I just received a 50% discount to watch my own presentation, at a conference for which I paid my own travel, lodging, and registration!
Wow! Love the business model!
#FASEB #IonChannels
Wow! Love the business model!
#FASEB #IonChannels
October 31, 2025 at 7:26 PM
I just received a 50% discount to watch my own presentation, at a conference for which I paid my own travel, lodging, and registration!
Wow! Love the business model!
#FASEB #IonChannels
Wow! Love the business model!
#FASEB #IonChannels
Exciting, provocative work from Radu and Claudio. These asymmetric intermediates of the GABA receptor diverge wildly from decades of dreams and wishes about how #ionchannels gate.
The mangled desensitized channel, with lipid invading,
could be a general principle.
www.biorxiv.org/content/10.1...
The mangled desensitized channel, with lipid invading,
could be a general principle.
www.biorxiv.org/content/10.1...
GABAA receptor gating imaged on the millisecond timescale
Type-A γ-aminobutyric receptors (GABAARs) are fast pentameric ligand gated ion channels (pLGICs)[1][1]–[5][2]. Within a millisecond, saturating agonist concentrations trigger activity bursts consistin...
www.biorxiv.org
October 13, 2025 at 6:09 PM
Exciting, provocative work from Radu and Claudio. These asymmetric intermediates of the GABA receptor diverge wildly from decades of dreams and wishes about how #ionchannels gate.
The mangled desensitized channel, with lipid invading,
could be a general principle.
www.biorxiv.org/content/10.1...
The mangled desensitized channel, with lipid invading,
could be a general principle.
www.biorxiv.org/content/10.1...
Investigating the Role of the I–II Linker in Nav1.5 Channel Function. New study from Emily Wagner, Jonathan Silva and colleagues @washuengineers.bsky.social: rupress.org/jgp/article/...
#Biophysics #Pathophysiology #IonChannels
#Biophysics #Pathophysiology #IonChannels
September 11, 2025 at 2:31 PM
Investigating the Role of the I–II Linker in Nav1.5 Channel Function. New study from Emily Wagner, Jonathan Silva and colleagues @washuengineers.bsky.social: rupress.org/jgp/article/...
#Biophysics #Pathophysiology #IonChannels
#Biophysics #Pathophysiology #IonChannels
An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities | Journal of General Physiology
#ionchannels
#openaccess
https://buff.ly/4fK0lSd
#ionchannels
#openaccess
https://buff.ly/4fK0lSd
November 28, 2024 at 11:39 AM
An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities | Journal of General Physiology
#ionchannels
#openaccess
https://buff.ly/4fK0lSd
#ionchannels
#openaccess
https://buff.ly/4fK0lSd
How does suzetrigine work!?... It targets the VSD2 domain of NaV1.8 channels, stabilizing their closed state and blocking pain signals! #pharmacology #ionchannels #painmanagement link.springer.com/article/10.1...
Pharmacology and Mechanism of Action of Suzetrigine, a Potent and Selective NaV1.8 Pain Signal Inhibitor for the Treatment of Moderate to Severe Pain - Pain and Therapy
Introduction There is a high unmet need for safe and effective non-opioid medicines to treat moderate to severe pain without risk of addiction. Voltage-gated sodium channel 1.8 (NaV1.8) is a genetical...
link.springer.com
April 22, 2025 at 7:58 PM
How does suzetrigine work!?... It targets the VSD2 domain of NaV1.8 channels, stabilizing their closed state and blocking pain signals! #pharmacology #ionchannels #painmanagement link.springer.com/article/10.1...
NALCN/Cch1 channelosome subunits originated in early eukaryotes. New study from Adriano Senatore @utoronto.ca and colleagues: rupress.org/jgp/article/...
#Lipids #membranes #MolecularPhysiology #ProteinStructure #ProteinDynamics #CellBiology #Evolution #IonChannels
#Lipids #membranes #MolecularPhysiology #ProteinStructure #ProteinDynamics #CellBiology #Evolution #IonChannels
September 12, 2025 at 2:15 PM
NALCN/Cch1 channelosome subunits originated in early eukaryotes. New study from Adriano Senatore @utoronto.ca and colleagues: rupress.org/jgp/article/...
#Lipids #membranes #MolecularPhysiology #ProteinStructure #ProteinDynamics #CellBiology #Evolution #IonChannels
#Lipids #membranes #MolecularPhysiology #ProteinStructure #ProteinDynamics #CellBiology #Evolution #IonChannels
From sensing touch to regulating blood pressure, mechanosensitive ion channels are vital players in mechanotransduction.
𝗞𝗲𝘆 𝗽𝗹𝗮𝘆𝗲𝗿𝘀: PIEZO (touch/pain), MET (hearing), OSCA (stress), K2P (stretch/temp), NOMPC (invertebrates).
Discover more: ow.ly/Qn8K50QMiZV
#IonChannels #Mechanosensation #APC
𝗞𝗲𝘆 𝗽𝗹𝗮𝘆𝗲𝗿𝘀: PIEZO (touch/pain), MET (hearing), OSCA (stress), K2P (stretch/temp), NOMPC (invertebrates).
Discover more: ow.ly/Qn8K50QMiZV
#IonChannels #Mechanosensation #APC
December 9, 2024 at 2:15 PM
From sensing touch to regulating blood pressure, mechanosensitive ion channels are vital players in mechanotransduction.
𝗞𝗲𝘆 𝗽𝗹𝗮𝘆𝗲𝗿𝘀: PIEZO (touch/pain), MET (hearing), OSCA (stress), K2P (stretch/temp), NOMPC (invertebrates).
Discover more: ow.ly/Qn8K50QMiZV
#IonChannels #Mechanosensation #APC
𝗞𝗲𝘆 𝗽𝗹𝗮𝘆𝗲𝗿𝘀: PIEZO (touch/pain), MET (hearing), OSCA (stress), K2P (stretch/temp), NOMPC (invertebrates).
Discover more: ow.ly/Qn8K50QMiZV
#IonChannels #Mechanosensation #APC
Here! Piezo #ionchannels https://rupress.org/jgp/article/156/12/e202213324/277062/Piezo2-interacts-with-E-cadherin-in-specialized
November 24, 2024 at 12:00 PM
Commentary: Lawrence Salkoff @washumedicine.bsky.social discusses new studies of potassium channel #evolution from the Jegla group (rupress.org/jgp/article/...) that contributes valuable insights into the evolution of complexity in electrical signaling. rupress.org/jgp/article/...
#IonChannels
#IonChannels
March 19, 2025 at 4:14 PM
Commentary: Lawrence Salkoff @washumedicine.bsky.social discusses new studies of potassium channel #evolution from the Jegla group (rupress.org/jgp/article/...) that contributes valuable insights into the evolution of complexity in electrical signaling. rupress.org/jgp/article/...
#IonChannels
#IonChannels
NaV1.8/NaV1.9 double knockout mice show their combined role in pain signaling & altered gene expression in DRG neurons. Valuable for studying human pain mutations #ionchannels #pain #neuroscience
buff.ly
March 28, 2025 at 4:06 PM
NaV1.8/NaV1.9 double knockout mice show their combined role in pain signaling & altered gene expression in DRG neurons. Valuable for studying human pain mutations #ionchannels #pain #neuroscience
#TRPC6 channels are implicated in pathogenesis of severe #nephrotic syndromes. This study of TRPC6 in normal physiological #podocyte functions reports roles in #MMP7-shedding of #nephrin ectodomains and #apoptosis.
doi.org/10.14814/phy...
#Renal #IonChannels
doi.org/10.14814/phy...
#Renal #IonChannels
November 3, 2025 at 10:15 AM
#TRPC6 channels are implicated in pathogenesis of severe #nephrotic syndromes. This study of TRPC6 in normal physiological #podocyte functions reports roles in #MMP7-shedding of #nephrin ectodomains and #apoptosis.
doi.org/10.14814/phy...
#Renal #IonChannels
doi.org/10.14814/phy...
#Renal #IonChannels
Enjoying a wonderful talk about #structuralbiology and #physiology of #ionchannels by our guest Prof. Anna Moroni from the @LaStatale @DBB_UniPV @unipv
January 18, 2025 at 10:57 AM
Enjoying a wonderful talk about #structuralbiology and #physiology of #ionchannels by our guest Prof. Anna Moroni from the @LaStatale @DBB_UniPV @unipv
OK if it's Friday and I'm messin about whilst I have a model running on my PC 😇
Here's mine. Looks a bit eclectic - apart from, obviously #IonChannels !
@auditorynerves.bsky.social
🧪👂🔬🧬💊
Here's mine. Looks a bit eclectic - apart from, obviously #IonChannels !
@auditorynerves.bsky.social
🧪👂🔬🧬💊
November 22, 2024 at 11:49 AM
OK if it's Friday and I'm messin about whilst I have a model running on my PC 😇
Here's mine. Looks a bit eclectic - apart from, obviously #IonChannels !
@auditorynerves.bsky.social
🧪👂🔬🧬💊
Here's mine. Looks a bit eclectic - apart from, obviously #IonChannels !
@auditorynerves.bsky.social
🧪👂🔬🧬💊
🗣️ ACCESS+ (a DEI-focused initiative for STEM societies) is seeking participants (18+) for a survey to share their perspectives as BPS members.
Help us understand member needs and guide improvements. Enter a drawing for one of five $250 Amazon gift cards.
survey.zohopublic.com/zs/0hBq69
Help us understand member needs and guide improvements. Enter a drawing for one of five $250 Amazon gift cards.
survey.zohopublic.com/zs/0hBq69
ACCESS Plus Survey of Member Experiences with STEM Professional Society Culture
Your response would be greatly appreciated.
survey.zohopublic.com
December 6, 2024 at 4:18 PM
🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1...
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
July 16, 2025 at 11:03 AM
🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1...
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
My lecture in the Cell Communication course centers around the ionic basis of the action potential #ionchannels I always show the intracellular recording of squid giant axon action potential by Hodgkin and Huxley (1939)
Image taken from a nice historical review by Schwiening
doi.org/10.1113/jphy...
Image taken from a nice historical review by Schwiening
doi.org/10.1113/jphy...
November 16, 2024 at 11:42 AM
My lecture in the Cell Communication course centers around the ionic basis of the action potential #ionchannels I always show the intracellular recording of squid giant axon action potential by Hodgkin and Huxley (1939)
Image taken from a nice historical review by Schwiening
doi.org/10.1113/jphy...
Image taken from a nice historical review by Schwiening
doi.org/10.1113/jphy...
August 27, 2025 at 8:34 AM
PhD studentship 6/6
Heart -> calmodulin -> #IonChannels
Heart -> calmodulin -> #IonChannels
Exploring the therapeutic potential of calmodulin in the context of inherited cardiac arrhythmia at University of Liverpool on FindAPhD.com
PhD Project - Exploring the therapeutic potential of calmodulin in the context of inherited cardiac arrhythmia at University of Liverpool, listed on FindAPhD.com
www.findaphd.com
January 13, 2025 at 11:00 AM
PhD studentship 6/6
Heart -> calmodulin -> #IonChannels
Heart -> calmodulin -> #IonChannels
Köster, Stiehl, @lampertlab.bsky.social and colleagues characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. https://buff.ly/4hku7gH
#Biophysics #Neuroscience #IonChannels
#Biophysics #Neuroscience #IonChannels
January 21, 2025 at 6:19 PM
PANX1 hexamers work but cells prefer heptamers: https://buff.ly/4jO3B1a Andrew Harris @Rutgers_NJMS provides commentary on new work from Gupta, @dougbayliss.bsky.social and colleagues (https://buff.ly/4iKt3UN).
February 12, 2025 at 10:32 PM
Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2 #ionchannels
www.nature.com/articles/s42...
www.nature.com/articles/s42...
March 15, 2025 at 11:39 AM
Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2 #ionchannels
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Nice “heart” but missed Valentine’s Day by a week!!
#ionchannels
#ionchannels
By molecular dynamics simulations and in silico electrophysiology, Alp Tegin Şahin and Ulrich Zachariae show how the #lipid PIP2 opens the human TPC2 #IonChannel and that its ion selectivity is established by an interplay of key structural elements of the pore. https://buff.ly/4gPpxq1
February 21, 2025 at 7:38 PM
Nice “heart” but missed Valentine’s Day by a week!!
#ionchannels
#ionchannels
Are you curious about ligand selectivity and modulation mechanisms of the voltage-gated potassium channel Kv7 family? Stop by Poster #39!
#EBSA2025 #IonChannels #StructuralBiology #ComputationalBiophysics
#EBSA2025 #IonChannels #StructuralBiology #ComputationalBiophysics
July 2, 2025 at 8:07 AM
Are you curious about ligand selectivity and modulation mechanisms of the voltage-gated potassium channel Kv7 family? Stop by Poster #39!
#EBSA2025 #IonChannels #StructuralBiology #ComputationalBiophysics
#EBSA2025 #IonChannels #StructuralBiology #ComputationalBiophysics
(1/2) “It’s fantastic that all this expertise exists in Sweden and I’m thrilled to have brought this team together” says @delemottelab.bsky.social who leads a project with researchers from 5 universities, aiming to develop a new strategy for designing drug molecules targeting #IonChannels 🧪
#MolBiol
#MolBiol
April 28, 2025 at 8:48 AM
(1/2) “It’s fantastic that all this expertise exists in Sweden and I’m thrilled to have brought this team together” says @delemottelab.bsky.social who leads a project with researchers from 5 universities, aiming to develop a new strategy for designing drug molecules targeting #IonChannels 🧪
#MolBiol
#MolBiol
Mouse retinal ganglion cells and night blindness |
TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cells
J.General Physiol. rupress.org/jgp/article/...
TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cells
J.General Physiol. rupress.org/jgp/article/...
October 22, 2025 at 10:39 AM
Mouse retinal ganglion cells and night blindness |
TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cells
J.General Physiol. rupress.org/jgp/article/...
TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cells
J.General Physiol. rupress.org/jgp/article/...