Boris Sieber
@borissieber.bsky.social
Postdoc @SophieMartinLab.bsky.social studying #GPCR and #MAPK signalling in fission yeast. Alumnus of @mjafreeman.bsky.social and @jordanraff.bsky.social
Pinned
Boris Sieber
@borissieber.bsky.social
· Sep 25
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Reposted by Boris Sieber
New must-read review article for all lovers of #centrioles and #centrosomes 😍👇
November 28, 2025 at 3:01 PM
New must-read review article for all lovers of #centrioles and #centrosomes 😍👇
Reposted by Boris Sieber
2/2 If you’re into #cellbio, cellular interfaces, #mechanobiology, #membranes, anything related, come to Münster, Germany, May 27–29!
www.uni-muenster.de/SFB1348/en/i...
Please spread the word. It’s a fantastic (and FREE!) meeting. And while you’re here, explore Münster… it’s worth it.
#Science
www.uni-muenster.de/SFB1348/en/i...
Please spread the word. It’s a fantastic (and FREE!) meeting. And while you’re here, explore Münster… it’s worth it.
#Science
November 28, 2025 at 8:34 AM
2/2 If you’re into #cellbio, cellular interfaces, #mechanobiology, #membranes, anything related, come to Münster, Germany, May 27–29!
www.uni-muenster.de/SFB1348/en/i...
Please spread the word. It’s a fantastic (and FREE!) meeting. And while you’re here, explore Münster… it’s worth it.
#Science
www.uni-muenster.de/SFB1348/en/i...
Please spread the word. It’s a fantastic (and FREE!) meeting. And while you’re here, explore Münster… it’s worth it.
#Science
Reposted by Boris Sieber
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
November 27, 2025 at 2:14 PM
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
Reposted by Boris Sieber
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
November 25, 2025 at 8:41 PM
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
Reposted by Boris Sieber
Exposing hydrophilic residues pushes misfolded ER proteins towards degradation. 🗑️
Ana Sanchez-Molina: “…this study reshapes our understanding of protein quality control…” #preprint from Rudolf Pisa & Tom A. Rapoport #HarvardMed
#preLight ⬇️ 👀
prelights.biologists.com/highlights/l...
Ana Sanchez-Molina: “…this study reshapes our understanding of protein quality control…” #preprint from Rudolf Pisa & Tom A. Rapoport #HarvardMed
#preLight ⬇️ 👀
prelights.biologists.com/highlights/l...
Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation - preLights
Exposing hydrophilic residues pushes misfolded ER proteins towards degradation.
prelights.biologists.com
November 25, 2025 at 10:20 AM
Exposing hydrophilic residues pushes misfolded ER proteins towards degradation. 🗑️
Ana Sanchez-Molina: “…this study reshapes our understanding of protein quality control…” #preprint from Rudolf Pisa & Tom A. Rapoport #HarvardMed
#preLight ⬇️ 👀
prelights.biologists.com/highlights/l...
Ana Sanchez-Molina: “…this study reshapes our understanding of protein quality control…” #preprint from Rudolf Pisa & Tom A. Rapoport #HarvardMed
#preLight ⬇️ 👀
prelights.biologists.com/highlights/l...
Reposted by Boris Sieber
In our new #Preprint, we pilot a revolutionary new idea: no supplemental data (it has 21 figures, though):
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
www.biorxiv.org/content/10.1...
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
www.biorxiv.org/content/10.1...
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
We have previously shown that the calcium sensing receptor (CaSR) activates different G proteins and second messengers in single cells, and that GPCR and G protein-mediated ERK activity can be highly ...
www.biorxiv.org
November 24, 2025 at 8:29 AM
In our new #Preprint, we pilot a revolutionary new idea: no supplemental data (it has 21 figures, though):
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
www.biorxiv.org/content/10.1...
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
www.biorxiv.org/content/10.1...
Reposted by Boris Sieber
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
November 23, 2025 at 11:18 PM
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
Reposted by Boris Sieber
interesting work revealing differences between evolutionary distant actins!
"..... ADP-actin filaments depolymerize faster and are mechanically more flexible in Saccharomyces cerevisiae compared to Schizosaccharomyces pombe. "
www.biorxiv.org/content/10.1...
"..... ADP-actin filaments depolymerize faster and are mechanically more flexible in Saccharomyces cerevisiae compared to Schizosaccharomyces pombe. "
www.biorxiv.org/content/10.1...
Rapid aging and disassembly of actin filaments from two evolutionary distant yeasts
Actin is an essential cytoskeletal protein that is extremely well conserved across the tree of life. Similarities and differences in the way actin from different species self-assembles into filaments ...
www.biorxiv.org
November 22, 2025 at 1:31 PM
interesting work revealing differences between evolutionary distant actins!
"..... ADP-actin filaments depolymerize faster and are mechanically more flexible in Saccharomyces cerevisiae compared to Schizosaccharomyces pombe. "
www.biorxiv.org/content/10.1...
"..... ADP-actin filaments depolymerize faster and are mechanically more flexible in Saccharomyces cerevisiae compared to Schizosaccharomyces pombe. "
www.biorxiv.org/content/10.1...
Reposted by Boris Sieber
“after becoming aware of just how wrong [it] can be, [AI workers] have begun urging friends not to use generative AI at all [and] encourage them to ask AI about something they are very knowledgable in so they can understand how fallible the tech is.” 1/2 www.theguardian.com/technology/2...
Meet the AI workers who tell their friends and family to stay away from AI
When the people making AI seem trustworthy are the ones who trust it the least, it shows that incentives for speed are overtaking safety, experts say
www.theguardian.com
November 22, 2025 at 5:54 PM
“after becoming aware of just how wrong [it] can be, [AI workers] have begun urging friends not to use generative AI at all [and] encourage them to ask AI about something they are very knowledgable in so they can understand how fallible the tech is.” 1/2 www.theguardian.com/technology/2...
Reposted by Boris Sieber
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
November 20, 2025 at 11:42 AM
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
Reposted by Boris Sieber
Is it a flagellate? A tiny ball with tentacles? Contamination in my ciliate culture? NEW SUPERGROUP OF EUKARYOTES? Yes to all 4! Meet Solarion - just out in #Nature doi.org/10.1038/s415... Huge congrats to Marek Valt, Cepicka Lab & the star team! Very happy to be part of this project. #ProtistsOnSky
November 19, 2025 at 9:39 PM
Is it a flagellate? A tiny ball with tentacles? Contamination in my ciliate culture? NEW SUPERGROUP OF EUKARYOTES? Yes to all 4! Meet Solarion - just out in #Nature doi.org/10.1038/s415... Huge congrats to Marek Valt, Cepicka Lab & the star team! Very happy to be part of this project. #ProtistsOnSky
Reposted by Boris Sieber
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 4:15 PM
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
Reposted by Boris Sieber
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Reposted by Boris Sieber
Our work on Naegleria Myosin 2 is out!
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage
Myosin 2-dependent actin contractility—the force that powers cell division and migration
in animals, fungi, and other Amorphea—had been previously unknown outside this single
eukaryotic group. Guest e...
www.cell.com
November 17, 2025 at 5:19 PM
Our work on Naegleria Myosin 2 is out!
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Reposted by Boris Sieber
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 14, 2025 at 10:35 AM
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Reposted by Boris Sieber
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 13, 2025 at 4:20 PM
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Boris Sieber
MPI–Weizmann Postdoc (4-year, co-mentored)
Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using cryo-EM of recombinant proteins, and cell imaging/CLEM. Apply here by 21.11.25 forms.gle/ZtDWUjcTBu4d...
Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using cryo-EM of recombinant proteins, and cell imaging/CLEM. Apply here by 21.11.25 forms.gle/ZtDWUjcTBu4d...
MPI-WIS postdoc application
Max-Planck–Weizmann Postdoc (4-year, co-mentored)
Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using recombinant pr...
forms.gle
November 13, 2025 at 4:31 PM
MPI–Weizmann Postdoc (4-year, co-mentored)
Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using cryo-EM of recombinant proteins, and cell imaging/CLEM. Apply here by 21.11.25 forms.gle/ZtDWUjcTBu4d...
Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using cryo-EM of recombinant proteins, and cell imaging/CLEM. Apply here by 21.11.25 forms.gle/ZtDWUjcTBu4d...
Reposted by Boris Sieber
November 13, 2025 at 7:23 PM
Reposted by Boris Sieber
We are looking for a PhD student to work on an exciting plastid endosymbiosis in microbial eukaryotes. This position involves sampling, exciting microscopy such as CARDFISH, ExM and FIBSEM, single-cell transcriptomics and more. #protistsonsky 1/2
November 12, 2025 at 9:50 AM
We are looking for a PhD student to work on an exciting plastid endosymbiosis in microbial eukaryotes. This position involves sampling, exciting microscopy such as CARDFISH, ExM and FIBSEM, single-cell transcriptomics and more. #protistsonsky 1/2
Reposted by Boris Sieber
1/6
PhD /PostDoc positions available. Exploration of physiological functions of the cell fusogen Fusexin1 in Archaea.
In a collaborative project between the Albers lab (Freiburg) and the Podbilewicz lab (Technion) starting in January 2026.
PhD /PostDoc positions available. Exploration of physiological functions of the cell fusogen Fusexin1 in Archaea.
In a collaborative project between the Albers lab (Freiburg) and the Podbilewicz lab (Technion) starting in January 2026.
November 12, 2025 at 7:53 AM
1/6
PhD /PostDoc positions available. Exploration of physiological functions of the cell fusogen Fusexin1 in Archaea.
In a collaborative project between the Albers lab (Freiburg) and the Podbilewicz lab (Technion) starting in January 2026.
PhD /PostDoc positions available. Exploration of physiological functions of the cell fusogen Fusexin1 in Archaea.
In a collaborative project between the Albers lab (Freiburg) and the Podbilewicz lab (Technion) starting in January 2026.
Reposted by Boris Sieber
Switzerland is joining Horizon Europe!
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
November 10, 2025 at 2:58 PM
Switzerland is joining Horizon Europe!
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
Reposted by Boris Sieber
Yanyan Li, Hongchang Li al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the plasma membrane, thereby promoting #myosin I–dependent membrane-to-cortex adhesion required for mitotic cell rounding rupress.org/jcb/article/...
#Mitosis #CellDivision #Genetics
#Mitosis #CellDivision #Genetics
November 10, 2025 at 5:02 PM
Yanyan Li, Hongchang Li al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the plasma membrane, thereby promoting #myosin I–dependent membrane-to-cortex adhesion required for mitotic cell rounding rupress.org/jcb/article/...
#Mitosis #CellDivision #Genetics
#Mitosis #CellDivision #Genetics
Reposted by Boris Sieber
Great career opportunity at @viennabiocenter.bsky.social: The @impvienna.bsky.social is looking for a new Junior Group Leader in cell and molecular biology, synthetic biology, genomics, gene regulation, development, cancer, immunology or infection biology.
More: www.imp.ac.at/career/open-...
More: www.imp.ac.at/career/open-...
Junior Group Leader Positions | Research Institute of Molecular Pathology
www.imp.ac.at
November 10, 2025 at 10:49 AM
Great career opportunity at @viennabiocenter.bsky.social: The @impvienna.bsky.social is looking for a new Junior Group Leader in cell and molecular biology, synthetic biology, genomics, gene regulation, development, cancer, immunology or infection biology.
More: www.imp.ac.at/career/open-...
More: www.imp.ac.at/career/open-...
Reposted by Boris Sieber
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
November 9, 2025 at 5:20 PM
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
Reposted by Boris Sieber
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X
October 30, 2025 at 11:44 AM
If you use PomBase, please help us to demonstrate our value, and make improvements by completing our user survey www.surveymonkey.com/r/7GXJL6X