Snezhka Oliferenko
@alebenoit.bsky.social
Reposted by Snezhka Oliferenko
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
October 30, 2025 at 11:44 AM
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
Homeostasis! Membranes! Evolution! Yay
Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes https://www.biorxiv.org/content/10.1101/2025.11.06.686945v1
November 7, 2025 at 11:29 PM
Homeostasis! Membranes! Evolution! Yay
Ahhh CUTE!!!
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:25 PM
Ahhh CUTE!!!
Reposted by Snezhka Oliferenko
Our paper describing enhanced hybridization-proximity labeling technology is finally out! Enhanced HyPro can identify proteins associated with small RNA compartments and even some individual transcripts, such as pathological C9orf72 transcripts: www.nature.com/articles/s41...
Enhanced hybridization-proximity labeling discovers protein interactomes of single RNA molecules - Nature Communications
Systematic discovery of proteins interacting with low-abundance RNAs is challenging. Here, the authors develop an enhanced HyPro technology to identify proteins associated with compact RNA compartment...
www.nature.com
October 21, 2025 at 8:46 AM
Our paper describing enhanced hybridization-proximity labeling technology is finally out! Enhanced HyPro can identify proteins associated with small RNA compartments and even some individual transcripts, such as pathological C9orf72 transcripts: www.nature.com/articles/s41...
Reposted by Snezhka Oliferenko
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
September 25, 2025 at 4:27 PM
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Reposted by Snezhka Oliferenko
Please visit our newly refreshed and updated website mcclellandlab.com We seem to be hard to find on Google for some reason, any tips from website savvy people?? 🙏
September 18, 2025 at 7:24 AM
Please visit our newly refreshed and updated website mcclellandlab.com We seem to be hard to find on Google for some reason, any tips from website savvy people?? 🙏
Cute!
De novo Golgi biogenesis requires coordinated transactivation of a Golgi regulon https://www.biorxiv.org/content/10.1101/2025.09.17.676727v1
September 18, 2025 at 9:01 AM
Cute!
Ahh so beautiful
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 24, 2025 at 7:33 AM
Ahh so beautiful
YES
Why would anyone want to be a scientist?
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
August 15, 2025 at 7:40 PM
YES
Reposted by Snezhka Oliferenko
We are pleased to share the Schizosaccharomyces orthogroup web resource (fsnibs10.github.io/SOG/) with the pombe community.
August 5, 2025 at 10:36 AM
We are pleased to share the Schizosaccharomyces orthogroup web resource (fsnibs10.github.io/SOG/) with the pombe community.
Yay YAY congrats to everyone - and am super happy for my neighbour (and friend!) Jody Rosenblatt! Jody doesn’t have Bluesky, let me bug her about that
Welcome and congratulations to the 60 new members and 9 associate members who have been elected to the EMBO Membership! This honour celebrates #research excellence and outstanding achievements in the #LifeSciences. 🧪
Learn more here:
www.embo.org/press-releas... #EMBOMembers2025
Learn more here:
www.embo.org/press-releas... #EMBOMembers2025
Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO
Sixty-nine new members join the community of leading life scientists in Europe and beyond
www.embo.org
July 2, 2025 at 7:46 PM
Yay YAY congrats to everyone - and am super happy for my neighbour (and friend!) Jody Rosenblatt! Jody doesn’t have Bluesky, let me bug her about that
Reposted by Snezhka Oliferenko
How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 24, 2025 at 7:22 PM
How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
OMG IN ALL CAPS
It’s out! The evolutionary origins of yeast point centromeres uncovered!
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
Ancient co-option of LTR retrotransposons as yeast centromeres
The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...
www.biorxiv.org
June 16, 2025 at 6:16 PM
OMG IN ALL CAPS
Reposted by Snezhka Oliferenko
Just out - a collaborative effort examining gene family evolution across yeast species. We found that fast-evolving yeasts lose more genes - especially ones for splicing, metabolism, and cell division. This is consistent with their narrow metabolic niche breadth.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Unique trajectory of gene family evolution from genomic analysis of nearly all known species in an ancient yeast lineage | Molecular Systems Biology
imageimageLarge-scale comparison of gene families across 1154 Saccharomycotina genomes revealed
that gene gains and losses drive yeast evolution. Faster-evolving lineages lose more
genes and speciate ...
www.embopress.org
May 27, 2025 at 6:31 PM
Just out - a collaborative effort examining gene family evolution across yeast species. We found that fast-evolving yeasts lose more genes - especially ones for splicing, metabolism, and cell division. This is consistent with their narrow metabolic niche breadth.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Omg AMAZEBALLS
Joining the race to the bottom has never been cooler...
www.biorxiv.org/node/4580343...
www.biorxiv.org/content/10.1...
www.biorxiv.org/node/4580343...
www.biorxiv.org/content/10.1...
A cellular entity retaining only its replicative core: Hidden archaeal lineage with an ultra-reduced genome
Defining the minimal genetic requirements for cellular life remains a fundamental question in biology. Genomic exploration continually reveals novel microbial lineages, often exhibiting extreme genome...
www.biorxiv.org
May 25, 2025 at 4:10 PM
Omg AMAZEBALLS
Reposted by Snezhka Oliferenko
Now published! Big congrats to first author @gginell.bsky.social
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
May 23, 2025 at 11:31 AM
Now published! Big congrats to first author @gginell.bsky.social
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
Reposted by Snezhka Oliferenko
Non-profit journals are on the critical list.
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
Thanks @mitodynamics.bsky.social for the fun interview and for saying it like it is:
“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
In our Special Issue: Cell Biology of Mitochondria we interview Guest Editor Heidi McBride @mitodynamics.bsky.social Heidi discusses her career path, the past, present & future of #mitochondria research & her role as guest editor at JCS.
journals.biologists.com/jcs/article/...
#JCSMitoSI
journals.biologists.com/jcs/article/...
#JCSMitoSI
May 23, 2025 at 11:54 AM
Non-profit journals are on the critical list.
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
Good efforts.
Here, I broke my tibia jumping in triumph after crossing the finishing line at a dog agility competition.
Here, I broke my tibia jumping in triumph after crossing the finishing line at a dog agility competition.
Broke my hand while shot putting
Tore a ligament in my thumb while long jumping
Ignited myself in the lab trying to test for borate
Tore a ligament in my thumb while long jumping
Ignited myself in the lab trying to test for borate
What's the stupidest way you've hurt yourself?
Oh I'm so glad you asked! I knocked myself out with a frozen bag of omelettes.
Oh I'm so glad you asked! I knocked myself out with a frozen bag of omelettes.
May 20, 2025 at 6:54 AM
Good efforts.
Here, I broke my tibia jumping in triumph after crossing the finishing line at a dog agility competition.
Here, I broke my tibia jumping in triumph after crossing the finishing line at a dog agility competition.
Ahh what fun
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay
Zhang et al. identify a regulatory mechanism for how cells adapt to nutrient scarcity through widespread −1 ribosomal frameshifts, culminating in accelerated mRNA decay. This process, dependent on codon optimality and conserved across species, establishes direct feedback coupling the translation of new proteins with the stability of the mRNA that encodes for them.
dlvr.it
May 18, 2025 at 9:06 AM
Ahh what fun
Auspicious morning I just knew it
May 15, 2025 at 10:43 AM
Auspicious morning I just knew it
Reposted by Snezhka Oliferenko
For those interested in yeast amino acid control, we've developed fluorescent reporters to simultaneously monitor amino acid synthesis and uptake activities (GAAC, TORC1, and SPS) in single cells: www.molbiolcell.org/doi/10.1091/...
May 9, 2025 at 7:08 AM
For those interested in yeast amino acid control, we've developed fluorescent reporters to simultaneously monitor amino acid synthesis and uptake activities (GAAC, TORC1, and SPS) in single cells: www.molbiolcell.org/doi/10.1091/...
Reposted by Snezhka Oliferenko
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Measurements of molecular size and shape on a chip
Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...
www.science.org
May 9, 2025 at 8:00 AM
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Reposted by Snezhka Oliferenko
The lab is on a roll. 2nd preprint in as many weeks!
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse.
Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social
www.biorxiv.org/content/10.1...
@biology-unige.bsky.social
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse.
Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social
www.biorxiv.org/content/10.1...
@biology-unige.bsky.social
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse
Cdc42 is a Rho-family GTPase conserved across eukaryotes, where it plays essential roles in cell polarization. In single-celled yeast systems, Cdc42 is a key driver of symmetry breaking and polarized ...
www.biorxiv.org
May 6, 2025 at 11:20 AM
The lab is on a roll. 2nd preprint in as many weeks!
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse.
Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social
www.biorxiv.org/content/10.1...
@biology-unige.bsky.social
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse.
Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social
www.biorxiv.org/content/10.1...
@biology-unige.bsky.social