Journal of General Physiology
@jgp.org
Journal of General Physiology publishes research in physiological problems at cellular and molecular level - Published by Rockefeller University Press @rupress.org
🌐 rupress.org/jgp
🌐 rupress.org/jgp
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📣#CallForPapers on the topic of SGP's (@sgpweb.bsky.social) 2025 Symposium “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) Learn more and submit your research 👉 rupress.org/JGP/pages/ca...
Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture, say Leander Vonk, Osman Esen, Tyler Kirby and colleagues @amsterdamumc.bsky.social: rupress.org/jgp/article/...
#CellBiology #CellularPhysiology #Contraction #SkeletalMuscle
#CellBiology #CellularPhysiology #Contraction #SkeletalMuscle
November 10, 2025 at 3:15 PM
Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture, say Leander Vonk, Osman Esen, Tyler Kirby and colleagues @amsterdamumc.bsky.social: rupress.org/jgp/article/...
#CellBiology #CellularPhysiology #Contraction #SkeletalMuscle
#CellBiology #CellularPhysiology #Contraction #SkeletalMuscle
📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers
#IonChannels #CallForPapers
November 5, 2025 at 9:45 PM
📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers
#IonChannels #CallForPapers
De Giorgis, Neely et al. show that the auxiliary β-subunit remodels only voltage sensor II and its allosteric contribution to CaV1.2 channel opening upon the translocation of two charges before reaching full activation. rupress.org/jgp/article/...
#IonChannels
#IonChannels
November 5, 2025 at 5:02 PM
De Giorgis, Neely et al. show that the auxiliary β-subunit remodels only voltage sensor II and its allosteric contribution to CaV1.2 channel opening upon the translocation of two charges before reaching full activation. rupress.org/jgp/article/...
#IonChannels
#IonChannels
Vonk, Esen, Kirby et al. @amsterdamumc.bsky.social report that 3D culture environments preserve #muscle fiber health and contractility better than 2D systems, offering an improved model for drug screening and testing genetic interventions. rupress.org/jgp/article/...
November 3, 2025 at 5:01 PM
Vonk, Esen, Kirby et al. @amsterdamumc.bsky.social report that 3D culture environments preserve #muscle fiber health and contractility better than 2D systems, offering an improved model for drug screening and testing genetic interventions. rupress.org/jgp/article/...
JGP's November issue is here! rupress.org/jgp/issue/15...
In the retina of a Trpm1-knockout mouse, rod bipolar cell axon terminals (PKCα, green) are smaller and show an altered distribution relative to starburst amacrine cells (ChAT, magenta).
From Horie et al. doi.org/10.1085/jgp....
In the retina of a Trpm1-knockout mouse, rod bipolar cell axon terminals (PKCα, green) are smaller and show an altered distribution relative to starburst amacrine cells (ChAT, magenta).
From Horie et al. doi.org/10.1085/jgp....
November 3, 2025 at 3:04 PM
JGP's November issue is here! rupress.org/jgp/issue/15...
In the retina of a Trpm1-knockout mouse, rod bipolar cell axon terminals (PKCα, green) are smaller and show an altered distribution relative to starburst amacrine cells (ChAT, magenta).
From Horie et al. doi.org/10.1085/jgp....
In the retina of a Trpm1-knockout mouse, rod bipolar cell axon terminals (PKCα, green) are smaller and show an altered distribution relative to starburst amacrine cells (ChAT, magenta).
From Horie et al. doi.org/10.1085/jgp....
Reposted by Journal of General Physiology
⏰ Abstract deadline tomorrow! Join us in Grindelwald, Feb 4–6, 2026 Worldwide Sodium Channel Conference!
Robert Stewart (Harvard) talks on Nav1.8 inhibition & new Nav blockers for pain 💥Accepted abstracts → special issue @jgp.org👉 sodiumchannelconference2026.org
#WSCC26 #SodiumChannels #PainResearch
Robert Stewart (Harvard) talks on Nav1.8 inhibition & new Nav blockers for pain 💥Accepted abstracts → special issue @jgp.org👉 sodiumchannelconference2026.org
#WSCC26 #SodiumChannels #PainResearch
November 1, 2025 at 8:21 AM
⏰ Abstract deadline tomorrow! Join us in Grindelwald, Feb 4–6, 2026 Worldwide Sodium Channel Conference!
Robert Stewart (Harvard) talks on Nav1.8 inhibition & new Nav blockers for pain 💥Accepted abstracts → special issue @jgp.org👉 sodiumchannelconference2026.org
#WSCC26 #SodiumChannels #PainResearch
Robert Stewart (Harvard) talks on Nav1.8 inhibition & new Nav blockers for pain 💥Accepted abstracts → special issue @jgp.org👉 sodiumchannelconference2026.org
#WSCC26 #SodiumChannels #PainResearch
Altered Naᵥ1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction. new study from Noortje van den Braak, Maike Dohrn and colleagues @rwth.bsky.social: rupress.org/jgp/article/...
#Pathophysiology #MolecularPhysiology #Nerve
#Pathophysiology #MolecularPhysiology #Nerve
October 31, 2025 at 1:45 PM
Altered Naᵥ1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction. new study from Noortje van den Braak, Maike Dohrn and colleagues @rwth.bsky.social: rupress.org/jgp/article/...
#Pathophysiology #MolecularPhysiology #Nerve
#Pathophysiology #MolecularPhysiology #Nerve
The origins of oscillations. Horie et al. (doi.org/10.1085/jgp....) explain why mice lacking TRPM1 exhibit oscillatory firing of their retinal ganglion cells, & suggest that the same mechanism causes similar oscillations in other outer retinal diseases. In Research News: rupress.org/jgp/article/...
October 29, 2025 at 2:31 PM
The origins of oscillations. Horie et al. (doi.org/10.1085/jgp....) explain why mice lacking TRPM1 exhibit oscillatory firing of their retinal ganglion cells, & suggest that the same mechanism causes similar oscillations in other outer retinal diseases. In Research News: rupress.org/jgp/article/...
📣 Call for Papers! 📣 You are invited to submit your research on Voltage-Gated Sodium Channels. Submit your paper by September 30, 2026, to be highlighted in a special issue. Learn more 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers #WSCC26
#IonChannels #CallForPapers #WSCC26
October 29, 2025 at 2:15 PM
📣 Call for Papers! 📣 You are invited to submit your research on Voltage-Gated Sodium Channels. Submit your paper by September 30, 2026, to be highlighted in a special issue. Learn more 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers #WSCC26
#IonChannels #CallForPapers #WSCC26
Reposted by Journal of General Physiology
We’re thrilled to welcome the Journal of General Physiology @jgp.org @rupress.org to our Affiliate Program! 🎉
Authors can now seamlessly transfer their #peerreviewedpreprint @reviewcommons.org @embo.org to JGP via our transfer portal.
Excited to start this new chapter with JGP @rupress.org!
Authors can now seamlessly transfer their #peerreviewedpreprint @reviewcommons.org @embo.org to JGP via our transfer portal.
Excited to start this new chapter with JGP @rupress.org!
October 29, 2025 at 9:06 AM
We’re thrilled to welcome the Journal of General Physiology @jgp.org @rupress.org to our Affiliate Program! 🎉
Authors can now seamlessly transfer their #peerreviewedpreprint @reviewcommons.org @embo.org to JGP via our transfer portal.
Excited to start this new chapter with JGP @rupress.org!
Authors can now seamlessly transfer their #peerreviewedpreprint @reviewcommons.org @embo.org to JGP via our transfer portal.
Excited to start this new chapter with JGP @rupress.org!
Reposted by Journal of General Physiology
🎙️ José Ángel Aibar, President of the Dravet Syndrome Foundation, joins #WSCC26 (Feb 4–6, 2026, Grindelwald 🇨🇭) to talk about advancing collaboration & discovery in Dravet syndrome.
🧠 Abstracts due Nov 2 – all published in a JGP special issue!
🔗 sodiumchannelconference2026.org/WELCOME/
🧠 Abstracts due Nov 2 – all published in a JGP special issue!
🔗 sodiumchannelconference2026.org/WELCOME/
October 29, 2025 at 10:10 AM
🎙️ José Ángel Aibar, President of the Dravet Syndrome Foundation, joins #WSCC26 (Feb 4–6, 2026, Grindelwald 🇨🇭) to talk about advancing collaboration & discovery in Dravet syndrome.
🧠 Abstracts due Nov 2 – all published in a JGP special issue!
🔗 sodiumchannelconference2026.org/WELCOME/
🧠 Abstracts due Nov 2 – all published in a JGP special issue!
🔗 sodiumchannelconference2026.org/WELCOME/
In two individuals w/ small fiber neuropathy carrying the p.(Tyr66Ser) variant in SCN11A, van den Braak, Dohrn et al. @rwth.bsky.social observed on/off-like axon hyperexcitability upon sine-wave stimulation, correlating w/ patch-clamp results of the Naᵥ1.9 channel variant rupress.org/jgp/article/...
October 24, 2025 at 4:33 PM
In two individuals w/ small fiber neuropathy carrying the p.(Tyr66Ser) variant in SCN11A, van den Braak, Dohrn et al. @rwth.bsky.social observed on/off-like axon hyperexcitability upon sine-wave stimulation, correlating w/ patch-clamp results of the Naᵥ1.9 channel variant rupress.org/jgp/article/...
A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness. New study from Sho Horie, Katsunori Kitano, Masao Tachibana, Chieko Koike and colleagues (Ritsumeikan University): rupress.org/jgp/article/...
#Neuroscience #Pathophysiology #CellularPhysiology
#Neuroscience #Pathophysiology #CellularPhysiology
October 23, 2025 at 1:15 PM
A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness. New study from Sho Horie, Katsunori Kitano, Masao Tachibana, Chieko Koike and colleagues (Ritsumeikan University): rupress.org/jgp/article/...
#Neuroscience #Pathophysiology #CellularPhysiology
#Neuroscience #Pathophysiology #CellularPhysiology
Latest in Research News: new study from Horie et al. (doi.org/10.1085/jgp....) explains why mice lacking TRPM1 exhibit oscillatory firing of their retinal ganglion cells, and suggests that the same mechanism causes similar oscillations in other outer retinal diseases. rupress.org/jgp/article/...
October 22, 2025 at 4:30 PM
Latest in Research News: new study from Horie et al. (doi.org/10.1085/jgp....) explains why mice lacking TRPM1 exhibit oscillatory firing of their retinal ganglion cells, and suggests that the same mechanism causes similar oscillations in other outer retinal diseases. rupress.org/jgp/article/...
#SUMOylation and an ATS1 variant converge to disrupt PIP₂-dependent gating of Kir2.1, say Aishwarya Chandrashekar, Leigh Plant and colleagues @nubouve.bsky.social: rupress.org/jgp/article/...
#Pathophysiology #IonChannels #SignalTransduction #CellularPhysiology #MolecularPhysiology
#Pathophysiology #IonChannels #SignalTransduction #CellularPhysiology #MolecularPhysiology
October 21, 2025 at 3:31 PM
#SUMOylation and an ATS1 variant converge to disrupt PIP₂-dependent gating of Kir2.1, say Aishwarya Chandrashekar, Leigh Plant and colleagues @nubouve.bsky.social: rupress.org/jgp/article/...
#Pathophysiology #IonChannels #SignalTransduction #CellularPhysiology #MolecularPhysiology
#Pathophysiology #IonChannels #SignalTransduction #CellularPhysiology #MolecularPhysiology
Voltage-gated sodium channels: Mechanisms, disease, and a growing research community. Hugues Abriel and Angelika Lampert (@lampertlab.bsky.social) introduce the Special Issue (rupress.org/jgp/search-r...) illustrating the richness and continuing momentum of this field. rupress.org/jgp/article/...
October 17, 2025 at 1:31 PM
Voltage-gated sodium channels: Mechanisms, disease, and a growing research community. Hugues Abriel and Angelika Lampert (@lampertlab.bsky.social) introduce the Special Issue (rupress.org/jgp/search-r...) illustrating the richness and continuing momentum of this field. rupress.org/jgp/article/...
Horie, Kitano, Tachibana, Koike et al. show that TRPM1 deficiency in ON bipolar cells produces retinal ganglion cell oscillations in association with rod bipolar cell axon remodeling and reduced ON bipolar cell outputs rupress.org/jgp/article/...
#Neuroscience
#Neuroscience
October 16, 2025 at 6:01 PM
Horie, Kitano, Tachibana, Koike et al. show that TRPM1 deficiency in ON bipolar cells produces retinal ganglion cell oscillations in association with rod bipolar cell axon remodeling and reduced ON bipolar cell outputs rupress.org/jgp/article/...
#Neuroscience
#Neuroscience
📣 #CallForPapers Reminder on the topic of SGP's (@sgpweb.bsky.social) 2025 Symposium “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) Deadline: December 15. Learn more and submit your research. 👉 rupress.org/JGP/pages/ca...
October 15, 2025 at 3:04 PM
📣 #CallForPapers Reminder on the topic of SGP's (@sgpweb.bsky.social) 2025 Symposium “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) Deadline: December 15. Learn more and submit your research. 👉 rupress.org/JGP/pages/ca...
Chandrashekar, Plant et al. @nubouve.bsky.social shows that #hypoxia-induced #SUMOylation and the Andersen-Tawil syndrome type 1-linked Kir2.1 mutation, R67Q, converge to impair channel function by destabilizing interactions with PIP₂. rupress.org/jgp/article/...
#IonChannels
#IonChannels
October 14, 2025 at 4:00 PM
Chandrashekar, Plant et al. @nubouve.bsky.social shows that #hypoxia-induced #SUMOylation and the Andersen-Tawil syndrome type 1-linked Kir2.1 mutation, R67Q, converge to impair channel function by destabilizing interactions with PIP₂. rupress.org/jgp/article/...
#IonChannels
#IonChannels
Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice. A new study from Rosa Scala, Colin Nichols et al. @colinnicholslab.bsky.social rupress.org/jgp/article/...
#IonChannels #MolecularPhysiology #Pathophysiology #SkeletalMuscle
#IonChannels #MolecularPhysiology #Pathophysiology #SkeletalMuscle
Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice
We assessed skeletal muscle properties in GOF knock-in mouse models of Cantu Syndrome. In isolated myofibers there was enhanced Mg-nucleotide activation in
rupress.org
October 14, 2025 at 2:13 PM
Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice. A new study from Rosa Scala, Colin Nichols et al. @colinnicholslab.bsky.social rupress.org/jgp/article/...
#IonChannels #MolecularPhysiology #Pathophysiology #SkeletalMuscle
#IonChannels #MolecularPhysiology #Pathophysiology #SkeletalMuscle
Cortical spreading depression dynamics are altered by topical D2 receptor ligands, say Sonia Carolina Guerrero Prieto, Michael Cabrera Baez, and Rubem Carlos Araújo Guedes
rupress.org/jgp/article/...
#Neuroscience #ComputationalBiology #MolecularPharmacology #SystemsPhysiology
rupress.org/jgp/article/...
#Neuroscience #ComputationalBiology #MolecularPharmacology #SystemsPhysiology
Cortical spreading depression dynamics are altered by topical D2 receptor ligands
Topical application of D2 receptor ligands modulates CSD propagation in a ligand- and time-dependent manner. Electrophysiological and immunohistochemical a
rupress.org
October 14, 2025 at 1:45 PM
Cortical spreading depression dynamics are altered by topical D2 receptor ligands, say Sonia Carolina Guerrero Prieto, Michael Cabrera Baez, and Rubem Carlos Araújo Guedes
rupress.org/jgp/article/...
#Neuroscience #ComputationalBiology #MolecularPharmacology #SystemsPhysiology
rupress.org/jgp/article/...
#Neuroscience #ComputationalBiology #MolecularPharmacology #SystemsPhysiology
This Special Issue rupress.org/jgp/search-r... brings together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, & structure-function analysis of voltage-gated sodium channels. Editorial by Abriel & @lampertlab.bsky.social: rupress.org/jgp/article/...
October 10, 2025 at 4:01 PM
This Special Issue rupress.org/jgp/search-r... brings together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, & structure-function analysis of voltage-gated sodium channels. Editorial by Abriel & @lampertlab.bsky.social: rupress.org/jgp/article/...
PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating, say Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G. Nichols, and Sun-Joo Lee rupress.org/jgp/article/...
@colinnicholslab.bsky.social
#IonChannels #Phospholipids
@colinnicholslab.bsky.social
#IonChannels #Phospholipids
October 10, 2025 at 1:26 PM
PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating, say Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G. Nichols, and Sun-Joo Lee rupress.org/jgp/article/...
@colinnicholslab.bsky.social
#IonChannels #Phospholipids
@colinnicholslab.bsky.social
#IonChannels #Phospholipids
Reposted by Journal of General Physiology
A reminder to join us for the SGP Cranefield Award Talks, taking place tomorrow, 8 October, from 12:00 pm to 1:30 pm Eastern. Register (no fee) at bit.ly/sgp2025crane....
October 7, 2025 at 9:43 PM
A reminder to join us for the SGP Cranefield Award Talks, taking place tomorrow, 8 October, from 12:00 pm to 1:30 pm Eastern. Register (no fee) at bit.ly/sgp2025crane....
Reposted by Journal of General Physiology
Check out our new publication "PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating" 🧪
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Eva-Maria Zangerl-Plessl, Sun-Joo Lee, et al. utilized MD simulations to reveal that PIP2 potentiated clockwise twisting motions in individual Kir2 #IonChannel cytoplasmic subunits, as well as concerted dynamics among the four subunits. rupress.org/jgp/article/...
@colinnicholslab.bsky.social
@colinnicholslab.bsky.social
October 7, 2025 at 8:40 PM
Check out our new publication "PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating" 🧪
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