Life Science Alliance
@lsajournal.org
#OpenAccess community-driven journal for peer-reviewed research in all areas of the life sciences. By EMBO Press (@embopress.org), Rockefeller University Press (@rupress.org), and Cold Spring Harbor Laboratory Press (@cshlpress.bsky.social).
Progeroid endothelial cells do not show a robust activation of the unfolded protein response, contrary to what has been reported in other arterial cell types such as vascular smooth muscle cells @maxperutzlabs.ac.at, @gekaragoz.bsky.social
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
December 2, 2025 at 4:06 PM
Progeroid endothelial cells do not show a robust activation of the unfolded protein response, contrary to what has been reported in other arterial cell types such as vascular smooth muscle cells @maxperutzlabs.ac.at, @gekaragoz.bsky.social
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
In our December issue, find out:
- How circadian rhythms in immune cells affect responses to cancer treatment.
- Links between acetyltransferase expression in the ER and progeria.
- Effects of schizophrenia-related genes on neurodevelopment, and much more!
www.life-science-alliance.org/content/8/12
- How circadian rhythms in immune cells affect responses to cancer treatment.
- Links between acetyltransferase expression in the ER and progeria.
- Effects of schizophrenia-related genes on neurodevelopment, and much more!
www.life-science-alliance.org/content/8/12
December 1, 2025 at 9:34 PM
In our December issue, find out:
- How circadian rhythms in immune cells affect responses to cancer treatment.
- Links between acetyltransferase expression in the ER and progeria.
- Effects of schizophrenia-related genes on neurodevelopment, and much more!
www.life-science-alliance.org/content/8/12
- How circadian rhythms in immune cells affect responses to cancer treatment.
- Links between acetyltransferase expression in the ER and progeria.
- Effects of schizophrenia-related genes on neurodevelopment, and much more!
www.life-science-alliance.org/content/8/12
Researchers have developed a streamlined 2D system that generates mini-oocytes, resembling oocytes, from mouse stem cells. This scalable model offers a new way to explore oocyte characteristics and roles.
#StemCellResearch #OocyteStudy
www.life-science-alliance.org/content/9/2/...
#StemCellResearch #OocyteStudy
www.life-science-alliance.org/content/9/2/...
December 1, 2025 at 4:04 PM
Researchers have developed a streamlined 2D system that generates mini-oocytes, resembling oocytes, from mouse stem cells. This scalable model offers a new way to explore oocyte characteristics and roles.
#StemCellResearch #OocyteStudy
www.life-science-alliance.org/content/9/2/...
#StemCellResearch #OocyteStudy
www.life-science-alliance.org/content/9/2/...
This study shows that SOX2 is not required for NUT carcinoma initiation or maintenance in vivo, challenging its assumed oncogenic role and refining therapeutic target prioritization. www.life-science-alliance.org/content/9/2/...
November 29, 2025 at 4:04 PM
This study shows that SOX2 is not required for NUT carcinoma initiation or maintenance in vivo, challenging its assumed oncogenic role and refining therapeutic target prioritization. www.life-science-alliance.org/content/9/2/...
Müller cell glutamine processing connects damage to photoreceptors and blood vessels in diabetic eye disease. #DiabeticRetinopathy #EyeHealth
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
November 28, 2025 at 9:34 PM
Müller cell glutamine processing connects damage to photoreceptors and blood vessels in diabetic eye disease. #DiabeticRetinopathy #EyeHealth
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
The authors developed a MALDI-MSI and LC-MS/MS workflow with a scoring algorithm (pepBridge) for confident spatial protein identification in the thymus. This revealed chemotherapy-induced spatiotemporal remodeling.
www.life-science-alliance.org/content/9/1/...
www.life-science-alliance.org/content/9/1/...
November 28, 2025 at 4:04 PM
The authors developed a MALDI-MSI and LC-MS/MS workflow with a scoring algorithm (pepBridge) for confident spatial protein identification in the thymus. This revealed chemotherapy-induced spatiotemporal remodeling.
www.life-science-alliance.org/content/9/1/...
www.life-science-alliance.org/content/9/1/...
Exciting developments in genomics: Machine learning is aiding researchers in identifying regulators of homologous recombination deficiency through somatic multi-omics data analysis. This could revolutionize cancer therapy and precision medicine.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
November 27, 2025 at 4:04 PM
Exciting developments in genomics: Machine learning is aiding researchers in identifying regulators of homologous recombination deficiency through somatic multi-omics data analysis. This could revolutionize cancer therapy and precision medicine.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
A diverse screening classifies unique categories of plant-based compounds that counteract tau-related disorders. #Tauopathy #NaturalProducts
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
November 25, 2025 at 4:04 PM
A diverse screening classifies unique categories of plant-based compounds that counteract tau-related disorders. #Tauopathy #NaturalProducts
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
A simplified 2D culture system produces oocyte-like mini-oocytes from mouse stem cells, providing a scalable model to study oocyte identity and function.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
November 24, 2025 at 4:04 PM
A simplified 2D culture system produces oocyte-like mini-oocytes from mouse stem cells, providing a scalable model to study oocyte identity and function.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
Sox2 is not required for the oncogenesis of NUT Carcinoma in a mouse model. www.life-science-alliance.org/content/9/2/...
November 22, 2025 at 4:04 PM
Sox2 is not required for the oncogenesis of NUT Carcinoma in a mouse model. www.life-science-alliance.org/content/9/2/...
This study reveals that early metabolic dysfunction in Müller cells disrupts the retinal cellular ecosystem, affecting photoreceptors and endothelial cells, prior to the emergence of classic vascular signs of diabetic retinopathy.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
November 21, 2025 at 9:34 PM
This study reveals that early metabolic dysfunction in Müller cells disrupts the retinal cellular ecosystem, affecting photoreceptors and endothelial cells, prior to the emergence of classic vascular signs of diabetic retinopathy.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
Introducing pepBridge: a scoring pipeline linking MALDI-MSI and LC-MS/MS signals to confidently map spatial proteomes. Applied to the thymus, it reveals how chemotherapy reshapes immune regeneration.
www.life-science-alliance.org/content/9/1/...
www.life-science-alliance.org/content/9/1/...
November 21, 2025 at 4:04 PM
Introducing pepBridge: a scoring pipeline linking MALDI-MSI and LC-MS/MS signals to confidently map spatial proteomes. Applied to the thymus, it reveals how chemotherapy reshapes immune regeneration.
www.life-science-alliance.org/content/9/1/...
www.life-science-alliance.org/content/9/1/...
Using somatic multi-omics data and explainable artificial intelligence , this study identifies novel alterations underlying homologous recombination repair deficiency across cancers. www.life-science-alliance.org/content/9/2/...
November 20, 2025 at 4:04 PM
Using somatic multi-omics data and explainable artificial intelligence , this study identifies novel alterations underlying homologous recombination repair deficiency across cancers. www.life-science-alliance.org/content/9/2/...
Reposted by Life Science Alliance
Gain the #skills you need to lead in #SingleCell #research at the EMBO Practical Course "Pipetting scRNA-seq data into computational cells" in Oeiras/Lisbon, Portugal, 18–23 May 2026.
Deadline: 15 February 2026
https://meetings.embo.org/event/26-scrna
#EMBOPipettescRNAseq #EMBOevents 🧪
Deadline: 15 February 2026
https://meetings.embo.org/event/26-scrna
#EMBOPipettescRNAseq #EMBOevents 🧪
November 20, 2025 at 6:02 AM
Gain the #skills you need to lead in #SingleCell #research at the EMBO Practical Course "Pipetting scRNA-seq data into computational cells" in Oeiras/Lisbon, Portugal, 18–23 May 2026.
Deadline: 15 February 2026
https://meetings.embo.org/event/26-scrna
#EMBOPipettescRNAseq #EMBOevents 🧪
Deadline: 15 February 2026
https://meetings.embo.org/event/26-scrna
#EMBOPipettescRNAseq #EMBOevents 🧪
VelB IDD encourages specific pairing of velvet proteins, crucial for fungal growth. #FungiDevelopment #ProteinInteractions
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
November 19, 2025 at 9:34 PM
VelB IDD encourages specific pairing of velvet proteins, crucial for fungal growth. #FungiDevelopment #ProteinInteractions
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
Take a look at this recently published research article in LSA:
Group 1 mGluR Stimulation Rescues APOE4-Mediated Translation Defects in Neurons www.life-science-alliance.org/content/9/2/...
Group 1 mGluR Stimulation Rescues APOE4-Mediated Translation Defects in Neurons www.life-science-alliance.org/content/9/2/...
November 19, 2025 at 4:04 PM
Take a look at this recently published research article in LSA:
Group 1 mGluR Stimulation Rescues APOE4-Mediated Translation Defects in Neurons www.life-science-alliance.org/content/9/2/...
Group 1 mGluR Stimulation Rescues APOE4-Mediated Translation Defects in Neurons www.life-science-alliance.org/content/9/2/...
This study reveals a new strategy for identifying therapeutic compounds that target tauopathy and provides mechanistic insight supporting the neuroprotective effects of plant-derived natural products.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
November 18, 2025 at 4:04 PM
This study reveals a new strategy for identifying therapeutic compounds that target tauopathy and provides mechanistic insight supporting the neuroprotective effects of plant-derived natural products.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
Our special collection of advances in neuroscience from the past year is here! Find exciting insights on neuroinflammation, axonal transport, and neuromuscular junctions; and important clinical findings on multiple sclerosis and Alzheimer’s disease.
www.life-science-alliance.org/content/neur...
www.life-science-alliance.org/content/neur...
November 17, 2025 at 4:04 PM
Our special collection of advances in neuroscience from the past year is here! Find exciting insights on neuroinflammation, axonal transport, and neuromuscular junctions; and important clinical findings on multiple sclerosis and Alzheimer’s disease.
www.life-science-alliance.org/content/neur...
www.life-science-alliance.org/content/neur...
Chameau (HBO1) gene function in starvation resistance is bypassed by slightly elevated temperatures in Drosophila, suggesting a temperature-dependent metabolic role.
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
November 14, 2025 at 4:04 PM
Chameau (HBO1) gene function in starvation resistance is bypassed by slightly elevated temperatures in Drosophila, suggesting a temperature-dependent metabolic role.
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
Our special collection of advances in neuroscience from the past year is here! Find exciting insights on neuroinflammation, axonal transport, and neuromuscular junctions, and important clinical findings on multiple sclerosis and Alzheimer’s disease.
www.life-science-alliance.org/content/neur...
www.life-science-alliance.org/content/neur...
November 13, 2025 at 9:34 PM
Our special collection of advances in neuroscience from the past year is here! Find exciting insights on neuroinflammation, axonal transport, and neuromuscular junctions, and important clinical findings on multiple sclerosis and Alzheimer’s disease.
www.life-science-alliance.org/content/neur...
www.life-science-alliance.org/content/neur...
Selective velvet domain heterodimer formation promotes fungal development.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
November 13, 2025 at 4:04 PM
Selective velvet domain heterodimer formation promotes fungal development.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
Group I mGluR stimulation in APOE4-treated neurons corrected protein synthesis issues via mTOR-dependent RPS6 phosphorylation. APOE4 treatment impaired response to LTP-inducing electrical stimulus, which mGluR stimulation restored.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
November 12, 2025 at 9:34 PM
Group I mGluR stimulation in APOE4-treated neurons corrected protein synthesis issues via mTOR-dependent RPS6 phosphorylation. APOE4 treatment impaired response to LTP-inducing electrical stimulus, which mGluR stimulation restored.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
Take a look at this recently published paper in LSA:
Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD #ALS #TDP-43
www.life-science-alliance.org/content/9/1/...
Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD #ALS #TDP-43
www.life-science-alliance.org/content/9/1/...
November 12, 2025 at 6:28 PM
Take a look at this recently published paper in LSA:
Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD #ALS #TDP-43
www.life-science-alliance.org/content/9/1/...
Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD #ALS #TDP-43
www.life-science-alliance.org/content/9/1/...
Glycolysis sustains STAT1 activity via STAT1 O-glycosylation, which is essential for human Th1 cell differentiation and IFNgamma production by maintaining STAT1 S727 phosphorylation. @mielenzlab.bsky.social
www.life-science-alliance.org/content/9/1/...
www.life-science-alliance.org/content/9/1/...
November 11, 2025 at 4:05 PM
Glycolysis sustains STAT1 activity via STAT1 O-glycosylation, which is essential for human Th1 cell differentiation and IFNgamma production by maintaining STAT1 S727 phosphorylation. @mielenzlab.bsky.social
www.life-science-alliance.org/content/9/1/...
www.life-science-alliance.org/content/9/1/...
The Chameau gene helps flies survive starvation at lower temps, but a mere 2{degree sign}C rise makes it obsolete! This temperature-dependent role in metabolism and resilience has big implications for climate change biology.
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
November 7, 2025 at 4:04 PM
The Chameau gene helps flies survive starvation at lower temps, but a mere 2{degree sign}C rise makes it obsolete! This temperature-dependent role in metabolism and resilience has big implications for climate change biology.
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...