Jon Humphries
@jdhl18.bsky.social
Cell Biologist. Manchester Metropolitan University.
Cell-ECM adhesion and proteomics, often in the context of cancer.
Google Scholar: https://scholar.google.com/citations?user=h9DWslsAAAAJ&hl=en
Orcid: https://orcid.org/0000-0002-8953-7079
Cell-ECM adhesion and proteomics, often in the context of cancer.
Google Scholar: https://scholar.google.com/citations?user=h9DWslsAAAAJ&hl=en
Orcid: https://orcid.org/0000-0002-8953-7079
Pinned
Jon Humphries
@jdhl18.bsky.social
· Oct 14
Just flagging up this conference that I'm helping with.
There will be fantastic speakers in sessions covering Melanoma evolution, microenvironment, host cell interactions, precision immunotherapy, emerging therapeutics and clinical trials / real-world data.
Scan the QR code for full details.
There will be fantastic speakers in sessions covering Melanoma evolution, microenvironment, host cell interactions, precision immunotherapy, emerging therapeutics and clinical trials / real-world data.
Scan the QR code for full details.
Spatial-proteomics reveals recombinant human laminin-111 restores adhesion-signaling to laminin-α2 deficient muscle
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
JCI Insight -
Spatial-proteomics reveals recombinant human laminin-111 restores adhesion-signaling to laminin-α2 deficient muscle
insight.jci.org
November 9, 2025 at 12:45 PM
Spatial-proteomics reveals recombinant human laminin-111 restores adhesion-signaling to laminin-α2 deficient muscle
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer - Cell Death Discovery
Cell Death Discovery - FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer
www.nature.com
November 9, 2025 at 12:41 PM
FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
from abstract: 'Degrading cell-surface αv integrins, rather than merely blocking their interactions with the extracellular matrix (ECM), produces a stronger anti-proliferative effect by more robustly modulating oncogenic signaling pathways.'
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
Integrins play a critical role in signaling events that regulate cell adhesion, migration, and proliferation, processes that, when dysregulated, contribute to cancer progression. Recently, innovati...
www.tandfonline.com
November 9, 2025 at 12:37 PM
from abstract: 'Degrading cell-surface αv integrins, rather than merely blocking their interactions with the extracellular matrix (ECM), produces a stronger anti-proliferative effect by more robustly modulating oncogenic signaling pathways.'
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
Integrins play a critical role in signaling events that regulate cell adhesion, migration, and proliferation, processes that, when dysregulated, contribute to cancer progression. Recently, innovati...
www.tandfonline.com
November 9, 2025 at 12:36 PM
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Ligand and integrin-independent mechano-sensitive EGFR activation in lung cancer cells
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Ligand and integrin-independent mechano-sensitive EGFR activation in lung cancer cells
Epidermal Growth Factor Receptor (EGFR) is a transmembrane receptor tyrosine kinase that plays important roles in cell proliferation, differentiation, and migration. EGFR overexpression or mutation is...
journals.biologists.com
November 9, 2025 at 12:33 PM
Ligand and integrin-independent mechano-sensitive EGFR activation in lung cancer cells
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition - Oncogene
Oncogene - A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition
www.nature.com
November 9, 2025 at 12:27 PM
A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulat...
advanced.onlinelibrary.wiley.com
November 9, 2025 at 12:21 PM
The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Very pleased to see this published and to have played a (minor) role. Congrats to all authors and in particular corresponding author Prof Tris McKay @manmetuni.bsky.social
CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival - Cell Death & Disease
Cell Death & Disease - CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival
www.nature.com
November 6, 2025 at 2:59 PM
Very pleased to see this published and to have played a (minor) role. Congrats to all authors and in particular corresponding author Prof Tris McKay @manmetuni.bsky.social
CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival - Cell Death & Disease
Cell Death & Disease - CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival
www.nature.com
November 6, 2025 at 2:50 PM
CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mechanochemical waves in focal adhesions during cell migration
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Mechanochemical waves in focal adhesions during cell migration
Traction force and FAK signaling exhibit oscillatory temporal coupling in adhesive structures.
www.science.org
November 3, 2025 at 11:56 AM
Mechanochemical waves in focal adhesions during cell migration
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Piezo1 regulates the mechanotransduction of soft matrix viscoelasticity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Piezo1 regulates the mechanotransduction of soft matrix viscoelasticity - Nature Communications
Matrix viscoelasticity regulates cell behavior in a stiffness-dependent manner. Here, the authors reveal that the mechanosensitive channel Piezo1 transduces soft matrix viscoelastic cues, through a co...
www.nature.com
November 3, 2025 at 11:55 AM
Piezo1 regulates the mechanotransduction of soft matrix viscoelasticity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Drak is a potential mechanotransduction partner of Filamin
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Drak is a potential mechanotransduction partner of Filamin
Mechanosensing involves proteins detecting mechanical changes in the cytoskeleton or at cell adhesion sites. These interactions initiate signaling cascades that produce biochemical effects such as pos...
www.biorxiv.org
November 3, 2025 at 11:52 AM
Drak is a potential mechanotransduction partner of Filamin
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Spatial Regulation of Endocytosis and Adhesion Formation Governs Breast Cancer Cell Migration Under Confinement
www.mdpi.com/2306-5354/12...
www.mdpi.com/2306-5354/12...
www.mdpi.com
November 3, 2025 at 11:36 AM
Spatial Regulation of Endocytosis and Adhesion Formation Governs Breast Cancer Cell Migration Under Confinement
www.mdpi.com/2306-5354/12...
www.mdpi.com/2306-5354/12...
Extracellular matrix-driven metabolic control of pancreatic endocrine lineage allocation
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Extracellular matrix-driven metabolic control of pancreatic endocrine lineage allocation | EMBO reports
imageimageThe extracellular matrix component laminin-411 drives endocrine fate choice during
pancreas development by linking mechanical and metabolic signaling. PDK4 plays a critical
role, controlling...
www.embopress.org
November 3, 2025 at 11:32 AM
Extracellular matrix-driven metabolic control of pancreatic endocrine lineage allocation
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Jon Humphries
Sex, drugs and the conscious brain: Francis Crick beyond the double helix
paging @matthewcobb.bsky.social
www.nature.com/articles/d41...
paging @matthewcobb.bsky.social
www.nature.com/articles/d41...
Sex, drugs and the conscious brain: Francis Crick beyond the double helix
A thoroughly researched account of the history and relationships that shaped the scientist who co-discovered the structure of DNA.
www.nature.com
November 3, 2025 at 10:47 AM
Sex, drugs and the conscious brain: Francis Crick beyond the double helix
paging @matthewcobb.bsky.social
www.nature.com/articles/d41...
paging @matthewcobb.bsky.social
www.nature.com/articles/d41...
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels - Nature Biotechnology
Epithelial organoids are grown without Matrigel using a single-chain antibody.
www.nature.com
November 3, 2025 at 11:15 AM
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Strained Actin Binding by the Prickle2 LIM Domains and their Regulation in the Full-Length Protein
www.molbiolcell.org/doi/abs/10.1...
www.molbiolcell.org/doi/abs/10.1...
Strained Actin Binding by the Prickle2 LIM Domains and their Regulation in the Full-Length Protein | Molecular Biology of the Cell
Cells sense mechanical changes in their cytoskeletal network via force-sensing actin-binding proteins. Recently, a novel force-sensing mechanism was described whereby LIM domains from diverse protein ...
www.molbiolcell.org
November 3, 2025 at 11:13 AM
Strained Actin Binding by the Prickle2 LIM Domains and their Regulation in the Full-Length Protein
www.molbiolcell.org/doi/abs/10.1...
www.molbiolcell.org/doi/abs/10.1...
John Gurdon obituary: Biologist who made cloning possible
www.nature.com/articles/d41...
www.nature.com/articles/d41...
John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
www.nature.com
November 3, 2025 at 8:53 AM
John Gurdon obituary: Biologist who made cloning possible
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Jon Humphries
ZO-1,cell-cell and cell-matrix interactions...
Cell-cell junction proteins like ZO-1 not only play a critical role in the mechanical interaction between cells, but also participate in the biochemical signalling to coordinate the cell sheet. Check out this review on collective cell migration here to learn more: doi.org/10.1016/j.cd...
October 25, 2025 at 4:54 PM
ZO-1,cell-cell and cell-matrix interactions...
Reposted by Jon Humphries
The ECM is no longer in the back seat when it comes to development. Check out our special issue "Dynamics of the extracellular matrix in development, cell physiology and disease" with 8 selected articles to learn more: A 🧵 www.sciencedirect.com/special-issu...
Cells & Development | Dynamics of the extracellular matrix in development, cell physiology and disease. | ScienceDirect.com by Elsevier
Extracellular matrices (ECMs) are everywhere in our body– from the sheet-like basement membranes that line epithelia and other tissues - to the loose stromal arrays of mesenchyme - to the rigid struct...
www.sciencedirect.com
October 30, 2025 at 5:48 PM
The ECM is no longer in the back seat when it comes to development. Check out our special issue "Dynamics of the extracellular matrix in development, cell physiology and disease" with 8 selected articles to learn more: A 🧵 www.sciencedirect.com/special-issu...
Reposted by Jon Humphries
Register for the Dynamic Cell VI conference, Reading, UK, April 2026! This conference focusses on all aspects of cell dynamics, co-organised by @bscb-official.bsky.social and @biochemsoc.bsky.social with @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology.
bit.ly/Dynamic-Cell-VI
bit.ly/Dynamic-Cell-VI
October 10, 2025 at 2:24 PM
Register for the Dynamic Cell VI conference, Reading, UK, April 2026! This conference focusses on all aspects of cell dynamics, co-organised by @bscb-official.bsky.social and @biochemsoc.bsky.social with @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology.
bit.ly/Dynamic-Cell-VI
bit.ly/Dynamic-Cell-VI
Reposted by Jon Humphries
Get out your calendars! The motors are out of quarantine and we plan to assemble in person on 8th May 2026 at University of Warwick Campus for a fun day on motors and the filaments they walk along. Livestream is planned too. More details on registration, travel bursaries etc. will be revealed soon.
October 30, 2025 at 2:18 PM
Get out your calendars! The motors are out of quarantine and we plan to assemble in person on 8th May 2026 at University of Warwick Campus for a fun day on motors and the filaments they walk along. Livestream is planned too. More details on registration, travel bursaries etc. will be revealed soon.
Reposted by Jon Humphries
“The bad review will come from your list of suggested reviewers”
October 31, 2025 at 7:39 AM
“The bad review will come from your list of suggested reviewers”
Reposted by Jon Humphries
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)