Aligning Science Across Parkinson's
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's
@asapresearch.parkinsonsroadmap.org
1.2K followers 130 following 530 posts
Global initiative rooted in Collaboration and Open Science to accelerate Parkinson's disease research. Programs include GP2 and CRN.

https://parkinsonsroadmap.org/#
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asapresearch.parkinsonsroadmap.org
CRN Team Alessi found that PPM1H has an allosteric binding site for non-phosphorylated Rab8A and Rab10, and that non-phosphorylated Rab GTPases keep PPM1H on membranes so it can reach its phosphoRab targets.

✏️ @suzannepfeffer.bsky.social, PhD

🔗 Read the full #publication: bit.ly/4pKzx9q
A model for PPM1H membrane recruitment and allosteric regulation.
December 23, 2025 at 4:23 PM
asapresearch.parkinsonsroadmap.org
We’re proud to support the @parkinsondotorg.bsky.social PD GENEration study of 30,000+ participants, including nearly 10,000 this year 🧪

This growth is building a diverse PD genetics registry & expanding access to testing & counseling at no cost.

See more in our 2025 #AnnualReport: bit.ly/48OZtcw
Graphic with the headline “Expanding Genetic Insight” and subhead “Building one of the most diverse PD genetics registries,” set against a blue digital data background. Logos for Aligning Science Across Parkinson’s (ASAP) and the Parkinson’s Foundation appear at the bottom.
December 22, 2025 at 3:46 PM
asapresearch.parkinsonsroadmap.org
We’re working with the Michael J. Fox Foundation to shift the #Parkinson’s timeline 🔬

This year, PPMI lowered its screening age to 40 to assess early disease stages.

Learn more through our 2025 #AnnualReport: bit.ly/48OZtcw
A dark blue graphic with thin, glowing lines and soft circular light spots. Large white text reads, “Accelerating Early Detection.” Below it, smaller text says, “Advancing biomarkers and shifting the Parkinson’s timeline.” Along the bottom, the ASAP logo and “Aligning Science Across Parkinson’s” appear on the left, separated by a white “X” from The Michael J. Fox Foundation for Parkinson’s Research logo on the right.
December 19, 2025 at 3:54 PM
asapresearch.parkinsonsroadmap.org
Grounded in discovery, powered by open science 🧪

This year, we pushed #Parkinsons research forward with new mechanistic insights, expanded global genetics studies, and progress in biomarker discovery across our programs.

Explore the highlights in our 2025 #AnnualReport: bit.ly/48OZtcw
A graphic titled “Objective 1: Funnel new ideas into the Parkinson’s disease R&D pipeline.” The text below states: “Through CRN discoveries, GP2 genetics, and PPMI biomarker work, we deepened understanding of Parkinson’s biology and laid groundwork for future therapies.” The background shows a purple neural-network-inspired illustration. A graphic titled “Objective 2: Facilitate the rapid exchange of scientific ideas.” Supporting text reads: “We brought our network together through meetings, webinars, and conferences to share results, learn new methods, and spark collaborations across the globe.” The background contains a dark blue, abstract pattern of interconnected nodes. A graphic titled “Objective 3: Ensure ASAP-funded work can be leveraged by others.” Below, a description reads: “By openly sharing datasets, code, tools, and biosamples—and integrating them with leading platforms—we made it easier for researchers everywhere to build on ASAP-funded science.” The background features a blue abstract data visualization pattern. A graphic titled “Objective 4: Establish a strong, diverse, and global pipeline of Parkinson’s researchers.” The text explains: “We invested in training, mentoring, and dependent-care support so early-career scientists can thrive and lead the next wave of Parkinson’s discoveries.” The background includes a green, abstract neural-network design.
December 18, 2025 at 3:32 PM
asapresearch.parkinsonsroadmap.org
GP2's 5th Annual Investigators Meeting in Honolulu brought together 230 investigators from 52 countries. It was an energizing event of new discoveries, expanded tools and training, and a big milestone as GP2 reached 100,000 genotyped samples.

📺 Watch the full video: bit.ly/4s7beUT
GP2's Annual Investigators Meeting 2025
In October 2025, 230 investigators from 52 countries met in Honolulu for GP2’s 5th Annual Investigators Meeting. The event was full of energy, collaboration, and progress, including new GWAS discoveries, expanded data tools, training opportunities. It also marked an exciting milestone for the program as GP2 reached 100,000 genotyped samples. Take a look inside the event and the community powering GP2, and check out our recap blog: https://gp2.org/how-far-weve-come-and-the-journey-ahead-the-2025-gp2-annual-investigators-meeting/ Follow us on social media for updates: 🔗 LinkedIn: https://www.linkedin.com/company/asap-research 🔗 Bluesky: https://bsky.app/profile/asapresearch.parkinsonsroadmap.org #ParkinsonsDisease #ParkinsonsResearch
bit.ly
December 17, 2025 at 4:48 PM
asapresearch.parkinsonsroadmap.org
In a new publication, Team Harper found that α-synuclein fibrils cause ESCRT-III loss through “collateral degradation,” weakening endolysosomes and promoting further aggregation🔬

🔗 Read the full #publication: bit.ly/4iPUayj
α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
December 16, 2025 at 4:08 PM
asapresearch.parkinsonsroadmap.org
This month’s Discover ASAP features Madeline Klinger, PhD, with Leonardo Parra-Rivas, PhD, of CRN Team Gradinaru 🧬

They discuss a CRISPR-based protocol to precisely edit and visualize α-synuclein in neurons, advancing tools to study its role in #Parkinsons and beyond.

📺 : bit.ly/4iMyG5i
December 15, 2025 at 4:06 PM
asapresearch.parkinsonsroadmap.org
This fall, global leaders joined GP2 in Hawai’i for our Annual Investigators Meeting. We shared progress and set future directions in #ParkinsonsDisease research. We’re grateful for the collaboration and momentum! 🌍

🔗 bit.ly/4rUL3Ay
A wide group photo from the GP2 Annual Investigators Meeting showing attendees gathered in a large conference ballroom. The image is framed with the GP2-branded border, with the GP2 logo in the bottom left.
December 12, 2025 at 3:50 PM
asapresearch.parkinsonsroadmap.org
The ASAP website has a fresh, new look, making it easier for researchers to find what they need.

Check out the new site to see the updates, including our new homepage, improved highlights overview, and a dedicated tools & resources section!

🔗 bit.ly/3Mey2RX
December 11, 2025 at 5:17 PM
asapresearch.parkinsonsroadmap.org
Our 2025 #AnnualReport drops next week 🔬

We will highlight advances across #Parkinsons mechanisms, genetics, biomarkers, and open science, plus the global collaborations that made them possible.

Stay tuned for our 2025 Year in Review.
A dark-colored graphic with a glowing blue network of interconnected lines and nodes on the left, resembling a molecular structure. Large white text at the top reads “Grounded in Discovery.” On the right side, additional white text reads “2025 Year in Review” with “Coming Soon!” beneath it. The background is a deep navy with faint scattered light points.
December 10, 2025 at 9:25 PM
asapresearch.parkinsonsroadmap.org
GP2’s 11th Data Release just passed 100k genotyped samples!

🧪 See how GP2 is shaping the future of #ParkinsonsResearch at bit.ly/4paucYC
Graphic titled ‘GP2’s 11th Data Release: By the Numbers’ indicating that the dataset includes more than 100,000 genotyped participants from around the world. Graphic titled ‘GP2’s 11th Data Release: By the Numbers’ noting that the dataset includes 30,511 genotyped participants from ancestries historically underrepresented in genetic studies, representing about one-third of the total dataset. Graphic titled ‘GP2’s 11th Data Release: By the Numbers’ showing that the release features data generated from over 148 international cohorts, highlighting the program’s global scale. Graphic titled ‘GP2’s 11th Data Release: By the Numbers’ stating that the release contains whole genome sequencing (WGS) data from 38,226 sequenced participants.
December 9, 2025 at 4:32 PM
asapresearch.parkinsonsroadmap.org
👏 A huge milestone for the Parkinson’s Foundation: 30,000 participants enrolled in PD GENEration!

This groundbreaking study is expanding access to free genetic testing and building a diverse PD genetics registry.

🔗 Learn more: bit.ly/3JDbwRL

@parkinsondotorg.bsky.social
December 8, 2025 at 6:15 PM
asapresearch.parkinsonsroadmap.org
🔬New preprint from Team Rio! They released a study on 12 familial PD mutations, using midbrain dopaminergic neurons to map mutation-specific splicing changes. These patterns point to potential biomarkers and future therapeutic targets.

🔗 Read the full #preprint: bit.ly/48QeuMr
Platform for the medium-throughput genome-editing of human embryonic stem cells (hPSCs) carrying relevant familial Parkinson’s mutations and differentiation of these cells to midbrain lineage cells.
December 8, 2025 at 4:01 PM
asapresearch.parkinsonsroadmap.org
📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Michael Rape, PhD, from the University of California.

👇 Reserve your spot using the link below.

📅 December 11
⏰ 11:00 AM EST
RSVP: bit.ly/44jzLeP
December 5, 2025 at 4:02 PM
asapresearch.parkinsonsroadmap.org
CRN Team Chen analyzed multi-year data from 564 participants to study how α-syn SAA status affects progression. They saw a trend toward faster motor decline in α-syn SAA-positive LRRK2 PD, but no significant differences in sporadic PD.

🔗 Read the full #publication: bit.ly/4if1y65
A horizontal graphic with a white center panel that reads “New Publication from Team Chen” in bold, dark teal text. A gradient border in green, blue, and purple surrounds the graphic, and the ASAP logo appears in the bottom right corner.
December 4, 2025 at 3:57 PM
asapresearch.parkinsonsroadmap.org
🧬 CRN Team De Camilli found that BLTP3A/UHRF1BP1 binds VAMP7 vesicles to lysosomes and activates the CASM pathway after lysosome damage. This drives mATG8 recruitment and helps restore lysosome integrity.

🔗 Check out the full #publication to read more about their findings: bit.ly/4o27nF0
Activation of CASM recruits BLTP3A to the surface of damaged lysosomes through an interaction with mATG8 proteins.
December 3, 2025 at 4:14 PM
asapresearch.parkinsonsroadmap.org
“For the first time, we have the power to answer questions that we could not address.”

Thanks to 100k+ genotyped samples, the Global Parkinson's Genetics Program is accelerating discovery toward targeted #Parkinsons therapies.

🧪 bit.ly/4pCpSkI
GP2 leader Andy Singleton speaks on camera against a blue-to-green gradient background with the GP2 Data Resources logo. Text on screen reads '11th Data Release," with a play-button icon.
December 2, 2025 at 4:32 PM
asapresearch.parkinsonsroadmap.org
GP2 just hit a major milestone 🎉

The 11th data release includes more than 100k samples from people around the world, including a strong share from underrepresented populations. This scale is helping researchers reveal more than 50 new genetic risk factors.

Read the blog: bit.ly/4rjqhdu
GP2 Data Resources logo featuring a DNA helix wrapped around a globe, surrounded by the text "Transforming Global Data Into Discovery"
December 1, 2025 at 4:01 PM
asapresearch.parkinsonsroadmap.org
This Thanksgiving, we’re thankful for the scientists, researchers, and advocates driving progress in Parkinson’s research. 🍂🦃

Each idea tested, discovery shared, and partnership formed moves us closer to a future transformed by science.

Thank you for advancing understanding and hope.
A collage of moments from ASAP events, including the CRN Meeting, GP2 Hackathon, GP2 Ghana Meeting, and the International Congress. Participants work together around laptops, and a small group stands for a photo. A collage of moments from ASAP events, including the CRN Meeting, GP2 Hackathon, GP2 Ghana Meeting, and the International Congress. Participants work together around laptops, and a small group stands for a photo. A collage of moments from ASAP events, including the CRN Meeting, GP2 Hackathon, GP2 Ghana Meeting, and the International Congress. Participants work together around laptops, and a small group stands for a photo. A collage of moments from ASAP events, including the CRN Meeting, GP2 Hackathon, GP2 Ghana Meeting, and the International Congress. Participants work together around laptops, and a small group stands for a photo.
November 27, 2025 at 2:41 PM
asapresearch.parkinsonsroadmap.org
New #publication and #preprint from @jakobssonasap.bsky.social!

⬅️ L1 retrotransposons in stem cells & organoids link L1s to CNS development 🔗 bit.ly/3XyLvGz

➡️ Transposable elements activate in the #Parkinsons brain, tied to interferon responses & a new pathological process 🔗 bit.ly/3LKC5Fo
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development. Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson’s disease.
November 26, 2025 at 3:36 PM
asapresearch.parkinsonsroadmap.org
CRN Team Cragg gathered in Oxford this fall for a two-day sprint of ideas, data, & cross-lab creativity.

They dug into emerging findings, tested new approaches, and mapped out next steps to push their work forward.

Here’s to more collaboration, more curiosity, & more discoveries on the horizon 📚
A large group of about 30 symposium attendees stands together in a library-style room with tall bookshelves lining the walls. They are posed in several rows, smiling toward the camera. Behind them, a projection screen displays a video call grid with additional participants joining virtually. The group includes a diverse mix of students, researchers, and collaborators, many wearing conference name badges. The setting is bright and academic, reflecting a collaborative gathering for the CRN Team Cragg Symposium.
November 25, 2025 at 3:59 PM
asapresearch.parkinsonsroadmap.org
📢 New #publication from CRN Team Wichmann!

Simulations using NEURON/NetPyNE showed that decreased PT5B neuron excitability increased beta-band power (~15 Hz) in the M1 network, revealing how small neuronal changes can amplify Parkinson's-related oscillations.

🔗 Read more: bit.ly/4omkIZj
Parkinsonian condition, simulated primary motor cortex (M1) activity, comparing resting state to movement state.
November 24, 2025 at 4:14 PM
asapresearch.parkinsonsroadmap.org
📣 Check out these new #publications from CRN Team Edwards!

⬅️ Developed a chemogenetic (DREADD) mouse model to increase dopamine neuron activity.
🔗 bit.ly/3XlA44T

➡️ Dopamine therapy, while easing motor symptoms in #Parkinsons, can trigger impulse control disorder (ICD).
🔗 bit.ly/3LyplBO
Chronic activation with AAV-hM3Dq-DREADDs is preferentially toxic to nigrostriatal axons. Pramipexole triggers bidirectional changes in striatal activity in parkinsonian mice.
November 21, 2025 at 4:39 PM
asapresearch.parkinsonsroadmap.org
🔬 November’s #OpenScience Champion is Chuyu Chen, PhD (Team Awatramani)!

She shared 4 image datasets from her recent preprint on the BioImage Archive, including confocal & 3D-SIM microscopy images, broadening access and collaboration across the CRN.

🔗 Read the full #preprint: bit.ly/3Lzu5Hd
A headshot of Chuyu Chen, PhD on a light blue background with dark blue text reading “Chuyu Chen, PhD, Team Awatramani.” The "Open Science Champion" badge and ASAP logo are also present.
November 20, 2025 at 3:59 PM
asapresearch.parkinsonsroadmap.org
🧠 CRN Team Sulzer used RNAseq, spatial transcriptomics, and T cell receptor (TCR) sequencing to analyze T cell and glial cell states in post-mortem #Parkinsons brain tissue.

🔗 Check out the full #publication to read more about their findings: bit.ly/498amYW
Single-nucleus RNA sequencing reports differences in gene expression patterns of PD lineages and identifies a PD T cell signature.
November 19, 2025 at 3:58 PM