Life Science Alliance
@lsajournal.org
#OpenAccess community-driven journal for peer-reviewed research in all areas of the life sciences. By EMBO Press (@embopress.org), Rockefeller University Press (@rupress.org), and Cold Spring Harbor Laboratory Press (@cshlpress.bsky.social).
Our special collection of advances in neuroscience from the past year is here! Find exciting insights on neuroinflammation, axonal transport, and neuromuscular junctions, and important clinical findings on multiple sclerosis and Alzheimer’s disease.
www.life-science-alliance.org/content/neur...
www.life-science-alliance.org/content/neur...
November 13, 2025 at 9:34 PM
Our special collection of advances in neuroscience from the past year is here! Find exciting insights on neuroinflammation, axonal transport, and neuromuscular junctions, and important clinical findings on multiple sclerosis and Alzheimer’s disease.
www.life-science-alliance.org/content/neur...
www.life-science-alliance.org/content/neur...
Selective velvet domain heterodimer formation promotes fungal development.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
November 13, 2025 at 4:04 PM
Selective velvet domain heterodimer formation promotes fungal development.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
Group I mGluR stimulation in APOE4-treated neurons corrected protein synthesis issues via mTOR-dependent RPS6 phosphorylation. APOE4 treatment impaired response to LTP-inducing electrical stimulus, which mGluR stimulation restored.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
November 12, 2025 at 9:34 PM
Group I mGluR stimulation in APOE4-treated neurons corrected protein synthesis issues via mTOR-dependent RPS6 phosphorylation. APOE4 treatment impaired response to LTP-inducing electrical stimulus, which mGluR stimulation restored.
www.life-science-alliance.org/content/9/2/...
www.life-science-alliance.org/content/9/2/...
Take a look at this recently published paper in LSA:
Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD #ALS #TDP-43
www.life-science-alliance.org/content/9/1/...
Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD #ALS #TDP-43
www.life-science-alliance.org/content/9/1/...
November 12, 2025 at 6:28 PM
Take a look at this recently published paper in LSA:
Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD #ALS #TDP-43
www.life-science-alliance.org/content/9/1/...
Aberrant NSUN1 Activity Connects m5C RNA Modification to TDP-43 Neurotoxicity in ALS/FTD #ALS #TDP-43
www.life-science-alliance.org/content/9/1/...
Glycolysis sustains STAT1 activity via STAT1 O-glycosylation, which is essential for human Th1 cell differentiation and IFNgamma production by maintaining STAT1 S727 phosphorylation. @mielenzlab.bsky.social
www.life-science-alliance.org/content/9/1/...
www.life-science-alliance.org/content/9/1/...
November 11, 2025 at 4:05 PM
Glycolysis sustains STAT1 activity via STAT1 O-glycosylation, which is essential for human Th1 cell differentiation and IFNgamma production by maintaining STAT1 S727 phosphorylation. @mielenzlab.bsky.social
www.life-science-alliance.org/content/9/1/...
www.life-science-alliance.org/content/9/1/...
The Chameau gene helps flies survive starvation at lower temps, but a mere 2{degree sign}C rise makes it obsolete! This temperature-dependent role in metabolism and resilience has big implications for climate change biology.
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
November 7, 2025 at 4:04 PM
The Chameau gene helps flies survive starvation at lower temps, but a mere 2{degree sign}C rise makes it obsolete! This temperature-dependent role in metabolism and resilience has big implications for climate change biology.
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
@reviewcommons.org
www.life-science-alliance.org/content/9/1/...
This study presents an in vitro analysis of centriole and cilium formation during early mouse embryonic development, using 3D models to mimic implantation, tissue patterning, and axis elongation. @chribue.bsky.social @isabellavoelkl.bsky.social www.life-science-alliance.org/content/9/1/...
November 6, 2025 at 4:04 PM
This study presents an in vitro analysis of centriole and cilium formation during early mouse embryonic development, using 3D models to mimic implantation, tissue patterning, and axis elongation. @chribue.bsky.social @isabellavoelkl.bsky.social www.life-science-alliance.org/content/9/1/...
The study shows that NSUN1-mediated m5C RNA methylation drives TDP-43 cytoplasmic accumulation and neurotoxicity, revealing a new pathway contributing to ALS/FTD pathogenesis. #ALS #TDP-43
www.life-science-alliance.org/content/9/1/...
www.life-science-alliance.org/content/9/1/...
November 5, 2025 at 4:04 PM
The study shows that NSUN1-mediated m5C RNA methylation drives TDP-43 cytoplasmic accumulation and neurotoxicity, revealing a new pathway contributing to ALS/FTD pathogenesis. #ALS #TDP-43
www.life-science-alliance.org/content/9/1/...
www.life-science-alliance.org/content/9/1/...
Using in vitro stimulation & CRISPR/Cas9-mediated gene editing, Abir et al. found that Th1 cell identity is anchored in glycolysis by fostering STAT1 O-glycosylation, STAT1 Ser727 phosphorylation & Th1 cell effector capacity.
@mielenzlab.bsky.social
www.life-science-alliance.org/content/9/1/...
@mielenzlab.bsky.social
www.life-science-alliance.org/content/9/1/...
November 4, 2025 at 9:34 PM
Using in vitro stimulation & CRISPR/Cas9-mediated gene editing, Abir et al. found that Th1 cell identity is anchored in glycolysis by fostering STAT1 O-glycosylation, STAT1 Ser727 phosphorylation & Th1 cell effector capacity.
@mielenzlab.bsky.social
www.life-science-alliance.org/content/9/1/...
@mielenzlab.bsky.social
www.life-science-alliance.org/content/9/1/...
BCL6 limits CD8 T cell responses to tumors by inhibiting Glut3 expression. Conditional deletion of Bcl6 in activated CD8 T cells or pharmacological inhibition of BCL6 in mice represses tumor growth. www.life-science-alliance.org/content/9/1/... @scripps.edu
November 4, 2025 at 4:05 PM
BCL6 limits CD8 T cell responses to tumors by inhibiting Glut3 expression. Conditional deletion of Bcl6 in activated CD8 T cells or pharmacological inhibition of BCL6 in mice represses tumor growth. www.life-science-alliance.org/content/9/1/... @scripps.edu
Our November issue is here! Two articles in this issue uncover amino acid sensing mechanisms and outcomes. Also, discover which T cell subset targets pediatric neuroblastoma, the evolutionary conservation of a meiotic protein, and much more! www.life-science-alliance.org/content/8/11
November 3, 2025 at 4:04 PM
Our November issue is here! Two articles in this issue uncover amino acid sensing mechanisms and outcomes. Also, discover which T cell subset targets pediatric neuroblastoma, the evolutionary conservation of a meiotic protein, and much more! www.life-science-alliance.org/content/8/11
Using HDX-MS, this study demonstrates that conformational flexibility in beetle luciferases governs bioluminescence color, revealing how active site dynamics and domain-specific mutations fine-tune red- and blue-shifted light emission. www.life-science-alliance.org/content/9/1/...
October 31, 2025 at 3:06 PM
Using HDX-MS, this study demonstrates that conformational flexibility in beetle luciferases governs bioluminescence color, revealing how active site dynamics and domain-specific mutations fine-tune red- and blue-shifted light emission. www.life-science-alliance.org/content/9/1/...
This exciting study by the Buecker lab @chribue.bsky.social & first author Isabella Voelkl @isabellavoelkl.bsky.social explores in vitro differentiation models for their usability in studying cilia and centriole formation in mouse embryonic development www.life-science-alliance.org/content/9/1/...
October 30, 2025 at 3:05 PM
This exciting study by the Buecker lab @chribue.bsky.social & first author Isabella Voelkl @isabellavoelkl.bsky.social explores in vitro differentiation models for their usability in studying cilia and centriole formation in mouse embryonic development www.life-science-alliance.org/content/9/1/...
DA-Raf efficiently associates with the plasma membrane phosphatidylserine via the RBD and CRD domains and thus predominates over Raf proteins in the binding to Ras, thereby preventing the ERK pathway. www.life-science-alliance.org/content/8/12...
October 29, 2025 at 3:09 PM
DA-Raf efficiently associates with the plasma membrane phosphatidylserine via the RBD and CRD domains and thus predominates over Raf proteins in the binding to Ras, thereby preventing the ERK pathway. www.life-science-alliance.org/content/8/12...
Luan & colleagues show that a lack of BCL6 expression in activated CD8 T cells or pharmacological BCL6 inhibition inhibits tumors. The findings suggest ways to improve the CD8 T cell function in cancer by changing their energy utilization @scripps.edu www.life-science-alliance.org/content/9/1/...
October 28, 2025 at 3:07 PM
Luan & colleagues show that a lack of BCL6 expression in activated CD8 T cells or pharmacological BCL6 inhibition inhibits tumors. The findings suggest ways to improve the CD8 T cell function in cancer by changing their energy utilization @scripps.edu www.life-science-alliance.org/content/9/1/...
Check out this research article:
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
October 27, 2025 at 3:07 PM
Check out this research article:
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
This study shows that DA-Raf localizes to the plasma membrane, binds preferentially to phosphatidylserine and active Ras via its Ras-binding and cysteine-rich domains (RBD/CRD), and thereby inhibits Raf activation and the Ras-ERK pathway. www.life-science-alliance.org/content/8/12...
October 22, 2025 at 3:07 PM
This study shows that DA-Raf localizes to the plasma membrane, binds preferentially to phosphatidylserine and active Ras via its Ras-binding and cysteine-rich domains (RBD/CRD), and thereby inhibits Raf activation and the Ras-ERK pathway. www.life-science-alliance.org/content/8/12...
Mitochondria-generated reactive oxygen species influence centrosome replication, leading to microtubule reorganization and impacting endosomal transport. #CellBiology #Research www.life-science-alliance.org/content/9/1/...
October 21, 2025 at 3:06 PM
Mitochondria-generated reactive oxygen species influence centrosome replication, leading to microtubule reorganization and impacting endosomal transport. #CellBiology #Research www.life-science-alliance.org/content/9/1/...
This study investigates effects of increased POLRMT levels and reports stimulation of mtDNA transcription initiation and enhanced exercise capacity without an effect on steady-state mRNA levels. www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
@kuhl-lab.bsky.social
October 20, 2025 at 3:29 PM
This study investigates effects of increased POLRMT levels and reports stimulation of mtDNA transcription initiation and enhanced exercise capacity without an effect on steady-state mRNA levels. www.life-science-alliance.org/content/8/12...
@kuhl-lab.bsky.social
@kuhl-lab.bsky.social
This review outlines the scientific utility and ethical imperatives of human brain slice cultures, calling for global ethical standards in ex vivo neuroscience research www.life-science-alliance.org/content/8/12...
October 17, 2025 at 8:34 PM
This review outlines the scientific utility and ethical imperatives of human brain slice cultures, calling for global ethical standards in ex vivo neuroscience research www.life-science-alliance.org/content/8/12...
Have you already seen this research article, recently published in LSA:
PARP10 is Critical for Stress Granule Initiation @leunglab.bsky.social www.life-science-alliance.org/content/8/12...
PARP10 is Critical for Stress Granule Initiation @leunglab.bsky.social www.life-science-alliance.org/content/8/12...
October 17, 2025 at 3:07 PM
Have you already seen this research article, recently published in LSA:
PARP10 is Critical for Stress Granule Initiation @leunglab.bsky.social www.life-science-alliance.org/content/8/12...
PARP10 is Critical for Stress Granule Initiation @leunglab.bsky.social www.life-science-alliance.org/content/8/12...
Exploring the pros and cons of AHR activation during gut infections: AHR can both aid in fighting off pathogens and potentially worsen inflammation. #GutHealth #AHRImpact www.life-science-alliance.org/content/8/12...
October 16, 2025 at 8:34 PM
Exploring the pros and cons of AHR activation during gut infections: AHR can both aid in fighting off pathogens and potentially worsen inflammation. #GutHealth #AHRImpact www.life-science-alliance.org/content/8/12...
Check out this recently published paper in LSA:
A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling @reviewcommons.org www.life-science-alliance.org/content/8/12...
A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling @reviewcommons.org www.life-science-alliance.org/content/8/12...
October 16, 2025 at 3:05 PM
Check out this recently published paper in LSA:
A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling @reviewcommons.org www.life-science-alliance.org/content/8/12...
A Drosophila screen of schizophrenia genes highlights neural and glial MMPs in neuronal remodeling @reviewcommons.org www.life-science-alliance.org/content/8/12...
This study shows that reactive oxygen species produced by mitochondria alter centrosome duplication, causing microtubule rearrangements that alter endosomal trafficking. www.life-science-alliance.org/content/9/1/...
October 14, 2025 at 3:04 PM
This study shows that reactive oxygen species produced by mitochondria alter centrosome duplication, causing microtubule rearrangements that alter endosomal trafficking. www.life-science-alliance.org/content/9/1/...
KANSL3 is an epigenetic regulator of hepatocyte metabolism and differentiation, essential for liver development and key to maintaining liver health. @mwiese.bsky.social www.life-science-alliance.org/content/8/12...
October 13, 2025 at 4:56 PM
KANSL3 is an epigenetic regulator of hepatocyte metabolism and differentiation, essential for liver development and key to maintaining liver health. @mwiese.bsky.social www.life-science-alliance.org/content/8/12...