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Gustavo Pacheco, Douglas DeSimone and colleagues discover that mitochondrial membrane potential is spatially regulated in collectively migrating tissue by integrin adhesion and signalling in leader row cells.

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#JCSMitoSI #Mitochondria
Figure showing that MMP in mesendoderm cells is dependent on integrin activation state and signalling.
May 15, 2025 at 9:58 AM
jcellsci.bsky.social
In our Special Issue: Cell Biology of Mitochondria we interview Guest Editor Heidi McBride @mitodynamics.bsky.social Heidi discusses her career path, the past, present & future of #mitochondria research & her role as guest editor at JCS.
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Heidi McBride
May 22, 2025 at 2:02 PM
jcellsci.bsky.social
Jason Casler @jasoncasler.bsky.social, Clare Harper and Laura Lackner @lllackner.bsky.social find that mitochondria–plasma membrane contact sites regulate the ER–mitochondria encounter structure.
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May 7, 2025 at 8:27 AM
jcellsci.bsky.social
Kailash Venkatraman, Nicolas-Frédéric Lipp & @ibudin.bsky.social examine the similarities between prokaryotic intracytoplasmic membranes & mitochondrial IMs, & discuss whether cristae evolution has driven specialisation of the #mito lipidome.
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Bacterial ICMs exhibit internal invaginations that resemble eukaryotic cristae. (A)TEM images showing tubular cristae-like ICM compartments in free-living Desulfobacterota, and similar cristae-like ICM tubules in Desulfovibrio carbinolicus strains. The eukaryotic model organism S. cerevisiae exhibits tubular cristae structures, whereas the commonly used HEK293 cell line exhibits predominantly lamellar cristae structures. Scale bars: 500 nm. (B) Eukaryotic mitochondria tend to exhibit lamellar, tubular or discoidal cristae morphology, whereas orders of the class alphaproteobacteria exhibit a range of ICM morphologies. Lamellar-like ICMs, which exhibit parallel cytoplasmic protrusions that do not contact the inner membrane, are commonly observed in nitrogen-fixing and several methanotrophic alphaproteobacteria. (C) This simplified and non-exhaustive cladogram indicates the two domains of life – bacteria and archaea – with proto-mitochondria emerging in early alphaproteobacteria. Eukaryogenesis is marked by the horizontal transfer (red dotted arrow) from Bacteria to Hordarchaeales in Asgard archaea. §, †, #, * and ‡ connect species listed in B to their respective clades in C.
May 12, 2025 at 9:05 AM
jcellsci.bsky.social
In their Review, Sukrut Kamerkar, Ao Liu and Henry Higgs discuss how individual aspects of mitochondrial fission might be integrated to give a more holistic understanding.
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#JCSMitoSI #Mitochondria
IMM fission. (A) Negative-stain EM micrograph of a mitochondrion from a HeLa cell, showing prominent inner membrane folds (cristae) as well as the non-cristae regions of the IMM, the inner boundary membrane (IBM). The cristae junction is the interface of the IBM and the cristae infolding. IMS, intermembrane space. Note the small diameter of the cristae lumen (typically ∼10 nm). Scale bar: 200 nm. Image taken by Radu Stan in the Dartmouth College Electron Microscopy Facility. (B) Schematic illustration of possible consequences of uncoordinated IMM–OMM fission. This could lead to cytosolic leakage of IMS or cristae lumenal components (e.g. cytochrome c) or matrix components (e.g. mtDNA) and subsequent activation of apoptosis or inflammatory pathways, respectively. Please note that these potential consequences are the authors' speculation and that mechanisms of actin IMM fission and coordination between IMM and OMM fission remain unclear. Created in BioRender by Kamerkar, S., 2025. https://BioRender.com/e48m132. This panel was sublicensed under CC-BY 4.0 terms.
May 8, 2025 at 2:01 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Gustavo Gavrel Pacheco: journals.biologists.com/jcs/article/...

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Gustavo Gavrel Pacheco
May 15, 2025 at 9:58 AM
jcellsci.bsky.social
In their Perspective, Thomas Simmen & Luca Pellegrini propose a model of cholesterol trafficking into & out of #mitochondria via phospholipids at mitochondria-associated membranes, challenging the traditional view of protein-driven transport.
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Screenshot of article titled,’ A lipid in transit – the journey of cholesterol into the heart of mitochondrial research’ published in Journal of Cell Science’s Special Issue: Cell Biology of Mitochondria.
May 21, 2025 at 2:00 PM
jcellsci.bsky.social
Our latest ‘Cell Scientist to Watch’ is Samantha Lewis. We caught up with Samantha to discuss her career path, the challenges for working on the ‘neglected’ mitochondrial genome and the exciting new frontiers in mitochondrial research.
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Samantha Lewis
May 20, 2025 at 2:06 PM
jcellsci.bsky.social
Soumyajit Mukherjee, Shreya Das, Arunima Sengupta, Alok Ghosh and colleagues find that pyruvate plus uridine augments mitochondrial respiration & prevents cardiac hypertrophy in zebrafish & H9c2 cells. #JCSMitoSI #JCSSnapshots
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youtu.be/PUqjJQu4oSA?...
JCS snapshot: pyruvate + uridine augments mitochondrial respiration & prevents cardiac hypertrophy
YouTube video by The Company of Biologists
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May 22, 2025 at 8:56 AM
jcellsci.bsky.social
In their Review, Eleonora Zilio, Elena Rugarli and colleagues @cecad.bsky.social @crc1218.bsky.social discuss the role of mitochondrial mRNA translation in cellular communication.
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#JCSMitoSI #Mitochondria
Cell-to-mitochondria communication by regulating the translation of NEM mRNAs. The translation of NEM mRNAs serves as a crucial communication node, integrating incoming signals and output cellular responses. Translation is regulated by binding to RBPs, which respond to incoming cellular signals (e.g. mTORC1, AMPK and insulin) and control translation in both time and space. In turn, ribosomal stress caused by stalled ribosomes transmits information about mitochondrial status and initiates stress responses. Created in BioRender by Rugarli, E., 2025. https://BioRender.com/d27y662. This figure was sublicensed under CC-BY 4.0 terms.
May 13, 2025 at 2:04 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Samruddhi Shembekar: journals.biologists.com/jcs/article/...
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Samruddhi Shembekar
May 8, 2025 at 8:16 AM
jcellsci.bsky.social
Following lipidomic and proteomic analyses, Vanessa Linke @massspecvanili.bsky.social Agnieszka Chacinska and colleagues identify a role for OCIAD1 at the mitochondria-peroxisome intersection balancing lipid metabolism.
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Figure showing organellar proteome and morphology changes upon OCIAD1 KO.
May 19, 2025 at 2:01 PM
jcellsci.bsky.social
In their Cell Science at a Glance article, Antigoni Diokmetzidou and Luca Scorrano summarise the mitochondrial contacts characterised in mammals, the molecular mechanisms underlying their formation, and their principal functions.
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JCS poster ‘Mitochondria–membranous organelle contacts at a glance’ Antigoni Diokmetzidou, Luca Scorrano
May 19, 2025 at 9:30 AM
jcellsci.bsky.social
Our ‘Cell Scientist to Watch’ interview is with Tom MacVicar. We caught up with Tom to discuss his career path, his advice on establishing research independence and why it’s an exciting time to be a mitochondrial biologist.
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Tom MacVicar
May 7, 2025 at 2:02 PM
jcellsci.bsky.social
We will be hosting a webinar to together with
@mitotalks.bsky.social to highlight research in our recent Special Issue: Cell Biology of Mitochondria.
Register here: focalplane.biologists.com/2025/06/09/m...
Explore our ToC: journals.biologists.com/jcs/issue/13...
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focalplane.bsky.social FocalPlane @focalplane.bsky.social · Jun 9
Our next #FocalPlaneFeatures webinar is in collaboration with @mitotalks.bsky.social. For this special webinar, Nuno Raimundo & @wanrooij20.bsky.social have selected 3 talks from @jcellsci.bsky.social's Special Issue: Cell Biology of Mitochondria.
📅3 July
focalplane.biologists.com/2025/06/09/m...
MITOtalks and FocalPlane features... Thursday 3 July 2025, 16:00 BST Image of Yuli Buckley - Fis1 regulates mitochondrial morphology, bioenergetics and removal of mitochondrial DNA damage Yuli Buckley (Case Western Reserve University School of Medicine) Image of Mireia Nager - Mitophagy is induced in human engineered heart tissue after simulated ischemia and reperfusion Mireia Nager (University Hospital of North Norway) Image of Dikaia Tsagkari - NHR-85 modulates mitochondrial and lipid homeostasis to protect against α-synuclein aggregation Dikaia Tsagkari (University of Crete) journals.biologists.com/jcs/issue/138/9 QR code FocalPlane and MITOtalks logo
June 10, 2025 at 12:42 PM
jcellsci.bsky.social
Our latest special issue is ‘Cell Biology of Mitochondria’. Over the next few weeks, we’ll be highlighting all the articles from this issue, which was guest edited by Ana Garcia-Saez and Heidi McBride @mitodynamics.bsky.social. Keep an eye on the hashtag #JCSMitoSI.
May 6, 2025 at 9:40 AM
jcellsci.bsky.social
Moritz Resch, Max Harner and colleagues @bmc-lmu.bsky.social find that the Mia40 substrate Mix17 exposes its N-terminus to the cytosolic side of the mitochondrial outer membrane.
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Working model of Mix17 biogenesis
May 14, 2025 at 8:33 AM
jcellsci.bsky.social
Metin Özdemir, Sven Dennerlein and colleagues define a TOM complex interactome, revealing diverse interaction partners that include the new interactors MAPL, ATAD1 and TRABD.
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#JCSMitoSI #Mitochondria
Figure showing the human TOM interactome.
May 15, 2025 at 2:01 PM
jcellsci.bsky.social
- Mitochondria – the CEO of the cell
Reviews on:
- The role of mitochondrial mRNA translation in cellular communication
- Origin & evolution of mitochondrial IM composition
- Mitochondrial fission – changing perspectives for future progress
journals.biologists.com/jcs/issue/13...
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Volume 138 Issue 9 | Journal of Cell Science | The Company of Biologists
journals.biologists.com
May 15, 2025 at 2:32 PM
jcellsci.bsky.social
Yuli Buckley, Jason Mears and colleagues find that Fis1 modulates bioenergetics and selective removal of mtDNA damage in response to radiation.
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Figure showing that Fis1 silencing blunts mitochondrial fission in GBM cells.
May 6, 2025 at 3:25 PM
jcellsci.bsky.social
Gordon Freedman from @mitoworld.bsky.social chats with JCS Executive Editor @seemagrewal.bsky.social ‬about our special issue on ‘Cell Biology of Mitochondria’.
#JCSMitoSI #Mitochondria

mitoworld.org/special-issu...
Special Issue: Cell Biology of Mitochondria - MitoWorld
The special issue of Journal of Cell Science (JCS) on the “Cell Biology of Mitochondria” looks to be one of the most comprehensive open series of papers, opinions, perspectives, interviews, reviews an...
mitoworld.org
May 23, 2025 at 8:43 AM
jcellsci.bsky.social
We are delighted to launch ‘JCS snapshots’, in collaboration with @focalplane.bsky.social. In these short talks, authors share the key findings of their research. Our first snapshots are from our Special Issue: Cell Biology of Mitochondria. #JCSMitoSI
focalplane.biologists.com/2025/05/21/i...
Introducing JCS snapshots - FocalPlane
Introducing JCS snapshots - News
focalplane.biologists.com
May 21, 2025 at 10:51 AM
jcellsci.bsky.social
In their Opinion article, Laurie Lee-Glover, Martin Picard and Timothy Shutt @mitomorph.bsky.social argue that mitochondria should be considered as the ‘Chief Executive Organelle’ – the CEO – of the cell. #JCSMitoSI #Mitochondria
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Schematic showing that mitochondria can be understood as the ‘Chief Executive Organelle’ of the cell! Mitochondria play key roles in determining cell fate, including regulation of cell division, stem cell differentiation, senescence and cell death, akin to decisions a CEO makes about the growth, diversification or closure of a company. Mitochondria also control key cell resources, including ATP and a variety of other metabolites. Furthermore, mitochondria act as signalling hubs, mediating both intracellular and intercellular signalling, much like communication lines within and between organizations, and regulate innate immune pathways that act as the security system of the cell. Given the many instructive roles mitochondria carry out, we argue that they should be considered the CEO of the cell. This figure was partly generated using Servier Medical Art, provided by Servier, licensed under a CC-BY 3.0 Unported license.
May 9, 2025 at 2:01 PM
jcellsci.bsky.social
In their Cell Science at a Glance article, Megan Balzarini, John Kim and Hilla Weidberg summarise the fate of un-imported mitochondrial proteins and the compartment-specific quality control pathways that regulate them.
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Quality control of un-imported mitochondrial proteins at a glance Megan Balzarini, John Kim, Hilla Weidberg
May 16, 2025 at 2:03 PM
jcellsci.bsky.social
Deepika Kumari, Ritu Pasrija and colleagues find that ER–mitochondria encounter structure (ERMES) connections determine drug sensitivity and virulence of Cryptococcus neoformans.
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#JCSMitoSI #Mitochondria
Figure showing that ERMES disruption influences melanin and capsule production.
May 14, 2025 at 2:00 PM