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alushinlab.bsky.social
Alushin Lab
@alushinlab.bsky.social
490 followers 330 following 38 posts
Alushin lab at Rockefeller University. Interested in cryo-EM, the cytoskeleton, and mechanosensation at the molecular level.
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Reposted by Alushin Lab
jdhl18.bsky.social
FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer
www.nature.com/articles/s41...
FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer - Cell Death Discovery
Cell Death Discovery - FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer
www.nature.com
November 9, 2025 at 12:41 PM
Reposted by Alushin Lab
www.science.org/doi/10.1126/...
Structural dissection of αβ-tubulin heterodimer assembly and disassembly by human tubulin–specific chaperones
Microtubule assembly requires a set of chaperones known as tubulin-binding cofactors (TBCs). We used cryo–electron microscopy to visualize how human TBCD, TBCE, TBCC, and guanosine triphosphatase (GTP...
www.science.org
October 31, 2025 at 4:02 AM
Reposted by Alushin Lab
rockefeller.edu
Greg Alushin (@alushinlab.bsky.social) is decoding how the body’s building blocks sense and respond to force, with implications for everything from cancer to developmental disorders. In this Q&A, he discusses where his work on the cytoskeleton could lead us:
How cells move and change shape--and why it matters for our health - News
Inside each of your cells, there's a microscopic scaffolding that helps determine what the cell looks like, how it moves, and how it responds to its surroundings. This internal structure, called the cytoskeleton, is constantly shifting and adjusting. It...
www.rockefeller.edu
October 24, 2025 at 7:13 PM
Reposted by Alushin Lab
woutoosterheert.bsky.social
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.

www.sciencedirect.com/science/arti...

Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
October 13, 2025 at 9:04 AM
Reposted by Alushin Lab
jamesbriscoe.bsky.social
The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
Reposted by Alushin Lab
sarahcpwilliams.bsky.social
How do cells move, divide, & sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer & birth defects follow. @alushinlab.bsky.social at @rockefeller.edu is developing new tools to probe this tiny, dynamic cell scaffolding.
www.rockefeller.edu/news/38446-h...
How cells move and change shape—and why it matters for our health - News
Inside each of your cells, there’s a microscopic scaffolding that helps determine what the cell looks like, how it moves, and how it responds to its surroundings. This internal structure, called the c...
www.rockefeller.edu
October 9, 2025 at 11:54 AM
Reposted by Alushin Lab
embo.org
Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.

Deadline: 20 December 2025

https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Structure and Function of the Cytoskeleton
The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …
meetings.embo.org
October 7, 2025 at 3:35 PM
Reposted by Alushin Lab
samaytekin.bsky.social
Garcia Lab did it again! Such a fantastic read if you are interested in FAs mechanics and biology. Congratulations to @garcialabgt.bsky.social
Mechanochemical waves in focal adhesions during cell migration
Traction force and FAK signaling exhibit oscillatory temporal coupling in adhesive structures.
www.science.org
October 6, 2025 at 3:13 PM
Reposted by Alushin Lab
Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii

www.biorxiv.org/content/10.1...
Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii
Toxoplasma gondii ( T. gondii ) is a single-celled Apicomplexan parasite that relies on a highly polarized endomembrane system for its invasion into and survival within host cells. Recent advancements...
www.biorxiv.org
October 4, 2025 at 12:19 PM
Reposted by Alushin Lab
biorxiv-biophys.bsky.social
Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii https://www.biorxiv.org/content/10.1101/2025.10.02.679852v1
October 4, 2025 at 5:47 AM
Reposted by Alushin Lab
sarawickstrom.bsky.social
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
Reposted by Alushin Lab
samreckpeterson.bsky.social
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
Reposted by Alushin Lab
agoren.bsky.social
And from other labs’ work this is really cool:
www.science.org/doi/10.1126/...
Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness
Epigenetic control of gene expression and cellular phenotype is influenced by changes in the local microenvironment, yet how mechanical cues precisely influence epigenetic state to regulate transcript...
www.science.org
September 28, 2025 at 2:56 PM
Reposted by Alushin Lab
asapresearch.parkinsonsroadmap.org
Using cryo-ET, CRN Team Reck-Peterson showed that full-length LRRK2 can oligomerize on microtubules in its autoinhibited state. Both WT-LRRK2 and PD-linked LRRK2 mutants formed filaments on microtubules.

🔗 Read the full #preprint to learn more about their recent research: bit.ly/3VrVNaB
Cryo-ET structure of the microtubule-associated autoinhibited LRRK2^I2020T.
September 26, 2025 at 3:29 PM
Reposted by Alushin Lab
schurlab.bsky.social
Huntingtin binds and bundles F-actin!
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin

doi.org/10.1126/scia...
September 25, 2025 at 3:01 PM
Reposted by Alushin Lab
drmichaelway.bsky.social
And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4
Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers
Nature Structural & Molecular Biology - Liu et al. show that SPIN90 dimerizes and binds two Arp2/3 complexes to nucleate two bidirectional actin filaments and the dimerization domain is...
rdcu.be
September 16, 2025 at 6:09 AM
Reposted by Alushin Lab
baym.lol
Some good news: the NIH has now reinstated my R35 since the termination was found unconstitutional (still waiting on NSF), though the government continues to withhold the contractually obligated funds
September 13, 2025 at 1:02 AM
Reposted by Alushin Lab
mbhatten.bsky.social
A. James Hudspeth, Who Unlocked Mysteries Behind Hearing, Dies at 79 www.nytimes.com/2025/09/05/s...
A. James Hudspeth, Who Unlocked Mysteries Behind Hearing, Dies at 79
www.nytimes.com
September 7, 2025 at 4:39 PM
Reposted by Alushin Lab
mrndhntr.bsky.social
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
www.nature.com
August 27, 2025 at 5:18 PM
alushinlab.bsky.social
Rockefeller is conducting a faculty search; apply to become our colleague!
rockefeller.edu The Rockefeller University @rockefeller.edu · Aug 20
Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.

Learn more below:
Faculty recruitment - Our Scientists
Applications for faculty positions are currently being accepted. Application deadline is October 6, 2025.
www.rockefeller.edu
August 20, 2025 at 3:22 PM
Reposted by Alushin Lab
lammerdinglab.bsky.social
Interested in #mechanobiology of the cell nucleus? The submission deadline for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation.
#MBNSRC

events.faseb.org/event/Mechan...
August 19, 2025 at 7:43 PM
Reposted by Alushin Lab
rockefeller.edu
We are deeply saddened to share that our friend and colleague Jim Hudspeth passed away on Saturday. We will remember and continue to be inspired by Jim’s integrity, his humility, and his unwavering commitment to discovery.
A. James Hudspeth, neuroscientist who unlocked secrets of hearing, has died - News
A. James Hudspeth, a Rockefeller neuroscientist who discovered how sound waves are converted into electrical signals in the ear's cochlea, died Saturday at his home in Manhattan. A pioneering scientist and dedicated mentor, he was the university's F.M. ...
www.rockefeller.edu
August 18, 2025 at 7:59 PM
Reposted by Alushin Lab
jcb.org
Han, Connolly, Ohi, Kenworthy et al. explore the evolutionary history of #caveolins. Using computational predictions & #CryoEM, the authors show both animal & choanoflagellate caveolins assemble into amphipathic disks composed of seven conserved structural elements. rupress.org/jcb/article/...
August 7, 2025 at 4:15 PM
Reposted by Alushin Lab
maxkozlov.bsky.social
BREAKING: Watchdog government agency finds the NIH and the Trump administration have illegally withheld funds in violation of the Impoundment Control Act, and rips into HHS for failing to justify its slow-walking of funds.

www.gao.gov/products/b-3...
Department of Health and Human Services—National Institutes of Health—Application of Impoundment Control Act to Availability of Funds for Grants
Congress appropriated amounts to the National Institutes of Health (NIH) to carry out various research objectives for fiscal year 2025. In accordance...
www.gao.gov
August 5, 2025 at 5:17 PM
Reposted by Alushin Lab
rezamehdipour.bsky.social
We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!!
www.biorxiv.org/content/10.1...
August 5, 2025 at 12:41 PM