talented @dvillarroelc.bsky.social. Lots of work has gone in to this and I have enjoyed seeing this story develop over the years. Congrats to all! @jamessleigh.bsky.social @joburrito.bsky.social @frattalab.bsky.social @uclqsion.bsky.social #axonaltransport
Neurotrophin-containing signalling endosomes travel from the distal axon to the soma. ALS-linked kinase TBK1 governs the directionality of their transport in motor neurons by phosphorylating Rab7.
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
February 9, 2026 at 12:41 AM
Recently published work lead by the very talented @dvillarroelc.bsky.social. Lots of work has gone in to this and I have enjoyed seeing this story develop over the years. Congrats to all! @jamessleigh.bsky.social @joburrito.bsky.social @frattalab.bsky.social @uclqsion.bsky.social #axonaltransport
The study reveals molecular details of cellular adaptation to mechanical strain involving autophagy-mediated focal adhesion remodeling and mitochondrial activation. www.life-science-alliance.org/content/9/4/...
February 8, 2026 at 9:34 PM
The study reveals molecular details of cellular adaptation to mechanical strain involving autophagy-mediated focal adhesion remodeling and mitochondrial activation. www.life-science-alliance.org/content/9/4/...
Fluid shear stress mechanotransduction by Notch1: flow stimulates Notch1 intracellular domain interactions to polarize receptors into microdomains, driving endocytosis and proteolytic activation.
@ctbatucsf.bsky.social
www.life-science-alliance.org/content/9/4/...
@ctbatucsf.bsky.social
www.life-science-alliance.org/content/9/4/...
February 8, 2026 at 4:04 PM
Fluid shear stress mechanotransduction by Notch1: flow stimulates Notch1 intracellular domain interactions to polarize receptors into microdomains, driving endocytosis and proteolytic activation.
@ctbatucsf.bsky.social
www.life-science-alliance.org/content/9/4/...
@ctbatucsf.bsky.social
www.life-science-alliance.org/content/9/4/...
The study shows that NCOA4 interacts with GATE16 via two linear motifs essential for ferritinophagy, highlighting LC3/GABARAP's role in ensuring specificity. It proposes that iron might regulate this by blocking one motif. More details are available at www.life-science-alliance.org/content/9/4/....
February 7, 2026 at 9:34 PM
The study shows that NCOA4 interacts with GATE16 via two linear motifs essential for ferritinophagy, highlighting LC3/GABARAP's role in ensuring specificity. It proposes that iron might regulate this by blocking one motif. More details are available at www.life-science-alliance.org/content/9/4/....
Neurotrophin-containing signalling endosomes travel from the distal axon to the soma. ALS-linked kinase TBK1 governs the directionality of their transport in motor neurons by phosphorylating Rab7.
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
February 7, 2026 at 4:04 PM
Neurotrophin-containing signalling endosomes travel from the distal axon to the soma. ALS-linked kinase TBK1 governs the directionality of their transport in motor neurons by phosphorylating Rab7.
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
Research by Satish Khurana's team suggests that frequent blood draws don't impair HSPC function. Instead, these events might help remove DNA damage accumulated over time. #ResearchInsights #HealthScience
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
February 6, 2026 at 9:34 PM
Research by Satish Khurana's team suggests that frequent blood draws don't impair HSPC function. Instead, these events might help remove DNA damage accumulated over time. #ResearchInsights #HealthScience
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
wgbstools allows compact data formats, fragment-level analysis, and visualization to reveal biological structure in DNA methylation sequencing beyond single-CpG analysis, while preserving privacy.
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
February 6, 2026 at 4:04 PM
wgbstools allows compact data formats, fragment-level analysis, and visualization to reveal biological structure in DNA methylation sequencing beyond single-CpG analysis, while preserving privacy.
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
Upon FcgammaR-phagocytosis Syk is palmitoylated by DHHC5 and desulfenylated on nearby Cys residues, and both modifications are important for Syk phosphorylation and phagocytosis.
@irim-life.bsky.social
www.life-science-alliance.org/content/9/4/...
@irim-life.bsky.social
www.life-science-alliance.org/content/9/4/...
February 5, 2026 at 9:34 PM
Upon FcgammaR-phagocytosis Syk is palmitoylated by DHHC5 and desulfenylated on nearby Cys residues, and both modifications are important for Syk phosphorylation and phagocytosis.
@irim-life.bsky.social
www.life-science-alliance.org/content/9/4/...
@irim-life.bsky.social
www.life-science-alliance.org/content/9/4/...
📢 New research from Japan shows amyloid-β deposits disrupt placenta formation and may contribute to #preeclampsia in #pregnancy. Check out the Technology Networks summary of the study published in @lsajournal.org www.life-science-alliance.org/content/9/4/...
technologynetworks.com/tn/news/alzh...
technologynetworks.com/tn/news/alzh...
Alzheimer’s Proteins Linked to Placental Defects in Preeclampsia
Researchers found that low oxygen in preeclamptic placentas increases BACE1 activity and amyloid-β production. These proteins form fibrils that disrupt placental cell fusion by triggering excessive…
technologynetworks.com
February 5, 2026 at 4:04 PM
📢 New research from Japan shows amyloid-β deposits disrupt placenta formation and may contribute to #preeclampsia in #pregnancy. Check out the Technology Networks summary of the study published in @lsajournal.org www.life-science-alliance.org/content/9/4/...
technologynetworks.com/tn/news/alzh...
technologynetworks.com/tn/news/alzh...
This study demonstrates that YAP6SA promotes cardiomyocyte cell cycling through TEAD-independent pathways, suggesting a novel therapeutic approach for heart repair. @bingxie2026.bsky.social @bcmhouston.bsky.social
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
February 2, 2026 at 4:05 PM
This study demonstrates that YAP6SA promotes cardiomyocyte cell cycling through TEAD-independent pathways, suggesting a novel therapeutic approach for heart repair. @bingxie2026.bsky.social @bcmhouston.bsky.social
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
Our February issue is here! Read about transcription factors that regulate fungal development, machine learning identification of DNA repair factors, and a new strategy to improve lung transplantation. Plus much more: www.life-science-alliance.org/content/9/2
February 2, 2026 at 2:03 PM
Our February issue is here! Read about transcription factors that regulate fungal development, machine learning identification of DNA repair factors, and a new strategy to improve lung transplantation. Plus much more: www.life-science-alliance.org/content/9/2
This study from Satish Khurana's group from IISER Thiruvananthapuram shows a probable advantage of resulting proliferative events in clearing DNA damage accumulated with age. www.life-science-alliance.org/content/9/4/...
January 31, 2026 at 9:34 PM
This study from Satish Khurana's group from IISER Thiruvananthapuram shows a probable advantage of resulting proliferative events in clearing DNA damage accumulated with age. www.life-science-alliance.org/content/9/4/...
🧬Tool Alert: wgbstools! A computational suite for high-throughput methylation sequencing 📉 Ultra-compact storage 🔍 Single-molecule analysis 🎯 genome segmentation & DMR ID 💻 github.com/nloyfer/wgbs_tools 📄 Paper: www.life-science-alliance.org/content/9/4/...
January 31, 2026 at 4:04 PM
🧬Tool Alert: wgbstools! A computational suite for high-throughput methylation sequencing 📉 Ultra-compact storage 🔍 Single-molecule analysis 🎯 genome segmentation & DMR ID 💻 github.com/nloyfer/wgbs_tools 📄 Paper: www.life-science-alliance.org/content/9/4/...
Notch signaling is crucial for maintaining multiciliated cell balance by regulating cilia length and ensuring the proximal-distal gradient. Mycobacterium tuberculosis disrupts this by likely interfering with the Notch-PROM1 pathway. #CellBiology
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
January 30, 2026 at 9:34 PM
Notch signaling is crucial for maintaining multiciliated cell balance by regulating cilia length and ensuring the proximal-distal gradient. Mycobacterium tuberculosis disrupts this by likely interfering with the Notch-PROM1 pathway. #CellBiology
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
Exploring CTLA4 stabilization through the induced proximity of a deubiquitinating enzyme (DUB) offers a model for a detailed examination of DUB-target interactions, thereby enhancing ENTAC development strategies. #Biotech #Research
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
January 30, 2026 at 4:04 PM
Exploring CTLA4 stabilization through the induced proximity of a deubiquitinating enzyme (DUB) offers a model for a detailed examination of DUB-target interactions, thereby enhancing ENTAC development strategies. #Biotech #Research
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
🔬 Take a look at this research article:
Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast syncytialization @nishi-kazu.bsky.social @reviewcommons.org 👇
www.life-science-alliance.org/content/9/4/...
Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast syncytialization @nishi-kazu.bsky.social @reviewcommons.org 👇
www.life-science-alliance.org/content/9/4/...
January 29, 2026 at 4:04 PM
🔬 Take a look at this research article:
Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast syncytialization @nishi-kazu.bsky.social @reviewcommons.org 👇
www.life-science-alliance.org/content/9/4/...
Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast syncytialization @nishi-kazu.bsky.social @reviewcommons.org 👇
www.life-science-alliance.org/content/9/4/...
This work uncovers a non-canonical function of YAP, a downstream effector of the Hippo signaling pathway, in stimulating cardiomyocyte re-proliferation.
@bingxie2026.bsky.social @bcmhouston.bsky.social
www.life-science-alliance.org/content/9/4/...
@bingxie2026.bsky.social @bcmhouston.bsky.social
www.life-science-alliance.org/content/9/4/...
January 27, 2026 at 9:34 PM
This work uncovers a non-canonical function of YAP, a downstream effector of the Hippo signaling pathway, in stimulating cardiomyocyte re-proliferation.
@bingxie2026.bsky.social @bcmhouston.bsky.social
www.life-science-alliance.org/content/9/4/...
@bingxie2026.bsky.social @bcmhouston.bsky.social
www.life-science-alliance.org/content/9/4/...
This study provides evidence that synthesis of Reticulon-1 restrains Spastin-mediated microtubule severing with implications for cortical axon outgrowth after injury.
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
January 27, 2026 at 4:04 PM
This study provides evidence that synthesis of Reticulon-1 restrains Spastin-mediated microtubule severing with implications for cortical axon outgrowth after injury.
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
Reposted by Life Science Alliance
📣 #CallForPapers 📣 Emerging Research on Ion Channels in Health and Disease. Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca...
January 26, 2026 at 4:15 PM
📣 #CallForPapers 📣 Emerging Research on Ion Channels in Health and Disease. Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca...
Reposted by Life Science Alliance
Researchers have discovered that amyloid-β deposits - similar to those found in #Alzheimers disease - disrupt the formation of the #placenta and may therefore contribute to the development of #preeclampsia during #pregnancy. Their insights are published in @lsajournal.org.
Researchers link Alzheimer’s disease protein to preeclampsia
Study sheds new light on leading cause of medically-induced premature birth
healthcare-in-europe.com
January 27, 2026 at 7:34 AM
Researchers have discovered that amyloid-β deposits - similar to those found in #Alzheimers disease - disrupt the formation of the #placenta and may therefore contribute to the development of #preeclampsia during #pregnancy. Their insights are published in @lsajournal.org.
A new Research Article @lsajournal.org,:
Apicortin defines the Plasmodium apical conoid body but is dispensable for the parasite life cycle.
@Zeeshan_MF @RitaTewari
www.life-science-alliance.org/content/9/4/...
Apicortin defines the Plasmodium apical conoid body but is dispensable for the parasite life cycle.
@Zeeshan_MF @RitaTewari
www.life-science-alliance.org/content/9/4/...
January 26, 2026 at 9:34 PM
A new Research Article @lsajournal.org,:
Apicortin defines the Plasmodium apical conoid body but is dispensable for the parasite life cycle.
@Zeeshan_MF @RitaTewari
www.life-science-alliance.org/content/9/4/...
Apicortin defines the Plasmodium apical conoid body but is dispensable for the parasite life cycle.
@Zeeshan_MF @RitaTewari
www.life-science-alliance.org/content/9/4/...
Combining super-resolution imaging and machine learning, we reveal that C. thermocellum shifts from a microbe-mediated strategy to dynamic cellulosome redistribution during growth on insoluble substrates.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
January 26, 2026 at 4:04 PM
Combining super-resolution imaging and machine learning, we reveal that C. thermocellum shifts from a microbe-mediated strategy to dynamic cellulosome redistribution during growth on insoluble substrates.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
Notch signaling regulates multiciliated cell homeostasis by stabilizing ciliary length and maintaining the proximal–distal gradient. This process is disrupted during Mycobacterium tuberculosis infection, likely via suppression of the Notch–PROM1 axis.
www.life-science-alliance.org/content/9/3/....
www.life-science-alliance.org/content/9/3/....
January 24, 2026 at 4:04 PM
Notch signaling regulates multiciliated cell homeostasis by stabilizing ciliary length and maintaining the proximal–distal gradient. This process is disrupted during Mycobacterium tuberculosis infection, likely via suppression of the Notch–PROM1 axis.
www.life-science-alliance.org/content/9/3/....
www.life-science-alliance.org/content/9/3/....