Henry De Belly
@henrydebelly.bsky.social
Postdoc in Orion Weiner's lab at UCSF. I work at the interface of Cell Biology and Biophysics.
I am into: #Actin, #Membrane, #CellMigration, #Polarity, #Cats, #Mechanobiology #Cheese #CellBiology
I am into: #Actin, #Membrane, #CellMigration, #Polarity, #Cats, #Mechanobiology #Cheese #CellBiology
Looking for curious and creative scientists (technicians, postdocs…) to join the team. Come do some cool imaging with me, such as this migrating neutrophil with front 🔴 and back 🔵 polarity biosensors!
More infos about the lab here: cri.utsw.edu/faculty/henr...
More infos about the lab here: cri.utsw.edu/faculty/henr...
October 16, 2025 at 10:00 PM
Looking for curious and creative scientists (technicians, postdocs…) to join the team. Come do some cool imaging with me, such as this migrating neutrophil with front 🔴 and back 🔵 polarity biosensors!
More infos about the lab here: cri.utsw.edu/faculty/henr...
More infos about the lab here: cri.utsw.edu/faculty/henr...
Every time I open Bluesky
November 14, 2024 at 8:26 PM
Every time I open Bluesky
Together we show that the actin cortex and plasma membrane function as an integrated mechanochemical system that is an essential feature of human lymphocyte polarization and motility
November 11, 2024 at 6:34 PM
Together we show that the actin cortex and plasma membrane function as an integrated mechanochemical system that is an essential feature of human lymphocyte polarization and motility
While we know that the front and back polarity programs locally inhibit one another, this alone isn't enough for stable polarization
Using optogenetics, mechanical manipulations, and math modeling, we found these two programs also mutually activate one another at a distance 🤝
Using optogenetics, mechanical manipulations, and math modeling, we found these two programs also mutually activate one another at a distance 🤝
November 11, 2024 at 6:34 PM
While we know that the front and back polarity programs locally inhibit one another, this alone isn't enough for stable polarization
Using optogenetics, mechanical manipulations, and math modeling, we found these two programs also mutually activate one another at a distance 🤝
Using optogenetics, mechanical manipulations, and math modeling, we found these two programs also mutually activate one another at a distance 🤝
Sharing my latest preprint as a re-introduction to bsky!
biorxiv.org/content/10.1...
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Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
biorxiv.org/content/10.1...
----
Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
November 11, 2024 at 6:34 PM
Sharing my latest preprint as a re-introduction to bsky!
biorxiv.org/content/10.1...
----
Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
biorxiv.org/content/10.1...
----
Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
It is really cool to see this big migration of 'science twitter' to bsky!! This makes me very hopeful. Here are some dancing primary T cells to celebrate 🕺
November 11, 2024 at 6:19 PM
It is really cool to see this big migration of 'science twitter' to bsky!! This makes me very hopeful. Here are some dancing primary T cells to celebrate 🕺
Another quite cool result is that expressing the worm TSP-1 in mammalian cells (HEK) is sufficient to give them elevated heat resistance! This is a great tool to allow you to easily increase heat resistance of your favorite cells!
January 26, 2024 at 8:04 PM
Another quite cool result is that expressing the worm TSP-1 in mammalian cells (HEK) is sufficient to give them elevated heat resistance! This is a great tool to allow you to easily increase heat resistance of your favorite cells!
A result that I find particularly interesting is that inducing TSP-1 expression without heat shock (gain of function) led to a massive increase in lifespan of the worm compared to WT!!! This suggest that TSP-1 may have a role in aging as well as modulating stress resistance.
January 26, 2024 at 8:03 PM
A result that I find particularly interesting is that inducing TSP-1 expression without heat shock (gain of function) led to a massive increase in lifespan of the worm compared to WT!!! This suggest that TSP-1 may have a role in aging as well as modulating stress resistance.
The paper has some nice characterization of the pathway of TSP-1 induction. Interestingly, they found that TSP-1 induction is independent from the canonical HSF (heat shock factor) response.
January 26, 2024 at 8:03 PM
The paper has some nice characterization of the pathway of TSP-1 induction. Interestingly, they found that TSP-1 induction is independent from the canonical HSF (heat shock factor) response.
They identified that this response is mediated by Testraspanin-1 (TSP-1), which forms a super stable web-like structure at the plasma membrane, playing a critical role in maintaining intestinal membrane barrier during external stresses (like heat).
January 26, 2024 at 8:02 PM
They identified that this response is mediated by Testraspanin-1 (TSP-1), which forms a super stable web-like structure at the plasma membrane, playing a critical role in maintaining intestinal membrane barrier during external stresses (like heat).
Wei showed that transient heat exposure in young worms leads to long lasting heat resilience of the organism, long after the initial heat stress.
January 26, 2024 at 8:01 PM
Wei showed that transient heat exposure in young worms leads to long lasting heat resilience of the organism, long after the initial heat stress.