Aligning Science Across Parkinson's
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's
@asapresearch.parkinsonsroadmap.org
1.2K followers 130 following 500 posts
Global initiative rooted in Collaboration and Open Science to accelerate Parkinson's disease research. Programs include GP2 and CRN.

https://parkinsonsroadmap.org/#
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asapresearch.parkinsonsroadmap.org
CRN Team Strick found temporal features of GPi neural responses were related to motor impairment severity in MPTP-induced parkinsonism, while variations in neural response magnitude & duration didn't reliably reflect symptom severity.

🔗 Read the #publication: bit.ly/42MJ0Dx
Movement-related activity in the internal globus pallidus of the parkinsonian macaque.
November 10, 2025 at 4:42 PM
asapresearch.parkinsonsroadmap.org
In their recent preprint, CRN Team Scherzer introduces EVscope, a new open-source computational pipeline designed to analyze extracellular vesicle (EV) RNA-seq data, which are often low in abundance and fragmented.

🔗 Check out the full #preprint to read more about EVscope: bit.ly/48Nzh3Q
EVscope: A Comprehensive Bioinformatics Pipeline for Accurate and Robust Analysis of Total RNA Sequencing from Extracellular Vesicles.
November 7, 2025 at 3:40 PM
asapresearch.parkinsonsroadmap.org
Exciting news! 🎉 This year marks significant progress for the BLAAC PD study–1,000 participants enrolled. As one of the most extensive studies of Black and African American people with Parkinson’s, BLAAC PD is advancing genetic diversity in global #ParkinsonsResearch.

Learn more: bit.ly/4of0OzX
Group photo of members of the BLAAC-PD study team standing together on a rooftop terrace with a city skyline in the background. The group smiles toward the camera on a sunny day, representing researchers and collaborators advancing Parkinson’s disease research through the GP2 BLAAC-PD study.
November 6, 2025 at 3:56 PM
asapresearch.parkinsonsroadmap.org
🎉 We’re proud to celebrate the incredible progress featured in the new CRN website’s Impact section!

Across 5 years & 35 teams, the CRN has advanced #ParkinsonsResearch through sharing 1,500+ research outputs, uniting 600+ PD donor brains, & integrating 100+ microbiome studies 🧪

🔗 www.asapcrn.org
November 5, 2025 at 3:57 PM
asapresearch.parkinsonsroadmap.org
We’re #hiring! 🧪

GP2 is looking for a Project Manager to lead global #Parkinson’s genetics research and advance discovery worldwide. Strong science background, PhD preferred, and PM experience. Share with others who may be interested!

Apply by November 7 👉 bit.ly/49dC32s
Graphic with a blue-to-green gradient background featuring the text “We’re Hiring” in large white letters. Below, it reads “Project Manager” in bold white font. A white-outlined box on the right says “Application Deadline: November 7, 2025.” The Global Parkinson’s Genetics Program (GP2) logo appears in the upper right corner.
November 4, 2025 at 4:05 PM
asapresearch.parkinsonsroadmap.org
CRN Team Schlossmacher investigated how nasally-acquired influenza A H1N1 infections interact with #ParkinsonsDisease genes to affect long-term neurological outcomes 🧪

🔗 Check out the full #preprint to read more about their findings: bit.ly/4h7OQFw
Mice that Survived an Influenza A Virus, H1N1 Infection Show Increased Levels of Oxidative Stress Six Weeks Post-Inoculation.
November 3, 2025 at 4:23 PM
asapresearch.parkinsonsroadmap.org
👏 This month’s Network Spotlight goes to Teams Kordower, Liddle, & Rio!

Their open-access protocols ranked among the top 100 most viewed on @protocolsio.bsky.social in August 🎉

➡️ Mouse Perfusions (bit.ly/4qH6rIY)
➡️ Y-Maze (bit.ly/47aITTC)
➡️ Culture/transfection of HEK293T cells (bit.ly/4o4ytfR)
Graphic with a dark teal background featuring three illustrated circular icons representing different research teams. On the left, Team Kordower icon shows colorful antibody shapes labeled “Neuro-Immune Interactions.” In the center, Team Liddle icon depicts a stylized brain with interconnected circuitry labeled “Circuitry and Brain-Body Interactions.” On the right, Team Rio icon shows a human head outline with a DNA strand inside, labeled “PD Functional Genomics.” A thin gradient line runs along the bottom, shifting from purple to blue to green, with the ASAP logo in the lower right corner.
October 31, 2025 at 3:05 PM
asapresearch.parkinsonsroadmap.org
The Collaborative Research Network has a new home! Explore the new CRN website, a designated space to discover research teams, working groups, and impact highlights driving discovery in #ParkinsonsDisease 🧪

👉 www.asapcrn.org
A dark, abstract background with blue and magenta light streaks resembling neural or network connections. White bold text in the center reads, “Explore the New CRN Website.” The “CRN” logo features a stylized DNA helix in place of the letter “R.” To the right of the text is a white circle containing a right-facing arrow, suggesting a clickable link or call to action.
October 29, 2025 at 2:40 PM
asapresearch.parkinsonsroadmap.org
13 countries. 16 trainees. 1 powerful hackathon 🌍

GP2 Hackathon united global minds in Lübeck, Germany to tackle #Parkinsons research with data, mentorship & collaboration.

🔗 Dive into the recap: bit.ly/4nfmeeX
Five participants collaborate closely at a table, focused on laptops during a GP2 hackathon session. Three GP2 hackathon participants sit together at a table, concentrating on a laptop screen while discussing data and taking notes. A small group of GP2 hackathon participants gather around laptops, engaged in conversation and sharing ideas during a breakout discussion. Large group of GP2 hackathon participants stand outdoors smiling for a group photo, holding GP2 tote bags under a bright blue sky.
October 28, 2025 at 6:02 PM
asapresearch.parkinsonsroadmap.org
October’s Open Science Champions are Teams Hardy, Hurley, and Strick 👏

They’ve maintained a near-perfect record of preprinting with a CC BY or CC0 license, advancing accessibility and collaboration across the research community.

#OpenScience
A blue background graphic featuring three research teams recognized as Open Science Champions by ASAP: Team Hardy and Team Hurley under PD Functional Genomics, and Team Strick under Circuitry and Brain-Body Interactions. Each team is represented by circular icons with illustrations of DNA strands and brain circuits in a blue background with the ASAP logo at the top.
October 27, 2025 at 3:07 PM
asapresearch.parkinsonsroadmap.org
CRN Team Hurley outputs with @jimhurley.bsky.social @mito911.bsky.social 🧪

⬅️ Identified a Mitophagic Stress Response (MitoSR) that supports mitochondrial quality. 🔗 bit.ly/4o3O4fD

➡️ Found that cells use autophagy to recycle damaged or unneeded material. 🔗 bit.ly/4hrGeKa
Rubicon inhibits lysosomal function and autophagosomal maturation. ATG2A Deficiency Alters PI3P Localization and Blocks Autophagosome Maturation.
October 24, 2025 at 5:11 PM
asapresearch.parkinsonsroadmap.org
GP2 is hiring a Project Manager!

Help lead global #Parkinsons genetics research, manage 15+ projects, and support diverse cohorts worldwide. PhD + PM experience preferred.

Mission-driven. Science-forward.

Apply now 👉 bit.ly/49dC32s
Graphic with a blue-to-green gradient background featuring the text “We’re Hiring” in large white letters. Below, it reads “Project Manager” in bold white font. A white-outlined box on the right says “Application Deadline: November 7, 2025.” The Global Parkinson’s Genetics Program (GP2) logo appears in the upper right corner.
October 23, 2025 at 2:41 PM
asapresearch.parkinsonsroadmap.org
New CRN Team Alessi outputs with @prosenjit.bsky.social

⬅️ New protein identified that may be a future drug target for PD.
#preprint 🔗 bit.ly/3W7KXH5

➡️ GBA1 mutations block a neuroprotective pathway by changing the lipid composition of primary cilia.
#publication 🔗 bit.ly/3W7LjgT
Comparisons of TMEM55B with the RBR E3 ligase RNF216. GBA1 Inhibition Decreases Ciliary Accessible Cholesterol and Hedgehog Signaling.
October 21, 2025 at 3:56 PM
asapresearch.parkinsonsroadmap.org
Open Access Week highlights the power of free, immediate access to research by ensuring science benefits all. Proud to join @parkinsondotorg.bsky.social, @parkinsons.org.uk, @cureparkinsons.org.uk, @alleninstitute.org, @dataseerai.bsky.social, @strategiesos.bsky.social, @orfg.bsky.social & others 🔓
A graphic titled “Open Access Week 2025 | An Invitation to Collaborate” appears against a gradient background of purple, blue, and teal. Below the title, the logos of 18 collaborating organizations are displayed in three rows: Top row (left to right): The Michael J. Fox Foundation for Parkinson’s Research Parkinson’s Foundation Parkinson’s UK Cure Parkinson’s Allen Institute Middle row (left to right): Catalyst Neuro DataSeer DataTecnica DNAstack Stratos Bottom row (left to right): Verily YLD AMP PD Open Research Funders Group Plan S
October 20, 2025 at 3:57 PM
asapresearch.parkinsonsroadmap.org
👏 Congrats to Monther Abu-Remaileh, PhD, of CRN Team Alessi, recipient of the 2026 Walter A. Shaw Young Investigator Award in Lipid Research, honoring his groundbreaking contributions to lipid biology!

🔗 bit.ly/3KzsOzz

@abu-remaileh.bsky.social
A headshot of Monther Abu-Remaileh, PhD, on a dark blue background with text reading “Monther Abu-Remaileh, PhD, Team Alessi.” The title says “CRN Member Wins 2026 Walter A. Shaw Young Investigator Award in Lipid Research,” and the CRN logo is present.
October 17, 2025 at 3:26 PM
asapresearch.parkinsonsroadmap.org
We are excited to welcome Huw Morris, MD, PhD, and Ed Jabbari, MBBS, PhD, from University College London as the October LRRK2 Central #webinar speakers.

👇 Reserve your spot using the link below.

📅 October 30, 2025
⏰ 1:00 PM ET
RSVP: bit.ly/47c5Ve9
October 16, 2025 at 3:51 PM
asapresearch.parkinsonsroadmap.org
🎉The LARGE-PD Annual Meeting brought together 76 researchers from 14 countries across Latin America and the Caribbean in Querétaro, Mexico, to exchange ideas, strengthen collaboration, and advance Parkinson’s research.

🔗 Check out the recap blog: bit.ly/3IzTmjy
Three people dressed in festive attire hold a Mexican flag during the 2025 LARGE-PD Annual Meeting in Querétaro, Mexico. The image has a green border, and the GP2 logo appears in the lower left corner.
October 15, 2025 at 5:04 PM
asapresearch.parkinsonsroadmap.org
GP2 just launched a new course: Return of Genetic Results!

Learn how to navigate genetic data, interpret findings, and understand their impact in #ParkinsonsDisease research 🧪

🔗 Create an account on our learning platform: bit.ly/4nJfarZ
👉 Access the course: bit.ly/46IASX9
Blue and green gradient background with white text reading "New Course on GP2's Learning Platform Return of Genetic Results," and the GP2 logo in the top right.
October 14, 2025 at 1:46 PM
asapresearch.parkinsonsroadmap.org
This month’s Discover ASAP features @rgast.bsky.social, PhD, of CRN Team Surmeier 🧪

He introduces PyRates, an open-source tool for generating code across languages to model complex biological systems. See how it advances computational neuroscience and #Parkinsons research.

📺 Watch: bit.ly/4h7Y5Wk
October 13, 2025 at 4:53 PM
asapresearch.parkinsonsroadmap.org
CRN Team Lee found that cellular vulnerability, independent from circuit connectivity, may be a significant factor in the spread of alpha-synuclein pathology.

🔗 Check out the full #publication to read more about their findings: bit.ly/4nV4ztR
Both soluble and insoluble fractions from ESL induce α-synucleinopathy in TgA53T mice.
October 10, 2025 at 3:15 PM
asapresearch.parkinsonsroadmap.org
Check out GP2 on last week’s episode of #TheGeneticsPodcast! Sonya Dumanis, PhD, and Andrew Singleton, PhD, share their transformative approach to #ParkinsonsDisease research and global collaboration 🧪

🎧 bit.ly/4mHbCFp
Screenshot from The Genetics Podcast featuring three speakers in a split-screen format. On the left, the person wearing a headset is Sonya Dumanis, PhD, Deputy Director of ASAP. In the center, Patrick Short, PhD, host of the podcast, is smiling with their hand resting near their chin. On the right, Andrew Singleton, PhD, GP2 Co-Lead, is smiling. Logos for The Genetics Podcast and Sano Genetics appear in the top corners. A red border surrounds the screenshot.
October 9, 2025 at 2:56 PM
asapresearch.parkinsonsroadmap.org
📣 New #publications from CRN Team Hurley!

➡️ Human transmembrane receptors initiate autophagosome biogenesis via ULK1 and WIPI–ATG13 complexes

🔗 bit.ly/47X259p

➡️ Neurons with pathogenic LRRK2 boost secretory autophagy and release exosomes for waste disposal and communication

🔗 bit.ly/45Mf1xx
NIX and BNIP3 initiate mitophagy through WIPI2 and WIPI3. Compensatory release of exosomes and SLAM-EVs.
October 8, 2025 at 4:11 PM
asapresearch.parkinsonsroadmap.org
GP2 is at the International Congress of Parkinson’s Disease and Movement Disorders® this week in Hawai’i!

Visit booth 8 in Exhibit Hall I to meet the team, check out our poster presentations tomorrow (10/8), and learn more about our global research progress.

🔗 Schedule: bit.ly/48Sqr4J
Four GP2 (Global Parkinson’s Genetics Program) team members pose behind an outreach booth at a conference. Two people are seated at a table covered in a light blue GP2 tablecloth, while two stand behind them smiling. The booth displays two tall banners, one on the left reading “Democratizing data” with text describing GP2’s effort to collect and genotype 150,000+ diverse Parkinson’s disease samples globally, and one on the right reading “Open science, global collaboration” with text about GP2’s commitment to understanding Parkinson’s genetics and sharing data securely. The table holds flyers, GP2-branded pens, and white stress balls designed like brains. A laptop and small sign with a QR code sit to the left.
October 7, 2025 at 4:12 PM
asapresearch.parkinsonsroadmap.org
📣 Don't miss out on the upcoming mito911 #webinar featuring Karin Reinisch, PhD, from the Yale School of Medicine.

👇 Reserve your spot using the link below.

📅 October 20
⏰ 11:00 AM ET
RSVP: bit.ly/4gPqCjo
October 6, 2025 at 3:52 PM
asapresearch.parkinsonsroadmap.org
GP2 is proud to be strongly represented at this year’s International Congress of Parkinson’s Disease and Movement Disorders®. Our global community will showcase 24 abstracts on innovation in #Parkinsons research and approaches.

In Hawai’i this week? Stop by and say hello!

@movedisorder.bsky.social
Graphic with a teal-to-green gradient background promoting GP2 at the 40th MDS Congress. At the top, large bold text reads: “Explore the latest from GP2 at the 40th MDS Congress.” Below, a blue box highlights the date: “Wednesday, October 8.” Underneath, a light blue panel lists names of presenters and groups in three columns: Column 1: Caroline Gabbert, Fulya Akçimen, GP2’s Data Analysis Working Group, Henry Mauricio Chaparro-Solano Column 2: Kajsa Atterling Brolin, Kamalini Ghosh Galvelis, Lara Lange, Manuela Tan, Maria Teresa Periñan, Miguel Martín-Bórnez Column 3: Mohamed H. Yousef, Naomi Louie, Paula Reyes-Pérez, Sara Bandres-Ciga, Spencer Grant
October 3, 2025 at 3:31 PM