Alushin Lab
@alushinlab.bsky.social
Alushin lab at Rockefeller University. Interested in cryo-EM, the cytoskeleton, and mechanosensation at the molecular level.
This mediates the formation of cooperative cadherin-catenin complex clusters along individual actin filament strands, which are associated with filament curvature. It will be interesting to see if similar assemblies form in cell-cell adhesions where forces are large, e.g. tricellular junctions.
February 18, 2025 at 3:37 AM
This mediates the formation of cooperative cadherin-catenin complex clusters along individual actin filament strands, which are associated with filament curvature. It will be interesting to see if similar assemblies form in cell-cell adhesions where forces are large, e.g. tricellular junctions.
After revision in response to very constructive reviewer comments, the paper features additional evidence that zyxin and other LIM proteins form force-dependent assemblies which lack underlying F-actin. Figuring out how these come together is the next frontier.
February 13, 2025 at 4:15 PM
After revision in response to very constructive reviewer comments, the paper features additional evidence that zyxin and other LIM proteins form force-dependent assemblies which lack underlying F-actin. Figuring out how these come together is the next frontier.