Journal of General Physiology
@jgp.org
Journal of General Physiology publishes research in physiological problems at cellular and molecular level - Published by Rockefeller University Press @rupress.org
🌐 rupress.org/jgp
🌐 rupress.org/jgp
Pinned
📣#CallForPapers on the topic of SGP's (@sgpweb.bsky.social) 2025 Symposium “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) Learn more and submit your research 👉 rupress.org/JGP/pages/ca...
A critical residue mediates proper assembly and gating of GIRK2 channels. New study from Ha Nguyen, Paul A. Slesinger and colleagues @sinaibrain.bsky.social: rupress.org/jgp/article/...
#Biochemistry #MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics #IonChannels
#Biochemistry #MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics #IonChannels
December 26, 2025 at 3:15 PM
A critical residue mediates proper assembly and gating of GIRK2 channels. New study from Ha Nguyen, Paul A. Slesinger and colleagues @sinaibrain.bsky.social: rupress.org/jgp/article/...
#Biochemistry #MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics #IonChannels
#Biochemistry #MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics #IonChannels
🔔 #CallForPapers on Chloride Channels and Transporters: NEW DEADLINE January 30, 2026 ⏰ We welcome papers on diverse membrane protein families involved in transporting anions 👉 rupress.org/JGP/pages/ca...
@sgpweb.bsky.social
@sgpweb.bsky.social
December 26, 2025 at 3:03 PM
🔔 #CallForPapers on Chloride Channels and Transporters: NEW DEADLINE January 30, 2026 ⏰ We welcome papers on diverse membrane protein families involved in transporting anions 👉 rupress.org/JGP/pages/ca...
@sgpweb.bsky.social
@sgpweb.bsky.social
Exploring voltage-gated sodium channel conformations and protein-protein interactions using #AlphaFold2. New study from Diego Lopez-Mateos, Kush Narang, & Vladimir Yarov-Yarovoy (@vyy-sf.bsky.social) @ucd-physiology.bsky.social: rupress.org/jgp/article/...
#ProteinStructure #Biophysics #IonChannels
#ProteinStructure #Biophysics #IonChannels
December 25, 2025 at 8:01 PM
Exploring voltage-gated sodium channel conformations and protein-protein interactions using #AlphaFold2. New study from Diego Lopez-Mateos, Kush Narang, & Vladimir Yarov-Yarovoy (@vyy-sf.bsky.social) @ucd-physiology.bsky.social: rupress.org/jgp/article/...
#ProteinStructure #Biophysics #IonChannels
#ProteinStructure #Biophysics #IonChannels
Caᵥβ dances the two-step with VSD II. New JGP study from De Giorgis et al. (rupress.org/jgp/article/...) reveals that the auxiliary Caᵥβ₃ subunit regulates the cardiac calcium channel Caᵥ1.2 by modulating the two-step activation of VSD II. More in Research News: rupress.org/jgp/article/...
December 25, 2025 at 2:45 PM
Caᵥβ dances the two-step with VSD II. New JGP study from De Giorgis et al. (rupress.org/jgp/article/...) reveals that the auxiliary Caᵥβ₃ subunit regulates the cardiac calcium channel Caᵥ1.2 by modulating the two-step activation of VSD II. More in Research News: rupress.org/jgp/article/...
Allosteric coupling of RyR calcium channels. Is it relevant to the [patho]physiology of heart and muscle? New review from Eduardo Rios (Rush University): rupress.org/jgp/article/...
#CardiacMuscle #SkeletalMuscle #ComputationalBiology #Biophysics
#CardiacMuscle #SkeletalMuscle #ComputationalBiology #Biophysics
December 24, 2025 at 3:45 PM
Allosteric coupling of RyR calcium channels. Is it relevant to the [patho]physiology of heart and muscle? New review from Eduardo Rios (Rush University): rupress.org/jgp/article/...
#CardiacMuscle #SkeletalMuscle #ComputationalBiology #Biophysics
#CardiacMuscle #SkeletalMuscle #ComputationalBiology #Biophysics
Nguyen et al. @sinaibrain.bsky.social show that Arg-92 in GIRK2 is essential for PIP2-dependent gating, with substitutions causing structural rearrangements that disrupt G protein & alcohol activation—likely a conserved mechanism among inward rectifier potassium channels rupress.org/jgp/article/...
December 19, 2025 at 5:00 PM
Nguyen et al. @sinaibrain.bsky.social show that Arg-92 in GIRK2 is essential for PIP2-dependent gating, with substitutions causing structural rearrangements that disrupt G protein & alcohol activation—likely a conserved mechanism among inward rectifier potassium channels rupress.org/jgp/article/...
On the mechanism of K⁺ transport through the inter-subunit tunnel of KdpFABC. New study from Hridya Valia Madapally, Himanshu Khandelia @khandeliagroup.bsky.social and colleagues @sdu.dk: rupress.org/jgp/article/...
#MembraneTransport #ProteinStructure #ProteinDynamics #Biophysics
#MembraneTransport #ProteinStructure #ProteinDynamics #Biophysics
December 19, 2025 at 2:15 PM
On the mechanism of K⁺ transport through the inter-subunit tunnel of KdpFABC. New study from Hridya Valia Madapally, Himanshu Khandelia @khandeliagroup.bsky.social and colleagues @sdu.dk: rupress.org/jgp/article/...
#MembraneTransport #ProteinStructure #ProteinDynamics #Biophysics
#MembraneTransport #ProteinStructure #ProteinDynamics #Biophysics
Reposted by Journal of General Physiology
Rounding out 2025 with a new @jgp.org article! @vyy-sf.bsky.social
New study from Lopez-Mateos, Narang, and @vyy-sf.bsky.social @ucd-physiology.bsky.social reveals potential of #DeepLearning methods to model multiple states of human voltage-gated sodium channels and their interactions with β-subunits and calmodulin. rupress.org/jgp/article/...
#IonChannels
#IonChannels
December 18, 2025 at 10:13 PM
Rounding out 2025 with a new @jgp.org article! @vyy-sf.bsky.social
New study from Lopez-Mateos, Narang, and @vyy-sf.bsky.social @ucd-physiology.bsky.social reveals potential of #DeepLearning methods to model multiple states of human voltage-gated sodium channels and their interactions with β-subunits and calmodulin. rupress.org/jgp/article/...
#IonChannels
#IonChannels
December 18, 2025 at 7:47 PM
New study from Lopez-Mateos, Narang, and @vyy-sf.bsky.social @ucd-physiology.bsky.social reveals potential of #DeepLearning methods to model multiple states of human voltage-gated sodium channels and their interactions with β-subunits and calmodulin. rupress.org/jgp/article/...
#IonChannels
#IonChannels
Towards a unified gating scheme for the CNBD ion channel family. A new study from Jenna Lin and Baron Chanda: rupress.org/jgp/article/...
#Biophysics #IonChannels
#Biophysics #IonChannels
December 18, 2025 at 6:34 PM
Towards a unified gating scheme for the CNBD ion channel family. A new study from Jenna Lin and Baron Chanda: rupress.org/jgp/article/...
#Biophysics #IonChannels
#Biophysics #IonChannels
Our latest Research News: JGP study (De Giorgis et al. rupress.org/jgp/article/...) reveals that the auxiliary Caᵥβ₃ subunit regulates the cardiac calcium channel Caᵥ1.2 by modulating the two-step activation of VSD II. rupress.org/jgp/article/...
#IonChannels
#IonChannels
December 18, 2025 at 5:02 PM
Our latest Research News: JGP study (De Giorgis et al. rupress.org/jgp/article/...) reveals that the auxiliary Caᵥβ₃ subunit regulates the cardiac calcium channel Caᵥ1.2 by modulating the two-step activation of VSD II. rupress.org/jgp/article/...
#IonChannels
#IonChannels
Eduardo Rios reviews the relevance for physiology and pathophysiology of the synchronous gating of sarco-endoplasmic reticulum Ca²⁺ release channels, reported in bilayer reconstitution experiments. rupress.org/jgp/article/...
#Biophysics #CardiacMuscle #ComputationalBiology #SkeletalMuscle
#Biophysics #CardiacMuscle #ComputationalBiology #SkeletalMuscle
December 17, 2025 at 5:15 PM
Eduardo Rios reviews the relevance for physiology and pathophysiology of the synchronous gating of sarco-endoplasmic reticulum Ca²⁺ release channels, reported in bilayer reconstitution experiments. rupress.org/jgp/article/...
#Biophysics #CardiacMuscle #ComputationalBiology #SkeletalMuscle
#Biophysics #CardiacMuscle #ComputationalBiology #SkeletalMuscle
🔔 #CallForPapers on Chloride Channels and Transporters: DEADLINE EXTENDED to January 30, 2026 ⏰ We welcome papers on diverse membrane protein families involved in transporting anions 👉 rupress.org/JGP/pages/ca...
@sgpweb.bsky.social
@sgpweb.bsky.social
December 16, 2025 at 6:30 PM
🔔 #CallForPapers on Chloride Channels and Transporters: DEADLINE EXTENDED to January 30, 2026 ⏰ We welcome papers on diverse membrane protein families involved in transporting anions 👉 rupress.org/JGP/pages/ca...
@sgpweb.bsky.social
@sgpweb.bsky.social
Madapally et al. @khandeliagroup.bsky.social @sdu.dk show that the potassium pump KdpFABC's inter-subunit tunnel is mainly water-filled & has a single stable K+ site, challenging the idea of a continuous ion-wire and highlighting a key barrier at the KdpA-KdpB interface. rupress.org/jgp/article/...
December 12, 2025 at 5:00 PM
Madapally et al. @khandeliagroup.bsky.social @sdu.dk show that the potassium pump KdpFABC's inter-subunit tunnel is mainly water-filled & has a single stable K+ site, challenging the idea of a continuous ion-wire and highlighting a key barrier at the KdpA-KdpB interface. rupress.org/jgp/article/...
Hiro Furukawa @lab-furukawa.bsky.social @cshlnews.bsky.social provides commentary on new work by Lotti et al. (rupress.org/jgp/article/...) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. rupress.org/jgp/article/...
December 12, 2025 at 3:05 PM
Hiro Furukawa @lab-furukawa.bsky.social @cshlnews.bsky.social provides commentary on new work by Lotti et al. (rupress.org/jgp/article/...) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. rupress.org/jgp/article/...
Jenna Lin and Baron Chanda compare different gating models to account for the diverse gating phenotypes observed across the cyclic nucleotide-binding domain (CNBD) family, including those arising from targeted mutations and chimeragenesis. rupress.org/jgp/article/...
#Biophysics #IonChannels
#Biophysics #IonChannels
December 11, 2025 at 4:33 PM
Jenna Lin and Baron Chanda compare different gating models to account for the diverse gating phenotypes observed across the cyclic nucleotide-binding domain (CNBD) family, including those arising from targeted mutations and chimeragenesis. rupress.org/jgp/article/...
#Biophysics #IonChannels
#Biophysics #IonChannels
Subtype-selective targeting of #NMDA receptors - A potent new compound emerges. New commentary from Hiro Furukawa @lab-furukawa.bsky.social @cshlnews.bsky.social on study work by Lotti and colleagues (rupress.org/jgp/article/...): rupress.org/jgp/article/...
December 10, 2025 at 7:30 PM
Subtype-selective targeting of #NMDA receptors - A potent new compound emerges. New commentary from Hiro Furukawa @lab-furukawa.bsky.social @cshlnews.bsky.social on study work by Lotti and colleagues (rupress.org/jgp/article/...): rupress.org/jgp/article/...
Novel binding mode for negative allosteric #NMDA receptor modulators, from James Lotti, Rasmus Clausen @ucph.bsky.social, Kasper Hansen and colleagues @umontana.bsky.social: rupress.org/jgp/article/...
#MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics
#MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics
December 10, 2025 at 3:15 PM
Novel binding mode for negative allosteric #NMDA receptor modulators, from James Lotti, Rasmus Clausen @ucph.bsky.social, Kasper Hansen and colleagues @umontana.bsky.social: rupress.org/jgp/article/...
#MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics
#MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics
Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel. New study from Akshay Sharma, Mitchell Goldfarb and collegaues @huntercollege.bsky.social: rupress.org/jgp/article/...
#IonChannels
#IonChannels
December 9, 2025 at 3:45 PM
Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel. New study from Akshay Sharma, Mitchell Goldfarb and collegaues @huntercollege.bsky.social: rupress.org/jgp/article/...
#IonChannels
#IonChannels
📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers
#IonChannels #CallForPapers
December 4, 2025 at 3:15 PM
📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers
#IonChannels #CallForPapers
New study from Lotti, Clausen, Hansen et al. @umontana.bsky.social describes a novel negative allosteric modulator that engages previously unexplored structural determinants in an allosteric binding site between #NMDA receptor subunits rupress.org/jgp/article/...
#MolecularPharmacology #Biophysics
#MolecularPharmacology #Biophysics
December 3, 2025 at 5:01 PM
New study from Lotti, Clausen, Hansen et al. @umontana.bsky.social describes a novel negative allosteric modulator that engages previously unexplored structural determinants in an allosteric binding site between #NMDA receptor subunits rupress.org/jgp/article/...
#MolecularPharmacology #Biophysics
#MolecularPharmacology #Biophysics
Sharma, Goldfarb et al. @huntercollege.bsky.social show the differential effects of CTD missense mutations on cardiac sodium channel activation, inactivation, persistent current, & accessory protein modulation and suggest the structural bases for these mutational effects. rupress.org/jgp/article/...
December 2, 2025 at 5:00 PM
Sharma, Goldfarb et al. @huntercollege.bsky.social show the differential effects of CTD missense mutations on cardiac sodium channel activation, inactivation, persistent current, & accessory protein modulation and suggest the structural bases for these mutational effects. rupress.org/jgp/article/...
β2 and β3a regulatory subunits can coassemble in the same BK channels, say Yu Zhou, Christopher Lingle (@chris-lingle.bsky.social) and colleagues @washumedicine.bsky.social: rupress.org/jgp/article/...
#CellularPhysiology #IntercellularSignaling #Biochemistry #Biophysics #IonChannels
#CellularPhysiology #IntercellularSignaling #Biochemistry #Biophysics #IonChannels
December 2, 2025 at 3:30 PM
β2 and β3a regulatory subunits can coassemble in the same BK channels, say Yu Zhou, Christopher Lingle (@chris-lingle.bsky.social) and colleagues @washumedicine.bsky.social: rupress.org/jgp/article/...
#CellularPhysiology #IntercellularSignaling #Biochemistry #Biophysics #IonChannels
#CellularPhysiology #IntercellularSignaling #Biochemistry #Biophysics #IonChannels
Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility, say Alejandro Alvarez-Arce, David Barefield @barefieldlab.bsky.social and colleagues @loyolachicago.bsky.social: rupress.org/jgp/article/...
#Myofilaments #CardiacMuscle
#Myofilaments #CardiacMuscle
November 26, 2025 at 3:45 PM
Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility, say Alejandro Alvarez-Arce, David Barefield @barefieldlab.bsky.social and colleagues @loyolachicago.bsky.social: rupress.org/jgp/article/...
#Myofilaments #CardiacMuscle
#Myofilaments #CardiacMuscle
Reposted by Journal of General Physiology
Simply a super paper! Beautiful and profound.
Yu Zhou, @chris-lingle.bsky.social et al. ask whether distinct β subunit isoforms coassemble in BK channel complexes or segregate into different complexes. They show that ternary β2:β3:α complexes form, consistent with a trinomial model of random mixing of β subunits. rupress.org/jgp/article/...
November 25, 2025 at 7:43 PM
Simply a super paper! Beautiful and profound.