Mechanobiology Institute
@mbisg.bsky.social
Wishing everyone a bright and happy Deepavali!
October 19, 2025 at 2:05 AM
Wishing everyone a bright and happy Deepavali!
Reposted by Mechanobiology Institute
How are tissue folds stabilized during animal organ development? Our latest preprint helps to answer this question, using the fruit fly wing disc as a model doi.org/10.1101/2025.... @poldresden.bsky.social @mpipks.bsky.social @dfg.de @janafuhrmann.bsky.social @vicioms.bsky.social @mbisg.bsky.social
Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc
Tissue folding is a fundamental process occurring in animal organ development. Here, we study the progression of fold shape and the underlying mechanics in the development of the Drosophila wing disc....
doi.org
October 11, 2025 at 3:09 AM
How are tissue folds stabilized during animal organ development? Our latest preprint helps to answer this question, using the fruit fly wing disc as a model doi.org/10.1101/2025.... @poldresden.bsky.social @mpipks.bsky.social @dfg.de @janafuhrmann.bsky.social @vicioms.bsky.social @mbisg.bsky.social
Reposted by Mechanobiology Institute
Delighted to host Anne Beghin (@mbisg.bsky.social) ✈️ and @merlinlange.bsky.social (Institut de la Vision and @czbiohub.bsky.social ) 🐟 for the Module 4 Multiscale analysis of 3D biological samples
Good science and great people.
#MiFoBio2025 is really a grand cru 🍷
@gdrimabio.bsky.social
Good science and great people.
#MiFoBio2025 is really a grand cru 🍷
@gdrimabio.bsky.social
October 15, 2025 at 9:45 AM
Delighted to host Anne Beghin (@mbisg.bsky.social) ✈️ and @merlinlange.bsky.social (Institut de la Vision and @czbiohub.bsky.social ) 🐟 for the Module 4 Multiscale analysis of 3D biological samples
Good science and great people.
#MiFoBio2025 is really a grand cru 🍷
@gdrimabio.bsky.social
Good science and great people.
#MiFoBio2025 is really a grand cru 🍷
@gdrimabio.bsky.social
Reposted by Mechanobiology Institute
I'm hiring a postdoc! If you're interested in researching mechanisms of 3D tissue morphogenesis and have experience studying cell dynamics and performing quantitative image analysis, consider joining us @mbisg.bsky.social! www.mbi.nus.edu.sg/jobs/seeking...
www.mbi.nus.edu.sg
October 15, 2025 at 1:45 AM
I'm hiring a postdoc! If you're interested in researching mechanisms of 3D tissue morphogenesis and have experience studying cell dynamics and performing quantitative image analysis, consider joining us @mbisg.bsky.social! www.mbi.nus.edu.sg/jobs/seeking...
Reposted by Mechanobiology Institute
Attention colleagues! Interested in an interdisciplinary #PhD? 🧬 Apply now for one of 12 PhD positions exploring biomolecular #condensates! This program involves several PoL PIs, bridging the gap between physics and biology.
Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October
Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October
October 9, 2025 at 2:32 PM
Attention colleagues! Interested in an interdisciplinary #PhD? 🧬 Apply now for one of 12 PhD positions exploring biomolecular #condensates! This program involves several PoL PIs, bridging the gap between physics and biology.
Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October
Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October
Reposted by Mechanobiology Institute
#Mifobio2025
Focus on the module 4 :
👉 Multi-scale imaging of biological systems
We are delighted to welcome Anne BEGHIN @mbisg.bsky.social
Lecture - “Breaking scale: Image Analysis–Based AI to Streamline multilevels 3D quantitative Imaging and Tackle the vEM Challenge”
#GDRimabio
Focus on the module 4 :
👉 Multi-scale imaging of biological systems
We are delighted to welcome Anne BEGHIN @mbisg.bsky.social
Lecture - “Breaking scale: Image Analysis–Based AI to Streamline multilevels 3D quantitative Imaging and Tackle the vEM Challenge”
#GDRimabio
October 5, 2025 at 12:01 PM
#Mifobio2025
Focus on the module 4 :
👉 Multi-scale imaging of biological systems
We are delighted to welcome Anne BEGHIN @mbisg.bsky.social
Lecture - “Breaking scale: Image Analysis–Based AI to Streamline multilevels 3D quantitative Imaging and Tackle the vEM Challenge”
#GDRimabio
Focus on the module 4 :
👉 Multi-scale imaging of biological systems
We are delighted to welcome Anne BEGHIN @mbisg.bsky.social
Lecture - “Breaking scale: Image Analysis–Based AI to Streamline multilevels 3D quantitative Imaging and Tackle the vEM Challenge”
#GDRimabio
Reposted by Mechanobiology Institute
We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy.
mikeinmemoriam.sciencesconf.org
mikeinmemoriam.sciencesconf.org
September 18, 2025 at 8:50 AM
We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy.
mikeinmemoriam.sciencesconf.org
mikeinmemoriam.sciencesconf.org
Reposted by Mechanobiology Institute
Have you ever wondered how microtubules withstand and respond to mechanical stress in cells?
Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.
Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.
September 16, 2025 at 6:43 AM
Have you ever wondered how microtubules withstand and respond to mechanical stress in cells?
Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.
Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.
We would like to once again, thank all the sponsors for their generosity in supporting #MBIMPG2025 @leicamicrosystems.bsky.social @nikoninst.bsky.social @oxfordinstruments.bsky.social, Optics11Life, BGI, Office of Naval Research Global and Paeonia Foundation.
September 12, 2025 at 8:55 AM
We would like to once again, thank all the sponsors for their generosity in supporting #MBIMPG2025 @leicamicrosystems.bsky.social @nikoninst.bsky.social @oxfordinstruments.bsky.social, Optics11Life, BGI, Office of Naval Research Global and Paeonia Foundation.
That closes out #MBIMPG2025! It would not have been possible without the efforts of the Scientific Organizing Committee, and special thanks to the admin team, A/V support, and student volunteers for ensuring a smooth conference 👏
September 12, 2025 at 8:53 AM
That closes out #MBIMPG2025! It would not have been possible without the efforts of the Scientific Organizing Committee, and special thanks to the admin team, A/V support, and student volunteers for ensuring a smooth conference 👏
Congratulations to our three poster prize winners for #MBIMPG2025!
🏆Rituraj Marwaha; Das Lab
🏆Boon Heng Ng; Chan Lab
🏆Marie Cutiongco ; @wtzhaolab.bsky.social
Thanks to all of the 115(!) poster presenters – our judges had a hard time deciding!
🏆Rituraj Marwaha; Das Lab
🏆Boon Heng Ng; Chan Lab
🏆Marie Cutiongco ; @wtzhaolab.bsky.social
Thanks to all of the 115(!) poster presenters – our judges had a hard time deciding!
September 12, 2025 at 8:53 AM
Congratulations to our three poster prize winners for #MBIMPG2025!
🏆Rituraj Marwaha; Das Lab
🏆Boon Heng Ng; Chan Lab
🏆Marie Cutiongco ; @wtzhaolab.bsky.social
Thanks to all of the 115(!) poster presenters – our judges had a hard time deciding!
🏆Rituraj Marwaha; Das Lab
🏆Boon Heng Ng; Chan Lab
🏆Marie Cutiongco ; @wtzhaolab.bsky.social
Thanks to all of the 115(!) poster presenters – our judges had a hard time deciding!
Remarkable intravital two-photon imaging videos from @hirashima0203.bsky.social @mbisg.bsky.social visualising sperm movement through the epididymal duct, revealing how epithelial contractions promote active turbulence of sperm collectives, essential for sperm to acquire motility. #MBIMPG2025
September 12, 2025 at 8:25 AM
Remarkable intravital two-photon imaging videos from @hirashima0203.bsky.social @mbisg.bsky.social visualising sperm movement through the epididymal duct, revealing how epithelial contractions promote active turbulence of sperm collectives, essential for sperm to acquire motility. #MBIMPG2025
Zhao Wenting @wtzhaolab.bsky.social shared two complementary studies highlighting how immune cells use curvature-sensitive mechanisms to leverage on nanoscale membrane deformations- both intrinsic and extrinsic—regulating signaling and motility. #MBIMPG2025
September 12, 2025 at 8:02 AM
Zhao Wenting @wtzhaolab.bsky.social shared two complementary studies highlighting how immune cells use curvature-sensitive mechanisms to leverage on nanoscale membrane deformations- both intrinsic and extrinsic—regulating signaling and motility. #MBIMPG2025
Kim Whye Leong @mbisg.bsky.social examined lumen development in ovarian follicles, a key step for ovulation transitions from a fluid network into a phase-separated state, regulated by cell-fluid surface tension—these dynamics may help nutrient exchange. #MBIMPG2025
September 12, 2025 at 7:21 AM
Kim Whye Leong @mbisg.bsky.social examined lumen development in ovarian follicles, a key step for ovulation transitions from a fluid network into a phase-separated state, regulated by cell-fluid surface tension—these dynamics may help nutrient exchange. #MBIMPG2025
Daniel Stedman @jtimaging.bsky.social presented a method using widefield fluorescence lifetime imaging microscopy to measure molecular tension changes at cell-cell interfaces within the beating zebrafish heart—both across a heartbeat and across developmental time. #MBIMPG2025
September 12, 2025 at 7:02 AM
Daniel Stedman @jtimaging.bsky.social presented a method using widefield fluorescence lifetime imaging microscopy to measure molecular tension changes at cell-cell interfaces within the beating zebrafish heart—both across a heartbeat and across developmental time. #MBIMPG2025
Returning to multi-dimensional models, Amit Pathak @washuengineers.bsky.social detailed how cell mechanical memory is retained from stiff 2D to fibrous 3D collagen matrices—even in hypoxic environments—to better understand tumor invasion in evolving microenvironments. #MBIMPG2025
September 12, 2025 at 6:46 AM
Returning to multi-dimensional models, Amit Pathak @washuengineers.bsky.social detailed how cell mechanical memory is retained from stiff 2D to fibrous 3D collagen matrices—even in hypoxic environments—to better understand tumor invasion in evolving microenvironments. #MBIMPG2025
Mineko Kengaku from Kyoto University continues the theme by sharing how Piezo-1 switches on a force generation mechanism in neuron migration and how DNA damage due to mechanostress in these narrow interstitial spaces is repaired by enhanced expression of topolsomerase IIb. #MBIMPG2025
September 12, 2025 at 6:24 AM
Mineko Kengaku from Kyoto University continues the theme by sharing how Piezo-1 switches on a force generation mechanism in neuron migration and how DNA damage due to mechanostress in these narrow interstitial spaces is repaired by enhanced expression of topolsomerase IIb. #MBIMPG2025
Next, Tamal Das @tifr.res.in revealed the influence of lysosomes in leader cell formation and the ER in supporting lamellipodial crawling and purse-string contraction, identifying them as key integrators of mechanochemical cues to drive collective cell migration. #MBIMPG2025
September 12, 2025 at 4:29 AM
Next, Tamal Das @tifr.res.in revealed the influence of lysosomes in leader cell formation and the ER in supporting lamellipodial crawling and purse-string contraction, identifying them as key integrators of mechanochemical cues to drive collective cell migration. #MBIMPG2025
Decoding the programming of biological shapes, @carldmodes.bsky.social @math-mpicbg.bsky.social models epithelial cell sheets as an active solid—studying in-plane collective cell behaviour in Drosophila development, moving up in complexity from the 1D cephalic furrow to 3D wing disc. #MBIMPG2025
September 12, 2025 at 4:01 AM
Decoding the programming of biological shapes, @carldmodes.bsky.social @math-mpicbg.bsky.social models epithelial cell sheets as an active solid—studying in-plane collective cell behaviour in Drosophila development, moving up in complexity from the 1D cephalic furrow to 3D wing disc. #MBIMPG2025
After an energizing morning, look forward to our final session of #MBIMPG2025! Session 7 will cover the mechanics of developmental biology, from collective cell migration to differentiation, across time and space!
September 12, 2025 at 3:18 AM
After an energizing morning, look forward to our final session of #MBIMPG2025! Session 7 will cover the mechanics of developmental biology, from collective cell migration to differentiation, across time and space!
Just one more day of #MBIMPG2025 left! But plenty to look forward to—one last Session of scientific talks, and two social excursions to the jungles! An exotic morning rainforest jungle walk and evening drinks at the concrete jungle roof-top bars @ Marina Bay! 🏞️🍹 See you there!
September 11, 2025 at 10:21 AM
Just one more day of #MBIMPG2025 left! But plenty to look forward to—one last Session of scientific talks, and two social excursions to the jungles! An exotic morning rainforest jungle walk and evening drinks at the concrete jungle roof-top bars @ Marina Bay! 🏞️🍹 See you there!
Ivan Yow @mbisg.bsky.social @schmidtsciences.bsky.social investigated the mechanics of 3D spheroid formation. Fyn initiates spheroid formation via the RhoA-ROCK pathway, leading to increased tissue viscosity and tension - and may initiate cardiomyocyte transdifferentiation! #MBIMPG2025
September 11, 2025 at 10:12 AM
Ivan Yow @mbisg.bsky.social @schmidtsciences.bsky.social investigated the mechanics of 3D spheroid formation. Fyn initiates spheroid formation via the RhoA-ROCK pathway, leading to increased tissue viscosity and tension - and may initiate cardiomyocyte transdifferentiation! #MBIMPG2025
Back to compressive stress with Frank van Drogen. Combining a phospho-proteomic approach with RNAi-based validation, he looked at the ERK5 pathway in mammary gland cells, showing how it reduces tension promoting the migratory response to compression. #MBIMPG2025
September 11, 2025 at 10:01 AM
Back to compressive stress with Frank van Drogen. Combining a phospho-proteomic approach with RNAi-based validation, he looked at the ERK5 pathway in mammary gland cells, showing how it reduces tension promoting the migratory response to compression. #MBIMPG2025
Great talk from Elizabeth Chen @echenlab.bsky.social on how cell-cell fusion is a conserved, asymmetric process - where one cell invades the other through invasive, mechanically stiff actin protrusions (bundled by dynamin & WIP!), to form a fusogenic synapse. #MBIMPG2025
September 11, 2025 at 9:59 AM
Great talk from Elizabeth Chen @echenlab.bsky.social on how cell-cell fusion is a conserved, asymmetric process - where one cell invades the other through invasive, mechanically stiff actin protrusions (bundled by dynamin & WIP!), to form a fusogenic synapse. #MBIMPG2025
Michel Steinmetz @psich.bsky.social showed how microtubules structurally interact with GEFH1 through its C1 domain. Identification and validation of microtubule-binding C1 domains in other signalling proteins revealed how microtubules can both receive and mediate signal transduction. #MBIMPG2025
September 11, 2025 at 9:46 AM
Michel Steinmetz @psich.bsky.social showed how microtubules structurally interact with GEFH1 through its C1 domain. Identification and validation of microtubule-binding C1 domains in other signalling proteins revealed how microtubules can both receive and mediate signal transduction. #MBIMPG2025