Wout Oosterheert
@woutoosterheert.bsky.social
Junior group leader at the Netherlands Cancer Institute (NKI) in Amsterdam.
Interests include biochemistry; structural biology; cryo-EM; the cytoskeleton; membrane proteins.
Interests include biochemistry; structural biology; cryo-EM; the cytoskeleton; membrane proteins.
Pinned
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
Reposted by Wout Oosterheert
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 7:14 AM
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
Are you excited to uncover the molecular mechanisms of actin filament assemblies that drive cell migration using cryo-EM?
Only 1.5 week to apply for this exciting PhD position in my newly established lab at the Netherlands Cancer Institute in Amsterdam: www.werkenbijavl.nl/vacatures/ph...
Only 1.5 week to apply for this exciting PhD position in my newly established lab at the Netherlands Cancer Institute in Amsterdam: www.werkenbijavl.nl/vacatures/ph...
PhD Student – Structural Biology of Actin Filament Assemblies | Werken bij AVL
www.werkenbijavl.nl
October 28, 2025 at 9:17 AM
Are you excited to uncover the molecular mechanisms of actin filament assemblies that drive cell migration using cryo-EM?
Only 1.5 week to apply for this exciting PhD position in my newly established lab at the Netherlands Cancer Institute in Amsterdam: www.werkenbijavl.nl/vacatures/ph...
Only 1.5 week to apply for this exciting PhD position in my newly established lab at the Netherlands Cancer Institute in Amsterdam: www.werkenbijavl.nl/vacatures/ph...
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
October 13, 2025 at 9:04 AM
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
Reposted by Wout Oosterheert
Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1 pubmed.ncbi.nlm.nih.gov/41075793/ #cryoem
October 12, 2025 at 9:33 PM
Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1 pubmed.ncbi.nlm.nih.gov/41075793/ #cryoem
Reposted by Wout Oosterheert
We just published this paper of which I am immensely proud: www.nature.com/articles/s41...
In the study, we uncover how the enzyme MPO disassembles #nucleosomes in a process called NETosis, a funky mechanism of #neutrophils to kill #pathogens that you might have never heard of.
Let's dive in... 🧵
In the study, we uncover how the enzyme MPO disassembles #nucleosomes in a process called NETosis, a funky mechanism of #neutrophils to kill #pathogens that you might have never heard of.
Let's dive in... 🧵
Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature
Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.
www.nature.com
September 18, 2025 at 3:39 PM
We just published this paper of which I am immensely proud: www.nature.com/articles/s41...
In the study, we uncover how the enzyme MPO disassembles #nucleosomes in a process called NETosis, a funky mechanism of #neutrophils to kill #pathogens that you might have never heard of.
Let's dive in... 🧵
In the study, we uncover how the enzyme MPO disassembles #nucleosomes in a process called NETosis, a funky mechanism of #neutrophils to kill #pathogens that you might have never heard of.
Let's dive in... 🧵
Thrilled to announce that from tomorrow (October 1st), I'll start as a junior group leader at the Netherlands Cancer Institute (NKI) @nkinl.bsky.social in Amsterdam 😄.
www.nki.nl/news-events/...
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www.nki.nl/news-events/...
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New group leader Wout Oosterheert: the devil is in the details | Netherlands Cancer Institute
www.nki.nl
September 30, 2025 at 12:54 PM
Thrilled to announce that from tomorrow (October 1st), I'll start as a junior group leader at the Netherlands Cancer Institute (NKI) @nkinl.bsky.social in Amsterdam 😄.
www.nki.nl/news-events/...
1/3
www.nki.nl/news-events/...
1/3
Reposted by Wout Oosterheert
Featuring #AlphaBridge features from @alvarezsalmoral.bsky.social, with @jonasteuwen.bsky.social and team, our new work from @nkinl.bsky.social nl.bsky.social @oncodeinstitute.bsky.social . Have a look at ahmpc.eu for more!
Integrating computational protein structure predictions and genetic dependencies yields an atlas of human multi-protein complexes (AHMPC) https://www.biorxiv.org/content/10.1101/2025.09.09.675133v1
September 13, 2025 at 12:27 PM
Featuring #AlphaBridge features from @alvarezsalmoral.bsky.social, with @jonasteuwen.bsky.social and team, our new work from @nkinl.bsky.social nl.bsky.social @oncodeinstitute.bsky.social . Have a look at ahmpc.eu for more!
Reposted by Wout Oosterheert
Nature research paper: Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases
go.nature.com/3HpdTqq
go.nature.com/3HpdTqq
Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases - Nature
Structural insights into ultrafast Ca2+ transport by plasma membrane Ca2+-ATPases are provided, highlighting an essential role for PtdIns(4,5)P2 dynamics.
go.nature.com
August 23, 2025 at 3:28 PM
Nature research paper: Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases
go.nature.com/3HpdTqq
go.nature.com/3HpdTqq
Happy to have made a tiny contribution to this work (including the shown movie 😄). Amazing work by Fakler lab @uni-freiburg.de and @raunser-lab.bsky.social @mpi-dortmund.bsky.social about Ca-ion transport by PMCA2-NPTN complexes, now out in @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 25, 2025 at 12:10 PM
Happy to have made a tiny contribution to this work (including the shown movie 😄). Amazing work by Fakler lab @uni-freiburg.de and @raunser-lab.bsky.social @mpi-dortmund.bsky.social about Ca-ion transport by PMCA2-NPTN complexes, now out in @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Wout Oosterheert
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 5, 2025 at 10:43 AM
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Wout Oosterheert
Some happy news. Pleased to see our paper showing how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex out in Science Advances: bit.ly/3EFpD6h
Afadin mediates cadherin-catenin complex clustering on F-actin linked to cooperative binding and filament curvature
Afadin strengthens adherens junctions by stabilizing cadherin-catenin complex clusters on curved F-actin.
bit.ly
February 18, 2025 at 3:37 AM
Some happy news. Pleased to see our paper showing how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex out in Science Advances: bit.ly/3EFpD6h
Reposted by Wout Oosterheert
Working on actin cytoskeleton and Arp2/3 complex? Check out our latest work～https://www.biorxiv.org/content/10.1101/2025.01.31.635869v1
In this work, we found SPIN90 forms a dimer, facilitating bidirectional actin filament nucleation by activating two Arp2/3 complex #Cryo-EM #Actin #Arp2/3
In this work, we found SPIN90 forms a dimer, facilitating bidirectional actin filament nucleation by activating two Arp2/3 complex #Cryo-EM #Actin #Arp2/3
January 31, 2025 at 9:42 PM
My first post on this forum! 😄
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund
January 23, 2025 at 9:08 AM
My first post on this forum! 😄
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund