Future work using our zebrafish model could reveal the underlying mechanisms by which low DHA status leads to neurodevelopmental abnormalities. These studies will also provide foundational support for maternal interventions that improve infant eye & brain health.

We found that low DHA status during development is associated with an abnormal eye phenotype. We also showed that even morphologically normal siblings exhibit dysregulated vision and stress response gene pathways.

We created a novel DHA-deficient larval zebrafish model using a two “finned” approach. This included: 1) disrupting elovl2, a critical gene in the DHA biosynthesis pathway with CRISPR/Cas9 genome editing, and 2) feeding mothers a DHA-deficient diet.

Docosahexaenoic acid (DHA), an omega-3 fatty acid crucial for vision & brain development, is lacking in Western diets. How does low DHA status impact neurodevelopment at the cellular & molecular level? With help from a zebrafish model, we can fill this knowledge gap and improve infant health.

Sure, study section can be a be a grind but there is a huge perk - the chance to connect with special former students who have relocated to DC. Here with the incomparable Alex Hughes and Nick George. #myelin 🧠🧪