Anthony Hessel, PhD
@hesselanthony.bsky.social
Muscle physiologist at Uni of Muenster. Founder, Accelerated Muscle Biotechnologies. Dog foster / diva boston terrier parent. My wife tolerates me well. He/him.🥼🧪🔬💪♥️ #MyoBlue #NoKing
Reposted by Anthony Hessel, PhD
A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations. New review from Anthony Hessel @hesselanthony.bsky.social, Christopher Rand @crand22.bsky.social, Khoi Nguyen and colleagues: rupress.org/jgp/article/...
#Myofilaments #SkeletalMuscle #CardiacMuscle
#Myofilaments #SkeletalMuscle #CardiacMuscle
February 4, 2026 at 3:45 PM
A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations. New review from Anthony Hessel @hesselanthony.bsky.social, Christopher Rand @crand22.bsky.social, Khoi Nguyen and colleagues: rupress.org/jgp/article/...
#Myofilaments #SkeletalMuscle #CardiacMuscle
#Myofilaments #SkeletalMuscle #CardiacMuscle
Reposted by Anthony Hessel, PhD
New review from our partners Accelerated Muscle Biotechnologies (Anthony Hessel, PhD, Katelyn Manross, Khoi Nguyen), co-authored with our Chris Rand & Matthew Borkowski. #MusclePhysiology #CardiacResearch
Check it out:
https://bit.ly/a-primer-on-the-methods-of-skeletal-and-cardiac-muscle-mechanics
Check it out:
https://bit.ly/a-primer-on-the-methods-of-skeletal-and-cardiac-muscle-mechanics
February 2, 2026 at 3:00 PM
New review from our partners Accelerated Muscle Biotechnologies (Anthony Hessel, PhD, Katelyn Manross, Khoi Nguyen), co-authored with our Chris Rand & Matthew Borkowski. #MusclePhysiology #CardiacResearch
Check it out:
https://bit.ly/a-primer-on-the-methods-of-skeletal-and-cardiac-muscle-mechanics
Check it out:
https://bit.ly/a-primer-on-the-methods-of-skeletal-and-cardiac-muscle-mechanics
Reposted by Anthony Hessel, PhD
💪 NEW VIDEO:
Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work.
Rendered using @bradyajohnston.bsky.social 's molecular nodes
Model based on the incredible work of the @raunser-lab.bsky.social lab
Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work.
Rendered using @bradyajohnston.bsky.social 's molecular nodes
Model based on the incredible work of the @raunser-lab.bsky.social lab
January 31, 2026 at 3:00 PM
💪 NEW VIDEO:
Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work.
Rendered using @bradyajohnston.bsky.social 's molecular nodes
Model based on the incredible work of the @raunser-lab.bsky.social lab
Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work.
Rendered using @bradyajohnston.bsky.social 's molecular nodes
Model based on the incredible work of the @raunser-lab.bsky.social lab
Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray diffraction experiments.
See LinkedIn post for details.
www.linkedin.com/posts/anthon...
See LinkedIn post for details.
www.linkedin.com/posts/anthon...
Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray… | Anthon...
Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray diffracti...
www.linkedin.com
January 29, 2026 at 10:10 AM
Accelerated Muscle Biotechnologies is looking for a subcontractor (muscle physiologist) for a 5 day project at Brookhaven National Laboratory, conducting muscle mechanics / small-angle X-ray diffraction experiments.
See LinkedIn post for details.
www.linkedin.com/posts/anthon...
See LinkedIn post for details.
www.linkedin.com/posts/anthon...
Really happy about this paper getting published, where we muse on some of the finer aspects of the permeablized fiber mechanics technique. Have things you wished were covered? Go write one of these up to! Science is better when we all share our "institutional knowledge"!
Review: @hesselanthony.bsky.social @crand22.bsky.social, Nguyen et al. provide useful tips and tricks for all those beginning their journey into permeabilized muscle fiber mechanics. rupress.org/jgp/article/...
#Myofilaments #SkeletalMuscle #CardiacMuscle
#Myofilaments #SkeletalMuscle #CardiacMuscle
January 28, 2026 at 7:43 PM
Really happy about this paper getting published, where we muse on some of the finer aspects of the permeablized fiber mechanics technique. Have things you wished were covered? Go write one of these up to! Science is better when we all share our "institutional knowledge"!
Anothee run at the P03 beamline PETRAIII complete. It was a exhausting run but we checked off all goals.
January 28, 2026 at 9:15 AM
Anothee run at the P03 beamline PETRAIII complete. It was a exhausting run but we checked off all goals.
Americans are supposed to be the good guys. It makes applying/enforcing laws harder but that is the burden of being the good guys. We rarely reach that ideal in practice but I will do all I can to support those who fight the good fight to bring us towards it. Protests comes in many ways. #NoKings
January 26, 2026 at 6:59 AM
Americans are supposed to be the good guys. It makes applying/enforcing laws harder but that is the burden of being the good guys. We rarely reach that ideal in practice but I will do all I can to support those who fight the good fight to bring us towards it. Protests comes in many ways. #NoKings
Reposted by Anthony Hessel, PhD
The National Institutes of Health has agreed to settle lawsuits over its handling of grant applications that conflicted with President Donald Trump’s directives. https://scim.ag/4jsQ7sc
After legal deal, NIH to review grant proposals frozen, denied, or withdrawn because of Trump directives
Agreement requires agency to evaluate hundreds of applications “in good faith” using its standard process
scim.ag
January 6, 2026 at 5:23 PM
The National Institutes of Health has agreed to settle lawsuits over its handling of grant applications that conflicted with President Donald Trump’s directives. https://scim.ag/4jsQ7sc
Reposted by Anthony Hessel, PhD
Our team at Københavns Universitet - University of Copenhagen will soon be looking for a postdoc with experience in AI-driven vHTS and cardiac sarcomere modeling. If interested please send me an email. Spread the word :-)
Ochala Group – University of Copenhagen
bmi.ku.dk
December 18, 2025 at 11:29 AM
Our team at Københavns Universitet - University of Copenhagen will soon be looking for a postdoc with experience in AI-driven vHTS and cardiac sarcomere modeling. If interested please send me an email. Spread the word :-)
Reposted by Anthony Hessel, PhD
First preprint from my PhD!
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
Piperine activates the thick filament of resting rat skeletal muscle, enhancing dynamic contractility in a fiber-type-dependent manner
Thick-filament activation, whereby myosin heads transition from an OFF to an ON state, is a key regulatory step in muscle contraction and a promising therapeutic target. The availability of ON-state m...
www.biorxiv.org
November 27, 2025 at 2:53 PM
First preprint from my PhD!
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
www.biorxiv.org/content/10.1...
We show that piperine:
1️⃣ increases ON myosin in resting skeletal muscle.
2️⃣ enhances dynamic contractility 3️⃣ in a muscle-type-dependent manner
@hesselanthony.bsky.social
Reposted by Anthony Hessel, PhD
In February 2025, Aurora Scientific formed a strategic partnership with Accelerated Muscle Biotechnologies (AMB). Watch this video interview with Anthony Hessel, PhD and Khoi Nguyen, PhD from AMB, and our own Chris Rand to learn about our partnership!
https://bit.ly/asi-amb-partnership-interview
https://bit.ly/asi-amb-partnership-interview
November 26, 2025 at 12:36 PM
In February 2025, Aurora Scientific formed a strategic partnership with Accelerated Muscle Biotechnologies (AMB). Watch this video interview with Anthony Hessel, PhD and Khoi Nguyen, PhD from AMB, and our own Chris Rand to learn about our partnership!
https://bit.ly/asi-amb-partnership-interview
https://bit.ly/asi-amb-partnership-interview
Reposted by Anthony Hessel, PhD
New #PNASNews paper: Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging. #Myoblue tinyurl.com/y5rayxmz
Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging | PNAS
Skeletal muscle is essential for movement, respiration, and metabolism, with mTORC1
acting as a key regulator of protein synthesis and degradation....
tinyurl.com
November 25, 2025 at 3:40 PM
New #PNASNews paper: Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging. #Myoblue tinyurl.com/y5rayxmz
Reposted by Anthony Hessel, PhD
Our collaborative effort unravelled puzzling results warranted more research on the topic of myosin and cardiac chamber specificities @ucph.bsky.social
Cardiac Chamber‐Specific Regulation of Myosin Biochemical Super‐Relaxation and Auto‐Inhibition
The combination of Mant-ATP (2′-(or-3′)-O-(N-Methylanthraniloyl) Adenosine 5′-Triphosphate) chase experiments and all-atomistic molecular dynamics simulations, revealed that myosin auto-inhibition an...
faseb.onlinelibrary.wiley.com
November 22, 2025 at 12:57 PM
Our collaborative effort unravelled puzzling results warranted more research on the topic of myosin and cardiac chamber specificities @ucph.bsky.social
Top recommendation for this post doc opportunity from my PhD lab group. Great mentor, lab, place to live. Amazing projects and an unusual amount of funding.
The Nishikawa lab at Northern Arizona University and the NSF-funded Integrative Movement Sciences Institute are hiring a postdoc to help develop multiscale muscle models - please apply and share widely! careers.nau.edu/cw/en-us/job...
Postdoctoral Scholar - Flagstaff, Arizona, United States
Special Information
This position is an on-site position which requires the incumbent to complete their work primarily at an NAU site, campus, or facility with or without accommodation. Opportunities...
careers.nau.edu
November 22, 2025 at 3:23 PM
Top recommendation for this post doc opportunity from my PhD lab group. Great mentor, lab, place to live. Amazing projects and an unusual amount of funding.
Reposted by Anthony Hessel, PhD
How great is the HPV vaccine?
It can even ⬇️ the risk of cervical cancer when given after precancerous cells are found.
I wonder why RFK Jr isn't talking about this study.🤔
www.thelancet.com/journals/lan...
It can even ⬇️ the risk of cervical cancer when given after precancerous cells are found.
I wonder why RFK Jr isn't talking about this study.🤔
www.thelancet.com/journals/lan...
Early and long-term effects of prophylactic and post-excision human papillomavirus vaccination on recurrent high-grade cervical intraepithelial neoplasia relative to margin status: a retrospective coh...
Regardless of timing, HPV vaccination has a beneficial long-term effect in lowering
the risk of CIN2+ recurrence. Despite the greater reduction in relapse achieved by
post-excision vaccination, the di...
www.thelancet.com
November 6, 2025 at 1:46 PM
How great is the HPV vaccine?
It can even ⬇️ the risk of cervical cancer when given after precancerous cells are found.
I wonder why RFK Jr isn't talking about this study.🤔
www.thelancet.com/journals/lan...
It can even ⬇️ the risk of cervical cancer when given after precancerous cells are found.
I wonder why RFK Jr isn't talking about this study.🤔
www.thelancet.com/journals/lan...
Reposted by Anthony Hessel, PhD
Excited to share our preprint using time-resolved small-angle X-ray diffraction to study myosin motor conformations during isometric twitch and tetanus contractions in the slow-twitch rat soleus skeletal muscle #myoblue
October 15, 2025 at 12:55 AM
Excited to share our preprint using time-resolved small-angle X-ray diffraction to study myosin motor conformations during isometric twitch and tetanus contractions in the slow-twitch rat soleus skeletal muscle #myoblue
Reposted by Anthony Hessel, PhD
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme
employment.ku.dk
September 29, 2025 at 11:11 AM
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
Reposted by Anthony Hessel, PhD
Excited to share the first paper from my PhD!
We looked at what traits help Aneides salamanders excel at climbing using museum specimens, CT scans, SEM, and more! No claws or toe pads, so how do they do it? In short, with long limbs, big feet and grippy toes! 🦎🧪
DM for PDF
doi.org/10.1098/rspb...
We looked at what traits help Aneides salamanders excel at climbing using museum specimens, CT scans, SEM, and more! No claws or toe pads, so how do they do it? In short, with long limbs, big feet and grippy toes! 🦎🧪
DM for PDF
doi.org/10.1098/rspb...
August 28, 2025 at 8:14 PM
Excited to share the first paper from my PhD!
We looked at what traits help Aneides salamanders excel at climbing using museum specimens, CT scans, SEM, and more! No claws or toe pads, so how do they do it? In short, with long limbs, big feet and grippy toes! 🦎🧪
DM for PDF
doi.org/10.1098/rspb...
We looked at what traits help Aneides salamanders excel at climbing using museum specimens, CT scans, SEM, and more! No claws or toe pads, so how do they do it? In short, with long limbs, big feet and grippy toes! 🦎🧪
DM for PDF
doi.org/10.1098/rspb...
Reposted by Anthony Hessel, PhD
This new #Methods article evaluates #freeze-drying to #RNAlater and three RNAlater-ICE-based protocols for #skeletal #muscle #biopsy tissue preservation for subsequent manual isolation of #fibers and other downstream applications.
doi.org/10.14814/phy...
#Physiology #MyoBlue
doi.org/10.14814/phy...
#Physiology #MyoBlue
doi.org
September 16, 2025 at 9:15 AM
This new #Methods article evaluates #freeze-drying to #RNAlater and three RNAlater-ICE-based protocols for #skeletal #muscle #biopsy tissue preservation for subsequent manual isolation of #fibers and other downstream applications.
doi.org/10.14814/phy...
#Physiology #MyoBlue
doi.org/10.14814/phy...
#Physiology #MyoBlue
Calling all BPS member / interested muscle people!!!
Sam Harris is spearheading a push towards make a new muscle subgroup at the Biophysical Society.
*Signatures from active members are needed*, but anyone with an interest can sign.
Please help the cause!
www.change.org/p/establish-...
Sam Harris is spearheading a push towards make a new muscle subgroup at the Biophysical Society.
*Signatures from active members are needed*, but anyone with an interest can sign.
Please help the cause!
www.change.org/p/establish-...
Sign the Petition
Establish a Dedicated Cardiac and Skeletal Muscle Research Subgroup Within The Biophysical Society
www.change.org
August 21, 2025 at 7:23 PM
Calling all BPS member / interested muscle people!!!
Sam Harris is spearheading a push towards make a new muscle subgroup at the Biophysical Society.
*Signatures from active members are needed*, but anyone with an interest can sign.
Please help the cause!
www.change.org/p/establish-...
Sam Harris is spearheading a push towards make a new muscle subgroup at the Biophysical Society.
*Signatures from active members are needed*, but anyone with an interest can sign.
Please help the cause!
www.change.org/p/establish-...
Reposted by Anthony Hessel, PhD
Congrats to Brent Scott from the Greenberg lab for this new paper on danicamtiv's mechanism of action.
www.pnas.org/doi/10.1073/...
Excited to see our FiberSim code being put to such good use.
campbell-muscle-lab.github.io/FiberSim/
www.pnas.org/doi/10.1073/...
Excited to see our FiberSim code being put to such good use.
campbell-muscle-lab.github.io/FiberSim/
Danicamtiv reduces myosin’s working stroke but activates the thin filament by accelerating actomyosin attachment | PNAS
Heart failure is a leading cause of death worldwide, and even with current treatments,
the 5-y transplant-free survival rate is only ~50 to 70%. As...
www.pnas.org
August 20, 2025 at 8:25 PM
Congrats to Brent Scott from the Greenberg lab for this new paper on danicamtiv's mechanism of action.
www.pnas.org/doi/10.1073/...
Excited to see our FiberSim code being put to such good use.
campbell-muscle-lab.github.io/FiberSim/
www.pnas.org/doi/10.1073/...
Excited to see our FiberSim code being put to such good use.
campbell-muscle-lab.github.io/FiberSim/
Reposted by Anthony Hessel, PhD
Can you really repair an engine while it's running? 👩🏽🔧
The heart can. 💪🏼🫀
Our latest @faseborg.bsky.social paper shows how the protein 'CapZ' helps heart muscle to keep running during exercise. ⛹🏼♀️🏊♂️
#Exercise #Heart #Muscle #BasicScience #Cardiology
faseb.onlinelibrary.wiley.com/doi/10.1096/...
The heart can. 💪🏼🫀
Our latest @faseborg.bsky.social paper shows how the protein 'CapZ' helps heart muscle to keep running during exercise. ⛹🏼♀️🏊♂️
#Exercise #Heart #Muscle #BasicScience #Cardiology
faseb.onlinelibrary.wiley.com/doi/10.1096/...
Cardiac CapZ Regulation During Acute Exercise in Female Mice
CapZ regulates actin addition at the barbed ends of sarcomeric actin. At rest, phosphorylated CapZIP slows addition, and dephosphorylated CapZIP promotes a wobble state to allow actin cycling. During...
faseb.onlinelibrary.wiley.com
August 20, 2025 at 3:48 PM
Can you really repair an engine while it's running? 👩🏽🔧
The heart can. 💪🏼🫀
Our latest @faseborg.bsky.social paper shows how the protein 'CapZ' helps heart muscle to keep running during exercise. ⛹🏼♀️🏊♂️
#Exercise #Heart #Muscle #BasicScience #Cardiology
faseb.onlinelibrary.wiley.com/doi/10.1096/...
The heart can. 💪🏼🫀
Our latest @faseborg.bsky.social paper shows how the protein 'CapZ' helps heart muscle to keep running during exercise. ⛹🏼♀️🏊♂️
#Exercise #Heart #Muscle #BasicScience #Cardiology
faseb.onlinelibrary.wiley.com/doi/10.1096/...
Reposted by Anthony Hessel, PhD
Global study: 2.08M people, 133 cohorts, 39 countries, 6 continents. 5 risk factors influence 50% of lifetime cardiovascular disease risk. PMID:40162648, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2415879 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1056/NEJMoa2415879
No description available
doi.org
August 16, 2025 at 12:10 PM
This may be a bit strongly worded. Some people took initiative to write grants even when in a secure post doc. Some wrote grants that were tailored-made to be impactful/career boosting. IMHO, no problem with career strategy in an ultra competitive funding landscape. Wayyy more deserve than spots.
Academia is basically a collection of people who got lucky early on and mistook it for genius. doi.org/10.1073/pnas...
August 5, 2025 at 6:02 PM
This may be a bit strongly worded. Some people took initiative to write grants even when in a secure post doc. Some wrote grants that were tailored-made to be impactful/career boosting. IMHO, no problem with career strategy in an ultra competitive funding landscape. Wayyy more deserve than spots.
Yes! NIAMS and NHLBI as well!
3. The POs for NIGMS and NIA have been phenomenal (as well as NIBIB, which is an aspiration for us). They have been very calm and reassuring, even as I know that their individual lives are very challenging. We are very lucky to have these staff and should be fighting for them whenever possible. 4/n
August 5, 2025 at 5:49 PM
Yes! NIAMS and NHLBI as well!